Вы находитесь на странице: 1из 42

##################>###

#############################################

##`
########################bjbj####################
###.#######h############################################################
#########################################################################@
#######@#######@#######@###$###d#################n###########################
###########u### #############

###
%#######'#######'#######'#######'#######'#######'###$###h###h#########K###i######
#####################
######################u#######u########
#######
######K###############################################################
#############
##"###############################%###############
#######################################################
######%#####################
################################################################################
#################x###

####u
#########@#######2
#######################L######0#################p#######
##"###p###########################################################################
###########p################################L#### ##6#########7
##,###c
##########################################################K#######K############
#############################
################################################################
#######
#######
#######
#########################################################################
#################################################################

###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
#################################################################################Ne
lson Textbook of Pediatrics, 18th edition##By Robert M. Kliegman, MD, Professor and
Chair, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI;
Richard E. Behrman, MD, Executive Chair, Pediatric Education Steering Committee,
Federation of Pediatric Organizations, Menlo Park, CA; Clinical Professor of
Pediatrics, Stanford University and the University of California, San Francisco, CA
and George Washington University, Washington, DC; Hal B. Jenson, MD, Chair,
Department of Pediatrics, Director, Center for Pediatric Research, and Senior VicePresident for Academic Affairs, Eastern Virginia Medical School and Children's
Hospital of the King's Daughters, Norfolk, VA; and Bonita F. Stanton, MD, Schotanus
Professor and Chair, Department of Pediatrics, Wayne State University, Detroit, MI,
USA ##ISBN 1416024506 / 9781416024507 Hardback 3200 Pages 1800 Illustrations
#Saunders Published August 2007 ##Price: 87.99For nearly three quarters of a
century, Nelson Textbook of Pediatrics has been the worlds most trusted resource
for best approaches to pediatric care. Now in full color for easier referencing,
this New Edition continues the tradition, incorporating a wealth of exciting
updates and changesensuring you have access to todays authoritative knowledge to
best diagnose and treat every pediatric patient you see. Whether youre treating
patients in the office or in the hospital, or preparing for the boards, Nelson
Textbook of Pediatrics, 18th Edition is your comprehensive guide to providing the
best possible care. #### INCLUDEPICTURE
"http://www.intl.elsevierhealth.com/images/clear.gif" \* MERGEFORMATINET #####
#Features Get an enhanced focus on general pediatrics with editorial contributions
from new editor Dr. Bonita F. Stanton. Treat your inpatient and ambulatory patients
more effectively with the absolute latest on new topics such as quality improvement
and patient care safety school violence and bullying preventive measures
vitamin deficiencies adolescent rape effect of war on children and more.
Improve your therapeutic skills with the newest knowledge on the principles of
antibiotic therapy antiviral therapy antiparasitic therapy antimycobacterial
therapy and others. Understand the principles of therapy and which drugs and
dosages to prescribe for every disease. Locate key content more easily and identify
clinical conditions quicker thanks to a new full-color design and full-color
photographs.##Contents Part I: The Field of Pediatrics#1 Overview of Pediatrics 2
Quality and Safety in Healthcare for Children 3 Ethics in Pediatric Care 4 Cultural
Issues in Pediatric Care 5 Maximizing Childrens Health: Screening, Anticipatory
Guidance, and Counseling##Part II: Growth, Development, and Behavior#6 Overview and
Assessment of Variability 6.1 Assessment of Fetal Growth and Development 7 The
Newborn 8 The First Year 9 The Second Year 10 Preschool Years 11 Middle Childhood
12 Adolescence 13 Sexual Behavior 13.1 The Development of Sexual Behavior 13.2
Gender Identity Disorder (GID) 13.3 Adolescent Homosexuality 14 Assessment of
Growth 15 Developmental Screening and Surveillance 16 Child Care: How Pediatricians
Can Support Children and Famillies 17 Separation, Loss, and Bereavement 18 Sleep
Medicine##Part III: Child and Adolescent Psychology #19 Assessment and Interviewing
20 Psychological Treatment of Children and Adolescents 20.1 Illness and Death 20.2
Psychopharmacology 20.3 Psychotherapy 20.4 Psychiatric Hospitalization 21
Psychosomatic Illness 22 Vegetative Disorders 22.1 Rumination Disorders 22.2 Pica
22.3 Enuresis (Bedwetting) 22.4 Encopresis 23 Habit and Tic Disorders 24 Anxiety
Disorders 25 Mood Disorders 25.1 Major Depression 25.2 Dysthymic Disorder 25.3
Bipolar Disorder 26 Suicide and Attempted Suicide 27 Anorexia Nervosa, Bulimia, and
Binge Eating 28 Disruptive Behavioral Disorders 29 Pervasive Developmental
Disorders and Childhood Psychosis 29.1 Autistic Disorder 29.2 Aspergers Disorder
29.3 Childhood Disintegrative Disorder 29.4 Rett's Disorder 29.5 Childhood
Schizophrenia 29.6 Acute Phobic Hallucinations 30 Patterns of Development and

Function in the School-Aged Child 31 Attention Deficit Hyperactivity Disorder 32


Specific Reading Disability 32.1 Language Development and Communication
Disorders##PART IV: Children with Special Needs #33 Adoption 34 Foster Care 35
Impact of Violence on Children 35.1 School Violence and Bullying 35.2 Effect of War
on Children 36 Abuse and Neglect of Children 36.1 Sexual Abuse 36.2 Munchausen
Syndrome by Proxy 36.3 Parental Styles 37 Failure to Thrive 38 Developmental
Disabilities and Chronic Illness 38.1 Mental Retardation (Intellectual Disability)
39 Organ Transplantation 40 Pediatric Palliative Care: The Care of Children with
Life-Limiting Illness 40.1 Grief and Bereavement##Part V: Nutrition#41 Nutritional
Requirements 42 The Feeding of Infants and Children 43 Food Insecurity, Hunger, and
Undernutrition 44 Overweight and Obesity 45 Vitamin A Deficiency and Excess 46
Vitamin B Complex Deficiency and Excess 46.1 Thiamin (Vitamin B-1) 46.2 Riboflavin
(Vitamin B-2) 46.3 Niacin 46.4 Vitamin B-6 (Pyridoxine) 46.5 Biotin 46.6 Folate
46.7 Vitamin B-12 (Cobalamin) 47 Vitamin C Deficiency (Ascorbic Acid) 48 Rickets
and Hypervitaminosis D 49 Vitamin E Deficiency 50 Vitamin K Deficiency 51
Micronutrient Deficiency##Part VI: The Pathophysiology of Body Fluids and Fluid
Therapy#52 Electrolyte and Acid-Base Disorders 52.1 Composition of Body Fluids 52.2
Regulation of Osmolality and Volume 52.3 Sodium 52.4 Potassium 52.5 Magnesium 52.6
Phosphorus 52.7 Acid-Base Balance 53 Maintenance and Replacement Therapy 54 Deficit
Therapy 55 Fluids and Electrolyte Treatment of Specific Disorders 55.1 Acute
Diarrhea and Oral Rehydration 55.2 Diarrhea in Chronically Malnourished Children
55.3 Pyloric Stenosis 55.4 Perioperative Fluids##Part VII: Pediatric Drug Therapy
#56 Pharmacogenetics, Pharmacogenomics, and Pharmacoproteins 57 Principles of Drug
Therapy 58 Poisonings 59 Herbal Medicines##Part VIII: Critical Care Medicine #60
Evaluation of the Sick Child in the Office and Clinic 61 Injury Control 62
Emergency Medical Services for Children 63 Interfacility Transfer of the Critically
Ill Infant and Child 64 Monitoring Techniques for the Critically Ill Infant and
Child 65 Scoring Systems and Predictors of Mortality 66 Pediatric Emergencies and
Resuscitation 67 Neurologic Emergencies and Stabilization 67.1 Brain Death 68 Shock
69 Respiratory Distress and Failure 70 Mechanical Ventilation 70.1 Chronic
Mechanical Ventilation 71 Acute Care of the Multiple Trauma Victim 72 Nutritional
Stabilization 73 Drowning 74 Burn injuries 75 Cold Injuries 76 Anesthesia and
Perioperative Care 77 Pediatric Pain Management##Part IX: Human Genetics#78 The
Genetic Approach in Pediatric Medicine 79 The Human Genome 80 Patterns of Genetic
Transmission 81 Cytogenetics 82 Genetics of Common Disorders: Diagnosis and
Management 83 Integration of Genetics into Pediatric Practice ##Part X: Metabolic
Diseases#84 An Approach to Inborn Errors of Metabolism 85 Defects in Metabolism of
Amino Acids 85.1 Phenylalanine 85.2 Tyrosine 85.3 Methionine 85.4 Cysteine/Cystine
85.5 Tryptophan 85.6 Valine, Leucine, Isoleucine, and Related Organic Acidemias
85.7 Glycine 85.8 Serine 85.9 Proline 85.1-0 Glutamic Acid 85.11 Urea Cycle and
Hyperammonemia (Arginine, Citrulline, Ornithine) 85.12 Histidine 85.13 Lysine 85.14
Aspartic Acid (Canavan Disease) 86 Defects in Metabolism of
L##################################################################################
############################################################i#p#i#d#s# #8#6#.#1#
#D#i#s#o#r#d#e#r#s# #o#f# #M#i#t#o#c#h#o#n#d#r#i#a#l# #F#a#t#t#y# #A#c#i#d# ###O#x#i#d#a#t#i#o#n# #8#6#.#2# #D#i#s#o#r#d#e#r#s# #o#f# #V#e#r#y# #L#o#n#g#
#C#h#a#i#n# #F#a#t#t#y# #A#c#i#d#s# #8#6#.#3# #D#i#s#o#r#d#e#r#s# #o#f#
#L#i#p#o#p#r#o#t#e#i#n# #M#e#t#a#b#o#l#i#s#m# #a#n#d# #T#r#a#n#s#p#o#r#t#:#
#E#p#i#d#e#m#i#o#l#o#g#y# #o#f# #B#l#o#o#d# #L#i#p#i#d#s# #a#n#d#
#C#a#r#d#i#o#v#a#s#c#u#l#a#r# #D#i#s#e#a#s#e# #8#6#.#4# #L#i#p#i#d#o#s#e#s#
#8#6#.#5# #M#u#c#o#l#i#p#i#d#o#s#e#s# #8#7# #Defects in Metabolism of Carbohydrates
87.1 Glycogen Storage Diseases 87.2 Defects in Galactose Metabolism 87.3 Defects in
Fructose Metabolism 87.4 Defects in Intermediary Carbohydrate Metabolism Associated
with Lactic Acidosis 87.5 Defects in Pentose Metabolism 87.6 Disorders of
Glycoprotein Degradation and Structure 88 Mucopolysaccharidoses 89 Disorders of
Purine and Pyrimidine Metabolism 90 Progeria 91 The Porphyrias 92
Hypoglycemia##Part XI: Perinatal and Neonatal Medicine#93 Overview of Mortality and
Morbidity 94 The Newborn Infant 94.1 History in Neonatal Pediatrics 94.2 Physical
Examination of the Newborn Infant 94.3 Routine Delivery Room Care 94.4 Nursery Care

