Name of Patient

F. S.

Age

35 y.o

Height

53

Diagnosis

G3P3 (3003) PU del. ceph. term live birth by 1oLSTCS +

BTL w/ variable deaceration; severe preeclampsia
M. M. Olmillo

Sex

Female

Weight

60 kg

Website

milkv.co.vu

A/N

youre welcome J

Author

DRUG DATA
Generic name:
Spirinolactone

CLASSIFICATION
Pharmacologic:
Aldosterone
antagonist

Trade name/s:
Aldactone,
Novospiroton
Patients dose:
50mg OD

MECHANISM OF
ACTION

Competitively blocks
the effects of
aldosterone in the
renal tubule, causing
loss of sodium and
water and retention of
potassium

Therapeutic:
Potassium-sparing
diuretic

Maximum Dose:
100 mg PO OD
Onset: 24-48hr
Minimum Dose:
50 mg PO OD

Pregnancy Category
Risk: C

Availability:
Tablets 25, 50,
100mg

Peak: 48-72 hr
Duration: 48-72 hr
Metabolism: hepatic,
20hr
Distribution: crosses
placenta, enters
breast milk
Excretion: feces,
urine

Source: 2011
Lippincotts NDG

Source: 2011
Lippincotts NDG

Source: 2011
Lippincotts NDG

INDICATIONS

General:
> diagnosis and
maintenance of
primary
hyperaldosteronis
m
> adjunctive
therapy in edema
> treatment or
prevention of
hypokalemia
> essential
hypertension
> treatment of
hirsutism, palliation
of symptoms of
PMS, treatment of
familial male
precocious
puberty; short-term
treatment of acne
vulgaris
Patients actual
indications:
Treatment of
pregnancy-induced
hypertension

Source: 2011
Lippincotts NDG

CONTRAINDICATI
ON

Contraindicated with
allergy to spirinolactone,
hyperkalemia, renal
disease, anuria,
amiloride or triamterene
use
Precautions:
Use cautiously with
pregnancy, lactation

ADVERSE
EFFECTS

CNS: dizziness,
headache,
drowsiness
Dermatologic:
rash, urticaria
GI: cramping,
diarrhea, dry
mouth
GU: impotence,
irregular menses,
amenorrhea

Interactions:
> drug-drug: increased
hyperkalemia with
potassium supplements,
ACE inhibitors, diets rich
in potassium, decreased
diuretic effect with
salicylates
> drug-food: increased
absorption when taken
with food
> drug-lab test:
interference with
radioimmunoassay for
digoxin; false increase in
serum digoxin levels
> drug-alternative
therapy: decreased
effectiveness if combined
with licorice therapy

Source: 2011
Lippincotts NDG

Hematologic:
hyperkalemia,
hyponatremia
Other:
carcinogenic in
animals,
deepening of the
voice, hirsutism,
gynecomastia

Source: 2011
Lippincotts NDG

NURSING
RESPONSIBILITIE
S

Before:
> Check doctors order.
> Review medication record.
> Determine potassium levels
> Determine renal, hepatic
impairment.
> Determine hypersensitivity.
During:
> Introduce self to client.
> Confirm clients identity.
> Read drug label.
> Inform drugs therapeutic effect.
> Inform of side effects
> Administer in the morning to
prevent nocturia
After:
> Evaluate therapeutic response.
> Watch for adverse effects.
> Warn patient to avoid excessive
ingestion of potassium-rich foods.
> Caution patient not to perform
hazardous activities if adverse CNS
reactions occur.
> Report to prescriber the adverse
reactions.
> document and record.

Source: 2011 Lippincotts Nursing

Drug Guide