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Nikethamide
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Nikethamide
Clinical data
AHFS/Drugs.com International Drug Names
Legal status
Pharmacokinetic data
Half-life
0.5 h
Identifiers
CAS number
59-26-7
ATC code
R07AB02
PubChem
CID 5497
ChemSpider
5296
UNII
368IVD6M32
KEGG
D07408
Synonyms
Formula
C10H14N2O
Molecular mass
178.231
SMILES[show]
InChI[show]
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Nikethamide is a stimulant which mainly affects the respiratory cycle. Widely known by its former
trade name of Coramine, it was used in the mid-twentieth century as a medical countermeasure
against tranquilizer overdoses, before the advent of endotrachealintubation and positive-pressure
lung expansion. It is now considered to be of no value for such purposes, and may in fact be
dangerous.[1]
In alternate terminology, it is known as nicotinic acid diethylamide, which meaningfully emphasizes
its laboratory origins, and of which its common name is derived as a blend.
Contents
[hide]
2 Use in sports
3 References
4 External links
Use in sports[edit]
In sports, nikethamide is listed by the World Anti-Doping Agency as a banned substance. Croatian
tennis player Marin ili was suspended from competition for nine months after he tested positive for
nikethamide in April 2013.[5] This ban was later reduced to four months after Cilic appealed and
claimed he had unintentionally ingested it in a glucose tablet bought at a pharmacy.
[6]
Polishkart driver Igor Walilko was given a two-year ban, later reduced to eighteen month, from
competition in 2010 due to testing positive for nikethamide after a win in Germany in July, 2010.[7]
References[edit]
1.
2.
Jump up^ Cullen, Pamela V., "A Stranger in Blood: The Case Files on Dr
John Bodkin Adams", London, Elliott & Thompson, 2006, ISBN 1-904027-19-9
3.
Jump up^ Doyle D (February 2005). "Adolf Hitler's medical care" (PDF). J.
R. Coll. Physicians Edinb. 35 (1): 7582. ISSN 14782715. OCLC 49953788. PMID 15825245. Retrieved2009-03-15.
4.
5.
6.
Jump up^ "Cilic cleared to play again after suspension reduced". Tennis. 25
October 2013. Retrieved 25 October 2013.
7.
Nikethamide
Overview
Nikethamide is a respiratory stimulant. It acts directly in the respiratory centres of brain.
Nikethamide is seldom useful except in respiratory depression due to severe chronic
bronchitis. Not used in treatment of respiratory depression due to drug overdosage.
Category:
24 Psychotherapeutic drugs
24.5 Psychostimulants, nootropics, and neurotonics
Primary Characterstics
Pharmacokinetics
Indications
Nikethamide is primarily indicated in conditions like Asphyxia, CNS depression,Respiratory
depression.
Contraindications
Nikethamide is contraindicated in conditions like Porphyria,Hypersensitivity to any
component of product.
Drug Interactions
No data regarding the interactions of Nikethamide was found.
Interference in Pathology
No data regarding the pathological interferences produced by Nikethamide is available.
Side Effects
The symptomatic adverse reactions produced by Nikethamide are more or less tolerable
and if they become severe, they can be treated symptomatically, these include Nausea,
Itching, Breathlessness, Paresthesias, Heat sensation.
Available Brands
Click on the appropriate strength of the dosage form to view its available brands.
Single Ingredient
Inj: 250 mg/ml,
Dosage
Nikethamide's dosage details are as follows:
Dose Single Dose
Adult Dosage
1.5 g 1.5 (1.5)
Frequency
As recommended.
Route
Instructions
IV