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Comprehensive Psychiatry 54 (2013) 933 942
www.elsevier.com/locate/comppsych
Abstract
Objective: The prognosis for eating disorders (ED) is unsatisfactory, and the literature about outcome indicators is controversial. The present
study evaluates the roles of self-esteem, personality disorders (PD), and dissociation as outcome predictors.
Method: Fifty-seven ED outpatients were recruited from a population beginning a Cognitive Behavioral Therapy-Enhanced (CBT-E)
treatment. All patients received the Structured Clinical Interview for DSM-IV Axis I (SCID-I), the Structured Clinical Interview for DSM-IV
Axis II (SCID-II), and completed the Eating Disorder Examination Questionnaire (EDE-Q), the Dissociation Questionnaire (DIS-Q), and the
Rosenberg Self-Esteem Scale (RSES). One month after the end of treatment, recovery was evaluated as meeting the DSM-IV criteria for EDs.
Results: A small group of patients recovered (42.2%). Low self-esteem and dissociation results correlated with a negative outcome.
Discussion: Dissociation may be an important moderator of psychotherapy and treatment success, as already suggested by previous studies
on non-eating-related disorders.
2013 Elsevier Inc. All rights reserved.
1. Introduction
The recovery rates in outcome studies on eating disorders
(EDs) range from 30% to 75% for anorexia nervosa (AN)
and from 50% to 70% for bulimia nervosa (BN) [111]. This
large variability is mainly related to methodological aspects.
Furthermore, diagnostic shifts between the different ED
diagnoses over time are common [12,13], and empirical
support for the current diagnostic division of ED is
controversial. There is an increasing emphasis on common
psychopathological features in various EDs, and a transdiagnostic theory has been proposed [14].
There is evidence that cognitive behavioral therapy
(CBT) is the most effective form of intervention for BN
and binge eating disorder (BED) patients [14], and, despite
less evidence to support the usage of CBT for AN [14,15], it
is one of the most commonly applied treatments. Enhanced
Corresponding author. Cognitive Psychotherapy Clinical Centre, P.
Box: Via Delle Porte Nuove, 10, 50144, Florence, Italy. Tel.: +39 055
3245357; fax: +39 055 3245357.
E-mail address: marzioma@katamail.com (M. Maglietta).
0010-440X/$ see front matter 2013 Elsevier Inc. All rights reserved.
http://dx.doi.org/10.1016/j.comppsych.2013.03.024
934
Moreover, the reported frequencies of personality disorders (PD) vary from 27% to 93% among clinical and
community samples with EDs [3136]. It is likely that
methodological problems account for this variation, and
personality features are affected by malnutrition [37,38].
Among the pretreatment variables associated with poor
outcomes, the presence of a comorbid PD is considered
relevant in several studies [21,3941]. The presence of
borderline PD (BPD) has been associated with poor
treatment responses in AN bingepurge types, BN
[36,42,43] and BED [44]. These results were not fully
replicated by other studies [4547]. Vrabel et al. [48]
showed a decreasing prevalence of PDs in a 5-year follow-up
of long-standing ED patients, indicating that meaningful
clinical changes in PDs do occur among ED patients,
especially during the period of treatment that focused on ED
symptoms. In the follow-up of the same series done by R
et al. [49], improvements in ED symptoms preceded changes
in PDs.
Several findings support the hypothesis that there is a
relationship between dissociation and EDs [5054]. Furthermore, dissociation has been found to play an important
role in bingeing severity for subjects with bulimic disorders
[5557], and it is probably involved in the most
accomplished theories about binge eating: the mood
modulation theory [5860] and the escape theory [61].
Dissociation has a long tradition in psychodynamic research
in which it is considered a negative prognostic factor [62],
but the body of evidence linking dissociation to a bad
outcome in psychotherapy has begun to grow recently [63].
Michelson et al. [64], in anxiety disorders, observed that
higher levels of dissociation prior to treatment were related
to higher psychopathology assessed after CBT. Likewise,
Rufer et al. [65] found that patients with obsessive
compulsive disorder who experienced higher levels of
dissociation in the beginning of the study experienced
higher symptom severity after CBT. Spitzer et al. [66]
confirmed the negative effect of dissociative experiences on
psychotherapy responses on patients with a broad range of
mental disorders. Many authors consider that the fragmentation of consciousness, memory and identity, which are
characteristics of dissociative experiences, may interfere
with learning processes and therefore negatively influence
the effectiveness of therapies grounded on those, such as
CBT [64,67,68].
The aims of the present study were to assess the roles of
self-esteem, PDs, and dissociative experiences as treatment
outcome predictors for CBT in ED patients.
We hypothesized that, after a minimum follow-up period
of 1 month after the end of a manual-based Cognitive
Behavioral Therapy-Enhanced (CBT-E) treatment for ED
patients, we would find that a negative outcome (not
recovered or dropout), compared to a positive outcome
(recovered), is correlated with lower levels of self-esteem,
the presence of a PD and higher levels of dissociation, as
measured during the assessment phase.
2. Methods
2.1. Participants
From November 2010 to November 2011, 61 Italian
women who suffered from EDs were recruited from a
population admitted consecutively to an outpatient treatment
program for EDs, which was administered in a specialized
unit: the Cognitive Psychotherapy Clinical Centre of
Florence, Italy. All patients were recruited during the initial
assessment phase of treatment, and all participants were
informed about the procedures and aims of the study and
provided written consent. The research was reviewed and
approved by the internal review board of the Cognitive
Psychotherapy Clinical Centre of Florence.
