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Simulation Equipment,
Techniques, and Applications
Ken B. Johnson Elizabeth M. Thackeray
CHAPTER OUTLINE
OVERVIEW
HIGH-FIDELITY HUMAN PATIENT SIMULATORS
Simulation of Pulmonary Function
Simulation of Cardiovascular Function
Simulation of Drug Administration
Physiologic Monitors
Importance of Orientation
Models of Organ Function and Drug Behavior
Importance of Integration
Cost Versus Fidelity
SIMULATION IMPLEMENTATION
Scenario Development
Importance of Debriefing
Crisis Resource Management
OVERVIEW
Simulation has become an integral part of teaching and
evaluation in anesthesia. Because a mannequin is used in
simulation, it provides an opportunity for anesthesia
practitioners to try out their skills in managing adverse
events without consequence to actual patients. They can
demonstrate their deployable knowledge, communication skills, and psychomotor dexterity to uncover weaknesses in response to potentially life-threatening events.
Simulation provides a means to train for difficult, unusual,
or infrequent adverse events. Simulation in anesthesia
seeks to recreate real experiences with simulated ones
that replicate important aspects of a real clinical environment in an interactive fashion.1 In its finest form, simulation seeks to immerse participants in a task-oriented
experience in which they suspend disbelief and behave
much as they would in a real-world clinical scenario.
It is not surprising that anesthesiologists have played a
critical role in the development of this technology. In
510
Interdisciplinary Teamwork
Limitations of Simulation
511
Definition
Simulation in anesthesia
Simulator
Computer or screen
simulators
Computer-based anesthetic
drug simulators
Virtual reality
Anesthesia crisis resource
management
Haptic feedback
Fidelity
Reliability
Validity
Standardized patient
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TABLE 25-2 C
ommercially Available HighFidelity Human Patient Simulators
Company
Type of Simulator
Laerdal Medical,
Stavanger, Norway
CAE Healthcare,
Montreal, Canada
(METI Learning)
Gaumard, Miami, FL
A
BOX 25-1 Sample Scenarios Available in HighFidelity Human Patient Simulators
Anaphylaxis
Bronchospasm
Congestive heart failure with severe hypotension
Laryngospasm
Hyperkalemia
Malignant arrhythmias
Malignant hyperthermia
Massive hemorrhagic shock
Myocardial ischemia
Subdural hematoma
Tension pneumothorax
Unanticipated difficult airway with hypoxia
Unstable ventricular arrhythmias
B
FIGURE 25-1 n A high-fidelity human patient simulator (SimMan
3G; Laerdal Medical, Stavanger, Norway). The simulator system
consists of a full-body mannequin (A and B), a control computer
(not shown), and a vital sign display (B).
513
Outputs
Configurations
Procedures
Sensors
Features
Organ System
Cardiovascular System
Anatomy
Arterial pulses
Outputs
ECG, five leads
Heart sounds synchronized with ECG
Noninvasive blood pressure via
Korotkoff sounds
Palpable pulses; pulse intensity synchronized with ECG and blood pressure
Simulated arterial, pulmonary artery,
pulmonary capillary wedge, and
central venous pressures
Simulated cardiac output
Bleeding ports (simulated hemorrhage)
Configurations
Range of heart sounds and intensities
Adjustable cardiac parameters (heart
rate, blood pressure, contractility,
afterload, etc.)
Jugular vein distention
Extremity hemorrhage and moulage
sites
Procedures
Defibrillation, pacing, and cardioversion
Chest compressions
Interosseus access (sternal and tibial)
IV access; bilateral peripheral (dorsal
vein and antecubital fossa)
Central (femoral and jugular) IV lines
Bilateral thigh autoinjection sites for
medication administration
Pericardiocentesis
Treatment of hemorrhage: pressure
points, tourniquets, surgical clamps
Sensors
Touch-activated recording of pulse
assessment
Pulmonary System
Anatomy
Tracheobronchial tree
Outputs
Breath sounds synchronized with
chest rise, both anterior and
posterior
End-tidal CO2
Inspiratory/expiratory O2
Tidal volumes
SpO2
Cyanosis
Gas exchange
Configurations
Adjustable pulmonary mechanics
(respiratory rate, tidal volume,
airway resistance, lung
compliance, etc.)
