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THERAPEUTIC TARGET DATABASES

http://bidd.nus.edu.sg/group/cjttd/TTD_HOME.
asp
A database to provide information about the known and explored therapeutic protein and nucleic
acid targets, the targeted disease, pathway information and the corresponding drugs directed at
each of these targets. Also included in this database are links to relevant databases containing
information about target function, sequence, 3D structure, ligand binding properties, enzyme
nomenclature and drug structure, therapeutic class, clinical development status. All information
provided are fully referenced.
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Statistics of this database

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This database currently contains 1,906 targets, including 358 successful, 251 clinical trial, 43
discontinued and 1,254 research targets, and 5,124 drugs, including 1,511 approved, 1,118 clinical
trial and 2,331 experimental drugs (3,257 small molecules and 652 antisense drugs with available
strucuture or oligonucleotide sequence). Targets and drugs in this database cover 61 protein
biochemical class and 140 drug therapeutic classes respectively.

Therapeutically Relevant Multiple Pathways Database

The Therapeutically Relevant Multiple Pathways Database is designed to provide information about such
multiple pathways and related therpaeutic targets described in the literatures, the targeted disease
conditions, and the corresponding drugs/ligands directed at each of these targets. This database currently
contains 11 entries of multiple pathways, 97 entries of individual pathways, 120 targets covering 72
disease conditions along with 120 sets of drugs directed at each of these targets. Each entry can be
retrieved through multiple methods including multiple pathway name, individual pathway name and
disease name. Additional information provided include protein name, synonyms, Swissprot AC number,
species, gene name and location, protein sequence (AASEQ) and gene sequence (NTSEQ) as well as
potential therapeutic implications while applicable. Cross-links to other databases are provided which
include Genecard, GDB, Locuslink, NCBI, KEGG, OMIM, SwissProt to facilitate the access of more
detailed information about various aspects of the particular target or non-target protein.

Query Methods
Queries can be submitted by entering or selecting the required information in any one or combination of the fields in
the form. User can specify full name or any part of the name in a text field, or choose one item from an selection
field. Wild character of '*' and '?' is supported in text field.

DRUG POTENCY DATABASES

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DPD is a relational database focusing on providing activity information of drugs, clinical trial
compounds and experimental agents directed at their corrosponding therapeutic targets. Also
included in this database are links to relevant databases containing information about target
function, sequence, 3D structure, ligand biding properties, enzyme nomenclature and drug
structure, therapeutic class, clinical development status. All infomration provied are fully
referenced.
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Currently this database contains 5000 records of activity for around 3000 compounds direced at
about 500 tagets. Near 300 compounds in DPD have already approved or been in the clinical trial
stage.

PDTD [Potential Drug Target Database]

http://www.dddc.ac.cn/pdtd/index.php
Introduction

PDTD is a dual function database that associates an informatics database to a structural

database of known and potential drug targets. PDTD is a comprehensive, web-accessible
database of drug targets, and focuses on those drug targets with known 3D-structures. PDTD
contains 1207 entries covering 841 known and potential drug targets with structures from the
Protein Data Bank (PDB).
Drug targets of PDTD were categorized into 15 and 13 types according to two criteria:
therapeutic areas and biochemical criteria.
The database supports extensive searching function using PDB ID, target name and
category, related disease.Each record of drug target was prudently annotated by hyperlinks to
other databases, such as DrugBank, TTD, ExPASy Proteomics Server and KEGG etc.
In conclusion, PDTD serves as the cornerstone for TarFisDock to identify the potential
binding targets in-silico.

Statistics

Distribution of targets by biochemical criteria

TarFisDock : a web server for identifying drug targets with docking approach
Given a small molecule which can be drug, drug candidate, natural product, or new synthetic
compound, TarFisDock docks it into the protein targets in PDTD (Potential Drug Target
Database), and outputs the top 2%, 5% or 10% candidates ranked by the energy score, including
their binding conformations and a table of the related target information.
The server is freely accessible for anonymous user. And one user's result is protected from being
retrieved by another. However users are encouraged to fill in a very simple registration form for
better safety and convenience.