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Includes all nerves traveling between the CNS and somatic and visceral sites?
Includes the diencephalon, cerebrum, cerebellum, brainstem, and spinal cord?
Responsible for perception, wakefulness, language, and consciousness?
Sensory neurons arise principally from what?
Sensory cell bodies and nuclei are located where?
Sensory neurons project onto neurons located where?
Somatic motor neurons arise from where?
Somatic motor neurons exit through what?
Somatic motor fibers join with what?
Somatic motor fibers innervate what?
Sympathetic PreG arise from where?
Adrenal Medulla is innervated by what?
Parasympathetic preganglionic neurons arise from where?
Where are parasympathetic ganglia located?
Cell bodies for the preganglionic sympathetics are located where in the spinal cord,
specifically?
Consists of 25 pairs of interconnected ganglia that lie on either side of the vertebral
column?
SNS ganglia that innverates pupil, salivary gland, lacrimal gland, blood vessels and sweat
glands in head and face?
PostG neurons arising in the middle/inferor cervical + thoracic ganglia, innervate what?
Adrenal medulla contains what type of cells?
Sympathetic agonist that can dilate the brochioles selectively?
Sympathetic antagonist that can selectively decrease the heart rate and contractility?
PreG fibers from CN III arise from a midbrain region called the?
PSNS Antagonist used locally to dilate the pupils or systemically to increase heart rate?
PSNS antagonist used to dilate the bronchioles?
Motor Cortex -> cross the medulla -> Descend through the cord to other neurons in
ventral horns?
Motor neurons in the ventral horn?
Projections that exit the ventral roots and mix with sensory are called?
Ascend through the dorsal columns in the SC and synapse with secondary neurons in the
contralateral medulla?
Synapse with secondary neurons in the posterior horn of the SC, cross in SC, ascend
contralateral spinothalamic tract?
Both the spinothalamic tract and dorsal column tract connect with third order neurons in
the?
Antagonists of NMJ activity used for paralysis during surgery?
Increase NMJ activity and used in the diagnosis of Myastenia Gravis
Commonly prescribed hypnotics and sedatives that potentiate the action of inhibitory NTs
in the cortex?
Consists of myelined axons that have an associated vascular network?
Caused by degeneration of a dopaminergic pathway that arises in the substania nigra in
the midbrain?
A component of sinemet medication that acts on the striatum to ameloriate symptoms of
parkinsons?
Caused by degeneration of the hippocampal formation?
Many drugs of abuse stimulate the brain-reward pathway, which includes a specific
structure noted in the text?
Not simply a signal relay, rather it filters and modulates sensory information - which
signals reach conscious awareness?
Neurons in the periaquaductal gray, send projections to the SC that modulate what?
Reticular Formation
NT system
Anithistamines
Cocaine
SC
Long tract
PNS
Modification
Divergent Signalling
Convergent Signalling
Center-surround signalling
Structural motif
excitory and inhibitory neurons
Processing information
Single-source
Diffuse system of organization
Myelin sheaths
Modulatory influence change over longer periods of time (rather than fractions of seconds)
Dopamine
Enable intended motion, emotion, thought, and memory storage
NE
Vigilance, responsiveness to unexpected stimuli
Serotonin
Perception of Pain
Depression
Reuptake of serotonin
The serotonergic system
PostG SNS
Ach and NE
Ach
AA NTs
Excitatory
Inhibitory
Excessive excitation of certain glutamate receptors
Felbamate
GABA
Tyrosine
Tryptophan
Histidine
Can't cross the BBB
Parkinsons Disease
Schizophrenia
Cytoplasm
Dopamine B-hydroxylase
Cytoplasm
Epinephrine
Clondine
TCAs
MAOIs
Serotonin
Donepezil
Scopolamine
Pilocarpine (drool, tear and sweat) - Sjogrens
Caffeine
Presynaptic noradrenergic neurons
Release of NE
Presynaptic neurons
Retrograde messenger
Spinal cord
BBB
Fenestrae
Tight junctions
Pinocytotic vesicles
Hexose Transporters (facilitated diffusion)
Astroglia
Large AA transporter
Protein
The AA transporter can become overwhelmed
Converts LDOPA -> DOPA
Inhibits DOPA decarboxylase to ensure that LDOPA does not get converted to something that
can not cross the BBB, like DOPA
Pharmacology - Chapter 26
GH is secreted in large amounts during what life period?
When do the largest pulses of GH get released?
What mediates the effects of GH?
What is IGF-1?
Can IGF-1 be measured?
When it is helpful to be measured?
Name some environmental factors that stimulate the release of GH?
Name some endogenous biological factors that stimulate the release of GH?
What is ghrelin?
What does grehlin act synergistically with?
What secretes ghrelin?
During what state is ghrelin released, fasting or fed
What are the most significant endogenous factors that inhibit GH release?
GH deficiency commonly results from what?
In GH insensitivity, what is reduced?