Lung sounds: wheezes, rales, absent,
unilateral
Unilateral chest rise
Flail chest
Tension pneumothorax or
hemothorax
Procedures
Manual or mechanical ventilation
Bilateral needle decompression
Bilateral chest tube placement
Sensors
Ventilation
ECG, electrocardiogram; IV, intravenous.
Features
Gastrointestinal System
Anatomy
Esophagus
Output
Bowel sounds
Genitourinary System
Anatomy
Interchangeable male or female genitalia
Output
Urine output (normal, none, polyuria)
Procedures
Bladder catheter placement
Central Nervous System
Anatomy
Eyes, eyelids, and pupils
Voice
Output
Configurations
Procedures
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Cardiovascular models are used to simulate rightand left-sided cardiac pressures and estimates of cardiac
output. Arterial blood pressures can be represented as
noninvasive (blood pressure cuff) or invasive (arterial
line) measurements. Pulmonary artery pressures, central venous pressures, and pulmonary capillary wedge
pressures are also available, assuming a pulmonary
artery catheter is in place. More sophisticated simulators can detect the inflation of a pulmonary artery catheter balloon using electromechanical sensors, and they
present the physiologic display estimates of the pulmonary capillary wedge pressure. Manipulation of these
parameters can be used to characterize cardiac function
in terms of preload, contractility, afterload, and heart
rhythm across a variety of cardiovascular states such as
hypovolemia, congestive heart failure, pulmonary
embolism, sepsis, and so on. These states can either be
operator controlled in real time or scripted to mimic a
selected cardiovascular state along with responses to
resuscitative interventions.
Physiologic Monitors
Pulmonary and cardiovascular simulators generate data
for presentation on a vital sign monitor. Some systems
require the use of a simulator-specific monitor, but others are configured to emit vital sign signals that conventional physiologic monitors can detect. This is an
important feature to consider if simulation goals or
research activities require the use of a specific physiologic
monitor. For example, anesthesiologists may want to
train with the physiologic monitor they are familiar with.
Scenario realism may be improved by having participants
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Importance of Orientation
Given the sophistication of current high-fidelity fullbody simulations, it is important to conduct an orientation to the simulator before participants using it. This
is especially important if the simulator is to be used in
an evaluation process. To achieve a high degree of
realism, a thorough review of the simulator functionality and its limitations is warranted to avoid participants
needlessly pursuing an incorrectly perceived aberrant
clinical finding from a simulation artifact. Orientation
may include listening to breath and heart sounds,
examining the airway, observing chest rise, palpating
pulses, hearing the mannequin speak, administering IV
drugs, obtaining IV access, and so on. If not addressed
prior to initiating a simulation session, participants
may focus on simulation artifacts and limitations
instead of exploring the limitations of their clinical
expertise.
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Importance of Integration
Unique to high-fidelity patient simulators is the ability to
integrate control of multiple organ simulators to create
realistic patient presentations. For example, alterations in
the size of the tongue and pharynx, cervical spine range of
motion, and vocal cords can be used to block visualization
of the glottic opening and/or prevent tracheal intubation.
Combined control of airway and pulmonary systems can
be used to mimic adverse airway and respiratory events
such as cant intubate/cant ventilate, cant intubate/can
ventilate, or can intubate/cant ventilate situations. This
is of particular relevance to anesthesia training, in that
tools are provided to build scenarios that address many of
the pathways in the difficult airway algorithm according
to the American Society of Anesthesiologists (ASA).16
COMPONENTS OF A SIMULATION
CENTER
A basic assumption in simulation is that simulation effectiveness improves as the precision in replicating realworld environments improves. Model fidelity in terms of
simulator output is often a trade-off between perceived
educational benefit and the cost of engineering resources
required to create the output.8 Recent work in simulation
has not supported this assumption. In some instances,
higher fidelity has not led to improved training outcomes,
and lower fidelity simulations, by contrast, have been
found to be effective.17 As technology in simulation
advances, it is apparent that features of realism necessary
Computer Room
Observation Area
Debriefing Room
One-Way Mirror
Simulation Suite #2
Control Room
One-Way Mirror
One-Way Mirror
Simulation Suite #1
FIGURE 25-2 n Floor plan illustrating basic features of a simulation center. Blue and gold represent essential and useful rooms, respectively. Ideal room configuration places the control room adjacent to the simulation suite and in proximity to the debriefing room.
debriefing room. Other useful rooms include a computer room, an observation room, and a storage room.
