University of San Agustin

College of Pharmacy & Medical Technology

Course Outline for Bio Sci 110M
Course Title: Histology
CHARTER STATEMENTS
VISION

A premier academic community of life-long learners working with

one mind and one heart to search for, discover and share the Truth
(Gaudium de Veritate) for the promotion of authentic human and
societal development.

MISSION The University of San Agustin is an Augustinian, Catholic and

Filipino educational institution that aims to form the members of its
academic community in virtus et scientia to serve Western Visayas
region, the Philippines and the world.
COLLEGE VISION AND MISSION STATEMENTS
Vision
A dynamic college upholding excellent Augustinian education for the holistic
formation of outstanding professionals in the fields of pharmacy and medical
technology.
Mission
The College of Pharmacy and Medical Technology commits itself to produce
competent and service oriented Augustinian pharmacists, medical
technologists/medical laboratory scientists and pharmacy technicians
working for the common good. Specifically, it aims to:
1. develop a strong sense of Christian-Augustinian values and
tradition;
2. provide students with knowledge, skills and competencies needed
to meet the demands of their respective professions
3. implement pharmacy and medical technology/medical laboratory
science internship programs in consonance to prescribed standards,
4. foster and sustain a culture of research among faculty, students and
alumni;
5. build and strengthen partnerships with public and private sectors
and the community;
6. enhance faculty and staff competencies and functions;
7. develop organizational capability and empowerment of faculty, staff
and students; and
8. improve infrastructure and office/laboratory facilities.
Course Description: This course deals with the study of cells and tissues
within an organism, and which serves as the foundation on
which pathology and histopathology are built. The
common goal is to better understand how structure and

function are integrated in the molecules, cells, tissues &

organs of a living body.
Prerequisite:

Human Anatomy & Physiology

Credit Units:
Contact Hours:
Placement:

3 units (2 units lecture; 1 unit lab)

2 hours lecture per week / 3 laboratory hours per week
Third Year BSMLS, First Timester

General Objectives: At the end of the course, the students should be able
to:
1. Explain the fundamentals of cells & tissues.
2. Explain the characteristics and functions of microscopic structures of cells
and tissues which serve as the foundation on which pathology &
pathophysiology are built.
3. Explain the functions of cellular organelles and their functional
interrelationship.
4. Manifest the following values: integrity, critical thinking, honesty,
creativity and concern for others.

Computation of Grades:
LECTURE (67%):
(Prelim/Midterm/Finals) - 50%
Quizzes
- 25%
Reporting
-15%
Assignmeent/Group Work
-10%
100%
LABORATORY (33%):

Practical Examination

50%
Quizzes
25%
Laboratory Performance
15%
Manual
10%
100%

Textbook:

Mescher, Anthony L. Junquieras Basic Histology Text

& Atlas, 13th Edition. McGraw-Hill of Companies, Inc.,
New York, USA. ,2013.

Laboratory Manual: Penaverde, Ferly V and Jose G. Perez, Jr. Laboratory

Manual in Histology. College of Pharmacy and Medical
Technology.
University of San Agustin. 2012
References:
1. Ash, John F., et al. The Big Picture: Histology. McGraw-Hill of Companies,
Inc., New York, 2013.
2. Baldwin, Kate M., Wheaters Review of Histology and Basic
Pathology. Churchill Livingstone. 2010
3. Cui, Dongmei. Atlas of Histology with functional & clinical
correlation. Lippincott Williams & Wilkins. 2011.
4. Eroschenko, Victor P. DiFiores Atlas of Histology with Functional
Correlations 12th Ed. Lippincott Williams & Wilkins. 2013
5. Gartner, Leslie P and James L. Hiatt. Concise Histology. Saunders,
Elselvier Inc. 2011.
6. Pakurar, Alice and John W. Bigbee. Digital Histology 2nd edition .
Wiley-Blackwell. 2009.
7. Young, Barbara, et al. Wheaters Functional Histology, A Text and
Colour Atlas. Elsevier Limited. 2006.

