Identifying Diseases that Mimic Strokes

Use these tools when assessing patients

By Richard A. Walker, MD, FACEP, FAAEM
Learning Objectives
>> Describe the key reasons that a rapid and correct diagnosis of stroke is critical for stroke patients and those with diseases that mimic strokes.
>> List four disorders that mimic strokes and are often misdiagnosed as strokes.
>> Describe key indicators that differentiate strokes from diseases that mimic strokes.
>> Describe why migraine headaches, hypoglycemia, multiple sclerosis, conversion disorders and seizures are often misdiagnosed as strokes.
Key Terms
Aphasia: A condition in which language function is disordered or absent because of an injury to certain areas of the cerebral cortex.
Aura: A sensation of light or warmth that often precedes a migraine or seizure.
Choreoathetosis: Irregular involuntary movements that may involve the face, neck, trunk, extremities or respiratory muscles.
Dysmetria: An inability or impaired ability to control the range of muscular movements and from properly measuring distances associated with
muscular acts.
Dysphasia: See aphasia.
Epilepsy: A group of neurologic disorders characterized by recurring convulsive seizures, sensory disturbances, abnormal behavior, loss of
consciousness or all of these.
Hemiparesis: Muscle numbness or weakness on one side of the body.
Hemiplegia: Paralysis of one side of the body.
Hyperglycemia: An abnormally high blood glucose level.
Hypoglycemia: An abnormally low blood glucose level.
Migraine: A recurring, severe throbbing headache, usually occurring on only one side of the head, often associated with sensitivity to light.
Todds paralysis: A temporary paralysis or weakness that infrequently occurs after seizures, particularly partial seizures.

Stroke Mimics Mnemonic

H: Hypoglycemia (and hyperglycemia)
E: Epilepsy
M: Multiple sclerosis (and hemiplegic migraine)
I: Intracranial tumors (or infections, such as meningitis, encephalitis and abscesses)
EMTs and paramedics need to make rapid assessments to provide the best clinical care possible for their patients. With the onus of caring for
critically ill patients with limited time and resources, responders run the risk of focusing too narrowly on what appear to be obvious illnesses and
subsequently miss an illness that mimics the signs and symptoms of a common disease. To minimize assessment errors when caring for patients
who present with a set of signs and symptoms that mimics a common disorder, providers must always seek to validate their assessments by
keeping an open mind and a high index of suspicion for alternate disease possibilities.
This can be accomplished by thoroughly reexamining and reevaluating patients with an open mind and performing every routine test and
assessment procedure, even after forming a firm impression about the patients condition. Some disorders tend to be misdiagnosed more than
others, because they present with signs and symptoms that overlap with other common diseases, such as a stroke being mimicked by a seizure,
migraine headache or hypoglycemia.
Behind heart disease and cancer, stroke is the third leading cause of death in the U.S. today, and someone dies from a stroke every four minutes.
Strokes affect more than 700,000 patients per year in the U.S., with someone experiencing a stroke every 40 seconds.(1) In one study, 2% of 9-11 calls were for patients with potential strokes.(2) The critical key to definitive stroke management is early identification and reperfusion
therapy, performed before neurologic injury becomes permanent.
With the advent of the use of tissue plasminogen activator (tPA) to treat strokes, theres great emphasis today on early recognition and
transportation to an emergency care facility so that tPA can be administered as soon as possible for maximum effectiveness with minimal side
effects. The window for administration is up to 4.5 hours, and because many patients and families dont recognize the severity of the signs of a
stroke, they fail to call 9-1-1 in time to allow for adequate field and hospital clinical assessments.
Further, administration of tPA for a stroke carries with it a much higher risk of intracranial hemorrhage than thrombolytic administration for an
acute ST-elevation myocardial infarction(3) (STEMI). Several studies with small sample sizes suggest that the use of tPA in stroke mimics has
been safe, with no incidences of intracranial hemorrhage.(4) Patients who present with focal neurologic impairment, aphasia or dysphasia

