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ATHEROSCLEROSIS
Atheroma Formation
RCAMBIDA 2015 |1
Calcification
atherosclerotic plaques also accumulate
calcium
osteocalcin, osteopontin, and bone
morphogenetic proteins
Plaque Evolution
complex balance between entry and egress
of lipoproteins and leukocytes, cell
proliferation and cell death, extracellular
matrix production, and remodeling, as well
as calcification and neovascularization
Hypertension
epidemiologic data support a relationship
between hypertension and atherosclerotic
risk
pharmacologic treatment of hypertension
can reduce the risk of stroke, heart failure,
and CHD events
Diabetes Mellitus, Insulin Resistance, and the
Metabolic Syndrome
diabetic dyslipidemia
o low HDL and elevated triglyceride
levels
elevated cardiovascular risk in patients with
type 2 diabetes
"tight" glycemic control may increase
adverse events in patients with type 2
diabetes, lending even greater importance
to aggressive control of other aspects of risk
in this patient population
RCAMBIDA 2015 |3
Lifestyle Modification
optimize risk factor profiles long before
atherosclerotic disease manifests
assess and minimize cardiovascular risk
counsel patients about the health risks of
tobacco use and provide guidance and
resources regarding smoking cessation
prudent dietary and physical activity habits
for maintaining ideal body weigh
at least 30 minutes of moderate-intensity
physical activity per day
REFERENCE
Homocysteine
accumulation correlate with thrombosis
and with coronary risk
Inflammation
plasma levels of CRP, as measured by a
high-sensitivity assay (hsCRP)
o also correlate with the outcome in
patients with acute coronary
syndromes
o validated biomarker of risk but
probably not as a direct contributor
to pathogenesis
RCAMBIDA 2015 |4