Lecture Course Content

Orientation

Specific Objectives
At the end of the unit the student should
be able to:

Time
frame
Week 1
1 hr

Unit I: Introduction
A. Definition of terms
B. Significance of histology
to Med Tech Profession
C. Basic Histologic
Techniques
Unit II: Cytology
A. Cell Structure and
Function
B. Cell Cycle & Cell Division
Mitosis
Meiosis
C. Medical Application

Unit III: Epithelial Tissue

1. Define histology, tissue and other

terms related to histology
2. Explain the significance of histology
to Med Tech profession
3. Differentiate the common techniques
for the study of tissues
1. Describe the different structures of
the cell
2. Explain the function of each part and
organelles of the cell in relation to its
structure
3. Discuss the stages of mitosis and
meiosis
4. Compare and contrast mitosis and
meiosis
5. Explain the significance of meiosis to
sexually reproducing organisms
1. Describe the general characteristics

Week 1
1 hr

of the epithelial tissue

2. Differentiate the epithelial tissues
according to structure, location and
function
3. Relate the structure of the epithelial
tissue to its function
4. Describe the modifications or
specializations in the epithelial
surfaces
Unit IV: Connective Tissue
1. Describe the composition of
A. Composition (cells, fibers
connective tissue
& matrix)
2. Describe the different types of
B. Types of Connective
connective tissues
Tissue
3. Identify the location of each
C. Function
4. Relate the function of each type f
D. Location
connective tissue to its structure
E. Histophysiology
5. Discuss the histophysiology,
F. Medical Application
histogenesis and regenerative
changes.
Unit V: Nervous Tissue
1. Describe the general characteristics
A. General characteristics
of nervous tissue
B. Cells of the Nervous
2. Describe the structure of the neuron
Tissue
3. Classify the neurons.
C. Neuronal Plasticity &
4. Contrast axon and dendrite in terms
regeneration
of function & location
D. Medical Application
5. Differentiate the cells of the nervous
tissue in terms of structure, function
& location
6. Explain neural plasticity,
degeneration & regeneration of the
nervous tissue.
Unit VI: Muscle Tissue
1. Describe the general characteristics
A. General characteristics
of muscle tissue
B. Types of Muscle Tissue
2. Differentiate the three types of
C. Location
muscle tissue
D. Function
3. Identify the specific location of each
E. Medical Application
type of muscle tissue
Week 5 (Thursday & Friday): Prelim
Unit VII: The Circulatory
1. Identify, compare & contrast the tissue
composition of the three tunics of the
System
wall of the heart
A. Heart
2. Relate the tissue composition of the
1. Tissue Composition
heart to its function
3.
Identify and compare the tissue
B. Blood Vessels
composition of the walls of the arteries,
C. Lymphatic Vessels
arterioles, capillaries, venules, veins
D. Blood
and lymphatics
E. Hematopoeisis
4.
Explain the function of the blood
1. Plasma
vessels & lymphatics in relation to their
2. Blood cells: Structure
structure (tissue composition)
& Function
5. Describe some cardiovascular diseases
associated with the changes in the
F. Medical Application
tissue composition of the walls of the
heart & blood vessels
6. Describe the general characteristics of
& composition of the blood
7. Describe the structure of the different
blood cells and platelets & give the
function of each
8. Describe the stages of hematopiesis
9. Enumerate & describe some disorders
A.
B.
C.
D.
E.

General Characteristics
Types of Epithelial Tissue
Location
Function
Specialization of the
Epithelial cell surface
F. Medical Application

Week 2
2 hrs

Week 3
2 hrs

Week 4
2 hrs

Week 5
1 hr.

