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5. Transmigration
Endothelial activation - increased
transcription and protein synthesis >>
increased expression of adhesion molecules
in response to locally produced cytokines and
inflammatory mediators from site of injury
IL-8 (interleukin 8) - stimulates transmigration
Roles of ICAM-1; cadherin, CD11/18; VLA-4 for
transmigration
VLA-4 (4 integrin) = binds endothelium for
transmigration
PHAGOCYTOSIS
Steps involved in phagocytosis:
1. Chemotaxis and adherence of microbe to
phagocyte
2. Ingestion of microbe to phagocyte
3. Formation of a phagosome
4. Fusion of the phagosome with a lysosome
to form
a phagolysosome
5. Digestion of ingested microbe by enzymes
NEUTROPHILS
LYMPHOCYTES
MONOCYTES
EOSINOPHILS
Function
Phagocytosis
Formed in the
bone marrow,
function in the
tissues
Immature
macrophage in
the blood
Forms in the
bone marrow
and migrate to
tissue to be
called
macrophage
Allergic
Reactions
Parasitic
infection. Can
help
neutrophil
phagocytose
parasites.
BASOPHILS
Allergic
reactions
Response to
certain antigens
and
inflammation
along with mast
cells
Circulate in the
blood for 10-24
hours
Migrate into
tissues for 1-2 days
Life cycle
Matures in 5-6
days
Circulate in
blood 8-12 hours
Migrate to
tissues then remain
for up to 4 days
Respond to
cytokines: IL-3, IL5, GM-CSF
few hours-few days
No visible granules
Pale blue cytoplasm
Red-staining(acidophilic)
Granules:
Histamine exposure to
allergens causes
degranulation, causes rashes
in the body.
Peroxidase
Ribonuclease
Lipases
Plasminogen