(speech and comprehension communication disorders), altered mental status, seizures and headaches have been shown to be misdiagnosed by
paramedics 27% of the time.(2)
Stroke mimics have been shown to be misdiagnosed by physicians in the hospital setting 31% of the time.(2) A prehospital assessment or field
diagnosis of stroke is typically derived from the patient history, the physical examination and clinical tests, such as blood glucose level and
neurologic tests (right- and left-side strength and compliance).(5) A key differential to distinguish strokes from those disorders that mimic a
stroke include the rapidity of onset, which tends to occur with strokes and not with most other mimics.
A mnemonic to help keep stroke mimics in mind is HEMI: hypoglycemia (and hyperglycemia), epilepsy, multiple sclerosis (and hemiplegic
migraine) and intracranial tumors (or infections, such as meningitis, encephalitis and abscesses).(6) Most errors in the misdiagnosis of stroke
occur when patients cant provide a past medical history due to impaired speech or altered mental status, or if their past medical history is
unreliable (e.g., in the presence of strangers who are unfamiliar with the patients past medical history). (See Table 1, pg 80, JEMS March 2011.)
Here, we present four case scenarios in which the patient appears to have had a stroke, but in fact has one of four stroke mimics: hypoglycemia,
hyperglycemia, migraine or seizure.
Hypoglycemia: Case Presentation #1
Mrs. Jackson calls EMS because she woke up in the morning to find her 35-year-old husband lying in bed confused, exhibiting a left-side facial
droop and not moving his left arm and leg. EMS arrived and see the patient lying in bed confused with slurred speech, left-side facial droop and
left side-paralysis. They administer oxygen (O2) via non-rebreather mask at 12 L/min and start an IV of normal saline TKO and transported to
the stroke center on the ECG monitor. En route, the crew checks his blood glucose serum level; its 35 mg/dL. They administer an amp (50 cc's)
of dextrose 50% D50 in water, and the symptoms cleared. At the hospital, the emergency department (ED) physician consults with the neurology
department, and an MRI is performed and found to be negative for stroke.
Hypoglycemia is the most easily detected stroke mimic, because a blood glucose level test is usually reliable and indicates the presence of low
blood sugar. Patients typically respond rapidly to the administration of a bolus of D50. Although hypoglycemia sometimes presents with
hemiplegia and aphasia, hypoglycemic patients who present with these signs will most often be alert and not also concurrently show the more
severe signs of confusion and altered mental status or coma.(7)
Hypoglycemia most often goes undetected as a stroke mimic when the field

provider becomes so convinced by the presenting signs and symptoms that the patient is having as stroke that they fail to follow the standard
altered mental status protocol and perform the blood glucose level test.
Hyperglycemia: Case Presentation #2
EMS responds to Mrs. Reynolds, a 50-year-old female with a history of hepatic encephalopathy and end-stage liver disease. Her husband called
9-1-1 because she suddenly began to have jerking movements of her upper left arm and hand. EMS providers check her blood glucose serum
level, which reads high. They transport her to the ED on O2 and start an IV of normal saline solution en route.
Mrs. Reynolds has intermittent choreo-athetotic movements of her left upper extremities en route. On further examination, there was dysmetria
of the left upper extremities and left lower extremities. Her Cincinnati Prehospital Stroke Scale level was 3, and the stroke team at the hospital
was activated. A screening MRI rules out stroke. Her blood glucose level came back at 1245 mg/dL. Symptoms were resolved with treatment for
hyperglycemia.
Hyperglycemia is most often confused with stroke when it presents with a generalized, global, altered mental status or coma. The lack of a past
medical history indicating a long and gradual onset combined with a nonspecific high blood glucose level reading leads to a reasonable
suspicion of stroke. Assessing the patient with a standardized assessment instrument, such as the Cincinnati Prehospital Stroke Scale is one of
the best ways to increase the specificity of assessment for strokes.(2) (See Table 2, pg. 81)
Hemiplegic Migraine: Case Presentation #3
Helen Bradshaw, a 50-year-old female in generally good health suddenly developed paralysis of her upper extremities. Her husband calls 9-1-1,
and the EMS crew arrives in seven minutes. They find her lying in bed with bilateral paralysis of her arms and hands. As the paramedics delve
deeper with their assessment questions about her medical history, they learn from her husband that shes had intermittent headaches for most of
her life but has never seen a doctor for them.
As they continue to ask pertinent questions to explore any associated symptoms about her headaches, she states that she noticed squiggly lines
in her visual fields and says it was just after she noticed those that she developed the weakness. As she relates this history, she reports that she
was having one of her throbbing, generalized headaches. As the paramedics gather the curious history, signs and symptoms, her weakness begins
to resolve, and her headache begins to throb with greater intensity. The ED physician treats Mrs. Bradshaw for her migraine headache, and the
symptoms completely resolve.