Week
5&6
2 1/2
hrs

of the blood
Unit VIII: The Immune
System & Lymphoid Organs
A. Characteristics
B. Functions
C. Cells of the Immune
System
D. Types of Immune
Responses
E. Primary & Secondary
Lymphoid Organs
F. Microscopic structure of
the Lymphoid Organs
G. Function of the Lymphoid
Organs
H. Medical Application
Unit IX: The Digestive
System
A. General Characteristics
& Functions of the
digestive tract
B. Microscopic structure of
the digestive tract
C. Organs associated with
the digestive tract
1. Structure
2. Function
D. Medical Application
Unit X: The Respiratory
System
A. Microscopic structure of
the respiratory system
B. Functions of the organs
of the respiratory system
C. Disorders of respiratory
system

Unit XI: The Integumentary

System
A. Microscopic structures of
the skin
B. Function of the tissues of
the different layers of
the skin
C. Accessory organs of the
skin
D. Medical Application

1. Describe the general characteristics of

the Immune System
2. Compare & contrast innate from
adaptive immunity, cellular from
humoral immunity
3. Describe the structure and function of
the cells of the immune system
4. Contrast primary & secondary
lymphoid organs
5. Describe the microscopic structures,
location & functions of the lymphoid
organs
6. Explain the specific functions of each
lymphoid organ in relation to its
structure & location in the body
7. Discuss some diseases associated with
the immune system
1. Describe the general characteristics
and functions of the digestive tract
2. Describe the microscopic structure of
the different segments of the digestive
tract
3. Explain the function of the different
segments of the digestive tract in
relation to their tissue composition
4. Describe the structure & function of the
accessory organs of the digestive
system
5. Describe some common diseases
associated with the digestive system
1. Describe the microscopic structures of
the respiratory system
2. Identify the tissue types lining the walls
of the respiratory tract
3. Compare & contrast the conducting &
respiratory structures in terms of tissue
composition
4. Relate the microscopic anatomy of the
respiratory organs to its function
5. Describe common respiratory disorders
due to abnormal changes of the
respiratory epithelium
1. Describe the structure and function of
the tissues in the epidermis, dermis &
hypodermis
2. Differentiate the four types of cells in
the epidermis as to structure, function
& location
3. Compare thick & thin skin as to tissue
composition and location
4. Identify and describe the tissue
composition of the hair follicles and
nail complexes
5. Relate the structure of the skin, hair
follicles and nail complexes
6. Differentiate the three types of
accessory glands of the skin as to
secretion and body location

Week
6&7
1 1/2

Week
7&8
3 hrs

Week
9
2 hrs

Week
10
2 hrs

Week 10
Unit XII: The Urinary System
A. Microscopic structures of
the organs of the urinary
system
B. Function of the organs of
the urinary system
C. Urine formation
D. Medical Application
Unit XIII: The Endocrine
System
A. Organs
1. Structure
2. Location
3. Tissue Composition

(Thursday & Friday): Midterm

1. Describe the microscopic structures
of the urinary system
2. Relate the tissue composition of the
urinary organs to its function

1. Describe the structure, location and

function of the components/organs of
the Endocrine system
2. Describe the tissue composition of
each organ
3. Identify the specific cells of each
endocrine organ/tissue and the
hormone they secrete
B. Hormone secretion
4.
Describe some disorders associated
C. Disorders of the
with
the abnormal function/s of the
Endocrine organs
endocrine glands
Unit XIV: The Male
1. Describe the structure of the male
reproductive organs & its tissue
Reproductive System
composition
A. Organ Structure & Tissue
2.
Relate the structure and tissue
Composition
composition of each organ to its
B. Function of the organs
function
C. Spermatogenesis
3. Explain the process of
D. Medical Application
spermatogenesis (production) &
spermiogenesis (maturation)
4. Describe some disorders associated
with changes in the structure of the
cells & tissues of the male
reproductive organs
Unit XV: The Female
1. Describe the structure of the female
reproductive organs & its tissue
Reproductive System
composition
A. Organ Structure & Tissue
2.
Relate the structure and tissue
Composition
composition of each organ to its
B. Function of the organs
function
C. Ovarian & Uterine
3. Explain the hormonal effect on
(Menstrual Cycle)
ovarian & uterine (menstrual) cycle
D. Medical Application
4. Discuss some disease associated with
changes in the tissues composition of
the female reproductive system
Unit XVI: The Special Senses
1. Describe the structure, location and
A. Structure & Tissue
function of the components of the
Composition
eyes, ears and tongue.
B. Function of the organs
2. Describe the tissue composition &
1. Eyes
the receptors found in each sense
2. Ears
organ
3. Relate the structure to function
C. Medical Application
4. Describe some disorders of the eyes
& ears
Week 14 (Thurs & Friday): Finals

