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Special medical
research issue
Medical Research
in the UK
Predicting a heart attack
Can antibiotics prevent
cardiac arrhythmias?
Future treatments with
stem cells
Childrens Rehabilitation
Special people
Family Hearts first
UK-wide events
Helping Hearts near you
MEDICALRESEARCH
in the UK
Thanks to the supporters who make medical research their
number one charitable cause, UK charities spend 1.3billion
a year on research. Thats over a third of all publicly funded
UK medical research, at 364 institutes, universities and NHS
facilities across the UK.
Medical research
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UK age
HR e P
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www.heartresearch.org.uk
NEWGRANTS
Translational Research (TRP) Grants
Heart Research UK has awarded 724,731 to six Translational Research Project Grants that aim to
bridge the gap between scientific research and patient care, bringing about clinical benefits in the
most efficient way.
All grant applications are rigorously assessed by leading scientific and medical experts across the world
to ensure that we award funding to the very best research projects. The first four grants demonstrate
how we invest in projects that could change current practice. The last two, involving stem cells, show
how the future could see new, pioneering ways of preventing and treating heart disease.
The Problem
Giving extra oxygen to patients with chest pain has been standard teaching practice in medical schools
for over 100 years. However, there is some evidence that increasing the oxygen level in the blood above
the normal level has harmful effects and may unexpectedly reduce the blood supply to heart muscle. It
is not entirely clear how this happens but research suggests this could be due to increased resistance in
the very small blood vessels of the heart.
The Project
Using magnetic resonance imaging (MRI) the project aims to show the effects of breathing high flow
oxygen on the blood supply to the heart muscle. MRI is a non-invasive way of measuring the blood flow
to the heart muscle and can also be used to assess the oxygen level in the heart tissues. Pilot work has
shown that breathing high flow oxygen reduced the blood flow to the heart muscle by up to 18 per cent
in patients with severe coronary artery disease and 15 per cent in healthy volunteers.
The Benefits
If the findings show that using high flow extra oxygen actually reduces the blood supply to the heart,
rather than increase it as one might expect, then it could radically alter the care given to patients with
chest pain.
www.heartresearch.org.uk/grants
Research Grants
Research Grants
Dr Georgina Ellison
Kings College London / 113,260 24 months
Studying the effects of new cancer drugs on
cardiac stem cells
The Problem
It has been discovered that, in the adult human
heart, there are groups of stem cells the master
cells capable of multiplying and developing into
new mature cells and can also help the recovery
of injured cells. In the heart this is essential, as
heart muscle cells are crucially important and
cannot replace themselves.
The Project
This project will examine the effects of a group
of new drugs on the stem cells present in the
adult heart. These drugs, called tyrosine kinase
inhibitors (Trk-Is), have recently been developed
to treat certain types of cancer. Although they
are effective, several have been shown to have
toxic effects on the heart but the cause of these
problems is not known. The researchers suspect
the drugs may be killing or damaging the cardiac
stem cells and will study the effects of Trk-I cancer
drugs on cardiac stem cells grown in the lab.
The Benefits
In the future, this research may pave the way for
the development of new treatments which prevent
toxic effects of Trk-I cancer drugs on the heart.
The work will also shed further light on the biology
of cardiac stem cells and may help scientists to
find ways of manipulating biochemical pathways
to increase the abilities of the cardiac stem cells
to repair cells and tissue, which may lead to better
treatments for heart failure.
Dr Enca Martin-Rendon
University of Oxford / 148,006 24 months
Developing a genetic test to improve
the success of stem cell treatment for
heart disease
The Problem
New treatments aimed at improving blood vessel
growth and maintain a well-working heart using
stem cells from bone marrow, blood and the heart
have been developed but trials with patients have
shown mixed results and not all patients benefit
from the treatment.
The Project
This research team has been developing new
treatments using stem cells isolated from the
patients own heart which will improve the blood
supply to the damaged tissue. In this project
they will use advanced genetic techniques that
can give information about the genetic makeup of these patients heart stem cells and can
distinguish those which can support blood vessel
formation from those which cannot.
