Haemorrhagic disease of the newborn

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Not to be confused with Hemolytic disease of the newborn.

Haemorrhagic disease of the newborn

Classification and external resources

Vitamin K1

ICD-10

P53

ICD-9

776.0

DiseasesDB

29544

MedlinePlus

007320

eMedicine

ped/966

MeSH

D006475

Haemorrhagic disease of the newborn is a coagulation disturbance in newborns due to vitamin

K deficiency. As a consequence of vitamin K deficiency there is an impaired production of
coagulation factors II, VII, IX, X, protein C and protein S by the liver.
Contents
[hide]

1 Signs and symptoms

2 Causes

3 Treatment

4 References

Signs and symptoms[edit]

The disease causes an increased risk of bleeding. The most common sites of bleeding are
the umbilicus, mucous membranes,gastrointestinal tract, circumcision and venipunctures.

Causes[edit]
Newborns are relatively vitamin K deficient for a variety of reasons. They have low vitamin K
stores at birth, vitamin K passes theplacenta poorly, the levels of vitamin K in breast milk are low
and the gut flora has not yet been developed (vitamin K is normally produced by intestinal
bacteria).

Treatment[edit]
Treatment consists of vitamin K supplementation. [1] This is often given prophylactically to
newborns shortly after birth.

References[edit]
1. Jump up^ Hubbard D, Tobias JD (November
2006). "Intracerebral hemorrhage due to hemorrhagic disease
of the newborn and failure to administer vitamin K at
birth". South. Med. J. 99 (11): 1216
20.doi:10.1097/01.smj.0000233215.43967.69. PMID 17195415
.
[hide]

Certain conditions originating in the perinatal period / fetal dise

placenta:

Placenta praevia
Placental insufficiency
Twin-to-twin transfusion syndrome

Maternal factors and

complications of pregnancy,

chorion/amnion:

labour and delivery

umbilical cord:

Length of gestation
and fetal growth

Chorioamnionitis
Umbilical cord prolapse
Nuchal cord
Single umbilical artery

Small for gestational age/Large for gestational age

Preterm birth/Postmature birth
Intrauterine growth restriction
scalp

Birth trauma

By system

Cephalhematoma
Chignon
Caput succedaneum
Subgaleal hemorrhage
Brachial plexus lesion
Erb's palsy
Klumpke paralysis
Intrauterine hypoxia
Infant respiratory distress syndrome

Cardiovascular

Haemorrhagic and
hematologic disease

Digestive

Integument and
thermoregulation

Infectious

Other

Pneumopericardium
Persistent fetal circulation
Vitamin K deficiency
Haemorrhagic disease of the newborn
HDN
ABO
Anti-Kell
Rh c
Rh D
Rh E
Hydrops fetalis
Hyperbilirubinemia
Kernicterus
Neonatal jaundice
Velamentous cord insertion
Intraventricular hemorrhage
Germinal matrix hemorrhage
Anemia of prematurity
Ileus
Necrotizing enterocolitis
Meconium peritonitis
Erythema toxicum
Sclerema neonatorum

Nervous system

Periventricular leukomalacia

Musculoskeletal

Gray baby syndrome

muscle tone
Congenital hypertonia
Congenital hypotonia

Vertically transmitted infection

Congenital rubella syndrome
Neonatal herpes simplex
Omphalitis
Neonatal sepsis
Group B streptococcal infection
Neonatal conjunctivitis
Perinatal mortality
Stillbirth
Infant mortality
Neonatal withdrawal

M: OBS

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Categories:
Haemorrhagic and haematological disorders of fetus and newborn

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