Each room has a unique function, with specific design
considerations and a variety of available technologies to
enhance functionality.
Facilities
Control Room
The control room represents the nerve center of a simulation center. It is equipped to monitor participant activities, control simulation equipment, and communicate
with actors and other personnel in the simulation suite.
To monitor activities, participants can be instrumented with wireless microphones, or the simulation
suites can be equipped with three to four strategically
placed microphones. Input from these microphones is fed
through an audio amplifier and is made available to simulation operators via either earphones or a speaker system
in the control room. This component of the simulation
control room is especially important when monitoring
participants communication with other participants and
actors and their verbal expressions of diagnostic and therapeutic interventions, which may require a response in
the progression of a simulated event. Additional monitoring is achieved with video cameras, and a simulation suite
can be instrumented with one to three video cameras that
are linked to the control room. Video displays within the
control room are used to present real-time video collected from these cameras. Fixed cameras capture video
from specific areas (e.g., the mannequin head and neck)
within the simulation suite. More-expensive cameras provide pan, tilt, and zoom features, and they steer and focus
the camera remotely from within the control room.
Physiologic data presented to participants in the simulation suite can be presented to control room personnel
via a secondary display. Using a digital audiovisual
mixer, video clips from the physiologic display can be
overlaid onto video clips of the simulation suite in real
time. Combined video from the simulation suite and
physiologic monitor are recorded and used for debriefing, investigational studies, or presentation in real time
to other participants in a remote location outside the
simulation suite.
To control simulation equipment, the primary interface
is through computer software that controls all possible
responses in a mannequin and/or physiologic display.
Additional diagnostic information can be introduced into
the simulation suite through the use of secondary displays,
such as chest radiograph, transesophageal echocardiography (TEE) video clips, data from an electronic medical
record or a digital anesthesia record, and so on. The simulator operator also provides audio input as appropriate
through a speaker system contained within the mannequin.
This includes prerecorded responses and statements or
scripted or impromptu responses offered by the operator.
It is our experience that auditory feedback from the mannequin as scenarios develop improves simulation realism.
Communication equipment is also used by the simulator
operator to guide actors in the execution of key events to
meet teaching or evaluation goals. This equipment consists
517
Importance of People
A simulation programs success is a function of the people
staffing a simulation center. S. Barry Issenberg wrote an
518
Simulation suite
Speaker
Microphone
Video camera
Video camera
Actor(s)
Speaker
Microphone
Mannequin
Auxiliary display
Physiologic monitor
One-way mirror
Simulation control
computer
Secondary display of
physiologic monitor
Speaker
Auxiliary computer
Simulation management
system
Wireless
transmitter
Amplifier
Microphone
earphones
Amplifier
Control room
Debriefing room
Data storage
FIGURE 25-3 n Schematic representation of equipment configuration in a high-resolution full-body simulation center. The black lines
represent the flow of information from the simulation control computer to control the behavior of the mannequin, physiologic displays,
and audio (voice) output from the mannequin. The blue lines represent the flow of audiovisual information captured from within the
simulation suite by the simulation management system. Audio from the microphones is also broadcast over the control room speaker
system or to earphones worn by the simulation operator. This system also captures events data (transitions from one simulated state
to another, drug administration, vital signs, etc.) from the simulation control computer. Integrated simulation data are then archived in
a storage device and made available as needed for playback and review in the debriefing room. The red lines represent the flow of data
from an auxiliary computer capable of presenting additional audio (music) or visual information (transesophageal echocardiography
clips) during a given scenario to an auxiliary screen or speakers within the simulation suite. The green lines represent the flow of audio
data from the microphone in the control room to actors (confederates) in the simulation suite to guide the progress of the simulation
or to provide real-time voice data to the mannequin. This figure represents only one of many useful configurations.