The Benefits
The aim of the project is to develop a genetic
test that will predict and improve the success
of heart stem cell transplantation. In this new
era, regenerative medicine has great potential.
However, selection of the right patients for
the right treatment is crucial to ensure more
successful and cost-effective treatments.
The Problem
Diffusion tensor MRI can be used in the heart
to provide information on the arrangement of
muscle cells, which could provide earlier diagnosis
and new insights into the many diseases affecting
the heart. However, due to the movement of
the heart when it beats and as people breathe,
diffusion tensor MRI in the heart is difficult.
The Problem
In certain heart patients, cardiac
resynchronisation therapy (CRT) with a particular
type of pacemaker can improve the pumping
function of the heart by synchronising the beating
of the ventricles.Unfortunately, up to a third of
patients who receive these devices do
not improve.
The Project
In this project, diffusion tensor and spiral MRI
techniques will be combined to produce a
technique which will give greater detail and
provide reliable and accurate information on the
microscopic structure of the heart muscle, for
example, in cases of thinned heart muscle after a
heart attack.
The Project
This research team has developed a new way of
delivering the resynchronising pacemaker wire
through a different route, passing it directly from
the easily accessible right ventricle to the inside of
the left ventricle through the septum, the muscle
wall that divides the two. There is evidence
that this can achieve better pumping than the
conventional technique.
The Benefits
The development of an advanced MRI technique
that can provide information relating to the cell
structure in thin heart muscle tissue, which is a
feature of many heart diseases. This technique
may provide earlier diagnosis, new information on
how diseases affect the heart and novel insights
into treatments.
8
Research Grants
The Benefits
This new technique has the potential to improve
the outcomes for patients with severe heart
failure who have few other effective treatment
options and it may benefit greater numbers of
patients compared with conventional CRT.
Heart Research UK has always been proud to encourage researchers of the future and our
latest venture gave 30,000 to fund two second-year University of Leeds students on the first
rung of the research ladder.
The two EXSEL programme scholarships allow the students to research aspects of medicine that are
linked with heart disease, which could help towards finding new treatments in the future. The latest
recipients were 26-year-old Christopher Jones and 20-year-old Jack Helliwell.
Chris, from Wakefield, has been looking at new exercise testing for patients with heart disease who
are having major surgery, as part of their pre-operative screening. He has been testing individuals
by putting them through a new exercise protocol which aims to fully work the heart and lungs. He
has been testing patients over two minutes, aiming to work them harder, which should give a more
accurate representation of whether it is safe for the patient to have heart surgery and make a good
recovery afterwards.
Jack, from Dewsbury, has researched new methods of treating chronic and non-healing venous and
diabetic leg ulcers by creating a new biological scaffold using pig skin, which is placed on the ulcer to
help regenerate new healthier cells. Evidence has shown that this new method will be less painful, more
cost-effective and time-efficient by working in just one application of the scaffold.
www.heartresearch.org.uk/grants
GRANTSUPDATE
International recognition
for our research project
Our translational research projects are aimed at benefitting patients as soon as possible. One,
a 98,000 grant at the University of Sheffield from Heart Research UK and healthcare provider
Simplyhealth, was showcased at an international audience of 19,000 delegates at the American
Heart Association annual meeting in Chicago.
Seven years ago health body NICE, recommended that dentists stop
giving antibiotics to patients who have certain types of heart disease. The
team of international researchers, led by Professor Martin Thornhill, at
the University of Sheffield School of Clinical Dentistry, discovered that,
since the recommendation, there has been an increase in the serious
heart infection infective endocarditis above the expected trend. By
March 2013, this accounted for an extra 35 cases per month.
In Prof Thornhills paper, also published in The Lancet, they identified that
the prescribing of antibiotics to these patients fell by 89 per cent - from
10,900 prescriptions a month before the 2008 guidelines, to 1,235 a
month by March 2008.
Although there is still more work to be done in this study, Prof Thornhill hopes that the data uncovered
will provide the information that guideline committees like NICE need to re-evaluate the benefits or not
of giving antibiotics in this case.
