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Department of Medicine, Division of Rheumatology, University of Padua, Via Giustiniani 2, 35128 Padua,
Italy
2
Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Affiliated with Sackler
Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel
Abstract: Lipid replacement therapy (LRT) is an anti-aging product which reverses age-related changes in the lipid
composition of organ and tissue cells. Since membrane lipids oxidation seems to be involved in the pathogenesis of
Chronic Fatigue Syndrome (CFS), their substitution with new lipids coming from dietary supplements is speculated to be
effective in CFS. We have analyzed some of the most recent articles about the effects of LRT in fatigue, showing the
evidences supporting this theory as well as alluding to the weak points of the studies.
Keywords: Lipid replacement therapy, Chronic Fatigue Syndrome, Reactive Oxygen Species, Mitochondrial
damage, Cancer, Phosphatidylcoline.
FOREWORD
Lipid replacement therapy (LRT) is an anti-aging
product invented and patented by Yechezkel Barenholz
and Elishalom Yechiel in 1989 [1]. They defined it as a
method of treating a relatively aged animal to reverse
age-related changes in the lipid composition of organ
and tissue cells. In fact, membrane lipid composition
changes
in
aging,
with
a
decrease
in
phosphatidylcholine levels and an increase of
sphingomyelin and cholesterol. These biochemical
changes are accompanied by a decrease in energy
production, as observed in murine myocardial cells in
culture, where the aging of membrane lipid composition
and the decrease of beating rate, run in parallel [2-4].
In particular, they performed an in vivo study [3] in
which murine myocardial cells were divided into three
groups. The first group was fed with phosphatidylcoline
for all the duration of the study, witch lasted 20 days.
During this time, the cells maintained a beating rate of
160 beats/minute. The second group was fed with a
broad cultured phosphatidylcoline-free. The beating
rate of cells began dropping off day after day till the
th
12 day, when their beating rate was only 20
beats/minute. The third group was fed with
th
phosphatidylcoline only till the 11 day. After that time
their beating rate dropped almost immediately in the
th
same way of the second group. On the 16 day,
phosphatidylcoline was added in the broad culture of
the second and third group and in just 24 hours the
29
Phosphoglycolipids
Growth Media
Foods and bacterial growth factors to support microflora colonies including rice bran extract,
arginine, beet root fiber, black strap molasses, glycine, magnesium sulfate, para-aminobenzoate, leek, pantethine (bifido growth factor), taurine, garlic, calcium borogluconate,
potassium citrate, calcium sulfate, spirulina, bromelain, natural Vitamin E, calcium ascorbate,
alpha-lipoic acid, oligosaccharides, B-6, niacinamide, riboflavin, inositol, niacin, calcium
pantothenate, thiamin, B-12, folic acid, chromium picolinate
30
Borella et al.
20 IU
1500 mg
180 mg
% Daily Value**
11
1%
1g
2%
Saturated Fat
0.2 g
1%
Cholesterol
1 mg
< 1%
0.11 g
< 1%
0 mg
0%
Total Fat:
Total Carbohydrates
Sodium
Protein
0.25 g
< 1%
8,125 IU
163%
150mg
250%
500 IU
125%
146 IU
487%
2.5 mcg
3%
6.25 mg
417%
30 mg
1765%
60 mg
300%
40 mg
2000%
200 mcg
50%
25 mcg
417%
Biotin
25 mcg
8%
25 mg
250%
400 mg
40%
50 mg
5%
18.75 mcg
13%
160 mg
40%
12.5 mg
83%
75 mcg
107%
0.3 mg
15%
2.5 mg
125%
50 mcg
42%
20 mcg
27%
12.8 mg
< 1%
300 mg
160 mg
180 mg
120 mg
31
32
Borella et al.
125 mg
Taurine
100 mg
70 mg
L-Tyrosine
60 mg
PABA
55 mg
50 mg
25 mg
N-Acetyl-L-Cysteine
25 mg
12.5 mg
Grapeseed extract (Vitis vinifera) (inner core of fruit) [Standardized for 95%
proanthocyanidins (4.75mg)]
5 mg
L-Glutathione (reduced)
5 mg
5 mg
5 mg
5 mg
500 mcg
12.5 mcg
1560 mg
[9]
[10]
[11]
[12]
[13]
[14]
[15]
[16]
[17]
[18]
[19]
[20]
[21]
[22]
[23]
CONCLUSION
In conclusion, on the basis of the scientific
evidences presented by Nicolson et al., new nutritional
supplements have been entering the market.
[2]
[3]
[4]
[5]
[6]
[7]
[8]
33
34
[24]
[25]
[26]
[27]
Received on 04-03-2014
DOI: http://dx.doi.org/10.12970/2310-9874.2014.02.01.5
Borella et al.
[28]
[29]
[30]
Accepted on 19-03-2014
Published on 26-03-2014