94.5 Parent-Infant Bonding 95 High-Risk Pregnancies 96 The Fetus 96.1 Fetal Growth
and Maturity 96.2 Fetal Distress 96.3 Maternal Disease and the Fetus 96.4 Maternal
Medication and Toxin Exposure and the Fetus 96.5 Teratogens 96.6 Radiation 96.7
Intrauterine Diagnosis of Fetal Disease 96.8 Treatment and Prevention of Fetal
Disease 97 The High-Risk Infant 97.1 Multiple Gestation Pregnancies 97.2
Prematurity and Intrauterine Growth Retardation 97.3 Post-Term
Infants 97.4 Large for Gestational Age 97.5 Infant Transport 98 Clinical
Manifestations of Diseases in the Newborn Period 99 Nervous System Disorders 99.1
The Cranium 99.2 Traumatic, Epidural, Subdural, and Subarachnoid Hemorrhage 99.3
Intracranial-Intraventricular Hemorrhage and Periventricular Leukomalacia 99.4
Brain Injury from Inflammation, Infection, and Medications 99.5 Hypoxia-Ischemia
99.6 Spine and Spinal Cord 99.7 Peripheral Nerve Injuries 100 Delivery Room
Emergencies 101 Respiratory Tract Disorders 101.1 Transition to Pulmonary
Respiration 101.2 Apnea 101.3 Congenital Central Hypoventilation Syndrome 101.4
Respiratory Distress Syndrome (Hyaline Membrane Disease) 101.5 Transient Tachypnea
of the Newborn 101.6 Aspiration of Foreign Material (Fetal Aspiration Syndrome,
Aspiration Pneumonia) 101.7 Meconium Aspiration 101.8 Persistent Pulmonary
Hypertension of the Newborn (Persistent Fetal Circulation) 101.9 Diaphragmatic
Hernia 101.10 Foramen of Morgagni Hernia 101.11 Paraesophageal Hernia 101.12
Eventration 101.13 Extrapulmonary Extravasation of Air (Pneumothorax,
Pneumomediastinum, Pulmonary Interstitial Emphysema) 101.14 Pulmonary Hemorrhage
102 Digestive System Disorders 102.1 Meconium Ileus in Cystic Fibrosis 102.2
Neonatal Necrotizing Enterocolitis (NEC) 102.3 Jaundice and Hyperbilirubinemia in
the Newborn 102.4 Kernicterus 103 Blood Disorders 103.1 Anemia in the Newborn
Infant 103.2 Hemolytic Disease of the Newborn (Erythroblastosis Fetalis) 103.3
Plethora in the Newborn Infant (Polycythemia) 103.4 Hemorrhage in the Newborn
Infant 104 Genitourinary System 105 The Umbilicus 106 Metabolic Disturbances 106.1
Maternal Selective Serotonin Reuptake Inhibitors and Neonatal Behavioral Syndromes
106.2 Fetal Alcohol Syndrome 107 The Endocrine System 107.1 Infants of Diabetic
Mothers 107.2 Hypoglycemia 108 Dysmorphology 109 Infections of the Neonatal Infant
109.1 Pathogenesis and Epidemiology 109.2 Modes of Transmission and Pathogenesis
109.3 Immunity 109.4 Etiology of Fetal and Neonatal Infection 109.5 Epidemiology of
Early- and Late-Onset Neonatal Infections 109.6 Clinical Manifestations of
Transplacental Intrauterine Infections 109.7 Diagnosis 109.8 Treatment 109.9
Complications and Prognosis 109.1'0 Prevention##Part XII: Adolescent Medicine #110
The Epidemiology of Adolescent Health Problems 111 Delivery of Health Care to
Adolescents 111.1 Legal Issues 111.2 Screening Procedures 111.3 Health Enhancement
112 Violent Behavior 113 Substance Abuse 113.1 Alcohol 113.2 Tobacco 113.3
Marijuana 113.4 Volatile Inhalants 113.5 Hallucinogens 113.6 Cocaine 113.7
Amphetamines 113.8 Opiates 113.9 Anabolic Steroids 114 The Breast 115 Menstrual
Problems 115.1 Amenorrhea 115.2 Abnormal Uterine Bleeding 115.3 Dysmenorrhea 115.4
Premenstrual Syndrome 116 Contraception 116.1 Barrier Methods 116.2 Spermicides
116.3 Combination Methods 116.4 Hormonal Methods 116.5 Emergency Contraception
116.6 Intrauterine Devices 117 Adolescent Pregnancy 118 Adolescent Rape 119
Sexually Transmitted Infections 120 Chronic Fatigue Syndrome##Part XIII: Immunology
#Section 1: Evaluation of the Immune Systems 121 Evaluation of Suspected
Immunodeficiency Section 2: The T-, B-, and NK-Cell Systems 122 T Lymphocytes, B
Lymphocytes, and Natural Killer Cells 123 Primary Defects of Antibody Production
123.1 Treatment of B-Cell Defects 124 Primary Defects of Cellular Immunity 125
Primary Combined Antibody and Cellular Immunodeficiencies 125.1 Severe Combined
Immunodeficiency (SCID) 125.2 Combined Immunodeficiency (CID) 125.3 Defects of
Innate Immunity 125.4 Treatment of Cellular or Combined Immunodeficiency 125.5
Immune Dysregulation with Autoimmunity or Lymphoproliferation Section 3: The
Phagocytic System 126 Neutrophils 127 Monocytes and Macrophages and Dendritic Cells
128 Eosinophils 129 Disorders of Phagocyte Function 130 Leukopenia 131 Leukocytosis
Section 4: The Complement System 132 The Complement System 133 Disorders of the
Complement System 133.1 Evaluation of the Complement System 133.2 Genetic
Deficiencies of Complement Components 133.3 Deficiencies of Plasma, Membrane, or
Serosal Complement Control Proteins 133.4 Secondary Disorders of Complement 133.5

Treatment of Complement Disorders Section 5: 134 Principles and Clinical


Indications 135 HSCT from Alternative Sources and Donors 136 Graft vs Host Disease
(GVHD) and Rejection 137 Infectious Complications of HSCT 138 Late Effects of
HSCT##Part XIV: Allergy#139 Allergy and the Immunologic Basis of Atopic Disease 140
Diagnosis of Allergic Disease 141 Principles of Treatment of Allergic Disease 142
Allergic Rhinitis 143 Childhood Asthma 144 Atopic Dermatitis (Atopic Eczema) 145
Insect Allergy 146 Ocular Allergies 147 Urticaria and Angioedema (Hives) 148
Anaphylaxis 149 Serum Sickness 150 Adverse Reactions to Foods 151 Adverse Reactions
to Drugs##Part XV: Rheumatology #152 Evaluation of Suspected Rheumatic Disease 153
Treatment of Rheumatic Diseases 154 Juvenile Rheumatoid Arthritis 155 Ankylosing
Spondylitis and Other Spondyloarthropathies 156 Reactive Arthritis 157 Systemic
Lupus Erythematosus 157.1 Neonatal Lupus 158 Juvenile Dermatomyositis 159
Scleroderma and Raynaud Syndrome 160 BehVets Disease 161 Sjgrens Syndrome 162
Hereditary Periodic Fever Syndromes 163 Amyloidosis 164 Sarcoidosis 165 Kawasaki
Disease 166 Vasculitis Syndromes 166.1 Henoch-Schnlein Purpura 166.2 Takayasu
Arteritis 166.3 Polyarteritis Nodosa 166.4 Wegener Granulomatosis 166.5 Other
Vasculitic Syndromes 167 Musculoskeletal Pain Syndromes 167.1 Fibromyalgia 167.2
Complex Regional Pain Syndrome (Reflex Sympathetic Dystrophy 167.3 Erythromelalgia
168 Miscellaneous Conditions Associated With Arthritis##Part XVI: Infectious
Diseases#Section 1. General Considerations 169 Diagnostic Microbiology Section 2.
Preventive Measures (NEW) 170 (NEW) Immunization Practices 170.1 (NEW)
International Immunization Practices 171 Infection Control and Prophylaxis 172
Childcare and Communicable Diseases 173 Health Advice for Children Traveling
Internationally 174 Fever 175 Fever Without a Focus 176 Sepsis, Septic Shock, and
System Inflammatory Response Syndrome (SIRS) 177 Infections in Immunocompromised
Persons 178 Infections Associated with Medical Devices Section 3. Antibiotic
Therapy (NEW) 179 Principles of Antibacterial Therapy Section 4. Gram-Positive
Bacterial Infections 180 Staphylococcus 180.1 Staphylococcus aureus 180.2 Toxic
Shock Syndrome 180.3 Coagulase-Negative Staphylococci 181 Streptococcus pneumoniae
(Pneumococcus) 182 Group A Streptococcus 182.1 Rheumatic Fever 183 Group B
Streptococcus 184 NonGroup A or B Streptococcus 184 Enterococcus 186 Diphtheria
(Corynebacterium diphtheriae) 187 Listeria monocytogenes 188 Actinomyces 189
Nocardia Section 5. Gram Negative Bacterial Infections 190 Neisseria meningitidis
(Meningococcus) 191 Neisseria gonorrhoeae (Gonococcus) 192 Haemophilus influenzae
193 Chancroid (Haemophilus ducreyi) 194 Pertussis (Bordetella pertussis and B.
parapertussis) 195 Salmonella 195.1 Nontyphoidal Salmonellosis 195.2 Enteric Fever
(Typhoid Fever) 196 Shigella 197 Escherichia coli 198 Cholera (Vibrio cholerae) 199
Campylobacter 200 Yersinia 200.1 Yersinia enterocolitica 200.2 Yersinia
pseudotuberculosis 200.3 Plague (Yersinia pestis) 201 Aeromonas and Plesiomonas
201.1 Aeromonas 201.2 Plesiomonas shigelloides 202 Pseudomonas, Burkholderia, and
Stenotrophomonas 202.1 Pseudomonas aeruginosa 202.2 Burkholderia 202.3
Stenotrophomonas 203 Tularemia (Francisella tularensis) 204 Brucella 205 Legionella
206 Bartonella 206.1 Bartonellosis (Bartonella bacilliformis) 206.2 Cat-Scratch
Disease (Bartonella henselae) 206.3 Trench Fever (Bartonella quintana) 206.4
Bacillary Angiomatosis and Bacillary Peliosis Hepatis (Bartonellahenselae and
Bartonella quintana) Section 6: Anaerobic Bacterial Infections 207 Botulism
(Clostridium botulinum) 208 Tetanus (Clostridium tetani) 209 Pseudomembranous
Colitis (Clostridium difficile) 210 Other Anaerobic Infections Section 7:
Mycobacterial Infections 211 (NEW) Principles of Antimycobacterial Therapy 212
Tuberculosis (Mycobacterium tuberculosis) 213 Hansen Disease (Mycobacterium leprae)
214 Nontuberculous Mycobacteria Section 8. Spirochectal Infections 215 Syphilis
(Treponema pallidum) 216 Nonvenereal Treponemal Infections 216.1 Yaws (Treponema
pertenue) 216.2 Bejel Endemic Syphilis (Treponema pallidum subsp. endemicum) 216.3
Pinta (Treponema carateum) 217 Leptospira 218 Relapsing Fever (Borrelia) 219 Lyme
Disease (Borrelia burgdorferi) Section 9. Mycroplasmal Infections 220 Mycoplasma
pneumoniae 221 Genital Mycoplasmas (Mycoplasma hominis, Mycoplasma Genitalium, and
Ureaplasma urealyticum) Section 10. Chlamydial Infections 222 Chlamydiophila
pneumoniae 223 Chlamydia trachomatis 223.1 Trachoma 223.2 Genital Tract Infections
223.3 Conjunctivitis and Pneumonia in Newborns 223.4 Lymphogranuloma Venereum (LGV)