2.2. Procedure
The present study used a longitudinal perspective. A
summary of the flow of participants through each stage of the
study is presented in Fig. 1. To determine the diagnosis, all
patients received the Structured Clinical Interview for DSMIV [69] Axis I (SCID-I) [70,71] and the Structured Clinical
Interview for DSM-IV [69] Axis II (SCID-II) [71,72] during
the assessment phase. Personal data were collected via a
paper questionnaire; psychiatrists measured both height and
weight. Psychologists trained in cognitive therapy (4-years
training, according to the criteria set forth by the Italian
Ministero dell'Istruzione, dell'Universit e della Ricerca,
and by the Societ Italiana di Terapia Comportamentale e
Cognitiva) assessed demographic data. The psychologists
administered the Italian versions of the SCID-I and the
SCID-II, and a battery of self-report questionnaires.
Criteria for inclusion in the study were as follows:
A Diagnostic and Statistical Manual of Mental Disorders
(DSM) diagnosis of an ED or an eating disorder not
otherwise specified (EDNOS) based on the SCID-I
A body mass index (BMI) above 17.5 kg/m 2
No actual or previously reported DSM diagnosis of mood
disorders, schizophrenia, or schizoaffective disorder
A minimum age of 18 years, mental competency, and the
ability to adequately comprehend written Italian.
935
Treatment:
Treatment:
End of treatment:
End of treatment:
24 assessed as recovered
24 Positive Outcome
6 AN, 9 BN, 9 EDNOS
33 Negative Outcome
12 AN, 12 BN, 9 EDNOS
Fig. 1. Consort diagram showing the flow of participants through each stage of the study.
attitudes regarding eating and overvalued thoughts regarding weight and shape. The global score represents the
mean value of the four subscale scores. Different studies
have shown that the EDE-Q has adequate testretest
reliability [73,74], good convergence with the EDE
interview [7577], and both discriminant and concurrent
validity [78,79]. To assess binge eating episodes, we
considered specific questions from the SCID-I [70,71] that
are relevant to the diagnosis of an ED and that investigate
episodes of uncontrolled overeating with reference to the
past 4 weeks.
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3. Results
Table 1
Correlations among eating psychopathology, dissociation and self-esteem in the whole sample (n = 57).
Variables rho; (p)
DIS-Q Total
DIS-Q Amnesia
DIS-Q Absorption
RSES
EDE-Q Total
EDE-Q Eating Concern
EDE-Q Weight Concern
EDE-Q Shape Concern
EDE-Q Restraint
0.556 (b
0.444 (b
0.464 (b
0.454 (b
0.363 (b
0.495 (b 0.01)
0.334 (b 0.05)
0.462 (b 0.01)
0.480 (b 0.01)
0.236 (0.08)
0.637 (b
0.467 (b
0.602 (b
0.590 (b
0.347 (b
0.527 (b
0.322 (b
0.484 (b
0.512 (b
0.335 (b
0.234 (0.08)
0.027 (0.84)
0.225 (0.09)
0.240 (0.07)
0.196 (0.14)
0.522 (b 0.01)
0.489 (b 0.01)
0.414 (b 0.01)
0.520 (b 0.01)
0.163 (0.23)
0.01)
0.01)
0.01)
0.01)
0.01)
0.01)
0.01)
0.01)
0.01)
0.01)
0.01)
0.05)
0.01)
0.01)
0.05)
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Table 2
Demographic variables.
Variables
PO (n = 24)
NO (n = 33)
2/F
Age (y)
Education (y)
Employed
Married
BMI
35.1 10.7
13.8 2.5
14 (58.3%)
10 (43.5%)
25.4 9.0
30.5 9.0
12.8 2.8
19 (57.6%)
13 (41.9%)
23.6 9.3
3.01
1.65
0.01
0.01
0.47
0.09
0.21
0.98
0.91
0.49
4. Discussion
The results of our study indicate a generally poor outcome
for the treatment of ED patients, especially considering a
Table 3
Psychometric scores.
Variables
PO (n = 24)
NO (n = 33)
EDE-Q Total
EDE-Q Eating Concern
EDE-Q Weight Concern
EDE-Q Shape Concern
EDE-Q Restraint
DIS-Q Total
DIS-Q Identity Confusion
DIS-Q Loss of Control
DIS-Q Amnesia
DIS-Q Absorption
RSES
1.624
1.059
1.680
1.454
1.002
2.174
1.793
1.680
1.906
0.734
1.582
b0.01
b0.22
b0.01
b0.05
b0.27
b0.01
b0.01
b0.01
b0.01
b0.66
b0.05
Abbreviations: PO: positive outcome group, NO: negative outcome group. Statistics: median [quartiles], KolmogorovSmirnov test.
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Table 4
Stepwise logistic regression analysis predicting positive outcome (dependent variable); n = 57.
Step models
Nagelkerke R 2
Step 1
Step 2
13.328
5.002
b0.01
b0.03
0.284
0.375
Standard error
Exp (B)
Step 1
0.583
1.135
0.509
0.103
0.489
b0.193
b0.501
b0.190
b0.049
b0.892
0.01
0.02
0.01
0.05
0.58
0.558
3.112
0.601
1.108
0.614
13.328
Step 2
DIS-Q
Constant
DIS-Q
RSES
Constant
Score
Step 1
b1.469
b4.806
b1.872
b0.108
b0.271
0.23
0.03
0.17
0.74
0.60
Step 2
EDE-Q Total
RSES
BPD
EDE-Q Total
BPD
9.359
5.002
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