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Chapter Nine
Thinking Through the Concepts
1. Draw the general structure of a nucleotide. Which parts are identical in all
nucleotides, and which can vary?
The phosphate and the sugar called deoxyribose remain the same, and
the nitrogen-containing base varies form (A) adenine, (G) guanine, (T)
thymine, or (C) cytosine.
2. Name the four types of nitrogen-containing bases found in DNA.
(A) Adenine, (G) guanine, (T) thymine, and (C) cytosine.
3. Which bases are complementary to one another? How are they held
together in the double helix of DNA?
Adenine is complementary of thymine, and guanine is complementary
of cytosine. The two DNA strands are held together by hydrogen bonds that
form between the protruding bases of the individual DNA strands.
4. Describe the structure of DNA. Where are the bases, sugars, and
phosphates in the structure?
DNA is in the shape of a double helix and has four nitrogen bases, (A)
adenine, (G) guanine, (T) thymine, and (C) cytosine. The backbone of DNA is
made up of phosphates and sugars. Attached to the backbone are the bases.
The number of hydrogen bonds depends on the type of base (pyrimidine and
purine).
5. Describe the process of DNA replication.
First, DNA helicase separate the parental DNA strands. Then, DNA
polymerase synthesises new DNA strands, and finally, segments of DNA are
joined together by DNA ligase, an enzyme that ties DNA together.
6. How do mutations occur? Describe the principal types of mutations.
Chapter Ten
Thinking Through the Concepts
1. How does RNA differ from DNA?
RNA is similar to DNA, but differs structurally in three respects: (1) RNA
is normally single-stranded; (2) RNA has the sugar ribose (instead of
deoxyribose) in its backbone; and (3) RNA has the base uracil instead of the
base thymine found in DNA.
2. What are the three types of RNA? What is the function of each?
There is messenger RNA (mRNA), ribosomal RNA (rRNA), and transfer
RNA (tRNA). The base sequence of mRNA carries the information for the
amino acid sequence of a protein. rRNA combines with proteins to form
ribosomes. The small subunit binds mRNA. The large subunit binds tRNA and
catalyses peptide bond formation between amino acids during protein
synthesis. Each tRNA carries a specific amino acid to a ribosome during
protein synthesis. The anticodon of tRNA pairs with a codon incorporated into
the protein. DNA is transcribed into mRNA, then translated into polypeptides
where each codon has a complementary anticodon on the tRNA.
3. Define the following terms: genetic code; codon; anticodon. What is the
relationship among the bases in DNA, the codons, of mRNA, and the
anticodons of tRNA?
The genetic code translates the sequence of bases in nucleic acids into
the sequence of amino acids in proteins. If a genetic code was deciphered by
using these artificial mRNAs, it is usually written in terms of base triplets in
mRNA (rather than DNA) that code for each amino acid. These mRNA triplets
are called codons. The ability of tRNA to deliver the proper amino acid
depends on specific base pairing between tRNA and mRNA. Each tRNA has
three exposed bases called the anticodon, which form base pairs with the
mRNA codon.