224 Psittacosis (Chlamydia psittaci) Section 11. Rickettsial Infections 225 Spotted
Fever Group Rickettsioses 225.1 Rocky Mountain Spotted Fever (Rickettsia
rickettsii) 225.2 Mediterranean Spotted Fever or Boutonneuse Fever (Rickettsia
conorii) 225.3 Rickettsialpox (Rickettsia akari) 226 Scrub Typhus (Orientia
tsutsugamushi) 227 Typhus Group Rickettsioses 227.1 Murine Typhus (Rickettsia
typhi) 227.2 Epidemic Typhus (Rickettsia prowazekii) 228 Ehrlichioses and
Anaplasmosis 229 Q Fever (Coxiella burnetii) Section 12. Fungal Infections 230
Principles of Antifungal Therapy 231 Candida 231.1 Neonatal Infections 231.2
Infections in Immunocompetent Children and Adolescents 231.3 Infections in
Immunocompromised Children and Adolescents 231.4 Chronic Mucocutaneous Candidiasis
232 Cryptococcus neoformans 233 Malassezia 234 Aspergillus 234.1 Hypersensitivity
Syndromes 234.2 Saprophytic (Noninvasive) Syndromes 234.3 Invasive Disease 235
Histoplasmosis (Histoplasma capsulatum) 236 Blastomycosis
(Blastomyces dermatitidis) 237 Coccidioidomycosis (Coccidioides immitis) 238
Paracoccidioides brasiliensis 239 Sporotrichosis (Sporothrix schenckii) 240
Zygomycosis (Mucormycosis) 241 Pneumocystis carinii (P. jiveci) Section 13. Viral
Infections 242 Principles of Antiviral Therapy 243 Measles 244 Rubella 245 Mumps
246 Polioviruses 247 Nonpolio Enteroviruses 248 Parvovirus B19 249 Herpes Simplex
Virus 250 Varicella-Zoster Virus 251 Epstein-Barr Virus 252 Cytomegalovirus 253
Roseola (Human Herpesviruses 6, 7) 254 Human Herpesvirus 8 255 Influenza Viruses
256 Parainfluenza Viruses 257 Respiratory Syncytial Virus 258 Human Metapneumovirus
259 Adenoviruses 260 Rhinoviruses 261 Coronavirus 261.1 Severe Acute Respiratory
Syndrome (SARS)-associated corona virus 262 Rotaviruses, Calicivirus, and
Astrovirus (new title) 263 Human Papillomaviruses 264 Arboviral Encephalitis in
North America 265 Arboviral Encephalitis Outside North America 265.1 Venezuelan
Equine Encephalitis 265.2 Japanese Encephalitis 265.3 Tick-Borne Encephalitis 266
Dengue Fever and Dengue Hemorrhagic Fever 267 Yellow Fever 268 Other Viral
Hemorrhagic Fevers 269 Lymphocytic Choriomeningitis Virus (LCMV) 270 Hantavirus
Pulmonary Syndrome 271 Rabies 272 Polyomaviruses (JC virus and BK Virus) 273
Acquired Immunodeficiency Syndrome (Human Immunodeficiency Virus) 274 Human T-Cell
Lymphotropic Viruses Types I and II 275 Transmissible Spongiform Encephalopathies
Section 14. Antiparasitic Therapy (NEW)276 Principles of Antiparasitic Therapy
Section 15. Protozoan Diseases 277 Primary Amebic Meningoencephalitis 278 Amebiasis
279 Giardiasis and Balantidiasis 279.1 Giardia lamblia 279.2 Balantidiasis 280
Cryptosporidium, Isospora, Cyclospora, and Microsporidia 281 Trichomoniasis
(Trichomonas vaginalis) 282 Leishmaniasis (Leishmania) 283 African Trypanosomiasis
(Sleeping Sickness; Trypanosoma brucei complex) 284 American Trypanosomiasis
(Chagas Disease; Trypanosoma cruzi) 285 Malaria (Plasmodium) 286 Babesiosis
(Babesia) 287 Toxoplasmosis (Toxoplasma gondii) Section 16. Helminthic Diseases 288
Ascariasis (Ascaris lumbricoides) 289 Hookworms (Necator americanus and
Ancylostoma) 289.1 Cutaneous Larva Migrans 290 Trichuriasis (Trichuris trichuria)
291 Enterobiasis (Enterobius vermicularis) 292 Strongyloidiasis (Strongyloides
stercoralis) 293 Lymphatic Filariasis (Brugia malayi, B. timori, and Wuchereria
bancrofti) 294 Other Tissue Nematodes 295 Toxocariasis (Visceral and Ocular Larva
Migrans) 296 Trichinosis (Trichinella spiralis) 297 Schistosomiasis (Schistosoma)
298 Flukes (Liver, Lung, and Intestinal) 299 Adult Tapeworm Infections 300
Cysticercosis 301 Echinococcosis (Echinococcus granulosus and E.
multilocularis)##Part XVII: The Digestive System#Section 1. Clinical Manifestations
of Gastrointestinal Disease 302 Normal Digestive Tract Phenomena 303 Major Symptoms
and Signs of Digestive Tract Disorders Section 2. The Oral Cavity 304 Development
and Developmental Anomalies of the teeth 305 Disorders of the Oral Cavity
Associated with Other Conditions 306 Malocclusion 307 Cleft Lip and Palate 308
Syndromes with Oral Manifestations 309 Dental Caries 310 Periodontal Diseases 311
Dental Trauma 312 Common Lesions of the Oral Soft Tissues 313 Diseases of the
Salivary Glands and Jaws 314 Diagnostic Radiology in Dental Assessment Section 3.
The Esophagus 315 Embryology, Anatomy, and Function of the Esophagus 315.1 Common
Clinical Manifestations and Diagnostic Aids 316 Congenital Anomalies: Esophageal
Atresia and Tracheoesophageal Fistula 316.1 Congenital Anomalies:
Laryngotracheoesophageal Clefts 317 Obstructing and Motility Disorders of the

Esophagus 318 Dysmotility 319 Hiatal Hernia 320 Gastroesophageal Reflux Disease
(GERD) 320.1 Complications of GERD 321 Non-GERD Esophagitis 322 Esophageal
Perforation 323 Esophageal Varices 324 Ingestions 324.1 Foreign Bodies in the
Esophagus 324.2 Caustic Ingestions Section 4. Stomach and Intestines 325 Normal
Development, Structure, and Function 326 Pyloric Stenosis and Other Congenital
Anomalies of the Stomach 326.1 Hypertropic Pyloric Stenosis 326.2 Congenital
Gastric Outlet Obstruction 326.3 Gastric Duplication 326.4 Gastric Volvulus 326.5
Hypertrophic Gastropathy 327 Intestinal Atresia, Stenosis, and Malrotation 327.1
Duodenal Obstruction 327.2 Jejunal and Ileal Atresia and Obstruction 327.3
Malrotation 328 Intestinal Duplications, Meckel Diverticulum, and Other Remnants of
the Omphalomesenteric Duct 328.1 Intestinal Duplication 328.2 Meckel Diverticulum
and Other Remnants of the Omphalomesenteric Duct 329 Motility Disorders and
Hirschsprung Disease 329.1 Chronic Intestinal Pseudo-Obstruction 329.2 Functional
Constipation 329.3 Congenital Aganglionic Megacolon (Hirschsprung Disease) 329.4
Intestinal Neuronal Dysplasia 329.5 Superior Mesenteric Artery Syndrome, Wilkie
Syndrome, Cast Syndrome, Arteriomesenteric Duodenal Compression Syndrome 330 Ileus,
Adhesions, Intussusception, and Closed-Loop Obstructions 330.1 Ileus 330.2
Adhesions 330.3 Intussusception 330.4 Closed-Loop Obstructions 331 Foreign Bodies
and Bezoars 331.1 Foreign Bodies in the Stomach and Intestine 331.2 Bezoars 332
Peptic Ulcer Disease in Children 332.1 Zollinger-Ellison Syndrome 333 Inflammatory
Bowel Disease 333.1 Chronic Ulcerative Colitis 333.2 Crohn Disease (Regional
Enteritis, Regional lleitis, Granulomatous Colitis) 333.3 Behet Syndrome 334 Food
Allergy (Food Hypersensitivity) 334.1 Eosinophilic Gastroenteritis 335 Disorders of
Malabsorption 335.1 Evaluation of Children with Suspected Intestinal Malabsorption
335.2 Gluten-Sensitive Enteropathy (Celiac Disease) 335.3 Other Malabsorptive
Sydromes 335.4 Intestinal Infections Associated with Malabsorption 335.5
Immunodeficiency Disorders 335.6 Immunoproliferative Small Intestinal Disease 335.7
Short Bowel Syndrome 335.8 Chronic Malnutrition 335.9 Enzyme Deficiencies 335.1-0
Liver and Biliary Disorders Causing Malabsorption 335.11 Defects of Absorption or
Transport 336 Intestinal Transplantation in Children 337 Acute Gastroenteritis in
Children (new) 337.1 Probiotics in Gastrointestinal Disorders (new) 338 Chronic
Diarrhea 338.1 Diarrhea from Hormone-Secreting Tumors 339 Recurrent Abdominal Pain
of Childhood 340 Acute Appendicitis 341 Surgical Conditions of the Anus, Rectum,
and Colon 341.1 Anorectal Malformations 341.2 Anal Fissure 341.3 Perianal Abscess
and Fistula 341.4 Hemorrhoids 341.5 Rectal Prolapse 341.6 Pilonidal Sinus and
Abscess 342 Tumors of the Digestive Tract 343 Inguinal Hernias Section 5. Exocrine
Pancreas 344 Embryology, Anatomy, and Physiology 344.1 Anatomic Abnormalities 344.2
Physiology 345 Pancreatic Function Tests 346 Disorders of the Exocrine Pancreas 347
Treatment of Pancreatic Insufficiency 348 Pancreatitis 348.1 Acute Pancreatitis
348.2 Chronic Pancreatitis 349 Pseudocyst of the Pancreas 350 Pancreatic Tumors
Section 6. The Liver and Biliary System 351 Morphogenesis of the Liver and Biliary
System 352 Manifestations of Liver Disease 352.1 Evaluation of Patients with
Possible Liver Dysfunction 353 Cholestasis 353.1 Neonatal Cholestasis 353.2
Cholestasis in the Older Child 354 Metabolic Diseases of the Liver 354.1 Inherited
Deficient Conjugation of Bilirubin (Familial Nonhemolytic Unconjugated
Hyperbilirubinemia) 354.2 Wilson Disease 354.3 Indian Childhood Cirrhosis 354.4
Neonatal Iron Storage Disease (NISD) 354.5 Miscellaneous Metabolic Diseases of the
Liver 355 Viral Hepatitis 356 Liver Abscess 357 Liver Disease Associated with
Systemic Disorders 358 Mitochondrial Hepatopathies 359 Autoimmune and Chronic
Hepatitis 360 Drug- and Toxin-Induced Liver Injury 361 Fulminant Hepatic Failure
362 Cystic Diseases of the Biliary Tract and Liver 363 Diseases of the Gallbladder
364 Portal Hypertension and Varices 365 Liver Transplantation Section 7. Peritoneum
366 Malformations 367 Ascites 367.1 Chylous Ascites 368 Peritonitis 368.1 Acute
Primary Peritonitis 368.2 Acute Secondary Peritonitis 368.3 Acute Secondary
Localized Peritonitis (Peritoneal Abscess) 369 Epigastric Hernia 369.1 Incisional
Hernia##Part XVIII: Respiratory System#Section 1. Development and Function 370
Respiratory Pathophysiology and Regulation 370.1 Lung Volumes and Capacities in
Health and Disease 370.2 Chest Wall 370.3 Pulmonary Mechanics and Work of Breathing
in Health and Disease 370.4 Airway Dynamics in Health and Disease 370.5

