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Kawasaki disease is an uncommon childhood illness that causes inflammation of the blood vessels. It
most commonly affects children ages 18 to 24 months; it is less commonly seen in people older than
age 8. It tends to be severe for several days, but then most children return to normal activities. After
your child gets better, the doctor will usually watch him or her for heart problems.
The disease is not contagious and occurs most often in the late winter and early spring.
Although a specific cause has not yet been identified, researchers suspect Kawasaki disease may be
related to a virus or bacteria.
Symptoms:
Diagnosis
Kawasaki disease can be difficult to diagnose. Although there is no specific test for Kawasaki disease,
a diagnosis can be made if a child has a fever that lasts at least 5 days and also has 4 of the 5 other
symptoms listed above. Less often, a diagnosis is made when a child has a fever that has lasted at least
5 days, two other symptoms from the list above, and some damage to the heart (coronary artery
disease).
Treatment
Treatment for Kawasaki disease may include medicine given through a vein (intravenous, or IV,
medicine) called immunoglobulin (IVIG) to reduce inflammation of the blood vessels, aspirin therapy
to lower the risk of blood clots, and possibly blood thinners (anticoagulants) to prevent new blood
clots.
Most children with Kawasaki disease get better and have no long-term effects, even if they do not
receive treatment. However, treatment shortens the illness and greatly reduces the chances of having
problems from Kawasaki disease.
About 20% of children who are not treated will have problems in the arteries that supply blood to the
heart (coronary artery disease). Weakened coronary arteries may get enlarged or can narrow or develop
blood clots. In very rare cases, this can lead to a heart attack.
The risk of heart attack is greatest within 1 year after the illness. However, studies in Japan indicate
that children who develop coronary artery damage are more prone to having a heart attack as young
adults.
Treatment Overview
Kawasaki disease is treated with medications. Long-term care may be needed and might include
continued medication, limited physical activity, and repeated testing.
Early treatment of Kawasaki disease prevents most blood vessel and heart damage. If children with
Kawasaki disease are hospitalized and treated within 10 days after the first signs of illness, the risk of
heart disease and aneurysms greatly decreases.
Medications
Medications used to treat Kawasaki disease include intravenous immunoglobulin (IVIG), aspirin, and
possibly anticoagulants.
Aspirin therapy. At first, high-dose aspirin is used to relieve inflammation and fever. If there are no
complications, smaller daily doses are then given for 2 to 3 months to lower the risk of dangerous
blood clots. Because of the risk of Reye's syndrome, aspirin should be given only under the guidance
of a doctor. If the child is exposed to or develops chickenpox or flu (influenza) while taking aspirin,
talk with a doctor right away. For more information, see the topic Reye's Syndrome.
Anticoagulants. Anticoagulants may be used if the child has a large aneurysm. Anticoagulants help
prevent new blood clots.
After initial treatment, the child's fever and inflammation should improve, but the child may still be
irritable, not have an appetite, and not be very active. The child may also develop deep lines across his
or her fingernails (Beau's lines). It may be several weeks before the child feels completely well.
Follow-up treatment
If echocardiogram results from follow-up exams are normal, the child probably will not need further
care.
However, if these test results show changes in the coronary arteries, long-term care of the disease may
be needed. This care may include:
• Repeated exams and tests every year or every 3 to 5 years, depending on the child's risk for heart
problems.
• Continued low-dose aspirin therapy, sometimes combined with other medications that lower the risk
of blood clots.
• Limited physical activity.
• Annual flu shot (influenza vaccine)
Treatment with immunoglobulin (IVIG) sometimes interferes with the effectiveness of immunizations
against measles, mumps, rubella (MMR) and chickenpox. MMR and chickenpox immunizations
should be postponed for 11 months in children who have received IVIG treatment.
Kawasaki disease is an illness that involves the skin, mouth, and lymph nodes, and most often affects
kids under age 5. The cause is unknown, but if the symptoms are recognized early, kids with Kawasaki
disease can fully recover within a few days. Untreated, it can lead to serious complications that can
affect the heart.
Kawasaki disease occurs in 19 out of every 100,000 kids in the United States. It is most common
among children of Japanese and Korean descent, but can affect all ethnic group
Congestive Heart Failure
Heart failure, also called congestive heart failure, is a condition in which the heart cannot pump enough
oxygenated blood to meet the needs of the body's other organs. The heart keeps pumping, but not as
efficiently as a healthy heart. Usually, the loss in the heart's pumping action is a symptom of an
underlying heart problem.