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SIMULATION IMPLEMENTATION
Scenario Development
When formulating a scenario for a simulation, several
components of the scenario merit consideration to optimize their educational value. The rationale for documenting a scenario in a rigorous and consistent format includes
ensuring that the scenario content is reproducible and
making sure it is easily shared among simulation programs. The simulation program at Duke University has
developed its own template, which is free and available
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Input to participant
Simulated scenario
Simulation control
computer
Event timeline
Simulator output
Physiologic monitor
Physiologic models
Pharmacologic models
Participant
Preoperative anesthesia
assessment
History
Physical exam
Laboratory values
Electronic medical records
Input from actors
Circulating nurse
Surgeons
Anesthesia assistant
Presence of:
Positive pressure ventilation
Chest compressions
Mannequin
FIGURE 25-4 n Schematic of information flow within a simulation. The simulation control computer uses information from multiple
sources (solid black lines) to control the mannequin and, with selected manufacturers, the physiologic monitor. The dashed black
lines illustrate how data are transmitted from the mannequin to the participant and anesthesia machine. Participants may examine
the simulated patient to auscultate the heart, and if the mannequin has an instrumented airway and is on mechanical ventilation,
simulated data characterizing pulmonary mechanics are sent via the mannequin to the anesthesia machine ventilator. The blue lines
represent information flow from devices, medical records, and actors within the simulation suite to the participant. The green line
represents information the simulator operator observes and uses to provide input to the simulation control computer during a simulation. The pink lines represent data sent to the simulation control computer. Sources of information include the simulator operator,
the mannequin, and the event look-up tables. Data from the mannequin are sent back to the simulation control computer as feedback to drive physiologic responses; that is, if the simulated patient is under neuromuscular blockade and is not mechanically
ventilated, the patient develops hypoxia.
online at http://simcenter.duke.edu/support.html. An
abbreviated version of the Duke template is presented in
Box 25-4 that uses a comprehensive approach to documenting a scenario in a reproducible format and contains
sections that address simulated patient demographics,
curricular information, preparation requirements, and
briefing information. Some examples of the scenarios
include a venous air embolism during a sitting-position
craniotomy,21 trauma and awareness,22 intraoperative
apnea as a result of a medication error,23 and defective
anesthetic gas delivery.24
Importance of Debriefing
Debriefing is an effective form of learning following a
simulation,25 and it helps participants develop and integrate insights from their simulated experience into clinical practice.26 It is an opportunity for reflection of what
participants thought, felt, and did during simulation in
order to improve future performance. Central to an
effective debriefing are concise, respectful critiques that
clarify participant perspectives. Rudolph and colleagues26
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filter, create, and apply meaning to the environment. Clinical frames shape actions. For example, if participants
believe that the patient has gastroesophageal reflux disease,
their actions will be very different than if they believe that
the patient is having an acute myocardial infarction.
Rudolph suggests that instructors learn what frames drive
trainee behaviors so that both their failures and successes
can be understood as an ingenious, inevitable, and logical
solution to the problem as perceived within their frames.27
Video recording of simulation sessions has become a
widely accepted technique in debriefing. Although popular, the value of this technology is not clear. Savoldelli
and colleagues28 explored the utility of video-assisted
feedback during debriefing compared with oral debriefing from the instructor or no debriefing at all. They
found that although participants who received debriefing
improved more than participants without debriefing,
improvement tended to be lower in the video-assisted
debriefing group than the oral debriefing group. They
concluded that an instructor-based approach to debriefing is acceptable and may be preferable.
In summary, debriefing is a key element of simulation
training and is as important, if not more important, than
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Interdisciplinary Teamwork
An emerging form of simulation in anesthesia combines
simulation-based education with other specialties and
clinicians in the perioperative environment. Rarely do
anesthesiologists respond to an adverse event as the sole
responder (Fig. 25-5). During most adverse events, surgeons, nurses, and other support personnel are present.