Interpretation of Clinical Signs to Localize the Site of Pathology 370.6


Ventilation-Perfusion (V/Q) Relationship in Health and Disease 370.7 Gas Exchange
in Health and Disease 370.8 Interpretation of Blood Gases 370.9 Pulmonary
Vasculature in Health and Disease 370.1-0 Immune Response of the Lung to Injury
370.11 Regulation of Respiration 371 Diagnostic Approach to Respiratory Disease 372
Sudden Infant Death Syndrome Section 2. Disorders of the Respiratory Tract 373
Congenital Disorders of the Nose 374 Acquired Disorders of the Nose 374.1 Foreign
Body 374.2 Epistaxis 375 Nasal Polyps 376 The Common Cold 377 Sinusitis 378 Acute
Pharyngitis 379 Retropharyngeal Abscess, Lateral Pharyngeal (Parapharyngeal)
Abscess, and Peritonsillar Cellulitis/Abscess 380 Tonsils and Adenoids 381 Chronic
or Recurrent Respiratory Symptoms 382 Acute Inflammatory Upper Airway Obstruction
(Croup, Epiglottitis, Laryngitis, and Bacterial Tracheitis) 382.1 Infectious Upper
Airway Obstruction 382.2 Bacterial Tracheitis 383 Congenital Anomalies of the
Larynx, Trachea, and Bronchi 383.1 Laryngomalacia 383.2 Congenital Subglottic
Stenosis 383.3 Vocal Cord Paralysis 383.4 Congenital Laryngeal Webs and Atresia
383.5 Congenital Subglottic Hemangioma 383.6 Laryngoceles and Saccular Cysts 383.7
Posterior Laryngeal Cleft (PLC) and Laryngotracheoesophageal Cleft (LTEC) 383.8
Vascular and Cardiac Anomalies 383.9 Tracheal Stenoses, Webs, and Atresia 383.1-0
Foregut Cysts 383.11 Tracheomalacia and Bronchomalacia 384 Foreign Bodies of the
Airway
384.1 Laryngeal Foreign Bodies 384.2 Tracheal Foreign Bodies 384.3 Bronchial
Foreign Bodies 385 Laryngotracheal Stenosis, Subglottic Stenosis 385.1 Congenital
Subglottic Stenosis 385.2 Acquired Laryngotracheal Stenosis 386 Bronchomalacia and
Tracheomalacia 387 Neoplasms of the Larynx, Trachea, and Bronchi 387.1 Vocal
Nodules 387.2 Recurrent Respiratory Papillomatosis (RRP) 387.3 Congenital
Subglottic Hemangioma 387.4 Vascular Anomalies 387.5 Other Laryngeal Neoplasms
387.6 Tracheal Neoplasms 387.7 Bronchial Tumors 388 Wheezing, Bronchiolitis, and
Bronchitis# #3#8#8#.#1# #W#h#e#e#z#i#n#g# #i#n# #I#n#f#a#n#t#s# #a#n#d#
#B#r#o#n#c#h#i#o#l#o#t#i#s# #3#8#8#.#2# #B#r#o#n#c#h#i#t#i#s# #3#8#9#
#E#m#p#h#y#s#e#m#a# #a#n#d# #O#v#e#r#i#n#f#l#a#t#i#o#n# #3#9#0# ##1##A#n#t#i#t#r#y#p#s#i#n# #D#e#f#i#c#i#e#n#c#y# #a#n#d# #E#m#p#h#y#s#e#m#a# #3#9#1#
#O#t#h#e#r# #D#i#s#t#a#l# #A#i#r#w#a#y# #D#i#s#e#a#s#e#s# #3#9#1#.#1#
#B#r#o#n#c#i#o#l#i#t#i#s# #O#b#l#i#t#e#r#a#n#s# #3#9#1#.#2# #F#o#l#l#i#c#u#l#a#r#
#B#r#o#n#c#h#i#t#i#s# #3#9#1#.#3# #P#u#l#m#o#n#a#r#y# #A#l#v#e#o#l#a#r#
#M#icrolithiasis 392 Congenital Disorders of the Lung 392.1 Pulmonary Agenesis and
Aplasia 392.2 Pulmonary Hypoplasia 392.3 Cystic Adenomatoid Malformation 392.4
Pulmonary Sequestration 392.5 Bronchogenic Cysts 392.6 Congenital Pulmonary
Lymphangiectasia 392.7 Lung Hernia 392.8 Other Congenital Malformations of the Lung
393 Pulmonary Edema 394 Aspiration Syndromes 395 Chronic Recurrent Aspiration 396
Parenchymal Disease with Prominent Hypersensitivity, Eosinophilic Infiltration, or
Toxin-Mediated Injury 396.1 Hypersensitivity to Inhaled Materials 396.2 Silo Filler
Disease 396.3 Paraquat Lung 396.4 Eosinophilic Lung Disease (Formerly Lffler
Syndrome) 397 Pneumonia 398 Bronchiectasis 399 Pulmonary Abscess 400 Cystic
Fibrosis 401 Primary Ciliary Dyskinesia (Immotile Cilia Syndrome) 402 Interstitial
Lung Diseases 403 Pulmonary Alveolar Proteinosis 404 Inherited Disorders of
Surfactant Metabolism 405 Pulmonary Hemosiderosis 406 Pulmonary Hemorrhage,
Embolism, and Infarction 406.1 Pulmonary Embolus and Infarction 406.2 Pulmonary
Hemorrhage and Hemoptysis 407 Atelectasis 408 Pulmonary Tumors 409 Pleurisy 409.1
Dry or Plastic Pleurisy 409.2 Serofibrinous Pleurisy 409.3 Purulent Pleurisy or
Empyema 410 Pneumothorax 411 Pneumomediastinum 412 Hydrothorax 413 Hemothorax 414
Chylothorax 415 Bronchopulmonary Dysplasia 416 Skeletal Diseases Influencing
Pulmonary Function 416.1 Pectus Excavatum (Funnel Chest) 416.2 Pectus Carinatum and
Sternal Clefts 416.3 Asphyxiating Thoracic Dystrophy (Thoracic-Pelvic-Phalangeal
Dystrophy) 416.4 Achondroplasia 416.5 Kyphoscoliosis: Adolescent Idiopathic
Scoliosis and Congential Scoliosis 416.6 Congenital Rib Anomalies 417 Neuromuscular
Diseases with Pulmonary Consequences 418 Extrapulmonary Diseases with Pulmonary
Manifestations 419 Chronic Severe Respiratory Insufficiency##Part XIX: The
Cardiovascular System#Section 1. Developmental Biology of the Cardiovascular System
420 Cardiac Development 420.1 Early Cardiac Morphogenesis 420.2 Cardiac Looping

