Академический Документы
Профессиональный Документы
Культура Документы
DOI 10.1007/s00253-011-3666-8
MINI-REVIEW
Received: 21 July 2011 / Revised: 3 October 2011 / Accepted: 22 October 2011 / Published online: 17 November 2011
# Springer-Verlag 2011
Introduction
Diversity creates a variety of biomolecule, and these
molecules are responsible for this diversity, either directly
V. K. Morya : J. Kim : E.-K. Kim (*)
National Research Lab of Bioactive Materials, Dept. Biological
Engineering, Inha University,
Incheon, South Korea 402-751
e-mail: ekkim@inha.ac.kr
72
73
74
Chemical composition
Adenocytis utricularis
Analipus japonicus
Ascophyllum nodosum
A. nodosum
Chorda filum
Dictyota menstrualis
Ecklonia kurome
Fucoidan structure
Reference
F. distichus
16 Lessonia vadosa
17 Macrocytis pyrifera
18 Padina pavonia
15 Laminaria saccharina
19 Pelvetia wrightii
3)--L-Fucp(2/4SO3)-(1and4)
--L-Fucp
(2SO3)-(1
Fucose, galactose, mannose, xylose, 1,3-linked fucose and 1,3-, 1,4-,
and sulfate
and 1,
6-linked galactose
Glc glucose, Gal galactose, NAc N-acetyl amines, Man mannose, GlcA glucuronic acid
75
Table 2 Various methods used to prepare low molecular weight fucoidan and their bioactivities
Applications
Method
Source
Reference
Antithrombotic
Radical
Ascophyllum nodosum
Radical
A. nodosum
Acid
Laminaria japonica
Acid
Egg jelly
Enzyme
Anticoagulant
Antioxidant
Gamma irradiation
Acid
L. japonica
Anticancer
Acid
Radical
A. nodosum
Radical
A. nodosum
Radical
A. nodosum
Acid
F. vesiculosus
Radical
Anti-inflammatory
Acid
76
Source organism
Nature
References
Alteromonadaceae sp.
Extracellular
Bacillus cereus
Extracellular
Bifidobacterium bifidum
Lactobacillus sp.
Intracellular
Extracellular
Wu et al. (2011)
Flavobacteriaceae sp.
Extracellular
Flavobacterium CZ1127
Intracellular
Intracellular
Fucophilus fucoidanolyticus
Intracellular
Littorina kurila
Extracellular
10
Intracellular
11
12
Extracellular
13
S. paucimobilis PF-1
Digestive
14
Extracellular
15
Sulfolobus solfataricus
Intracellular
16
Verrucomicrobia sp.
Digestive
77
78
Conclusions
In spite of their potential as biologically active compounds,
the high molecular mass and viscous natures of fucoidan
have hampered their applications, especially as a therapeutic agent. To obtain oligosaccharide with more diverse
bioactivities, LMWF can be prepared by chemical, radical,
or enzymatic means. Therefore, an extensive research
requires for boosting the generation of more and more
information regarding the LMWF as safer and enhanced
bioactivity without cross reactivity. This review is an
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