5/29/2015

Nanoparticlepurificationmethods.
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GabrielDeCrozals 15.77

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ClaudeBernardUniversityLyon1

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Nanoparticlepurificationmethods.
I'mwonderingwhatthebestmethodtopurifynanoparticlesaftermodificationwitha
moleculeis(IwanttoseparateNPfromnonreactingmolecules).I'velookedat
dialysisorcentrifugalfiltrationbutI'mworriedthatdialysisistimeconsumingthat
theremaybeariskofaggregationwithcentrifugation.What'syourexperience?Any
othersuggestions?

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NanoparticleResearch

Nanoparticles

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Nanomaterials

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Jan30,2013

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MathiasBrust 53.91 803.91UniversityofLiverpool

Inmyexperience,nothingbeatsrepeatedcentrifugation.Ifthematerialis
wellligandstabilizedthereshouldbenoriskofaggregation.Centrifugal
filtrationisalsogoodbutoftenleadstolossesbyparticlesstickingtothe
filter.Ofcourse,youhavethewholerangeofchromatographiesyoucan
try,butthisisalsoquitetimeconsuming.Insomeselectedcasesyoucan
alsoflocculatetheparticlesbyadditionofanonsolvent(ornon
dispersant,tobepedantic)and,ifyouarelucky,canwashawayall
impuritiesbeforeredispersionoftheparticles.Ifyouwanttopurify

BibekThapa
UniversityofPuertoR...

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chargestabilizedcolloids,rememberthatthisisnotroutinelypossible.
Evendialysiswilloftencompromisetheircolloidalstabilityandleadto
aggregation.Thisisinthenatureofcolloidsandcannotbeavoidedsince
theirstabilityasadispersiondependsonthepresenceofotherfactorsin
thesystem,forexampleioniccharge.

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10/0Feb13,2013Flag

ALLANSWERS (7)

AbhishekTyagi 14.38
Pleasegothroughthefollowinglink,Ihopeitmayhelpyouout.
http://www.ncbi.nlm.nih.gov/pubmed/20039604
2/0Jan30,2013

AnirbanGhosh 19.66 53.3TataChemicalsLtd.

Dependingonhydrophobicity/hydrophilicityoftheheadgroup,the
functionalizednanoparticlecouldbephasetransferredtoadifferent
solventsystem.Checkthispaperfordetails.PNAS2008,105,98869891
Jan31,2013

AlmiraRamanaviciene 45.57 375.66VilniusUniversity

Magneticgoldnanoparticles.
MagneticgoldnanoparticlesinSERSbasedsandwichimmunoassayforantigen
detectionbywellorientedantibodies.
JulijaBaniukevic,IsmailHakkiBoyaci,AkifGoktugBozkurt,UgurTamer,Arunas
Ramanavicius,AlmiraRamanaviciene
Feb4,2013

https://www.researchgate.net/post/Nanoparticle_purification_methods

1/2

5/29/2015

Nanoparticlepurificationmethods.
MathiasBrust 53.91 803.91UniversityofLiverpool
Inmyexperience,nothingbeatsrepeatedcentrifugation.Ifthematerialis
wellligandstabilizedthereshouldbenoriskofaggregation.Centrifugal
filtrationisalsogoodbutoftenleadstolossesbyparticlesstickingtothe
filter.Ofcourse,youhavethewholerangeofchromatographiesyoucan
try,butthisisalsoquitetimeconsuming.Insomeselectedcasesyoucan
alsoflocculatetheparticlesbyadditionofanonsolvent(ornon
dispersant,tobepedantic)and,ifyouarelucky,canwashawayall
impuritiesbeforeredispersionoftheparticles.Ifyouwanttopurify
chargestabilizedcolloids,rememberthatthisisnotroutinelypossible.
Evendialysiswilloftencompromisetheircolloidalstabilityandleadto
aggregation.Thisisinthenatureofcolloidsandcannotbeavoidedsince
theirstabilityasadispersiondependsonthepresenceofotherfactorsin
thesystem,forexampleioniccharge.
10/0Feb13,2013

ParsantaVermaIndianInstituteofTechnologyDelhi
Malsowonderingforthis.Butican'tusecentrifugaion...anyother
method?
1/0Jun11,2013

JamesByrne 0.86UniversityofNorthCarolinaatChapelHill
Tangentialflowfiltrationworkswell
2/0Jun24,2013

ArunasRamanavicius 54.62 430.7VilniusUniversity

Bestwayistopreparepurenanoparticles,withminimumadditives.An
exampleonpreparationofconductingpolymerbasednanoparticlesis
attached.
PolymerizationModelforHydrogenPeroxideInitiatedSynthesisofPolypyrrole
Nanoparticles
KarolisLeonavicius,AlmiraRamanaviciene,ArunasRamanavicius
Nov26,2013

BibekThapaUniversityofPuertoRicoatRioPiedras
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