420.3 Cardiac Septation 420.4 Aortic Arch Development 420.5 Cardiac Differentiation
420.6 Developmental Changes in Cardiac Function 421 The Fetal to Neonatal
Circulatory Transition 421.1 The Fetal Circulation 421.2 The Transitional
Circulation 421.3 The Neonatal Circulation 421.4 Persistent Pulmonary Hypertension
of the Neonate (Persistence of Fetal Circulatory Pathways) 421.5 The Influence of
Fetal Environmental Factors on Adult Cardiovascular and Metabolic Disease Section
2. Evaluation of the Cardiovascular System 422 History and Physical Examination 423
Laboratory Evaluation 423.1 Radiologic Assessment 423.2 Electrocardiography 423.3
Hematologic Data 423.4 Echocardiography 423.5 Exercise Testing 423.6 MRI, MRA, CT,
and Radionuclide Studies 423.7 Diagnostic and Interventional Cardiac
Catheterization Section 3. Congenital Heart Diseases 424 Epidemiology oicular
Septal Defects (Ostium Primum and Atrioventricular Canal or Endocardial Cushion
Defects) 426.6 Ventricular Septal Defect 426.7 Supracristal Ventricular Septal
Defect with Aortic Insufficiency 426.8 Patent Ductus Arteriosus 426.9
Aorticopulmonary Window Defect 426.1-0 Coronary-Arteriovenous Fistula (CoronaryCameral Fistula) 426.11 Ruptured Sinus of Valsalva Aneurysm 427 Acyanotic
Congenital Heart Disease: The Obstructive Lesions 427.1 Pulmonary Valve Stenosis
with Intact Ventricular Septum 427.2 Infundibular Pulmonary Stenosis and DoubleChamber Right Ventricle 427.3 Pulmonary Stenosis in Combination with an
Intracardiac Shunt 427.4 Peripheral Pulmonary Stenosis 427.5 Aortic Stenosis 427.6
Coarctation of the Aorta 427.7 Coarctation with Ventricular Septal Defect 427.8
Coarctation with Other Cardiac Anomalies and Interrupted Aortic Arch 427.9
Congenital Mitral Stenosis 427.1-0 Pulmonary Venous Hypertension 428 Acyanotic
Congenital Heart Disease: Regurgitant Lesions 428.1 Pulmonary Valvular
Insufficiency and Congenital Absence of the Pulmonary Valve 428.2 Congenital Mitral
Insufficiency 428.3 Mitral Valve Prolapse 428.4 Tricuspid Regurgitation 429
Cyanotic Congenital Heart Disease: Evaluation of the Critically Ill Neonate with
Cyanosis and Respiratory Distress 430 Cyanotic Congenital Heart Lesions: Lesions
Associated with Decreased Pulmonary Blood Flow 430.1 Tetralogy of Fallot 430.2
Tetralogy of Fallot with Pulmonary Atresia 430.3 Pulmonary Atresia with Intact
Ventricular Septum 430.4 Tricuspid Atresia 430.5 Double-Outlet Right Ventricle with
Pulmonary Stenosis 430.6 Transposition of the Great Arteries with Ventricular
Septal Defect and Pulmonary Stenosis 430.7 Ebstein Anomaly of the Tricuspid Valve
431 Cyanotic Congenital Heart Disease: Lesions Associated with Increased Pulmonary
Blood Flow 431.1 d-Transposition of the Great Arteries 431.2 d-Transposition of the
Great Arteries with Intact Ventricular Septum 431.3 Transposition of the Great
Arteries with Ventricular Septal Defect 431.4 l-Transposition of the Great Arteries
(Corrected Transposition) 431.5 Double-Outlet Right Ventricle Without Pulmonary
Stenosis 431.6 Double-Outlet Right Ventricle with Transposition of the Great
Arteries (Taussig-Bing Anomaly) 431.7 Total Anomalous Pulmonary Venous Return 431.8
Truncus Arteriosus 431.9 Single Ventricle (Double-Inlet Ventricle, Univentricular
Heart) 431.10 Hypoplastic Left Heart Syndrome 431.11 Abnormal Positions of the
Heart and the Heterotaxy Syndromes (Asplenia, Polysplenia) 432 Other Congenital
Heart and Vascular Malformations 432.1 Anomalies of the Aortic Arch 432.2 Anomalous
Origin of the Coronary Arteries 432.3 Pulmonary Arteriovenous Fistula 432.4 Ectopia
Cordis 432.5 Diverticulum of the Left Ventricle 433 Pulmonary Hypertension 433.1
Primary Pulmonary Hypertension 433.2 Pulmonary Vascular Disease (Eisenmenger
Syndrome) 434 General Principles of Treatment of Congenital Heart Disease 434.1 The
Adult with Congenital Heart Disease Section 4. Cardiac Arrhythmias 435 Disturbances
of Rate and Rhythm of the Heart 435.1 Principles of Antiarrhythmic Therapy 435.2
Sinus Arrhythmias and Extrasystoles 435.3 Supraventricular Tachycardia 435.4
Ventricular Tachyarrhythmias 435.5 Long Q-T Syndrome 435.6 Sinus Node Dysfunction
435.7 AV Block 436 Sudden Death Section 5. Acquired Heart Disease 437 Infective
Endocarditis 438 Rheumatic Heart Disease Section 6. Diseases of the Myocardium and
Pericardium 439 Diseases of the Myocardium 439.1 Dilated Cardiomyopathy 439.2
Hypertrophic Cardiomyopathy 439.3 Restrictive Cardiomyopathies 439.4 Myocarditis
439.5 Nonviral Causes of Myocarditis 439.6 Endocardial Fibroelastosis 440 Diseases
of the Pericardium 440.1 Acute Pericarditis 440.2 Constrictive Pericarditis 441
Tumors of the Heart Section 7. Cardiac Therapeutics (Heart Failure and End-Stage

Cardiac Disease) 442 Heart Failure 442.1 Cardiogenic Shock 443 Pediatric Heart and
Heart-Lung Transplantation 443.1 Pediatric Heart Transplantation 443.2 Heart-Lung
and Lung Transplantation Section 8. Diseases of the Peripheral Vascular System 444
Disease of the Blood Vessels (Aneurysms and Fistulas) 444.1 Kawasaki Disease (see
also Ch 165) 444.2 Arteriovenous Fistulas 445 Systemic Hypertension##Part XX:
Disease of the Blood#Section 1. The Hematopoietic System 446 Development of the
Hematopoietic System 447 The Anemias Section 2. Anemias of Inadequate Production
448 Congenital Hypoplastic Anemia (Diamond-Blackfan Anemia ) 449 Pearson MarrowPancreas Syndrome 450 Acquired Pure Red Blood Cell Anemias 451 Anemia of Chronic
Disease (ACD) and Renal Disease 451.1 Anemia of Chronic Disease 451.2 Anemia of
Renal Disease 452 Congenital Dyserythropoietic Anemias (CDA) 453 Physiologic Anemia
of Infancy 454 Megaloblastic Anemias 454.1 Folic Acid Deficiency 454.2 Vitamin B12
(Cobalamin) Deficiency 454.3 Other Rare Megaloblastic Anemias 455 Iron-Deficiency
Anemia 456 Other Microcytic Anemias Section 3. Hemolytic Anemias 457 Definitions
and Classification of Hemolytic Anemias 458 Hereditary Spherocytosis 459 Hereditary
Elliptocytosis 460 Hereditary Stomatocytosis 461 Other Membrane Defects 462
Hemoglobinopathies 462.1 Sickle Cell Disease 462.2 Sickle Cell Trait (Hemoglobin
AS) 462.3 Other Hemoglobinopathies 462.4 Unstable Hemoglobin Disorders 462.5
Abnormal Hemoglobins with Increased Oxygen Affinity 462.6 Abnormal Hemoglobins
Causing Cyanosis 462.7 Hereditary Methemoglobinemia 462.8 Syndromes of Hereditary
Persistence of Fetal Hemoglobin (HPFH) 462.9 Thalassemia Syndromes 463 Enzymatic
Defects 463.1 Pyruvate Kinase (PK) Deficiency 463.2 Other Glycolytic Enzyme
Deficiencies 463.3 Glucose-6-Phosphate Dehydrogenase (G6PD) and Related
Deficiencies 464 Hemolytic Anemias Resulting from Extracellular Factors 465
Hemolytic Anemias Secondary to Other Extracellular Factors Section 4. Polycythemia
(Erythrocytosis) 466 Primary Polycythemia (Polycythemia Rubra Vara) 467 Secondary
Polycythemia Section
5. The Pancytopenias 468 The Constitutional Pancytopenias 469 The Acquired
Pancytopenias Section 6. Risks of Blood Component Transfusions 470 Red Blood Cell
Transfusions and Erythropoietin Therapy 471 Platelet Transfusions 472 Neutrophil
(Granulocyte) Transfusions 473 Fresh Frozen Plasma Transfusions 474 Risks of Blood
Transfusions Section 7. Hemorrhagic and Thrombotic Diseases 475 Hemostasis 475.1
The Clinical and Laboratory Evaluation of Hemostasis 476 Hereditary Clotting Factor
Deficiencies (Bleeding Disorders) 476.1 Factor VIII or Factor IX Deficiency
(Hemophilia A or B) 476.2 Factor IX Deficiency (Hemophilia C) 476.3 Deficiencies of
the Contact Factors (Non-bleeding Disorders) 476.4 Factor VII Deficiency 476.5
Factor X Deficiency 476.6 Prothrombin (Factor II) Deficiency 476.7 Factor V
Deficiency 476.8 Combined Deficiency of Factors V and VIII 476.9 Fibrinogen
Deficiency 476.10 Factor XIII Deficiency (Fibrin-Stabilizing Factor or
Transglutaminase Deficiency) 476.11 Antiplasmin or Plasminogen Activator Inhibitor
(PAI) Deficiency 477 von Willebrand Disease 478 Hereditary Predisposition to
Thrombosis 479 Acquired Thrombotic Disorders 480 Post-Neonatal Vitamin K Deficiency
481 Liver Disease 482 Acquired Inhibitors of Coagulation 483 Disseminated
Intravascular Coagulation 484 Platelet and Blood Vessel Disorders 484.1 Idiopathic
Thrombocytopenic Purpura (ITP) 484.2 Drug-Induced Thrombocytopenia 484.3 Nonimmune
Platelet Destruction 484.4 Hemolytic-Uremic Syndrome (HUS) 484.5 Thrombotic
Thrombocytopenic Purpura (TTP) 484.6 Kasabach-Merritt Syndrome 484.7 Sequestration
484.8 Congenital Thrombocytopenic Syndromes 484.9 Neonatal Thrombocytopenia 484.10
Thrombocytopenia Due to Acquired Disorders Causing Decreased Production 484.11
Platelet Function Disorders 484.12 Acquired Disorders of Platelet Function 484.13
Congenital Abnormalities of Platelet Function 484.14 Disorders of the Blood Vessels
Section 8. The Spleen 485 Anatomy and Function of the Spleen 486 Splenomegaly 487
Hyposplenism, Splenic Trauma, and Splenectomy Section 9. The Lymphatic System 488
Anatomy and Function of the Lymphatic System 489 Abnormalities of Lymphatic vessels
490 Lymphadenopathy##Part XXI: Cancer and Benign Tumors#491 Epidemiology of
Childhood and Adolescent Cancer 492 Molecular and Cellular Biology of Cancer 493
Principles of Diagnosis 494 Principles of Treatment 495 The Leukemias 495.1 Acute
Lymphoblastic Leukemia 495.2 Acute Myelogenous Leukemia 495.3 Down Syndrome and
Acute Leukemia and Myeloproliferation 495.4 Chronic Myelogenous Leukemia 495.5