10
Research Grants
RESEARCHFEATURE
A brief guide to congenital heart disease
Congenital heart disease is a general term covering a wide range of heart conditions or defects
that are present at birth. Current figures show that around 1 in 180 babies in the UK are born
with a heart problem. There are many different types of congenital heart disease and most
defects either obstruct blood flow in the heart or nearby blood vessels, or cause the blood
to take the wrong route through the heart. Such heart conditions include holes between the
chambers of the heart, narrowed heart valves and more complex defects.
As well as funding pioneering medical research, Heart Research UK is Helping Little Hearts with
its unique rehabilitation for children. See page 14 for the full story.
11
MASTERCLASS in
major
Our pioneering Masterclasses, running for the last three years, show that we are truly Helping
Hearts near you by giving clinicians from local hospitals around the UK the chance to learn new
techniques from international experts in their field.
Our latest Masterclass in Liverpool saw Consultant Cardiac Surgeons from Swansea, Hull, Cambridge,
Blackpool, Cardiff, Nottingham, Oxford ,Manchester, Brighton, Basildon, Liverpool, London and Bristol
learning a technique for patients that need life-saving aortic arch surgery - a complex, specialist area
with which the majority of heart surgeons rarely come into contact. Above all, patients across the
country will benefit as more surgeons will have the expertise to carry out this lifesaving operation in their
own hospitals.
The class gave these young clinicians the rare opportunity to expand their knowledge of major aortic
arch surgery as well as invaluable hands-on experience.
The Masterclass, funded entirely by Heart Research UK, was held in the Human Anatomy Resource
Centre at the University of Liverpool. It was led by Mr Aung Oo and Miss Deborah Harrington, part
of a team of the consultant cardiac surgeons that leads the way in this highly specialised surgery at
Liverpool Heart and Chest Hospital.
Joining the team were two internationally-renowned surgeons ; Professor Di Bartolomeo,
Professor of Cardiac Surgery in the Cardiovascular Department at the University of
Bologna and Professor Malakh Shrestha , Chief Staff Surgeon of Cardiothoracic
Transplantation and Vascular Surgery and Director of Aortic Surgery at Hannover
Medical School.
Deborah Harrington said:
12
Masterclass
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M Pag
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se
complex
Consultant Cardiac Surgeon, Govind Chetty, from the University Hospital of Wales,
Cardiff, said:
This course has provided invaluable insight into operative measures, especially on
cerebral protection and a direct hands-on experience of tackling this life-threatening
condition from experts in this field, which will no doubt give me more confidence in my
future practice.
Cardiothoracic Surgeon, Marius Berman from Papworth Hospital, Cambridge said:
This is one of the best courses I have been to. It took on a hands-on approach and
performed to a very high standard.
13
Childrens rehabilitation
Heart Research UK wants every child heart patient in the country to know that they can be as active
as other children with the help of an exercise toolkit and unique prescription advising them on
how much activity their condition allows.
In the UK, around one in 180 babies is born with congenital heart disease and the number of operations
increased by 60% between 2000 and 2010. At the moment, adult heart patients leave hospital with
rehabilitation advice to help make sure their hearts stay in the best condition but with these child heart
patients this rarely happens. This leaves the youngster missing out on vital exercise that our research at
Exeter University has shown, can help improve their condition.
We unveiled the exercise toolkit and innovative prescription to young heart patients at the Bristol Royal
Hospital for Children, the first time in the UK. This was quickly followed by a launch at Leeds General
Infirmary soon to be followed by Cardiff, Oxford, Exeter, Southampton and Birmingham. These pilots will
give the information we need to refine the toolkit before it is rolled-out in other centres across the UK.
14
www.heartresearch.org.uk/spending-money
Join us on Facebook www.facebook.com/heartresearchuk
15
events
HRUK
got round in 31 minutes and the event was so well organised and fun. Without heart
research we wouldnt have the amazing treatments and medications that can help
people have a good quality of life after a heart attack.
This years events are in Belfast, Blackpool, Cambridge, Cardiff, Edinburgh, Leeds, London, Manchester,
Motherwell, Newcastle, Sheffield and Birmingham. A tasty, satisfying, SUBWAY lunch is included in the
entry fee of 6.99. Children under-12 are free.