Heart failure often occurs in children with congenital (present at birth) heart defects. Other medical
problems that can cause heart failure include, but are not limited to, the following:
• systemic right ventricle (right ventricle is the only ventricle or the right and left ventricles are
transposed so that the right ventricle pumps blood out to the body rather than the lungs) that is unable
to meet demand
• inefficient pumping of the ventricles due to enlargement of the heart and/or too much volume in
the circulatory system
• heart valve disease caused by past rheumatic fever or other infections
• infections of the heart valves and/or heart muscle (i.e., endocarditis)
• cardiac arrhythmias (irregular heartbeats)
• cardiomyopathy, or another primary disease of the heart muscle
• chronic lung disease
• anemia
• high blood pressure (hypertension)
• hemorrhage (excessive bleeding)
• post-operative complications over time, following repair or palliation procedure(s)
Many congenital heart defects have the potential to lead to heart failure over time, whether or not the
defect is treated surgically. Congenital heart defects that more often develop heart failure include, but
are not limited to, the following:
Altered Physiology
Heart failure can affect the right side of the heart, the left side of the heart, or both sides.
When the right side of the heart begins to function less efficiently, it is unable to pump much blood
forward into the vessels of the lungs. Because of the congestion in the right side of the heart, blood
flow begins to back up into the veins. Eventually, swelling is noticed in the feet, ankles, eyelids, and
abdomen due to fluid retention.
When the left side of the heart fails, it is unable to pump blood forward to the body efficiently. Blood
begins to back up into the vessels in the lungs, and the lungs become stressed. Breathing becomes
faster and more difficult. Also, the body does not receive enough blood to meet its needs, resulting in
fatigue and poor growth.
The following are the most common symptoms of heart failure. However, each child may experience
symptoms differently. Symptoms may include:
• visible swelling of the legs, ankles, eyelids, face, and (occasionally) abdomen
• fast breathing during rest or exercise
• shortness of breath or labored breathing
• fatigue
• a child needing to take frequent rest breaks while playing with friends
• nausea
• falling asleep when feeding or becoming too tired to eat
• lack of appetite
• weight gain over a short period of time, even when the appetite is poor
• cough and congestion in the lungs
• sweating while feeding, playing, or exercising
• breathing difficulty with activity, especially while feeding, walking, or climbing stairs)
• loss of interest in feeding (poor appetite, loss of muscle mass, overall weight loss)
• failure to gain weight
• swelling around the eyes or over the flanks (between the ribs and the upper border of the hip bone)
• abdominal distension (enlargement) and/or pain over the right side (liver area)
• change in skin temperature and color (cold and clammy, or sweaty, flushed, and warm)
The severity of the condition and symptoms depends on how much of the heart's pumping capacity has
been affected.
The symptoms of heart failure may resemble other conditions or medical problems. Always consult
your child's physician for a diagnosis.
Diagnosis
Your child's physician will obtain a complete medical history and physical examination, asking
questions about your child's appetite, breathing patterns, and energy level. Other diagnostic procedures
for heart failure may include:
Specific treatment for heart failure will be determined by your child's physician based on:
If heart failure is caused by a congenital (present at birth) heart defect or an acquired heart problem
such as rheumatic valve disease, surgical repair of the problem may be necessary. Medications are
often helpful in treating heart failure initially. Eventually, medications may lose their effectiveness and
many congenital heart defects will need to be repaired surgically. Medications may also be used after
surgery to help the heart function during the healing period.
Medications that are commonly prescribed to treat heart failure in children include the following:
• digoxin - a medication that helps strengthen the heart muscle, enabling it to pump more
efficiently.
• diuretics - helps the kidneys remove excess fluid from the body.
• potassium-sparing diuretics - helps the body retain potassium, an important mineral that is often
lost when taking diuretics.
• potassium supplements - replaces the potassium lost when taking diuretics.
• ACE (angiotensin-converting enzyme) inhibitors - dilates the blood vessels, making it easier for
the heart to pump blood forward into the body.
• beta blockers - decrease the heart rate and blood pressure, and improve heart function by blocking
the stress hormone adrenalin.
Cardiac resynchronization therapy, or device therapy, is a newer treatment for heart failure.
Device therapy uses a type of pacemaker that paces both sides of the heart simultaneously to
coordinate contractions and improve pumping ability.