Juvenile Chronic Myelocytic Leukemia 495.6 Infant Leukemia 496 Lymphoma 496.1
Hodgkins Disease 496.2 Non-Hodgkins Lymphoma (NHL) 497 Brain Tumors in Childhood
498 Neuroblastoma 499 Neoplasms of the Kidney 500 Soft Tissue Sarcomas 501
Neoplasms of Bone 501.1 Malignant Tumors of Bone 501.2 Benign Tumors and Tumor-like
Processes of Bone 502 Retinoblastoma 503 Gonadal and Germ Cell Neoplasms 504
Neoplasms of the Liver 505 Benign Vascular Tumors 505.1 Hemangiomas 505.2
Lymphangiomas and Cystic Hygromas 506 Rare Tumors 506.1 Thyroid Tumors 506.2
Melanoma 506.3 Nasopharyngeal Carcinoma 506.4 Adenocarcinoma of the Colon and
Rectum 506.5 Adrenocortical Carcinoma 506.6 Desmoplastic Small Round Cell Tumor 507
Histiocytosis Syndromes of Childhood 507.1 Class I Histiocytoses 507.2 Class II
Histiocytoses: Hemophagocytic Lymphohistiocytosis (HLH) 507.3 Class III
Histiocytoses##Part XXII: Nephrology#Section 1. Glomerular Disease 508 Introduction
to Glomerular Diseases 508.1 Anatomy of the Glomerulus 508.2 Glomerular Filtration
508.3 Glomerular Diseases Section 2. Conditions Particularly Associated with
Hematuria 509 Clinical Evaluation of the Child with Hematuria 510 Isolated
Glomerular Disease with Recurrent Gross Hematuria 510.1 IgA Nephropathy (Berger
Nephropathy) 510.2 Alport Syndrome 510.3 Thin Glomerular Basement Membrane Disease
511 Glomerulonephritis Associated with Infections 511.1 Acute Poststreptococcal
Glomerulonephritis 511.2 Other Chronic Infections 512 Membranous Glomerulopathy
(Glomerulonephritis) 513 Membranoproliferative (Mesangiocapillary)
Glomerulonephritis 514 Glomerulonephritis Associated With Systemic Lupus
Erythematosus 515 Henoch-Schonlein Purpura Nephritis 516 Rapidly Progressive
(Crescentic) Glomerulonephritis 517 Goodpasture Disease 518 Hemolytic-Uremic
Syndrome 519 Upper Urinary Tract Causes of Hematuria 519.1 Interstitial Nephritis
519.2 Toxic Nephropathy 519.3 Cortical Necrosis 519.4 Pyelonephritis 519.5
Nephrocalcinosis 519.6 Vascular Abnormalities 519.7 Renal Vein Thrombosis 519.8
Idiopathic Hypercalciuria 520 Hematologic Diseases Causing Hematuria 520.1 Sickle
Cell Nephropathy 520.2 Coagulopathies and Thrombocytopenia 521 Anatomic
Abnormalities Associated with Hematuria 521.1 Congenital Anomalies 521.2 Autosomal
Recessive Polycystic Kidney Disease 521.3 Autosomal Dominant Polycystic Kidney
Disease 521.4 Trauma 521.5 Renal Tumors 522 Lower Urinary Tract Causes of Hematuria
522.1 Infectious Causes of Cystitis and Urethritis 522.2 Hemorrhagic Cystitis 522.3
Heavy Exercise 522.4 Munchhausen by Proxy Section 3. Conditions Particularly
Associated with Proteinuria 523 Introduction to the Child with Proteinuria 524
Transient Proteinuria 525 Orthostatic (Postural) Proteinuria 526 Fixed Proteinuria
526.1 Glomerular Proteinuria 526.2 Tubular Proteinuria 527 Nephrotic Syndrome 527.1
Idiopathic Nephrotic Syndrome 587.2 Secondary Nephrotic Syndrome 527.3 Congenital
Nephrotic Syndrome Section 4. Tubular Disorders 528 Tubular Function 529 Renal
Tubular Acidosis 529.1 Proximal (Type II) Renal Tubular Acidosis 529.2 Distal (Type
I) Renal Tubular Acidosis 529.3 Hyperkalemic (Type IV) Renal Tubular Acidosis 529.4
Rickets Associated with Renal Tubular Acidosis 530 Nephrogenic Diabetes Insipidus
531 Bartter/Gitelman Syndromes and Other Inherited Tubular Transport Abnormalities
531.1 Bartter Syndrome 531.2 Gitelman Syndrome 531.3 Other Inherited Tubular
Transport Abnormalities 532 Tubulointerstitial Nephritis Section 5. Toxic
Nephropathies: Renal Failure 533 Toxic Nephropathy 534 Cortical Necrosis 535 Renal
Failure (Chap Head only; not chapter) 535.1 Acute Renal Failure 535.2 Chronic
Kidney Disease 535.3 End-Stage Renal Disease 536 Renal Transplantation##Part XXIII:
Urologic Disorders in Infants and Children #537 Congenital Anomalies and Dysgenesis
of the Kidneys 538 Urinary Tract Infections 539 Vesicoureteral Reflux 540
Obstruction of the Urinary Tract 541 Anomalies of the Bladder 542 Neuropathic
Bladder 543 Voiding Dysfunction 544 Anomalies of the Penis and Urethra 545
Disorders and Anomalies of the Scrotal Contents 546 Trauma to the Genitourinary
Tract 547 Urinary Lithiasis##Part XXIV: Gynecologic Problems of Childhood#548
History and Physical Examination 549 Vulvovaginitis 550 Bleeding 551 Breast
Disorders 552 Hirsutism 553 Neoplasms 554 Vulvovaginal and Mllerian Anomalies 555
Special Gynecologic Needs 556 Gynecologic Imaging##Part XXV: The Endocrine
System#Section 1. Disorders of the Hypothalamus and Pituitary Gland 557 Hormones of
the Hypothalamus and Pituitary 558 Hypopituitarism 559 Diabetes Insipidus 559.1
Causes of Hypernatremia 560 Other Abnormalities of Arginine Vasopressin Metabolism

and Action 561 Hyperpituitarism 562 Physiology of Puberty 563 Disorders of Pubertal
Development 563.1 Gonadotropin-Dependent Precocious Puberty 563.2 Precocious
Puberty Resulting from Organic Brain Lesions 563.3 Precocious Puberty Following
Irradiation of the Brain 563.4 Syndrome of Precocious Puberty and Hypothyroidism
563.5 Gonadotropin-Secreting Tumors 563.6 McCune-Albright Syndrome (Precocious
Puberty with Polyostotic Fibrous Dysplasia and Abnormal Pigmentation) 563.7
Familial Male Gonadotropin-Independent Precocious Puberty 563.8 Incomplete
(Partial) Precocious Development 563.9 Medicational Precocity Section 2. Disorders
of the Thyroid Gland 564 Thyroid Development and Physiology 564.1 Thyroid Hormone
Studies 565 Defects of Thyroxine-Binding Globulin 566 Hypothyroidism 567
Thyroiditis 568 Goiter 568.1 Congenital Goiter 568.2 Endemic Goiter and Cretinism
568.3 Acquired Goiter 568.4 Intratracheal Goiter 569 Hyperthyroidism 569.1 Graves
Disease 569.2 Congenital Hyperthyroidism 570 Carcinoma of the Thyroid 570.1
Solitary Thyroid Nodule 570.2 Medullary Carcinoma Section 3. Disorders of the
Parathyroid Glands 571 Hormones and Peptides of Calcium Homeostasis and Bone
Metabolism 572 Hypoparathyroidism 573 Pseudohypoparathyroidism (Albright Hereditary
Osteodystrophy 574 Hyperparathyroidism Section 4 Disorders of the Adrenal Glands
575 The Physiology of the Adrenal Gland 575.1 Histology and Embryology 575.2
Adrenal Steroid Biosynthesis 575.3 Regulation of the Adrenal Cortex 575.4 Adrenal
Steroid Ho#r#m#o#n#e# #A#c#t#i#o#n#s# #5#7#5#.#5# #A#d#r#e#n#a#l# #M#e#d#u#l#l#a#
#5#7#6# #A#d#r#e#n#o#c#o#r#t#i#c#a#l# #I#n#s#u#f#f#i#c#i#e#n#c#y# #5#7#6#.#1#
#P#r#i#m#a#r#y# #A#d#r#e#n#a#l# #I#n#s#u#f#f#i#c#i#e#n#c#y# #5#7#6#.#2#
#S#e#c#o#n#d#a#r#y# #A#d#r#e#n#a#l# #I#n#s#u#f#f#i#c#i#e#n#c#y# #5#7#7#
#C#o#n#g#e#n#i#t#a#l# #A#d#r#e#n#a#l# #H#y#p#e#r#p#l#a#s#i#a# #a#n#d#
#R#e#l#a#t#e#d# #D#i#s#o#r#d#e#r#s# #5#7#7#.#1# #C#o#n#g#e#n#i#t#a#l#
#A#d#r#e#n#a#l# #H#y#p#e#r#p#l#a#s#i#a# #d#u#e# #t#o# #2#1#-#H#y#d#r#o#x#y#l#a#s#e#
#D#e#f#i#c#i#e#n#c#y# #5#7#7#.#2# #C#o#n#g#e#n#i#t#a#l# #A#d#r#e#n#a#l#
#H#y#p#e#r#p#l#a#s#i#a# #d#u#e# #t#o# #1#1##-#H#y#d#r#o#x#y#l#a#s#e#
#D#e#f#i#c#i#e#n#c#y# #5#7#7#.#3# #C#o#n#g#e#n#i#t#a#l# #A#d#r#e#n#a#l#
#H#y#p#e#r#p#l#a#s#i#a# #d#u#e# #t#o# #3##-#H#y#d#r#o#x#y#s#t#e#r#i#o#d#
#D#e#h#y#d#r#o#g#e#n#a#s#e# #D#e#f#i#c#i#e#n#c#y# #5#7#7#.#4# #C#o#n#g#e#n#i#t#a#l#
#A#d#r#e#n#a#l# #H#y#p#e#r#p#l#a#s#i#a# #d#u#e# #t#o# #1#7#-#H#y#d#r#o#x#y#l#a#s#e#
#D#e#f#i#c#i#e#n#c#y# #5#7#7#.#5# #L#i#p#o#i#d# #Adrenal Hyperplasia 577.6
Deficiency of P5450 oxioreductase (Antley-Bixler Syndrome) 577.7 Aldosterone
Synthase
Deficiency 577.8 Glucocorticoid-Suppressible Hyperaldosteronism 578 Cushing
Syndrome 579 Primary Aldosteronism 580 Adrenal Tumors 580.1 Virilizing
Adrenocortical Tumors 580.2 Feminizing Adrenal Tumors 581 Pheochromocytoma 582
Adrenal Masses 582.1 Adrenal Incidentaloma 582.2 Adrenal Calcification Section 5.
Disorders of the Gonads 583 Development and Function of the Gonads 584 Hypofunction
of the Testes 584.1 Hypergonadotropic Hypogonadism in the Male (Primary
Hypogonadism) 584.2 Hypogonadotropic Hypogonadism in the Male (Secondary
Hypogonadism) 585 Pseudoprecocity Resulting from Tumors of the Testes 586
Gynecomastia 587 Hypofunction of the Ovaries 587.1 Hypergonadotropic Hypogonadism
in the Female (Primary Hypogonadism) 587.2 Hypogonadotropic Hypogonadism in the
Female (Secondary Hypogonadism) 588 Pseudoprecocity Due to Lesions of the Ovary 589
Disorders of Sex Development (Intersex) 589.1 46,XX DSD 589.2 46,XY DSD 589.3
Ovotesticular DSD Section 6. Diabetes Mellitus In Children 590 Diabetes Mellitus
590.1 Introduction and Classification 590.2 Type 1 Diabetes Mellitus (Immune
Mediated) 590.3 Type 2 Diabetes Mellitus (T2DM) 590.4 Other Specific Types of
Diabetes##Part XXVI: Neurology #591 Neurologic Evaluation 592 Congenital Anomalies
of the Central Nervous System 592.1 Neural Tube Defects (Dysraphism) 592.2 Spina
Bifida Occulta 592.3 Meningocele 592.4 Myelomeningocele 592.5 Encephalocele 592.6
Anencephaly 592.7 Disorders of Neuronal Migration 592.8 Agenesis of the Corpus
Callosum 592.9 Agenesis of the Cranial Nerves 592.10 Microcephaly 592.11
Hydrocephalus 592.12 Craniosynostosis 593 Seizures in Childhood 593.1 Febrile
Seizures 593.2 Unprovoked Seizures 593.3 Partial Seizures 593.4 Generalized
Seizures 593.5 Mechanisms of Seizures 593.6 Treatment of Epilepsy 593.7 Neonatal
Seizures 593.8 Status Epilepticus 594 Conditions that Mimic Seizures 595 Headaches