16
HRUK Events
s
nt 35
ra 2tg 3
ar age
He e P
se
Interested?
For
details visit www.heartresearch.org.uk/events
HRUK in the
Midlands
17
events
HRUK
Its a great way to see some spectacular scenery and get one
of the great walks under your belt. Many people come back
each year to take on the challenge and, to encourage even
more, weve introduced a new less-demanding valleys route,
a guided walk over 16 miles that skirts round the main peaks to
give a picturesque and gentler walk for those who dont fancy
the longer climbs.
Among those who took part last year was Professor Chris
Denning, who is working on a Heart Research UK-funded
project at the University of Nottingham looking into abnormal
heart rhythms. He said: There was a real sense of
Its FREE to enter and all we ask is that you raise as much money as you can for Heart Research
UK. Get a team from work or family or friends to join you and the challenge is on.
18
HRUK Events
Interested?
For
details visit www.heartresearch.org.uk/events
HRUK in the
Midlands
19
Special
People
Heart Research stands on
the shoulders of heroes
We need volunteers now more than ever so
please join our team.
We firmly believe that volunteers are heroes
and without them the pioneering work we do
would not be possible. They contribute in so
many valuable ways from helping at our events,
offering their skills, attending collections and
being ambassadors for the work we do all over
the UK. Volunteering is an extremely rewarding
experience and we need more of you across the
UK to help us now more than ever.
Were looking for local volunteers throughout
the country to join our team and help us at
street and supermarket collections, look after
collecting cans in their local area, help at events
or even organise their own events such as coffee
mornings or tea parties.
There are also opportunities to be Heart
Research UK Ambassadors and officially
represent our charity in your local area. In this
role you will give talks on our behalf, outlining our
work in helping hearts near you ,as well as collect
cheques for us from our valued supporters. Full
training will be provided so you can represent
Heart Research UK with confidence.
20
Special People
Roxanne Zarpak
Rachel Foxton
Adrian Purtell
Cath Lewis
21
Special
People
New Years Honour
Heart Research UKs President, Keith Loudon,
has been made an Officer of the Order of the
British Empire (OBE) in the New Years Honours
List for his services to business and to the
community in Leeds. As a founding member
of Redmayne-Bentley Stockbrokers, a former
Lord Mayor of Leeds and a supporter of many
charities and local groups, Keith has been a
key figure in Leeds business and politics for
decades as well as a champion for many local
causes, especially Heart Research UK.
Keith has been a trustee of Heart Research UK for more than 19 years and was Board Chairman, 1996
2011. Under his stewardship, we went from strength to strength, developing from a Leeds-based charity
to the growing national charity it is today. As Tony Knight, our current Chairman of Trustees said:
The special thing about Keith is that he gave his time, the most valuable thing he could
give. Organisations need forward-looking, strong leaders. Keith is certainly that and we
could not be more proud.
22
Special People
Donations in Memory
23
Look
what
weve been up to
5,000 children and counting
Shes given healthy heart presentations to 33 schools and
over 5,000 pupils and shes not stopping there. Sharron
Bright, our schools coordinator, has been spreading the
healthy heart message to children through her classroom
sessions and the response has been fantastic. Her sessions
cover why the heart is so important, what it does and how
to keep your heart healthy by eating a healthy diet, being
active and not smoking. The presentation has gone down
a storm with schools and Sharron is delighted that the
programme, funded by grants from healthcare provider,
Simplyhealth, and Drax Power, can be rolled out to more
children across the country.
Head Teacher, Toni Thomason from Spring Brook Special School in Oldham:
The presentation was fantastic. All the pupils were engaged and interested throughout, which
considering we are a special school and our pupils struggle with this, is an achievement!
If youre interested in a session in your school, contact Sharron Bright on 0113 297 6214
or e-mail her at schools@heartresearch.org.uk
HRUK
HRUK
theMidlands
Midlands
ininthe
Were Brindleyplace winners
After competing against 19 other charities, we are now one of three charity
partners for popular business spot, Brindleyplace, Birmingham, over the
next two years. Making it down to the final three, we were given the chance
to showcase what the charity is all about and talk to members of the public
about how all the money raised in the Midlands is spent in the Midlands.
