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unaffected grandparent the risk of HD is low, if the allele is inherited from the
affected grandparent, the risk of HD is 50% b/c it is not known whether the
allele inherited from the affected grandparent is the allele w/ or without the
mutation.
The most prominent concerns include failure or inaccuracy of the standard testing
protocol, ambiguous clinical implications of repeat expansions in the nonpenetrant
range & the ambiguity of negative presymptomatic testing results in the absence
of info about molecular diagnosis of affected family members