Академический Документы
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Inside:
2
10 Crown Initiative
11 Elly update
12 Contact details
Completed Portfolio
Medal
MRI to Establish Diagnosis Against Laparoscopy
Number of patients: 250 women
Number of sites: 6 centres
Funder: NIHR HTA
KT Sites: The Royal London (Miss Elizabeth Ball),
Whipps Cross (Mr Funlayo Odejinmi), Newham
(Mr Antonios Antoniou), Homerton (Miss Sandra
Watson), Southend (Mr Winston Justin).
Grant award: 1,325,199.71 NIHR Funding
Prep
Prediction of Risk of complication in early
onset Pre-eclampsia
Number of patients: 936 women
No of sites: 53 centres
Funder: NIHR HTA
KT Sites: The Royal London (Mr Rehan Khan),
Whipps Cross (Mr Manish Gupta), Newham
(Mr Vincent Oon), Southend (Mr Raajkumar
Sundararajah), Queens Romford (Miss Celia
Burrell), North Middlesex (Miss Zeudi Ramsey
Marcelle), West Middlesex (Miss Louise Page),
The Royal Free (Miss Rezan Kadir).
Grant award: 847,249 NIHR Funding
Salvo
Cell salvage during caesarean section
Number of patients: 3050 women
No of sites: 22 centres
Funder: NIHR HTA
KT Sites: The Royal London (Matthew Hogg),
Whipps Cross (Sajith Philip), Romford
(Vinod Patil).
Grant award: 1.8 million NIHR funding
Empire
Antiepileptic Drug Monitoring in Pregnancy
Number of patients: 564 women
No of sites: 51 centres
Funder: NIHR HTA
KT Sites: The Royal London (Dr Rehan Khan),
Whipps Cross (Dr Sujatha Thamban), Newham
(Dr A Shah), Romford (Dr Leye Thompson).
Grant award: 1.8 million NIHR Funding
Esteem
Effect of simple, targeted diet in pregnant women
with metabolic risk factors on pre-eclampsia.
Number of patients: 3640 women
No of sites: 3 centres
Funder: NIHR HTA
KT Sites: The Royal London (Dr Rehan Khan),
Whipps Cross (Dr Manish Gupta), Newham
(Mr Vincent Oon).
Grant award: 498,898 Barts Charity
PrePro
Probiotics in the prevention of preterm birth
pilot randomised trial (PrePro) is a Barts Charity
funded feasibility trial to determine the biological
effects of probiotics on the vaginal flora and
examine the components that will be essential
to the success of a double-blind, placebocontrolled randomised trial (RCT) on the effects
of oral probiotics administered daily from early
pregnancy on the risk of pre-term birth.
528
97
44
34
26
1
310
196
20
Heidi Chandler
Alison Anstead
Administrative Assistant:
Syvella Kirwan
Dr Simona Cicero
Barts
Whipps Cross
Newham
Queens
Participants
Site
Royal London
35
3
3
3
7
1
169
121
20
19
9
9
1
1
216
74
4
6332
6
6
The Mens Safer Sex (MenSS) Trial: a website to increase condom use
Pre-term Cord Clamping Trial
CCRN 2850 Multifollicular development
HABSelect Hyaluronic Acid Binding Sperm Selection
Start at the beginning
SAFE Special non-invasive Advances in Foetal and neonatal Evaluation
The immunological basis of preterm delivery
ASPRE Combined Multi-Marker Screening and Randomised Patient Treatment
with Aspirin for Evidence-based Pre-eclampsia Prevention
82
16
5
112
55
14
7
2
31
Homerton
183
11
7
Royal Free
Southend
CRN: North Thames is hosted by Barts Health NHS Trust covers the geography of North Central
London, Essex and Hertfordshire (a population of 5.7m; 10% of the NHS) and over 10% of the NIHR
portfolio is lead from CRN. Trusts within the Katherine Twining Network are therefore covered by
CRN: North Thames and the research which takes place is looked after by the team in Division 3.
Dawn Beaumont-Jewell
Currently within the Katherine Twining Network, there are 11 studies open and recruiting. In the
14/15 financial year, uploaded recruitment data to date is showing that the Katherine Twining
Network has recruited 8,825 participants. As the total number of recruits to the Reproductive
Health and Child Birth specialty for the whole of North Thames is about 14, 824 participants,
this represents a contribution of almost 60% well done!
We thank you for all your hard work and hope that this support continues!
Elly Update
The unwarranted variation in reporting of trial outcomes can result in difficulties
in synthesising evidence to generate recommendations for clinical practice which
ultimately is detrimental to the health of women and their babies. The Core Outcomes
in Womens health (CROWN) initiative is an international initiative, led by journal editors,
to address this problem by harmonising outcome reporting in womens health research.
Aims of the Core Outcomes in Womens Health
(CROWN) Initiative
Form a consortium among all womens health
journals to promote core outcome sets in all
areas of our specialty.
Encourage researchers to develop core
outcome sets using robust consensus
methodology involving multiple stakeholders,
including patients.
Strongly encourage the reporting of results
for core outcome sets.
Organise robust peer-review and effective
dissemination of manuscripts describing
core outcome sets.
Facilitate embedding of core outcome sets
in research practice, working closely with
researchers, reviewers, funders, and
guideline makers.
Although checklists exist for the reporting of
clinical trials, core outcome sets (COS) differ
because they are a disease-specific agreed set
of outcomes that are established as a reporting
standard minimum for all relevant clinical trials.
For example, COS for medical treatment of
menorrhagia might include, number of days
taken off work, haemoglobin level and use of
sanitary protection but a COS for trials
assessing the effectiveness of cervical sutures
for preventing late miscarriage and preterm
birth would be likely to include gestational age
at delivery and rates of chorioamnionitis.
www.ellyappeal.org.uk