Therapeutic Rationale
* Reduce salt and water retention: Diuretics are the first line drugs for use in most uncomplicated
cases of congestive heart failure. (Restriction of sodium intake is desirable but sometimes difficult to
achieve.) Reduction of blood volume decreases the size of the heart, allowing it to function on a
more favorable portion of the ventricular
function curve, and reduces the intracapillary pressure that leads to edema.
* Increase the force of cardiac contraction: Positive inotropic drugs such as digitalis glycosides are
effective in many cases of chronic failure and move the heart to a higher ventricular function curve.
They are generally more toxic than the diuretics. Several positive inotropic substitutes for digitalis
are available for use in special circumstances.
* Reduce vascular tone: Vasodilators reduce the work of the heart and improve cardiac ejection and
tissue perfusion. They are especially useful in acute failure, eg, that associated with myocardial
infarction and severe hypertension
Mechanism
* Diuretics: Their efficacy in congestive heart failure reflects the magnitude of the salt retention that
occurs in failure.
* Positive inotropic drugs:
- Digitalis glycosides: Digitalis drugs act by inhibiting membraneNa,K-ATPase, thereby causing an
increase in intracellular sodium. Increased intracellular sodium results in an increase in in tracellular
calcium. The latter ion directly modulates the contractile process.
- Sympathomimetics: Beta-1 adrenoceptor stimulants such as dobutamine and dopamine are valuable
in some cases of acute failure since they increase cardiac contractility and cause some vasodilation. In
favorable cases, increased contractility is not accompanied by significant tachycardia.
- Amrinone, milrinone, methylxanthines, and other PDE inhibitors: These drugs cause an increase in
cylic AMP by inhibiting cardiac phosphodiesterase. The increase in cAMP results in an increase in
transmembrane calcium flux and a secondary increase in cardiac contractility. The same
biochemical action increases cAMP in vascular smooth muscle and results in vasodilation.
* Vasodilators: Direct-acting agents (eg, nitrates, nitroprusside), sympathoplegics (eg, prazosin), and
angiotensin converting enzyme inhibitors (eg, captopril) reduce cardiac workload and increase cardiac
output in failure associated with high vascular pressures. Captopril also decreases aldosterone
levels, thereby reducing salt and water retention.
Endocarditis
Endocarditis is caused by bacteria (or rarely, fungi) that enter the bloodstream and settle on the inside of
the heart, usually on the heart valves. Bacteria can invade your bloodstream in many ways, including
during some dental and surgical procedures. If you don't take care of your teeth, having your teeth
cleaned or even brushing your teeth can cause bacteria to enter the bloodstream.
If you have a normal heart, you have a low risk for developing endocarditis. But if you have a problem
with your heart that affects normal blood flow, it is more likely that bacteria or fungi will attach to heart
tissue. This puts you at a high risk for endocarditis.
If you have certain heart conditions, getting endocarditis is even more dangerous for you. These heart
conditions include:
Other risk factors that put you at risk for getting endocarditis include:
Some heart problems can put you at risk for endocarditis. These heart conditions include:
If you have any of these heart conditions, you may need to take antibiotics before you have certain
dental and surgical procedures. The antibiotics lower your risk of getting endocarditis. These procedures
include:
Maintaining good oral hygiene is especially important to prevent endocarditis if you are at risk.
Your doctor can give you a card to carry in your wallet that states that you need preventive antibiotics
before certain procedures.
The symptoms of endocarditis progress as the bacteria or fungi grow in your heart. Vague, flu-like
symptoms, such as a low-grade fever and fatigue, often occur first. Most people with endocarditis begin
to have symptoms within 2 weeks after becoming infected with bacteria or fungi.
But a powerful strain of bacteria may cause symptoms to appear much faster, within a few days.
Symptoms include:
Although symptoms are vague and may not seem worth telling your doctor about, if they don't go away
or if you know you are at risk for endocarditis, contact your doctor.
If endocarditis is not treated, the bacteria that cause endocarditis can form growths on or around the
heart valves. The growths prevent the heart valves from opening and closing properly. This interrupts
the normal blood flow through the valves and interferes with the heart's pumping action. Blood can leak
backwards instead of being pumped forward. Over time, heart failure can develop because your heart
may not be able to pump enough blood to meet your body's needs.
• Abnormal heartbeat.
• Stroke.
• Kidney failure.
Diagnoses
The doctor will ask about medical history and do a physical exam. If your doctor thinks that you may
have endocarditis, he or she will check for signs of the infection, such as a heart murmur, an enlarged
spleen, skin rashes, and bleeding under your nails.