Week
11
2 hrs

Week
12
2 hrs

Week
13
1 hrs

Week
13
1 hrs

Week
14
1 hr

Laboratory
Course Content
Class Orientation
Introduction to
Histology
A. Preparation of
Tissues for Study
B. Interpretation of
Tissue Sections
Exercise I: The
Compound
Microscope

Specific Objectives
At the end of the class, the student should be able
to:

Time
frame
Week 1
1 hr

1. Recall the laboratory rules and proper waste

management
2. Describe the steps in preparing tissue for
histologic examination
3. Correlate two-dimensional tissue sections with
the real three-dimensional tissues.
4. Identify artifacts that causes tissue distortion.
2 hrs
At the end of the exercise, the student should be
able to:
4. Identify the parts of the microscope
5. Describe the function of each part of the
Microscope
6. Demonstrate the proper use and care of the
microscope
7. Record accurately microscopic observation

Exercise II: The

Animal Cell

Exercise III: The

Epithelial Tissue

Exercise IV: The

Connective Tissue

Exercise V: The
Nervous Tissue

6. Identify the different parts and organelles of

the animal cell
7. Describe the function of each part and
organelles of the cell
8. Identify the parts of the cell in wet mount &
prepared slides
5. Define epithelium
6. Classify the types of epithelium and glandular
tissue and give example of each
7. Differentiate the epithelial types and
glandular tissues as to structure, function &
location
8. Identify the types of epithelial tissue & glands
in micrographs & specimen
9. Relate the structure of epithelial tissue and
glands to its function
6. Describe the composition of connective tissue
7. Describe the different types of connective
tissues
8. Identify the location of each type of connective
tissue
9. Relate the function of each type f connective
tissue to its structure
10.Identify the different connective tissues in
micrographs and specimen
7. Describe the general characteristics of
nervous tissue
8. Describe the structure of the neuron
9. Identify the different types of neurons in
micrographs & specimen
10.Contrast axon and dendrite in terms of
function & location
11.Distinguish the neurons and neuroglia in
specimen & micrographs

Week 1
1 hr

Week
2:
3 hrs:

Week
3
4 hrs

Week 4
1.5 hrs

Exercise VI: The

Muscle Tissue

Exercise VII: The

Cardiovascular
System: Heart &
Blood Vessels

Exercise VIII: The

Cardiovascular
System: Blood

Exercise IX:
Hematopoiesis

Exercise X: The
Lymphoid System

Exercise XI: The

Digestive System

Exercise XII: The

12.Contrast the neuroglia cells in terms of

structure, function & location
4. Describe the general characteristics of muscle
tissue
5. Identify the three types of muscle tissue in
specimen & micrographs
6. Contrast the three types of muscle tissues as
to structure, location & function
Week 5: Prelim
10.Differentiate tissue composition of the three
tunics of the heart to wall
11.Relate the tissue composition of the heart to
its function.
12.Compare the tissue composition of the
arteries, arterioles, capillaries, venules, veins
and lymphatics
13.Identify & differentiate veins & arteries n
microscopic specimens and in micrographs
14.Relate the structure of the blood vessels &
lymphatic vessels to their function
1. Describe the general characteristics of blood
2. Discuss major functions of the blood
3. List the major componenets of blood and
describe the function of each
4. Identify the different formed elements of the
blood in stained smears & micrographs
5. Distinguish variations in RBC morphology
6. Give examples of disorders associated with
RBC morphology
1. Describe the stages of hematopoiesis
2. Identify the blood cells in each step of blood
formation in micrographs & in bone marrow
smears
3. List the hematopoietic growth factors of the
particular progenitor cell
4. Give examples of disorders associated with
presence of immature blood cells in blood
circulation.
8. Describe the general characteristics of the
lymphoid organs in relation to their functions
9. Identify the lymphoid organs in charts &
models
10.Identify the histologic components of the
lymphatic system in specimen and in
micrograph
11.Describe the functions of the cell of the
immune system
12.Enumerate some diseases associated with the
immune system
6. Describe the general characteristics &
functions of the digestive tract
7. Describe the microscopic structure of the
digestive tract
8. Compare & contrast the four tunics of the
walls of digestive tract in relation to their
tissue composition and function
9. Describe the structure & function of the
accessory organs of the digestive system
6. Identify the tissue types lining the walls of the