595.1 Migraine 595.2 Organic Headaches 595.3 Tension or Stress Headaches 596
Neurocutaneous Syndromes 596.1 Neurofibromatosis 596.2 Tuberous Sclerosis 596.3
Sturge-Weber Syndrome 596.4 Von Hippel-Lindau Disease 596.5 Linear Nevus Syndrome
596.6 PHACE Syndrome 597 Movement Disorders 597.1 Ataxias 597.2 Chorea, Athetosis,
Tremor 597.3 Dystonia 597.4 Tics 598 Encephalopathies 598.1 Cerebral Palsy 598.2
Mitochondrial Encephalomyopathies 598.3 Other Encephalopathies 599
Neurodegenerative Disorders of Childhood 599.1 Sphingolipidoses 599.2 Neuronal
Ceroid Lipofuscinoses 599.3 Adrenoleukodystrophy 599.4 Sialidosis 599.5
Miscellaneous Disorders 600 Demyelinating Disorders of the CNS 600.1 Multiple
Sclerosis (MS) 600.2 Acute Disseminated Encephalomyelitis 601 Acute Stroke
Syndromes 601.1 Arterial Thrombosis/Embolism 601.2 Venous Thrombosis 601.3
Intracranial Hemorrhage 601.4 Differential Diagnosis of Stroke-Like Events 602
Central Nervous System Infections 602.1 Acute Bacterial Meningitis Beyond the
Neonatal Period 602.2 Viral Meningoencephalitis 602.3 Eosinophilic Meningitis 603
Brain Abscess 604 Pseudotumor Cerebri 605 Spinal Cord Disorders 605.1 Tethered Cord
605.2 Diastematomyelia (Split Spinal Cord Malformation) 605.3 Syringomyelia 605.4
Spinal Cord Tumors 605.5 Spinal Cord Trauma 605.6 Transverse Myelitis 605.7
Arteriovenous Malformation##Part XXVII: Neuromuscular Disorders#606 Evaluation and
Investigation 607 Developmental Disorders of Muscle 607.1 Myotubular Myopathy 607.2
Congenital Muscle Fiber-Type Disproportion (CMFTD) 607.3 Nemaline Rod Myopathy
607.4 Central Core Disease and Minicore Myopathy 607.5 Myofibrillar Myopathies
607.6 Brain Malformations and Muscle Development 607.7 Amyoplasia 607.8 Muscular
Dysgenesis (Proteus Syndrome Myopathy) 607.9 Benign Congenital Hypotonia 607.1`0
Arthrogryposis 608 Muscular Dystrophies 608.1 Duchenne and Becker Muscular
Dystrophies 608.2 Emery-Dreifuss Muscular Dystrophy 608.3 Myotonic Muscular
Dystrophy 608.4 Limb-Girdle Muscular Dystrophy 608.5 Facioscapulohumeral Muscular
Dystrophy 608.6 Congenital Muscular Dystrophy 609 Endocrine and Toxic Myopathies
610 Metabolic Myopathies 610.1 Periodic Paralyses (Potassium-Related) 610.2
Malignant Hyperthermia 610.3 Glycogenoses 610.4 Mitochondrial Myopathies 610.5
Lipid Myopathies 610.6 Vitamin E Deficiency Myopathy 611 Disorders of Neuromuscular
Transmission and of Motor Neurons) 611.1 Myasthenia Gravis 611.2 Spinal Muscular
Atrophies 611.3 Other Motor Neuron Disorders 612 Hereditary Motor-Sensory
Neuropathi 612.1 Peroneal Muscular Atrophy (Charcot-Marie-Tooth Disease, HMSN Type
I) 612.2 Peroneal Muscular Atrophy (Axonal Type) 612.3 Djerine-Sottas Disease
(HMSN Type III) 612.4 Roussy-Lvy Syndrome 612.5 Refsum Disease 612.6 Fabry Disease
612.7 Giant Axonal Neuropathy 612.8 Congenital Hypomyelinating Neuropathy 612.9
Tomaculous Neuropathy 612.10 Leukodystrophies 613 Toxic Neuropathies 614 Autonomic
Neuropathies 614.1 Familial Dysautonomia 614.2 Other Autonomic Neuropathies 615
Guillain-Barr Syndrome 616 Bell Palsy##Part XXVIII: Disorders of the Eye#617
Growth and Development 618 Examination of the Eye 619 Abnormalities of Refraction
and Accommodation 620 Disorders of Vision 621 Abnormalities of Pupil and Iris 622
Disorders of Eye Movement and Alignment 623 Abnormalities of the Lids 624 Disorders
of the Lacrimal System 625 Disorders of the Conjunctiva 626 Abnormalities of the
Cornea 627 Abnormalities of the Lens 628 Disorders of the Uveal Tract 629 Disorders
of the Retina and Vitreous 630 Abnormalities of the Optic Nerve 631 Childhood
Glaucoma 632 Orbital Abnormalities 633 Orbital Infections 633.1 Orbital Cellulitis
633.2 Dacroadenitis and Dacrocystadenitis 634 Injuries to the Eye##Part XXIX: The
Ear#635 The Ear 636 Hearing Loss 637 Congenital Malformations 638 External Otitis
(Otitis Externa) 639 Otitis Media 640 The Inner Ear and Diseases of the Bony
Labyrinth 641 Traumatic Injuries of the Ear and Temporal Bone 642 Tumors of the Ear
and Temporal Bone##Part XXX: The Skin#643 Morphology of the Skin 644 Evaluation of
the Patient 644.1 Cutaneous Manifestations of Systemic Diseases 645 Principles of
Therapy 646 Diseases of the Neonate 647 Cutaneous Defects 648 Ectodermal Dysplasias
649 Vascular Disorders 650 Cutaneous Nevi 651 Hyperpigmented Lesions 652
Hypopigmented Lesions 653 Vesiculobullous Disorders 654 Eczematous Disorders 655
Photosensitivity 656 Diseases of the Epidermis 657 Disorders of Keratinization 658
Diseases of the Dermis 659 Diseases of Subcutaneous Tissue 660 Disorders of the
Sweat Glands 661 Disorders of Hair 662 Disorders of the Nails 663 Disorders of the
Mucous Membranes 664 Cutaneous Bacterial Infections 665 Cutaneous Fungal Infections

666 Cutaneous Viral Infections 667 Arthropod Bites and Infestations 668 Acne 669
Tumors of the Skin 670 Nutritional Dermatoses##Part XXXI: Bone and Joint
Disorders#Section 1. Orthopaedic Problems 671 Growth and Development 672 Evaluation
of the Child 673 The Foot and Toes 673.1 Metatarsus Adductus 673.2 Calcaneovalgus
Feet 673.3 Talipes Equinovarus (Clubfoot) 673.4 Congenital Vertical Talus 673.5
Hypermobile Pes Planus (Flexible Flatfeet) 673.6 Tarsal Coalition 673.7 Cavus Feet
673.8 Osteochondroses 673.9 Puncture Wounds of the Foot 673.10 Toe Deformities
673.11 Painful Foot 673.12 Shoes 674 Torsional and Angular Deformities 674.1 Normal
Developmental of Limb 674.2 Evaluation 674.3 Torsional Deformities 674.4 Coronal
Plane Deformities 674.5 Congenital Angular Deformities of the Tibia and Fibula 675
Leg Length Discrepancy 676 The Knee 676.1 Discoid Lateral Meniscus 676.2 Popliteal
Cyst 676.3 Osteochondritis Dissecans 676.4 Osgood-Schlatter Disease 676.5
Idiopathic Adolescent Anterior Knee Pain Syndrome 676.6 Patellar Subluxation and
Dislocation 677 The Hip 677.1 Developmental Dysplasia of the Hip 677.2 Transient
Monoarticularsynovitis (Toxic Synovitis) 677.3 Legg-Calv-Perthes Disease 677.4
Slipped Capital Femoral Epiphysis 678 The Spine 678.1 Idiopathic Scoliosis 678.2
Congenital Scoliosis 678.3 Neuromuscular Scoliosis, Genetic Syndromes, and
Compensatory Scoliosis 678.4 Kyphosis 678.5 Back Pain in Children 678.6
Spondylolysis and Spondylolisthesis 678.7 Disk Space Infection 678.8 Intervertebral
Disk Herniation/Slipped Vertebral Apophysis 678.9 Tumors 679 The Neck 679.1
Torticollis 679.2 Klippel-Feil Syndrome 679.3 Cervical Anomalies and Instabilities
680 The Upper Limb 681 Arthrogryposis 682 Common Fractures 682.1 Unique
Characteristics of Pediatric Fractures 682.2 Pediatric Fracture Patterns 682.3
Upper Extremity Fractures 682.4 Fractures of Lower Extremity 682.5 Operative
Treatment 682.6 Complications of Fractures in Children 682.7 Outcomes Assessment
683 Osteomyelitis (new title) 684 Supperative Arthritis (Septic Arthritis) Section
2. Sports Medicine 685 Epidemiology and Prevention 686 Management of
Musculoskeletal Injury 686.1 Growth Plate Injuries 686.2 Shoulder Injuries 686.3
Elbow Injuries 686.4 Low Back Injuries 686.5 Hip and Pelvis Injuries 686.6 Knee
Injuries 686.7 Lower Leg Pain: Shin Splints and Stress Fractures and Chronic
Compartment Syndrome 686.8 Ankle Injuries 686.9 Foot Injuries 687 Head and Neck
Injuries 688 Heat Injuries 689 Female Athletes: Menstrual Problems and Risk for
Osteopenia 690 Ergogenic Aids 691 Specific Sports and Associated Injuries Section
3. The Skeletal Dysplasias 692 General Considerations 693 Disorders of Involving
Cartilage Matrix Proteins 694 Disorders Involving Transmembrane Receptors 695
Disorders Involving Ion Transporter 696 Disorders Involving Transcription Factors
697 Disorders Involving Defective Bone Resorption 698 Disorders for Which Defects
Are Poorly Understood or
Unknow##################################+###,###0###B#########
##
##
##
##3###R###S###]###^###j###k################################ ###!###z###{###|
###}###~############wh##########################h
`?#<#CJ##OJ##QJ##^J##aJ####jQ####h`?#CJ##OJ##QJ##U##^J##aJ####j#####h`?
#CJ##OJ##QJ##U##^J##aJ####h`?#CJ##aJ#####h`?#CJ##OJ##QJ##^J##aJ### #h`?
#5#CJ##OJ##QJ##\#^J##aJ### #h`?#5#CJ##OJ##QJ##\#^J##aJ#####h`?
#CJ##OJ##QJ##^J##aJ#####h`?#CJ##OJ##QJ##^J##aJ### #h`?
#5#CJ##OJ##QJ##\#^J##aJ##$###########
###~###################################################################r###
#########j############b############Q############Q#####################
&##F###d##d##$#If####[$#\$#######$#If#########$#a$#gd`?
#J##kd####$##$#If#####T############################
###
###########6#####################3#######4#######a###p
#######T###:##kd#####$##$#If#####T#################################6######
###############3#######4#######a###T######$#If#########
#################################################################################
###################################################################################
###################################################################################
###################################################################################

