SciFinder

Page 1

1. Single Step

Overview
Steps/Stages

Notes

1.1

Reactants: 1, Reagents: 1, Solvents: 2, Steps:

1, Stages: 1, Most stages in any one step: 1

R:H3PO4, S:H2O, S:EtOH, 1 h, reflux

References
Process for synthesis of nifuratel for treating
vaginal infection
By Zhang, Qinghua et al
From Faming Zhuanli Shenqing, 103664923,
26 Mar 2014
CASREACT : Copyright 2015 American Chemical Society. All Rights Reserved. CASREACT contains reactions
from CAS and from: ZIC/VINITI database (1974-1999) provided by InfoChem; INPI data prior to 1986; Biotransformations
database compiled under the direction of Professor Dr. Klaus Kieslich; organic reactions, portions copyright 1996-2006
John Wiley & Sons, Ltd., John Wiley and Sons, Inc., Organic Reactions Inc., and Organic Syntheses Inc. Reproduced
under license. All Rights Reserved.
9. Single Step

55%
Overview
Steps/Stages

Notes

1.3

third stage slow addition, stirring, then gradual

warming; fourth stage ice water quench,
regioselective, Reactants: 1, Reagents: 2,
Solvents: 1, Steps: 1, Stages: 4, Most stages
R:HNO3, R:H2SO4, 2-2.3 h, -10C 5C; 30-40 min, 5C; 5C in any one step: 4

1.4

0C
S:H2O, 0C

1.1
1.2

R:H2SO4, rt -10C
-10 - 5C

References
Preparation of 5-r1-2[(n-r2)-furfurylidene;
thiophenyliden] semicarbazones and
thiosemicarbazones as a drug for the
treatment of Chagas disease
By Garcia Mellado, Olivia and Cortes Cortes,
Eduardo
From Mex. Pat. Appl., 2007013128, 22 Apr
2009

CASREACT : Copyright 2015 American Chemical Society. All Rights Reserved. CASREACT contains reactions
from CAS and from: ZIC/VINITI database (1974-1999) provided by InfoChem; INPI data prior to 1986; Biotransformations
database compiled under the direction of Professor Dr. Klaus Kieslich; organic reactions, portions copyright 1996-2006
John Wiley & Sons, Ltd., John Wiley and Sons, Inc., Organic Reactions Inc., and Organic Syntheses Inc. Reproduced
under license. All Rights Reserved.

SciFinder

Page 2

10. Single Step

95%
Overview
Steps/Stages
1.1

R:AcOH, C:1258980-63-0 immobilized on superparamagnetic

iron oxid, C:Cu(NO3)2, C:10377-66-9, S:98-08-8, 2 h, 50C

Notes
solid-supported catalyst, chemoselective,
catalyst recyclable, >99% selectivity, [3-[4-(1hydroxy-2,2,6,6-tetramethylpiperidin-4yloxymethyl)-2,3-dihydro-[1,2,3]triazol-1yl]propyl]phosphonic acid immobilized on
superparamagnetic iron oxide nanoparticles
with final TEMPO loading 0.50-0.93 mmol per
gram used as catalyst, Reactants: 1,
Reagents: 1, Catalysts: 3, Solvents: 1, Steps:
1, Stages: 1, Most stages in any one step: 1
References
Simple Preparation and Application of
TEMPO-Coated Fe3O4 Superparamagnetic
Nanoparticles for Selective Oxidation of
Alcohols
By Tucker-Schwartz, Alexander K. and
Garrell, Robin L.
From Chemistry - A European Journal,
16(42), 12718-12726, S12718/1-S12718/31;
2010

CASREACT : Copyright 2015 American Chemical Society. All Rights Reserved. CASREACT contains reactions
from CAS and from: ZIC/VINITI database (1974-1999) provided by InfoChem; INPI data prior to 1986; Biotransformations
database compiled under the direction of Professor Dr. Klaus Kieslich; organic reactions, portions copyright 1996-2006
John Wiley & Sons, Ltd., John Wiley and Sons, Inc., Organic Reactions Inc., and Organic Syntheses Inc. Reproduced
under license. All Rights Reserved.
13. 2 Steps

Overview
Steps/Stages

Notes

SciFinder
1.1

S:Ac2O, rt -6C

1.2

R:HNO3, S:H2O, -5 - 6C; 5-6 h, rt

2.1

R:H2SO4, S:H2O, 3-4 h, 100C

Page 3
Reactants: 2, Reagents: 2, Solvents: 2, Steps:
2, Stages: 3, Most stages in any one step: 2
References
Preparation of 2-thiophene- or 2furancarboxaldehyde phenylhydrazone
derivatives for the treatment of chagas'
disease
By Garcia Mellado, Olivia and Cortes Cortes,
Eduardo
From Mex. Pat. Appl., 2007012608, 13 Apr
2009

CASREACT : Copyright 2015 American Chemical Society. All Rights Reserved. CASREACT contains reactions
from CAS and from: ZIC/VINITI database (1974-1999) provided by InfoChem; INPI data prior to 1986; Biotransformations
database compiled under the direction of Professor Dr. Klaus Kieslich; organic reactions, portions copyright 1996-2006
John Wiley & Sons, Ltd., John Wiley and Sons, Inc., Organic Reactions Inc., and Organic Syntheses Inc. Reproduced
under license. All Rights Reserved.
15. 2 Steps

Overview
Steps/Stages

Notes

1.1

R:HNO3, R:H2SO4, S:Ac2O, 0C; 1 h, 0C

Reactants: 2, Reagents: 3, Solvents: 2, Steps:

2, Stages: 3, Most stages in any one step: 2

1.2

R:NaOH, S:H2O, 30 min, rt; 1 h, 50C, pH 2.5

2.1

R:H2SO4, S:H2O, 2 min, reflux; cooled

References
Lead optimization and anti-plant pathogenic
fungi activities of daphneolone analogues
from Stellera chamaejasme L.
By Jin, Hong et al
From Pesticide Biochemistry and Physiology,
93(3), 133-137; 2009

CASREACT : Copyright 2015 American Chemical Society. All Rights Reserved. CASREACT contains reactions
from CAS and from: ZIC/VINITI database (1974-1999) provided by InfoChem; INPI data prior to 1986; Biotransformations
database compiled under the direction of Professor Dr. Klaus Kieslich; organic reactions, portions copyright 1996-2006
John Wiley & Sons, Ltd., John Wiley and Sons, Inc., Organic Reactions Inc., and Organic Syntheses Inc. Reproduced
under license. All Rights Reserved.