Blood cultures will be done to check for bacteria in your bloodstream, and other tests, such as an
echocardiogram, may be done to check your heart function and look at your heart valves.
It is important to treat endocarditis as soon as possible to avoid permanent damage to the heart muscle or
heart valves.
Treatment
Antibiotics given through a vein (intravenously, or by IV) are the usual treatment for endocarditis. If
your heart valves are damaged by the infection or if you have an artificial heart valve, surgery to repair
or replace the valve may be needed. You may also need surgery if your endocarditis is caused by a
fungus. If it is not treated, endocarditis can be fatal.
Antibiotic resistance
Antibiotic resistance occurs when bacteria (such as those that cause endocarditis) develop the
ability to resist drugs that were previously able to kill them. Although antibiotic resistance is most
common in situations that involve improper, unnecessary, and incomplete use of prescription
antibiotics, resistance can also develop through correct antibiotic usage.
Antibiotic resistance is dangerous, because one type of bacteria can acquire the ability to survive
certain drugs and then exchange this ability with other types of bacteria. When resistance to a
particular medicine is widespread, the antibiotic becomes ineffective, and scientists must find an
adequate replacement. Since the only way for bacteria to develop resistance is through exposure
to these antibiotics, doctors try to use these drugs only when appropriate and necessary, reducing
the chances of resistance.
Always attempt to prevent antibiotic resistance, since resistant bacteria are more dangerous to
your valves. This can be done by:
• Completing the course of drugs that you have been given. Antibiotics generally take
several days to kill bacteria, and if you take a partial course, you are teaching bacteria to
survive the antibiotic.
• Not stockpiling partial prescriptions and self-dosing with antibiotics.
Rheumatic Fever
Definition
Rheumatic fever is an inflammatory disease that may develop after an infection with Streptococcus
bacteria (such as strep throat or scarlet fever). The disease can affect the heart, joints, skin, and brain.
Causes
Rheumatic fever mainly affects children ages 6 -15, and occurs approximately 20 days after strep
throat or scarlet fever. In up to a third of cases, the strep infection that caused rheumatic fever may not
have had any symptoms.
About 3% of people with untreated strep infections get rheumatic fever. People who had a case of
rheumatic fever are likely to develop flare-ups with repeated strep infections.
Symptoms
Fever
• Joint pain, arthritis (mainly in the knees, elbows, ankles, and wrists)
• Joint swelling; redness or warmth
• Abdominal pain
• Skin rash (erythema marginatum)
o Skin eruption on the trunk and upper part of the arms or legs
o Eruptions that look ring-shaped or snake-like
• Skin nodules
• Sydenham's chorea (emotional instability, muscle weakness and quick, uncoordinated
jerky movements that mainly affect the face, feet, and hands)
• Nosebleeds (Epistaxis)
• Heart (cardiac) problems, which may not have symptoms, or may result in shortness of
breath and chest pain
Because this disease has different forms, there is no specific test that can firmly diagnose it. Your
doctor will perform a careful exam, which includes checking your heart sounds, skin, and joints.
You may have blood samples taken to test for recurrent strep infection (such as anASO test), complete
blood counts, and sedimentation rate (ESR).
Several major and minor criteria have been developed to help standardize rheumatic fever diagnosis.
Meeting these criteria, as well as having evidence of a recent streptococcal infection, can help confirm
that you have rheumatic fever.
The minor criteria include fever, joint pain, high ESR, and other laboratory findings.
You'll likely be diagnosed with rheumatic fever if you meet two major criteria, or one major and two
minor criteria, and signs that you've had a previous strep infection.
Treatment
People who test positive for strep throat should also be treated with antibiotics. You may have to take
low doses of antibiotics (such as penicillin, sulfadiazine, or erythromycin) over the long term to
prevent the disease from returning.
Outlook (Prognosis) Rheumatic fever is likely to come back in people who don't take low-dose
antibiotics continually, especially during the first 3 -5 years after the first episode of the disease. Heart
complications may be severe, particularly if the heart valves are involved.
Possible Complications
Damage to heart valves (in particular, mitral stenosis and aortic stenosis)
• Endocarditis
• Heart failure
• Arrhythmias
• Pericarditis
• Sydenham's chorea
Call your health care provider if you develop symptoms of rheumatic fever. Because several other
conditions have similar symptoms, you will need careful medical evaluation.
If you have symptoms of strep throat, tell your health care provider. You will need to be evaluated and
treated if you do have strep throat, to decrease your risk of developing rheumatic fever.