As a Brindleyplace Official
Charity Partner, we will
be able to use the popular
city centre space which
attracts over 4,000,000
visitors a year.
The day of the vote was tense with lots of people coming down to
Brindleyplace to make it a great experience. Our ambassador, TV cook
Sally Bee, four times World Kick Boxing Champion, Kash the Flash and
local singing star, Lauren Alexander, who performed a fantastic duet as
Lady and the Sax, all showed their support. What was so rewarding was
the number of our supporters and office workers who came to cast their
vote for Heart Research UK. Were very grateful and will make sure our time
with Brindleyplace is full of events for all ages. Watch our website for whats
happening at Brindleyplace.
www.heartresearch.org.uk/near-you/midlands-events
25
HRUK
HRUK
theMidlands
Midlands
ininthe
Hampers and Coffee with the Au Pairs
Its daunting being on your own in a foreign country. The answer
from three Au Pairs was to get involved with a charity. Caroline from
Sweden, Nicole from Germany and Valentina from Italy, walked
into the Midlands office and pronounced they were ready for work.
The Midlands office was a hive of activity filling hampers with tasty
goodies from companies all around the UK. Our team of Au Pairs
worked for days on the impressive, beautifully-packed hampers.
Thanks to Foxs Biscuits, Deans of Huntly, Benedict Bittermints,
Just Oil & Just Crisps, Mrs Darlington and Daughters, Bonne
Maman, Barry M Cosmetics, The Bay Tree, Taylors of Harrogate,
Whitworths, Rowse Honey, United Biscuits-KP Foods, Waitrose, Harborne and Cadbury World
for their very generous donations.
Their next venture was a coffee morning at Piccolinos in Brindley Place. It was the perfect way to get to
know other Au Pairs and their host families .
Centenary Lunch
The 1914-18 War was
remembered when
Financial Services
Company, Premier
Planning, chose Heart
Research UK as its main
charity at a Centenary
Lunch sponsored by
PricewaterhouseCoopers.
The lunch, run by Richard Usmar, Mark Smith and Mark
Grainger raised an outstanding 22,000 to help fund a
38,000 monitoring system to support babies, as well
as parents, when bringing their youngster home from
Birmingham Childrens Hospital for the first time after
complex heart surgery. The monitoring system provides a fastalert system back to a nurse at the hospital and brings peace
of mind to families and gives the best start to youngsters.
26
A sign of
our times
For the first time, Heart
Research UK had our name
in lights, shining above the
A38 as it wends its way into
Birmingham, thanks to a
very generous donation
of free space by Elonex
Outdoor Media. This busy
route into Birmingham sees
nearly 400,000 vehicles a
day and our sign was in the
perfect position to capture
drivers attention and give
them an eyeful of our high
profile message every day.
Thanks
Thanks
to our Midlands supporters
Mrs M Marshall | in memory of a close friend | 10
Ms H Sanga | 100 donation
27
Company Help
Over 1,100 DS Smith staff adopt healthy lifestyles
Weve been helping hearts with leading European packaging company DS Smith, getting over 1,100 of
its staff heart healthy with healthy heart checks from our Lifestyle team at 17 of its depots around the
UK. The company, wont be leaving it there, as more visits will follow across other DS Smith sites from
Launceston and Plymouth to Lockerbie.
Our confidential on-site lifestyle checks included cholesterol/diabetes tests, calculating BMI and waist
measurement and a blood pressure check, all supported with practical information and advice and backed
up by HRUKs lifestyle leaflets, which went down very well:
28
Company Help
Join our Healthy Heart Mark scheme call 0113 297 6206
29
Lifestyle
A new report from the National Obesity Forum says that tackling obesity must be amongst the
priorities of a new government and should be the subject of a cross-party pledge.