Week 4
1.5 hrs

Week
6
1 1/2
hrs

Week
6
1 1/2
hrs

Week
6:
1 hr

Week
7:
3 hrs

Week
8:
3 hrs

Week 9

Respiratory System

Exercise XIII: The

Integumentary
System

Exercise XIV: The

Urinary System

Exercise XV: The

Endocrine System

Unit XVI: The Male

Reproductive
System

respiratory tract
7. Compare the walls of the upper and the lower
respiratory tracts in terms of tissue
composistion and arrangement
8. Relate the microscopic anatomy of the
respiratory organs to its function
9. Enumerate some respiratory disorders due to
abnormal changes of the respiratory
epithelium
Week 10: Midterm
7. Identify the components of the skin in chart,
micrograph & prepared slides
8. Describe the structure and function of the
tissues in the epidermis, dermis & hypodermis
9. Differentiate the four types of cells in the
epidermis as to structure, function & location
10.Compare thick & thin skin as to tissue
composition and location
11.Identify and describe the tissue composition of
the hair follicles, nail complexes & accessory
glands
12.Relate the structure to function
3. Identify the organs of the urinary system in
charts and micrograph
4. Identify the microscopic structure of the
kidneys in micrograph & specimen
5. Identify the structure and tissue composition
of the parts of the nephron
6. Relate the microscopic anatomy of the
nephrons to its function of urine production
7. Identify the tissue composition of the ureter &
urinary bladder
8. Relate the tissue composition of the ureter &
urinary bladder to their function
5. Describe the structure, location and function of
the components/organs of the Endocrine
system
6. Describe the tissue composition of each organ
7. Identify the specific cells of each endocrine
organ/tissue
8. Enumerate the hormone they secrete
9. Enumerate some disorders associated with the
abnormal function/s of the endocrine glands
5. Identify the microscopic structure & tissue
composition in specimen and micrograph
6. Relate the structure and tissue composition of
each organ to its function
7. Identify Sertoli cells, Leydig cells &
spermatozoa in specimen & micrograph
8. Compare & contrast Sertoli cells, Leydig cells
& spermatozoa in terms of location, structure,
function & embryonic origin
9. Identify sperm cells and its parts in specimen
& micrograph
10.Describe the histologic structures and location
of the three erectile bodies of the penis
11.Identify sperm cells in its different stages of
maturation
12. Describe some disorders associated with
changes in the structure of the cells & tissues

3 hrs

Week
11:
2 hrs

Week
11:
2 hrs

Week
12:
2 hrs

Week
12:
2 hrs

Exercise XVII: The

Female
Reproductive
System

Unit XVIII: The

Special Senses

of the male reproductive organs

5. Identify the gross & microscopic structure of
the female reproductive system
6. Identify the ovarian follicles at different stages
of development in specimen and in
micrograph
7. Identify the tissues of the uterine wall, uterine
tubes and the ovary
8. Relate the structure and tissue composition of
each organ to its function
9. Differentiate the 3 layers of the uterine wall as
to tissue composition
10.Differentiate the epithelial cells lining the
lumen of the uterine tubes in terms of height,
apical specialization & secretory activity
5. Describe the structure, location and function of
the components of the eyes, ears and tongue.
6. Describe the tissue composition & the
receptors found in each sense organ
7. Identify the different sensory receptors in
specimen and in micrograph
8. Classify the types of receptors found in each
sense organ
9. Relate structure to function
Week 14: Finals

ALMA MARIA B. DAGUAY, MD

Lecturer

Week
13:
3 hrs

Week
13:
1 hr