Full-scale simulations of low-frequency but high-risk
events, such as chemical gas exposure, or complex procedures known to be error prone, such as unanticipated
aortic dissection during cannulation for coronary artery
bypass, that focus on teamwork among clinicians will
likely save lives. Although a few centers conduct
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Limitations of Simulation
Any simulator system imposes multiple trade-offs by virtue of the system constructs, learning objectives, and cost
and the availability of technology, physical space, and
support staff. Participants in a simulation scenario must
be familiar with any variables that may affect their care of
the patient, such as the presence of breath sounds in
particular locations and their nonpathologic absence in
others. Mathematical models of physiologic variables and
responses to medications or procedures are estimates
based on past experience and thus imperfectly represent
reactions of every possible patient. Validity and reliability
of participant assessments are increasingly difficult to
achieve with increasing task complexity, because the
closer control of variables in a scenario provides a more
robust test of participant ability, whereas less instructor
control provides greater fidelity.32,34
Participants often find themselves being hypervigilant,
because they know that the simulator is an opportunity to
test them, whereas others may be cavalier, thinking that it
does not really matter much, because a simulator is not a
real patient. The Heisenberg uncertainty principle,
whereby observation changes the observed behavior, is
extremely likely in simulation; but given the tremendous
resources required to observe anesthesiologists routinely
in the OR in hopes of assessing behavior, it is a limitation
we must accept.32
Airway Trainers
A complete airway trainer will include an articulated neck
and anatomically correct nasopharynx, oropharynx, and
laryngopharynx. Such a device will allow endotracheal
and esophageal intubations and the use of common airway adjuncts, such as laryngeal mask airways (LMAs) or
lightwands, with appropriate chest rising or filling of the
abdomen (Fig. 25-6). Some models, such as the Laerdal
difficult airway trainer, will allow transtracheal jet ventilation and cricothyrotomy. Laerdals airway trainer also
allows the instructor to enlarge the tongue to increase
difficulty with intubation. The RespiTrainer Advance
(IngMar Medical, Pittsburgh, PA) includes the inflatable
tongue and breakout teeth and also provides real-time
ventilation parameters (volume, flow, and pressure) in
both training and test modes. More differentiated partial
task trainers, such as the Nasco Life/form (Fort Atkinson,
WI) cricothyrotomy simulator, also exist.
Central Venous Vascular Access Trainers
Vascular access trainers include torsos for internal jugular and subclavian vein cannulation as well as femoral
vein models. Blue Phantom (Advanced Medical Technologies, Redmond, WA) produces a torso amenable to
ultrasound visualization of the internal jugular vein and
carotid artery with options for a nonpulsatile artery,
hand-pump arterial pulsations, and automated arterial
pulsations (Fig. 25-7). The model can tolerate full placement of a central venous catheter given its self-healing
skin and vessels. Self-healing skin has its limitations,
however; after multiple cannulations, visible leakage
from former sites makes identification of vessels easier.
Use of the manufacturers lubricant may lessen the
amount of needle damage and extend the life of the simulated tissue, but manufacturers recommend replacing the
self-healing skin after several hundred needle insertions.
These issues may be more troublesome in the adult and
child intraosseous part task trainers. Landmarks for cannulation of the subclavian vein can become misplaced
and require some internal adjustment with padding.
Within the neck and torso, the vein vessel length is truncated, and a guidewire can be advanced only a few centimeters past the access needle tip.
524
FIGURE 25-6 n The Airway Management Trainer and the Deluxe Difficult Airway Trainer (Laerdal Medical, Stavanger, Norway). A, Airway trainer with an exposed thoracic cavity allows visualization of the lungs, esophagus, and stomach. B, With bag/mask ventilation
or mechanical ventilation, the lungs expand during positive pressure ventilation. C, Airway trainers consist of an anatomic airway,
bronchial tree, inflatable lungs, esophagus, stomach, articulating cervical spine, and articulating mandible; a more advanced airway
trainer is presented here. D, In addition to conventional laryngoscopy and tracheal intubation, a trainer can simulate an obstructed
airway or tongue edema and can accommodate a surgical airway using the manual inflation bulbs (C).
FIGURE 25-7 n Central line vascular access trainers consisting of a head, neck, and torso. The model presented in A simulates right
subclavian central line access (Vascular Access Trainer; Laerdal Medical, Stavanger, Norway). A subclavian vein and lung and rib
cage are simulated underneath the skin. Users can puncture the subclavian vein (B) but cannot thread a guidewire; the tubing that
makes up the vein is not long enough. If the needle is misplaced, users can puncture the lung. Ultrasound imaging is not available on
this model. The model presented in C simulates right internal jugular vein access (central venous access and regional anesthesia
model, Blue Phantom; Advanced Medical Technologies, Redmond, WA). It accommodates ultrasound visualization of the carotid
artery and internal jugular vein for ultrasound-guided insertion of a central line. The chest and neck on the right side have been modified for ultrasound imaging. This model also does not accommodate guidewire placement.