###################################################################################
###################################################################################
#####################################################################S
#######7#########"##"########)##)##E5##c5##k8##8##8##8##8##8##:##:##
;##;##<###=##=##=##g?##}?
##B##B##B##B###C###C##D##D##F##F##J##J##K##K##|
L##L##M##M##^N##
#### #h`?
#6#CJ##OJ##QJ##]#^J##aJ### #h`?#5#CJ##OJ##QJ##\#^J##aJ#####h`?
#CJ##aJ#####h`?
#CJ##OJ##QJ##^J##aJ########T##X##X###Y###Y###[##"[##]##]##]##]##r^##}^###`##(
`##gb##rb##l##l##m##m##q##q##r##r##r##r##zu##u##
##C##D##O########
##/##:##o##z######H##S##C##N#####1##2##=#######
## ##D##O####
#
#####'########B##M####
##O#
##q##5##J##K##V########
##
#h`?#5#CJ##OJ##QJ##\#^J##aJ#####h`?#CJ##OJ##QJ##^J##aJ### #h`?
#6#CJ##OJ##QJ##]#^J##aJ##R####G##R##V##a##P#######,#####!##"####x####J##U##.##7######)##4##
##"#####@######d##v##y############S##^##x#########2##
=####$##y#############
<##################################################################################
################################h`?####h`?#CJ##OJ##QJ##^J##aJ####U## #h`?
#5#CJ##OJ##QJ##\#^J##aJ#####h`?#CJ##OJ##QJ##^J##aJ### #h`?
#6#CJ##OJ##QJ##]#^J##aJ##4n 699 Osteogenesis Imperfecta 700 Marfan Syndrome
Section 4. Metabolic Bone Disease 701 Bone Structure, Growth, and Hormonal
Regulation 702 Primary Chondrodystrophy (Metaphyseal Dysplasia) 703
Hypophosphatasia 704 Hyperphosphatasia 705 Osteoporosis ##Part XXXII: Environmental
Health Hazards #706 Biologic Effects of Radiation on Children 707 Chemical
Pollutants 708 Heavy Metal Poisoning 709 Lead Poisoning 710 Nonbacterial Food
Poisoning 710.1 Mushroom Poisoning 710.2 Solanine Poisoning 710.3 Seafood Poisoning
711 Biologic and Chemical Terrorism 712 Animal and Human Bites 712.1 Rat-Bite Fever
712.2 Monkeypox 713 Envenomations##PART XXXIII: Laboratory Medicine#714 Laboratory
Testing in Infants and Children 715 Reference Ranges for Laboratory Tests and
Procedures 716 Medications
###################################################################################
###################################################################################
######################################################################,#1h##.
A!##"####$#%######

#################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
######################################################O##$##$#If####!
v##h#5######v###:V######6#####5######3#######4###
###T##:###D#d##############################################################P###
#
#########
##S##,####A#####

##################c#l#e#a#r###############b#########
%@#a){##r##############n#j#####%@#a){#PNG
#
###
IHDR#############(4####PLTEf3#
f3#f3#ff
ffff3f#3333f333#####f#3##f3#
f3#

f3
# f
fffff3f#3333f333#####f#3##
f3#
f3#

f3#ff
ffff3f#33
3 3f333###
# #f#3##ffffff3f#f
ff
fff3f#ffffff3f#fffffffffff3ff#f3f3f3f3ff33f3#f#f#f#f#ff#3f
##3333f333#333
3 f333#3333f333#3f3f3f3ff3f33f#33333333f
33333#3#3#3#3#f3#33######f#3#####
# f#3######f#3###f#f#f
#ff#f3#f##3#3#3#3f#33#3#########f##3#####################################
###################################################################################
#l###tRNS

#A####bKGD###H
###

cmPPJCmp0712####H#s###
IDAT#Wc####8}####IENDB`t##$##$#If####!v##h#5######v###:V##
###
###########6#####,####5######3#######4###
###p
#######T##O##$##$#If####!
v##h#5######v###:V######6#####5######3#######4###
###T##############################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
##################################################################################
##################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
##############################################################@##@##@#

###########N#o#r#m#a#l#########CJ##_H##aJ##mH
###################D#A@#D#

#sH

#tH

###########D#e#f#a#u#l#t# #P#a#r#a#g#r#a#p#h# #F#o#n#t#####R#i@#R#

#########

#T#a#b#l#e# #N#o#r#m#a#l#########4###
#l#4#######a#########(#k@#(#############N#o#
#L#i#s#t###############h#####################
###~######################7
##
##
##
##g##j######0########################0#######################0##########
######## #####0#########################0##################
#####0#########################0#######################
#0####################### #0####################### #0#######################
#0####################### #0#########################0##################
#@###0##################@###0#######################0#####0##############
######t##0#######################0#####################t##0##############
#########0#####################d##0########################0#############
###########0###################### ##0########################0
########################o#####

################################0
##############^N#######w###z###|###}##############x###{##########y### ###z###|
###h###C#####8##################################@####################
####################0######(#####
######################
###############B#####
############S####################### ###?
######################f#e#a#t#u#r#e#s###t#o#c####
##j#############
##j##############L#6#########$#########t26#########t66#########6##
########+##T##j#########################################+##T##j#########
#################9#######*urn:schemas-microsoftcom:office:smarttags#place#>#######*urn:schemas-microsoft-com:office:smarttags
PersonName#

####^a###############################################:###B###k###u#############
######

###B###L#############

##############################<###E###X###]###4###=#####################
######
##
##
##
##
##
##
###
##=
##F
##a
##j
##
##
##
##
##(###-###############

##

##

##

##B###L#########1###;###########################o###}#########Z###`###t
###}#############2########################################
###)###;###K###M###]###c###s###Q###^##############7###L###V###[###h###q###z#########
#######t###}######G##j##########################################################
###################################################################################
###################################################################################
################################################Q9##9##W;##;###D###D##>D##D##TO#
#XO##QT##T####D##,##1######V##7##N##Q####>##j####3###3###3###3###3###
3###3###3###3###3###3###3############# ##
##j################j######47t|
ZM################################################^#`CJ##OJ#
#QJ##o(#######################################^#`CJ##OJ##QJ##o(###o#
############################p######p##^p#`CJ##OJ##QJ##o(##############
#################@######@##^@#`CJ##OJ##QJ##o(##########################
###############^##`CJ##OJ##QJ##o(#################################
######^#`CJ##OJ##QJ##o(#######################################^#
`CJ##OJ##QJ##o(#######################################^#`CJ##OJ##
QJ##o(###############################P######P##^P#`CJ##OJ##QJ##o(####
###47t|###############################################`?############
###~######### ##
##j###################################@###g##g########g######g#######d#
######r###r###rr##rs##r##r##T##h##`####@##`##&####`##P#@##`##|
####`###@##`######`###@##`###@########U#n#k#n#o#w#n#####################
####################G#############z# ##################T#i#m#e#s#
#N#e#w#
#R#o#m#a#n###5#####################################S#y#m#b#o#l###3&############
z# ##################A#r#i#a#l###;&############z#
##################H#e#l#v#e#t#i#c#a###?5#####
######z#
##################C#o#u#r#i#e#r#
#N#e#w###;#####################################W#i#n#g#d#i#n#g#s###"###1######
h#####sD&vD&###########"##Q####t###########"##Q####t##########!
##################################################################################
###################################################################################
###################################################################################
#########################################################################24###
###d###########################################################################
#######2##################################HX####)####?#####
##
`?
##############################+#N#e#l#s#o#n# #T#e#x#t#b#o#o#k# #o#f#
#P#e#d#i#a#t#r#i#c#s#,# #1#8#t#h#
#e#d#i#t#i#o#n#########E#l#s#e#v#i#e#r###E#l#s#e#v#i#e#r###########################
########

###################################################################################
###################################################################################
###################################################################################
###################################################################################
###############################################################################
Oh###+'0###############################################################
##### ###,#######8###
###X###

###d######p#######|###################################,###Nelson Textbook of
Pediatrics, 18th edition#################

###Elsevier################################

###Normal.dot######

###Elsevier############1###########Microsoft Office Word###@####Ik####@####


#
#@####

q
##############"######Q###########################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
#############################################.####+,0### ###

#######h#######p###########################################################
######

######################REED
Elsevier##############t########################################################
,###Nelson Textbook of Pediatrics, 18th edition#

###############Title###############################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
##### ###
#######

############################################################################## ###!
###"#######$###%###&###'###(###)###*###+###,######.###/###0###1###2###3###4###5###6###7###8###9###:###;###<###=###>###?
###@###A###B###C###D###E###F###G###H###I###J###K###L###M###N###O###P###Q###R###S###
T###U###V###W###X###Y###Z###[###\###]###^###_###`###a###b###c###d###e###f###g###h##
#i###j###k###l###m###n###o###p###q###r###s###t###u###v###w###x###y###z###{###|
###}###~###################################################
######################################################
###

R#o#o#t#
#E#n#t#r#y######################################################
############F#############u
###########D#a#t#a#########################################################
##################################################1#T#a#b#l#e#########
###############################################################################
#######################W#o#r#d#D#o#c#u#m#e#n#t###################################
##########################################################.#########S#u#m#m#a#r
#y#I#n#f#o#r#m#a#t#i#o#n###########################(###################
#################################D#o#c#u#m#e#n#t#S#u#m#m#a#r#y#I#n#f#o#r#m#a#t#i#o
#n###########8########################################################C#o#
m#p#O#b#j##############################################################
###############################q###################################################
#######################################################################
#####

###
###
############F####Microsoft Office Word Document#
###MSWordDoc#####Word.Document.8#9q##############################################
###################################################################################
###################################################################################
###################################################################################
###################################################################################
#################################