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concentrations of lymphocytes
contained in a meshwork of
reticular cells.
localized concentration of lymphocytes
found: -in walls of alimentary
canal
-respiratory passages
-genitourinary tract.
These concentrations are called
lymphatic nodules or lymphatic
follicles, which are defined and
encapsulated.
Primary nodule - lymphatic nodule
consisting chiefly of
small lymphocytes
Secondary nodule most common
-have distinctive
features that follows:
Germinal center - in the
central region of nodule. Appears
lightly stained (in histologic)
-morphologic indication
of lymphatic tissue
response to antigen.
-Represents a cascade
of events:
Activation and proliferation of
lymphocytes -> differentiation of
plasma cells -> antibody
production
Follicular dendritic cells
(FDCs) present in germinal
centers interdispersed between
populations of B- Lymphocyetes.
***Number of FDCs and macrophages
in germinal center increases after a
period of intense response to Ag.