Академический Документы
Профессиональный Документы
Культура Документы
Table of Contents
Introduction and the F.A.C.T Program
About this handbook......................................................................3
About Pharmacosmos and Uniferon.........................................4-5
What is the F.A.C.T program and its benefits?...........................6-7
Industry-Accepted Iron Standards
Why high Hb levels matter............................................................8
Benefits of high haemoglobin level . .............................................9
Is your pig at risk of an iron gap?................................................10
Benefits of second iron injection.................................................. 11
Iron Deficiency Anaemia Detection and Treatment
How do you know if a piglet is suffering from anaemia?............. 12
How iron treatment sources differ................................................13
The benefits of injection and technique..................................14-15
Every drop counts.......................................................................16
When and how to select pigs for evaluating herd level anaemia....... 17
How to test your selected pigs....................................................18
Blood test for diagnosing anaemia (pen-side and lab)...........19-20
Other Anaemia Contributors and Conditions
What if my pigs get infected with a virus?...................................21
About vitamin E deficiency and mycotoxins in feed?.............22-23
Resources and References
Uniferon benefits........................................................................24
Iron expert board.........................................................................25
Pharmacovigilant anaemia care..................................................26
The basics of adverse events in parenteral Iron......................... 27
Resources and references.....................................................28-29
Contacts......................................................................................30
About Pharmacosmos
Pharmacosmos is the leading manufacturer and developer of
prevention and treatment of iron deficiency anaemia in humans
and animals. Our Uniferon (Iron(III) Dextran) is the only prevention
and treatment of piglet anaemia approved by health authorities in
Europe, Asia and by FDA in the US.
Uniferon is manufactured according to highest quality in our
manufacturing facilities in Denmark. Pharmacosmos works closely
with pig breeders, veterinarians and partners around the world to incorporate best practice solutions into our treatments - and Uniferon
is a simple way to realize higher production yields and higher profits.
Learn more about Pharmacosmos, the leading treatment and
prevention of iron deficiency anaemia in piglets.
Learn more - visit www.pharmacosmos.com
About Uniferon
Uniferon from Pharmacosmos is an iron supplement for piglets
containing 200 mg iron per ml. Uniferon promotes better health and
faster growth.
It is well known that iron supplementation of pigs on day 3 post
farrowing has been the industry standard for addressing iron
deficiency anaemia through injection of 200 mg iron.
Uniferon is the only world wide brand for preventing and treatment
of iron deficiency anaemia, and:
Ensure high haemoglobin levels1
Helps ensure optimal average daily gain (ADG)1
Promotes higher growth post weaning1,3
Completely absorbed with a high safety profile7
Global approval
Only high dose (200 mg/ml) FDA approved iron product in US8
F.A.C.T
The acronym F.A.C.T stands for
300
250
200
150
100
50
0
70
80
90
100
110
Hb
120
130
140
150
300
250
200
150
-100
-150
-200
-250
Iron consumption in
relation to growth
50
24
98
8,
72
46
8,
7,
20
7,
94
69
7,
7,
43
6,
17
91
6,
6,
6,
39
5,
13
5,
87
61
5,
35
5,
4,
09
83
4,
4,
57
4,
31
06
3,
3,
80
3,
54
28
3,
2,
02
2,
76
2,
2,
1,
0
-50
50
50
65
Second administration
(before day 17)
100
1,
Hypothetical
model for
Iron Gap5
Fe 3+ reserve (mg)
Iron Gap
10
325
306
2 injections of Uniferon
1 injection of Uniferon
Day 34-50
(post weaning)
Haemoglobin (g/l)
123
113
Day 34
(at weaning)
11
13
14
Injection technique
For successful anaemia care, it is important to practice correct
injection technique. This is necessary in order to ensure that
the iron is dosed correctly and that the iron medication enters
effectively via the tissue. Otherwise you will likely experience
anaemia in the pig. Ensure that all involved persons are aware of
the proper injection techniques to help ensure optimal iron care.
1. Choose injection site.
Parenteral administration
can be either intramuscular
or subcutaneously and the
approved/recommended site
can vary by country:
Intramuscular:
Hold the piglets body towards
you. Injection should be
intramuscular in the neck
2.5 - 5 cm behind the ear.
Subcutaneously:
Hold the piglet in its hind
legs, so it hangs head down
with its abdomen facing
you. Injection should be
subcutaneously in the
inguinal skin fold.
2. Check that the injection
site is clean and dry. If the
piglets skin is dirty or wet,
16
17
18
3. P
lace the cuvette in the
HemoCue 201+ Hb photometer
4. R
esults for haemoglobin concentration
are obtained in less than a minute
19
Significance
Notes
Blood
Measures amount of Hb in blood Blood Hb may be
normal in initial stages
haemoglobin
Value <90 g/l suggestive of
of IDA
severe IDA
Value <110 g/l suggestive of IDA
RBC count
Hematocrit
TIBC
473
6.38
Haemoglobin (mmol/l)
6.62
523
Day 12-32
Day 12-32
21
22
23
Uniferon benefits
Uniferon 200 mg/ml parenteral iron injection has proven beneficial
for preventing iron deficiency anaemia
Uniferon 200 mg/ml is research-proven to boost haemoglobin
levels and average daily gain
Uniferon is the only iron supplement supported by research
trials worldwide
Uniferon adheres to the highest standards of quality, safety and
efficacy, and has approval in Europe, Asia and North America
(including FDA approval in the United States)
#1 iron supplement in the world
24
25
0.0002%
0.00003%
26
27
Resources
To learn more about Uniferon and Iron Deficiency Anaemia
please visit:
uniferon.com
Determine the potential mean iron need within a litter with our online
Iron/Weight Gain Optimizer (I/WGO):
uniferon.com/iwgo
Determine the investment advantage of iron supplementation for
your operation with our online F.A.C.T Calculator:
fact.uniferon.com
28
References
1
H
augegaard, J. et al., 2008: Effect of supplementing fast-growing,
late-weaned piglets twice with 200 mg iron dextran intramuscularly
The Pig Journal (2008) 61, 69 73
N
ielsen, J.P. et al., 2013: Herd diagnosis of iron deficiency in piglets.
In: Proc. 5th ESPHM Cong., May 2013
N
ielsen, J.P. & S. Bhattarai 2014: Association of haematological status
at weaning and weight gain post-weaning in piglets.
In: Proc. 23rd IPVS Cong., June 2014
B
ach, J. et al., 2006: Effect of an additional iron injection in a PMWS
positive herd in respect to hematocrit, haemoglobin and growth rate.
In: Proc. 19th IPVS Cong., June 2006
P
eriodic Safety Update Report (PSUR); Product: Veterinary iron dextran,
solution for injection; Period of reporting: 01.08.2009 31.07.2012
h
ttp://www.hemocue.com/
29
Contacts
Pharmacosmos Corporate Headquarters:
Pharmacosmos A/S
Roervangsvej 30
DK-4300 Holbaek
Denmark
T: +45 59 48 59 59
F: +45 59 48 59 60
E: uniferon@pharmacosmos.com
If you have any questions, or want to share your thoughts or
advice, we would like to hear from you.
For a complete global Uniferon partners please visit:
uniferon.com
30
T: +45 59 48 59 59
E: uniferon@pharmacosmos.com
V2015-03 v 1.0
T: +45 59 48 59 59
E: uniferon@pharmacosmos.com