30
Healthy Hearts
Most of us are aware of the alarming rates of obesity both in the UK and globally. Currently, around
a third of children in the UK are classed as overweight or obese, with rates continuing to grow
among adolescents. Whats more, as overweight children are more likely to become overweight
adults, and the growing risks of health complications that this creates, its really important to start
early with those heart-healthy habits.
Children look up to adults in their lives and often mirror their behaviour. This is why Heart Research UK
is encouraging parents to be heart-healthy role models to set their children on course for long, healthy,
happy lives.
Make healthy lifestyles the norm in your household
Get cooking
Spend some time together in the kitchen
and get the kids involved with the cooking.
Encouraging children to be involved with
basic food preparation like weighing out
ingredients and mixing will teach them
valuable cooking skills and may make them
more likely to try new things if theyve
helped to make it.
Keep trying
Getting children to eat heart-healthy
vegetables and oily fish can be a bit of
a struggle, but dont give up. Evidence
shows that kids need to try new foods up
to ten times before accepting them. If
eating greens or other items do become a
persistent problem, try mixing them in with
other foods to start with so kids will still get
that all-important goodness.
Its always easier to make changes if the whole familys on board and, as children are likely
to pick up the habits of the adults around them, starting out on the road towards heart
healthier lifestyles will encourage them to follow in your footsteps.
31
Latest
HRUK
Healthy Heart Grants
In our latest round, we introduced, especially
for smaller organisations, Healthy Heart Grants
of up to 5,000. It also gives more projects in
more locations.
Thanet - Skip2BFit
Learn2BFit, 10,000
Skipping and learning about healthy eating and positive lifestyle
choices is a programme for over 3,500 pupils in the most
deprived communities of Thanet. Skipping ropes with counters
will help them track their progress, all topped off with a twominute challenge to earn their free blueberries.
32
33
Latest
HRUK
Healthy Heart Grants
Bury Jigsaw
Heart Smart 2 - Bigger, Better - This Time
Together, 9,000
In a repeat grant, families and carers of disabled young people
attending the sports and social group will benefit from Burys
Exercise and Therapy Service (BEATS), Family Cookery
sessions, Healthy Living classes and Family sport.
34
35
Test yourself with a new challenge in 2015. Remember, too, that everything you raise will be spent near
you on pioneering medical research, encouraging the experts of tomorrow or in Helping Little Hearts.
Channel Swim
Ever fancied swimming the English Channel without having to negotiate one
of the worlds biggest shipping lanes? Well, now you can, just do the 22.5
miles in the relative calm of your local swimming baths.
fes a
journey...
This testing challenge will take you across one of the New Seven Wonders
of the World. For five days you will trek amidst breathtaking mountains and
valleys, and through ancient battlements, knowing you are raising money to
help people live healthier, happier, longer lives.
Skythe
diving
..enjoy
ride!
Ever fancied a skydive? Youve a choice of June or September at Hibaldstow
London to Paris Sponsored Bike Ride
in Brigg, North Lincolnshire where youll have the chance to take the
InAirfield
aid of Heart
Research UK
jump of a lifetime whilst harnessed to a qualified instructor.
Fancy a cycle ride to the heart of the French capital? With a trip planned in
September, as well as more next year, there are plenty of opportunities to
get on the saddle, raise money and cycle for your heart.
ng
ure
nt
le
3 June 2015
or 16 September 2015
eartresearch.org.uk
Follow heartresearchuk
ventsadmin@heartresearch.org.uk
art Research UK Suite 12D, Josephs Well, Leeds LS3 1AB. T: 0113 234 7474 F: 0113 297 6208 info@heartresearch.org.uk Registered charity number 1044821.
ndd 1
02/02/2015 12:29
If you would like to discuss a bespoke partnership for your business then please contact
corporate@heartresearch.org.uk or call 0113 297 6202
Heart Research UK, Suite 12D, Josephs Well, Leeds LS3 1AB
or call 0113 234 7474 Fax: 0113 297 6208
Email: mail@heartresearch.org.uk
Website: www.heartresearch.org.uk
Registered Charity No. 1044821 Registered Office: Suite 12D, Josephs Well, Leeds LS3 1AB
Company limited by guarantee No. 3026813 Registered in England.