525
Carotid artery
FIGURE 25-8 n The Blue Phantom ultrasound-guided regional anesthesia trainer, consisting of a head, neck, and torso, accommodates
ultrasound imaging on the right neck (A) and has segments of the brachial plexus (central venous access and regional anesthesia
model). B, Visualization of nerve fascicles in proximity to the right internal jugular vein and carotid artery when imaging from the
interscalene groove. (Courtesy Blue Phantom, Redmond, WA.)
FIGURE 25-9 n A right arm radial arterial line trainer (Arterial Stick
Arm Trainer; Laerdal Medical, Stavanger, Norway). A radial
artery is simulated beneath the skin with manual squeezing of a
pressure bulb. The task trainer accommodates a guidewire and
allows cannulation of the vessel.
526
FIGURE 25-10 n Spinal injection trainer (Spinal Injection Simulator; Nasco Life/form, Fort Atkinson, WI). A, This trainer consists of a
lumbar spine with vertebral bodies, spinal cord with dura, ligament tissue, subcutaneous tissue, and skin. B, It can accommodate
needle puncture of the dura for aspiration of cerebral spinal fluid.
527
or continuous-infusion dosing regimen. They use population pharmacokinetic models to estimate drug concentrations, and for selected drugs, they can account for
patient age, weight, and gender.
Gas Man is a computer-based program that was developed and distributed by a nonprofit organization, Med
Man Simulations (www.gasmanweb.com/index.html). It
is intended to teach uptake, distribution, and pharmacokinetics of inhaled anesthetics, accompanied by a written
tutorial explaining the concepts and the computer simulations.39,40 Gas Man graphically illustrates these principles over time and allows the user to experiment with
various settings that include fresh-gas flow, inhaled agent,
delivered anesthetic, minute ventilation, cardiac output,
oxygen flush, and circuit characteristics (Fig. 25-14).
More sophisticated systems include tools that illustrate the effects of combined anesthetic techniques
(desflurane and fentanyl) on patient responses such as
level of responsiveness and analgesia and muscle relaxation.41-44 With these tools, clinicians are able to visualize the onset and duration of effect, either in real time
during patient care or off-line during educational activities designed to explore the behavior of various dosing
regimens (Fig. 25-15). For example, users can explore
the onset and duration of effect for 1) a fentanyl bolus
alone, 2) a bolus in the presence of 1 minimum alveolar
concentration (MAC) isoflurane, or 3) a 50 g/kg/min
propofol drip. This is an especially interesting area of
development, given that both Drger Medical (Telford,
PA) and GE Healthcare (Waukesha, WI) have recently
marketed drug display systems.45 Limiting these simulation systems is their inability to account for changes
in pharmacokinetics and pharmacodynamics as a result
of chronic exposure to opioids, benzodiazepines, and
disease states known to significantly alter cardiopulmonary physiology.
528
BRONCHOSCOPE VIEW
MIDDLE LOBE
LOWER LOBE
Posterior
basal
Lateral
basal
LINGULA
Anterior
basal
Interior
Superior
UPPER LOBE
Posterior
basal
Anterior
basal
Medial
basal
Superior
Lateral
basal
LOWER LOBE
Medial
Superior
Lateral
Anterior
Anterior
Posterior
Apical posterior
UPPER LOBE
Apical
LEFT LUNG
Diagram Zoom
RIGHT LUNG
LABELING CONTROLS
Bronchial Tree Labels
Bronchial Tree Diagram
Manufacturer/Author
PK/PD, pharmacokinetics/pharmacodynamics.
Virtual Reality
Virtual reality simulators are currently used in industries
such as aviation, manufacturing, and retail store design.
At its best, virtual reality provides an immersive experience in which an electronically displayed environment
responds to participant movements with limited physical
529
FIGURE 25-14 n Inhaled agent drug simulator. The GasMan simulator (www.gasmanweb.com/index.html) predicts inhalation
agent concentrations over time in the alveolus (ALV); arterial
blood (ART); vessel-rich organs, labeled vessel-rich group
(VRG); muscle (MUS); fat (FAT); and venous blood (VEN). It
allows users to adjust gas flow, vaporizer setting, and ventilatory settings for commonly used inhalation agents. (Courtesy
Med Man Simulations, Boston, MA.)
components and mechanical stresses making up the prototype, a degree of knowledge that we approximate less
fully with regard to a human patient. Even with that full
understanding, however, an airplane will still undergo
wind tunnel tests to further replicate real-life conditions.
