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As with various medical conditions, early diagnosis is key to effective therapy in management of
neurodegenerative disorders.
In Alzheimers disease early diagnosis allows patients and their families to:
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MANAGEMENT
There is no definitive care for Alzheimers disease and dementia but there are pharmacologic and nonpharmacologic interventions which are used for optimal therapy and management of cognitive,
behavioral and physiological symptoms of Alzheimers disease and dementia.
Management Goals include:
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Pharmacologic Interventions
A. Medication Two classes of drugs are used in alleviating the cognitive problems of
Alzheimers disease: They include:
a. Acetyl-cholinesterase inhibitors: Tacrine, Rivastigmine, Donepezil, Galantamine
b. NMDA receptor antagonists: Mematine
c. Antipsychotics: Risperidon, Huperzine A, etc.
B. Mechanisms of Action of these medications
a. Acetylcholinesterase inhibitors increase cholinergic activity of cholinergic neurons by
inhibiting breakdown of acetylcholine by acetylcholinesterase
b. Glutamate is an excitatory neurotransmitter of the nervous system. Alzheimers and
other neurological diseases e.g. Parkinsons and multiple sclerosis exhibit excitoxicity
as a result of overstimulation of glutamate receptors. Blockade by NMDA receptor
antagonist blocks overactivity of glutamate at these sites.