Prevention
The most important way to prevent rheumatic fever is by getting quick treatment for strep throat and
scarlet fever.
Reye's syndrome
Reye's syndrome is a rare but serious disease that most often affects children 6 to 12 years old. It
seems to be related to the use of aspirin to treat some viral illnesses, such as chickenpox. Reye's
syndrome primarily targets the brain and liver. Brain swelling and chemical changes in the blood
from liver damage affect the entire body. Drowsiness, confusion, seizures, coma, and in severe
cases, death may result.
Reye's syndrome is a potentially fatal disease that causes numerous detrimental effects to many
organs, especially the brain and liver. It is associated with aspirin consumption by children with
viral diseases such as chickenpox.
The disease causes fatty liver with minimal inflammation, and severe encephalopathy (with
swelling of the brain). The liver may become slightly enlarged and firm, and there is a change in
the appearance of the kidneys. Jaundice is not usually present. Early diagnosis is vital, otherwise
death or severe brain damage may follow
The cause of Reye's syndrome is unknown. However, the disease most often develops in children
who have recently had chickenpox (varicella) or flu (influenza) and who have also taken
medications that contain aspirin. Reye's syndrome is not contagious.
The most important step you can take to prevent Reye's syndrome is to avoid giving aspirin or
products that contain aspirin to anyone younger than 20 unless a health professional has
specifically prescribed it.
symptoms
Often symptoms of Reye's syndrome appear during recovery from a viral infection, such as the
flu or chickenpox, that has been treated with aspirin products. Symptoms usually develop 3 to 7
days after a viral illness starts. The symptoms develop rapidly over several hours to a day or two.
• Sudden onset of retching or vomiting that is not clearly due to stomach flu.
• Sluggishness, lack of energy, and loss of interest in surroundings.
• Strange behavior, such as staring, irritability, personality change, and slurred speech.
• Drowsiness that may lead to severe sleepiness (stupor).
If Reye's syndrome is not recognized and treated promptly, death can occur.
How is Reye's syndrome diagnosed?
• Your child has recently had a viral illness such as flu or chickenpox and has taken
medication that contains aspirin.
• A change in mental status (such as confusion) is noticed and liver problems are
identified.
• There is no evidence to suggest that symptoms are caused by other diseases or conditions,
such as kidney failure or problems with metabolism.
Lab tests, if needed, include blood and urine tests, a liver biopsy, a CT scan of the head, and a
lumbar puncture (spinal tap) to check for infection in the spinal fluid and to measure the pressure
of the fluid within the spinal column.
Treatment
If your child has symptoms of Reye's syndrome, seek medical care immediately. Early
treatment increases the chance for full recovery. If the disease is diagnosed early, most children
recover from Reye's syndrome in a few weeks. However, some children develop permanent brain
damage.
The goal of treatment is to stop damage to the brain and liver and to prevent complications. All
children with Reye's syndrome are treated in a hospital intensive care unit.
Home treatment is not appropriate if your child has symptoms of Reye's syndrome. Seek medical
care immediately, even if your child has not had a recent viral infection or taken aspirin. Early
medical treatment lowers the risk of long-term complications and death.
You can help prevent Reye's syndrome. Because there is a strong link between the use of aspirin
in children and the development of Reye's syndrome, do not give aspirin or products that
contain aspirin to anyone younger than 20 unless directed by a health professional. This is
especially important if the child has chickenpox (varicella) or the flu (influenza).
Aspirin is found in many nonprescription medicines. Read labels carefully before giving a
nonprescription medicine to your child. Aspirin is also called:
• Acetyl salicylate.
• Acetylsalicylic acid.
• Salicylic acid.
• Salicylate or subsalicylate.
Certain childhood illnesses, such as rheumatoid arthritis, may require aspirin as part of the
treatment. However, give aspirin to a child only with direction from your health professional.
If your child is taking aspirin and gets chickenpox (varicella) or the flu (influenza), contact your
health professional immediately.
The Nursing Care of the Child with
Cardiovascular Disorder
Group Members:
Balderas, Leiza E.
Azures, Joy Khristine H.
Coronado, Alyssa
Nazareno, Jimelda
Nocon, Kristen
III. Identification
Enumeration.
1. Common drugs helpful in resuscitation procedures that should be available on a
pediatric emergency resuscitation cart include 1-3
2. Steps for resuscitation? .4-6
3. Example of acquired heart disease? 6-10