In medicine, virtual reality simulator use is increasing,
particularly for surgical training, and virtual reality part
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FIGURE 25-15 n Drug interaction display. This pharmacokinetic/pharmacodynamic (PK/PD) display (Medvis, Salt Lake City, UT) demonstrates drug effect over timepast, present, and futureas a result of a combined anesthetic technique, induction with propofol and
fentanyl, followed by maintenance with sevoflurane and fentanyl. Combined PK/PD models are used to predict drug effects. Anesthetic effects are divided into probability of unconsciousness (middle plot), analgesia framed in terms of loss of response to laryngoscopy (bottom plot), and muscle relaxation (not shown). Fentanyl effects are represented by the blue line; sedative effects are
represented by the bright yellow line for propofol and the dark yellow line for sevoflurane; and white lines represent drug interactions. For example, the white line on the analgesia plot illustrates the large synergistic interaction between propofol, sevoflurane, and
fentanyl on analgesia and, to a lesser extent, the synergistic interaction on loss of consciousness. PLAN A refers to predictions of drug
effect, if the dosing scheme presented in the future window is carried out (sevoflurane 1.8% with 100-g fentanyl bolus). The two
vertical lines represent a scrollable pointer to identify predicted drug effect at any point during the anesthetic (left line) and the current
predictions (right line). (Courtesy Medvis, Salt Lake City, UT.)
Regional Anesthesia
Anesthesiologists and biomedical engineers have created a
prototype virtual reality simulator for regional anesthesia
intended specifically for training anesthesiologists in celiac
plexus blocks, a relatively rare procedure in which the needle is in proximity to several vital structures.49 Using the
National Library of Medicines Visible Human Project
male computed topography dataset,50 they generated the
visualized simulator dataset, which was then combined
with the haptic data. Empiric haptic data were obtained on
forces encountered in various tissue types with actual needle insertions on unfixed cadavers within 72 hours of
death. This simulator consists of a head-mounted display
coupled with the haptic feedback device to create a virtual
patient on which to practice celiac plexus blocks. The visualized portion can have skin rendered opaque or transparent, with the patient positioned prone, supine, or upright.
A similar approach to virtual reality for regional anesthesia was reported by Grottke and colleagues.51 Magnetic resonance imaging (MRI) and magnetic resonance angiogram
531
532
have come together to advance simulation use for training in health care. In 2003, two organizations focused on
the advancement of medical simulation were formed.
One was the Advanced Initiative for Medical Simulation
(AIMS) and the other was the Society for Medical Simulation (SMS), which in 2006 changed its name to the
Society for Simulation in Healthcare (SSH).55
AIMS holds an annual symposium in Washington, DC,
to create a forum for federal legislators and policymakers
to interact with leaders in the simulation community and
to advocate for legislation to fund simulation programs.56
SSH launched a multidisciplinary journal entitled the
Journal of Healthcare Simulation in 2006, which recently
gained citation by the National Library of Medicine. Since
its inception, anesthesiologists have consistently contributed original work describing how simulation can be used
to train, educate, and test anesthesia practitioners. The
SSH also sponsors an annual meeting that in recent years
has grown to encompass postgraduate training, workshops, training tracks, and scientific sessions with healthy
contribution of abstracts from the scientific community.56
Over the past decade, simulation in anesthesia has enjoyed
increasing support from several prominent foundations
that include the Anesthesia Patient Safety Foundation
(APSF) and the Foundation for Anesthesia, Education,
and Research. These foundations have sponsored numerous projects to explore new techniques in, and the benefits
of, simulation training.
533
534
49. Martin DP, Blezek DJ, Robb RA: Simulating lower extremity
nerve blocks with virtual reality, Tech Reg Anesth Pain Manag
3:5861,1999.
50. Ackerman MJ: The Visible Human Project: a resource for anatomical visualization, Stud Health Technol Inform 52 Pt(2):10301032,
1998.
51. Grottke O, Ntouba A, Ullrich S, etal: Virtual reality-based simulator
for training in regional anaesthesia, Br J Anaesth 103:594600, 2009.
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