Академический Документы
Профессиональный Документы
Культура Документы
vtcmag@vtcmag.com
of swallowing is critical. The rapidly disintegrating tablet in mouth or orally dispersible tablets are advantageous because
they overcome all of the above problems
and thus offer a more viable alternate of
oral medication, which provides patients
with a more convenient means of taking
their medication without any difficulty
(Figure 2).
Vacuum-drying techniques allow
preparation of such mouth dissolving
tablets that are processed through the wet
granulation stage, which is a central unit
operation in the drug processing industry,
where vacuum drying plays a central role
in bringing the final product flawless [3].
Researchers prepared mouth-dissolving
tablets that were formulated from granules containing Nimesulide, camphor,
crospovidone and lactose. Vacuum drying
was applied during the granulation stage
and it was found that the subsequently formed tablets were of higher quality
than those where the vacuum was applied
to the already compressed tablets. The
vacuum-drying technique was therefore
considered to be an effective alternative
approach compared with the use of more
expensive adjuvants in the formulation of
mouth-dissolving tablets [2].
In a related work on fast dissolving
tablets, Baclofen was prepared using vacuum drying technique. Baclofen is struc-
Concluding Remarks
Vacuum drying has proven to be an indispensable method for the preparation of
mouth dissolving drugs. Several medically and clinically important fast dissolving
drugs have been prepared by vacuum drying. The future of vacuum drying process
appears to be bright with more new applications that are anticipated. However,
more R&D needs to be done on the further optimization of the process.
References for Further Reading
1. Parikh D.M., Vacuum drying: basics and
application, Chemical engineering, 2015.
2.Gohel M., Patel M., Amin A., Agrawal R.,
Dave R., Bariya N. Formulation Design
and Optimization of Mouth Dissolve Tablets of Nimesulide Using Vacuum Drying
Technique, AAPS PharmSciTech 2004; 5
(3) e36.
3.
Venkatesh K., Shravani B., Kumar G.V.,
Rao N.G.R. Formulation and evaluation
baclofen fast dissolving tablets by vacuum
drying technique, Indo American Journal
of Pharmaceutical Research, 2013; 3 (5):
3721-3733.
4.
Kaur T., Gill B., Kumar S., Gupta G.D.
Mouth Dissolving Tablets: A novel approach to drug delivery, International Journal of Current Pharmaceutical Research,
2011; 3 (1):1-7.
5.Patil B. S and Rao N.G.R. Formulation and
evaluation of fast dissolving tablets of Granisetron hydrochloride by vacuum drying
technique, Journal of Applied Pharmaceutical Science 2011; 01 (04): 83-88.
6.
Sharma S and Gupta G.D. Development
and optimization of fast-dissolving tablets
of Promethazine Theoclate using vacuum
drying technology by 3-factor, Der Pharmacia Lettre, 2010; 2(6):124-135.
7.Metker V., Kumar A., Pathak N., Padhee
K., Sahoo S. Formulation And Evaluation
Of Orodispersible Tablets Of Lornoxicam,
International Journal of Drug Development
& Research, 2011; 3 (1): 281-285.
8.
Berteli M.N., Marsaioli A.J., Rodier E.
Study of a microwave assisted vacuum
drying process applied to the granulated
pharmaceutical drug hydrochlorthiazide, J
Microw Power Electromagn Energy. 2007;
40 (4):241-50.
vtcmag@vtcmag.com