Secondary GH deficiency?
Teritary GH deficiency?
GH excess?
GHRH analogues (for the treatment of GH or IGF-1 insufficiency)?
Recombinant HGH?
Diagnosis required for HGH treatment?
Name for recombinant IGF-1?
Mecasermin is approved to treat what?
Gigantism?
Acromegaly?
Mainstay of medical therapy to treat GH excess?
Synthetic long-lasting analogues of somatostatin?
Puberty
At night
IGF-1
A hormone released into the circulation by hepatocytes in response to stimulation by GH
a bound and stable protein in the circulation at steady concentrations
In the diagnosis of acromegaly
hypoglycemia, sleep, exercise, and adequate nutritional status
hypothalamic GHRH, sex steroids, dopamine, ghrelin
important endogenous growth hormone-releasing peptide
with GHRH to promote the release of GH (acts on a receptor that is different from GHRH's
receptor)
Gastric Fundal Cells
Fasting, links growth with nutritional status and energy balance
Somatostatin, IGF-1, and GH
defective hypothalamic release OR pituitary insufficiency
IGF-1, GH is secreted but the liver is unresponsive to the it's effect
Unresponsive Anterior Pituitary, secretes reduced amounts of GH
Lack of GHRH from the hypothalamus -> less GH -> less IGF-1
Usually from adenoma of the anterior pituitary, negative feedback of increased IGF-1 is shot.
Sermorelin (synthetic GHRH) - currently unavailable
Tesamorelin (novel GHRH analogue) - Augments basal and puslatile GH secretion
Glucagon
Insulin-induced hypoglycemia
Arginine
Clonidine
Somatotropin
confirmed GH deficiency or panhypopituitarism
Mecasermin
Laron Dwarfism (GH insufficiency)
IGF excess occurs before the epiphyses close, increased longitudinal growth
IGF excess after the epiphyses close, increased hand thinckness, shoe size, fatigue and
hyperhidrosis
SRLs (Somatostatin Receptor Ligands)
Octreotide
Lanreotide
Pasireotide (Investigational)
Nausea, diarrhea, gallstones, and headache
Bromocriptine
Cabergoline
Acromegaly
Less effecitve, usually used as a second line treatment
2
Dimerization
Pegvisomant
Pegvisomant
increased GH levels due to lack of IGF1 negative feeback
Prolactin
Under tonic inhibition by dopamine
TRH and estrogen
Increased prolactin levels
Pharmacology - Chapter 30
GLP-1 does what?
Counter-regulatory hormones do what?
Why is hypoglycemia so dangerous?
Why is chronic hyperglycemia so dangerous?
Which organ receives the highest concentration of Insulin concurrently with nutrients
absorbed from GI tract?
Which organs are the primary targets for insulin?
Leptin plays a role in what?
Leptin is secreted from what?
Leptin's concentration in the plamsa is proportional to what?
Leptin also supresses what?
This suppression switches the body from energy accumulating state to?
Is a transcription factor that serves as the master regulator of adispose differentiation?
Activation PPAR decreases serum FA levels and promotes what?
Lowering the fat content of the liver and skeletal muscles increases these tissues
sensativity to what?
PPAR is the target for what class of drugs?
Secreted from -cells?
Secreted from -cells?
Secreted from -cells?
Secreted from -cells, GI tract, and Hypothalamus?
Secreted from the Adrenal Medulla?
Secreted from the Adrenal Cortex?
Secreted from the Ileum?
Secreted from Adipocytes?
Promotes glycogenolysis and gluconeogenesis?
Promotes uptake of glucose, AA, and FA from blood into cells for storage as glycogen,
protein, and triglyceride?
Decreases the release of Insulin and Glucagon, Decreases GI tract motility and hormone
release, decreases GH?
Antagonizes insulin at target tissues, promotes gluconeogenesis in liver and protein
breakdown in muscle?
Signals adequacy of body energey stores, decreases food intake, and permits energy
intensive neuroendocrine functions?
Surpresses glucagon release, slows gastric emptying, and decreases food intake?
Promotes glycogenolysis in liver and lipolytic via activation of hormone senstitive lipase?
Increases -cell mass and insulin secretion, delays gastic emptying, and decreases food
intake and glucagon secretion?
Amylin primarily acts where?
Somatostatin primarily acts where?
What substance discussed above works on the endocrine pancreas, stomach, brain and
heart?
What has a primary site of action at the CNS (basomedial hypothalamus)?
In low energy states, what enzyme triggers a shift from anabolic to catabolic activities?
Breaks down dietary complex carbohydrates into simple sugars in the GI brush border?
Glucose metabolism in -cells increases what to trigger insulin secretion?
Promotes the conversion of glucose into TGs in adipocytes?
Glucose enters -cells via a specific transporter?
Drugs that delay gastric emptying?
Drugs that inhibit -glucosidases?
Drugs that augment (increase) insulin secretion?