Familial hemiplegic migraine (FHM) is a rare variant of migraine with an aura. Symptoms include hemiparesis, visual disturbances (aura) and
dysphasia. Set criteria exist to establish the diagnosis, but diagnosis at the first attack may be impossible.8 Clues to this disorder are a family
history of migraines, in particular FHM and a typical throbbing headache with an aura. Stroke may present with headache, but a prominent
headache suggests a diagnosis other than ischemic stroke. Hypertensive intracerebral hemorrhage, subarachnoid hemorrhage and FHM may all
present with headache and hemiparesis.
Epilepsy (Todds Paralysis): Case Presentation #4
Ralph Morris, a 47-year-old male, planned to go fishing at 5 a.m. with his son, Larry. But when Larry tried to wake up Ralph, he found that his
dad was confused and couldnt move his left arm and leg. Larry calls 9-1-1, and EMS arrives in 12 minutes. The crew starts O2 via nonrebreather mask at 12 L/min. and an IV of normal saline TKO and places ECG leads.
They find Ralph confused, with slurred speech and left-side paralysis, and are certain he had a stroke. As the paramedics continue to ask Larry
about what happened prior to their arrival, he mentions his dads left hand had been jerking a little when he first went in to wake him up. Larry
also mentions hed noticed that his dads eyes were slanted to the left and he had drooled a little, as well. The paramedics transport Ralph
expeditiously to the closest ED for treatment for a possible stroke.
A routine blood glucose level test in the ED shows 50 mg/dL, and 25 g of D50W is administered. The IV is switched to D10W. Ralph responds
quickly to the glucose and can answer questions. He lets them know that he has a past history of epilepsy and hasnt been taking his medications
recently. He also lets them know hed experienced an episode of hemiparesis in the past following one of his seizures. The ED physician has the
nursing staff explain to Ralph the importance of compliance when taking anti-seizure medications, and hes discharged with no further ED
treatment needed.
Robert Bentley Todd (18091860) was an anatomist, pathologist and physiologist and the first person to present an electrical theory of epilepsy.
He stated, in 1849, that some patients who recover from a severe fit, or from frequently repeated fits of epilepsy, are often found to labor under
hemiplegia, or other modifications of palsy.
Multiple neurologists subsequently described the same phenomena.(9) The patient presents with a hemiparesis and possibly aphasia after having
had a seizure of variable duration. The stroke-like symptoms resolve after a variable amount of time, ranging from a few minutes to several
weeks.(10) The key to diagnosis is the history of a seizure or seizures. A clue on physical exam is a bite mark on the lateral side of the tongue,
which may be seen in up to 64% of patients who die during a seizure. Another clue to a possible seizure is the presence of a postictal state (i.e.,

confusion) which is gradually improving.

A definite seizure at the onset of stroke symptoms is a contraindication to thrombolytic therapy.(3) Failing to obtain or report the history of a
seizure risks a hospital misdiagnosis of stroke and subsequent thrombolytic therapy and a risk for intracranial hemorrhage.
Conclusion
A number of disorders mimic strokes, and the consequences can be serious for the patient. Conducting a careful, comprehensive history and
physical examination, with a thorough scan of the patients environment, and diligently performing all appropriate available tests are the surest
ways to make a correct assessment and provide a clinically sound assessment to the receiving hospital. Speed is the primary key to getting stroke
patients to reperfusion therapy as quickly as possible, although a thorough patient assessment performed with a high index of suspicion for
possible mimics is the best way to avoid having a patient receive unnecessary and potentially dangerous thrombolytic therapy. JEMS