3,4-Dimethoxyamphetamine

The Drug Enforcement Administration's Special Testing and Research Laboratory

generated this monograph using structurally confirmed reference material.

NH2

O
H 3C

CH3

H 3C

1. GENERAL INFORMATION
IUPAC Name:

1-(3,4-dimethoxyphenyl)propan-2-amine

CAS#:

120-26-3

Synonyms:

3,4-DMA

Source:

DEA Reference Material Collection

Appearance:

White powder (HCl)

UVmax (nm):

Not Determined

2. CHEMICAL AND PHYSICAL DATA

2.1 CHEMICAL DATA

Form

Chemical Formula

Molecular Weight

Melting Point ( oC)

Base

C11H17NO2

195

Not Determined

HCl

C11H17NO2 . HCl

231

151.1

Latest Revision: 12/16/2013

SWGDRUG.org/monographs.htm

Page 1 of 5

3,4-Dimethoxyamphetamine
The Drug Enforcement Administration's Special Testing and Research Laboratory
generated this monograph using structurally confirmed reference material.
3. QUALITATIVE DATA
3.1 NUCLEAR MAGNETIC RESONANCE
Method NMR D 2O
Sample Preparation: Dilute analyte to ~10 mg/mL in D2O containing TSP for 0 ppm reference and maleic
acid as quantitative internal standard.
Instrument:
Parameters:

400 MHz NMR spectrometer

Spectral width: at least containing -3 ppm through 13 ppm
Pulse angle: 90o
Delay between pulses: 45 seconds

H NMR: 3,4-dimethoxyamphetamine HCl Lot # MP150-151 Batch 1; D2O; 400 MHz

HDO

3.5
3.0
2.5

Maleic Acid

2.0
1.5
1.0
TSP

0.5

solvent impurity

0
111
8

6 1
6

0.4

3
2

Chemical Shift (ppm)

1.0

0.3
0.2

0.5

0.1
0

0
1

Chemical Shift (ppm) Chemical S... Chemical Shift (ppm)

Latest Revision: 12/16/2013

SWGDRUG.org/monographs.htm

3
Chemical Shift (ppm)

Page 2 of 5

3,4-Dimethoxyamphetamine
The Drug Enforcement Administration's Special Testing and Research Laboratory
generated this monograph using structurally confirmed reference material.
3.2 Gas Chromatography/Mass Spectrometry
Sample Preparation: Dilute analyte ~1 mg/mL base extracted into chloroform.
Instrument:

Agilent gas chromatograph operated in split mode with MS detector

DB-1 MS (or equivalent); 30m x 0.25 mm x 0.25 m

Column:
Carrier Gas:

Helium at 1 mL/min
Injector: 280oC
MSD transfer line: 280oC
MS Source: 230 oC
MS Quad: 150oC
Oven program:
1) 100oC initial temperature for 1.0 min
2) Ramp to 300 oC at 12 oC/min
3) Hold final temperature for 9.0 min
Split Ratio = 20:1, 1 L injected

Temperatures:

Injection Parameters:
MS Parameters:

Mass scan range: 30-550 amu

Threshold: 100
Tune file: stune.u
Acquisition mode: scan
8.184 min

Retention Time:
5
Intensity [x 10 ]

44

EI Mass Spectrum: 3,4-dimethoxyamphetamine HCl Lot # MP150-151 Batch 1

160

180

195

179
180

164

137
140

200 m/z

195

179
180

164

152

121

107

120

137

107

91
100
91

80
77

65

60
51

44

40

77

51

EI+

3
Intensity [x 10 ]

65

121

152

EI+
40

60

Latest Revision: 12/16/2013

80

100

120

140

SWGDRUG.org/monographs.htm

160

180

200 m/z

Page 3 of 5

3,4-Dimethoxyamphetamine
The Drug Enforcement Administration's Special Testing and Research Laboratory
generated this monograph using structurally confirmed reference material.
3.3 INFRARED SPECTROSCOPY (FTIR)
Insrument:
Scan Parameters:

FTIR with diamond ATR attachment (3 bounce)

Number of scans: 32
Number of background scans: 32
Resolution: 4 cm-1
Sample gain: 8
Aperture: 150

461

563

768
795
850
1011

440

625
739

930

1120

1024
1144

1232

30

1153

1508

1267

40

1043

1338
1429 1443
1466

2833

50

1599

2908

60

2939
2974

3163

70

2509
2573
2590
2605
2700

%Transmittance

FTIR ATR (Diamond, 3 Bounce): 3,4-dimethoxyamphetamine HCl Lot # MP150-151 Batch 1

20
1500

Wavenumber (cm-1)

600
461

625
563

1011

768
795

850

440

739

804

1043
1024

1144

1232

1508

30

1153

1267

40

1120

50

2000

1203

1599

60

2500

893
916
930
958
989

70

3000

1338
1363
1371
1389 1417
1429 1443
1452
1466

%Transmittance

3500

20
1700

1600

1500

Latest Revision: 12/16/2013

1400

1300

1200

1100

1000

SWGDRUG.org/monographs.htm

900

800

700 Wavenumber (cm-1)

Page 4 of 5

3,4-Dimethoxyamphetamine
The Drug Enforcement Administration's Special Testing and Research Laboratory
generated this monograph using structurally confirmed reference material.
4. ADDITIONAL RESOURCES
Wikipedia
http://en.wikipedia.org/wiki/Dimethoxyamphetamine

Latest Revision: 12/16/2013

SWGDRUG.org/monographs.htm

Page 5 of 5