Research Updates Homeopathy Volume 4 Issue 3 (2015)

ISSN 2278-4500
A research awareness e-Journal by
2015 | Volume 4, Issue: 3 | Page: 31 - 44

Published by Dr. Saurav Arora
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Table of Contents
Application of High dilution in Basic and Allied Homeopathic Research: Glimpses of Indias
Major Contributions ..................................................................................................................................................31
Studies to be Read ......................................................................................................................................................40
Fundamental Research .............................................................................................................................................40
1.
Syzygium jambolanum and Cephalandra indica homeopathic preparations inhibit albumin
glycation and protect erythrocytes: an in vitro study .............................................................................................. 40
2.
rats
Effects of Tarantula cubensis D6 on aflatoxin-induced injury in biochemical parameters in

40
3.
Homeopathic remedies with antineoplastic properties have immunomodulatory effects in
experimental animals ................................................................................................................................................................ 40
4.
An evaluation of Avogadros number in the light of HRTEM and EDS studies of high dilutions
of Ferrum metallicum 6, 30, 200, 1M, 10M and 50Mc .............................................................................................. 40
5.
The Association of Ponderal Benznidazole with its Ultra-high Diluted Formula Reduces the
Toxic Effects and Allows Increasing of Dose in Dose-dependent Protocol in Mice Infected with
Trypanosoma cruzi ..................................................................................................................................................................... 40
6.
Chemometrics meets homeopathy-an exploratory analysis of infrared spectra of
homeopathic granules............................................................................................................................................................... 40
Clinical Research ...........................................................................................................................................................40
1.
Model validity of randomised placebo-controlled trials of individualised homeopathic
treatment ......................................................................................................................................................................................... 40
2.
Utilization of psychotropic drugs by patients consulting for sleeping disorders in
homeopathic and conventional primary care settings: the EPI3 cohort study ........................................... 40
3.
The homeopathic choice for children: a qualitative research on the decision making process
of the families ................................................................................................................................................................................ 41
4.
Some intrapersonal qualities of SA homeopaths who have established successful private
practices ........................................................................................................................................................................................... 41
5.
Data collection: Treat every variable as a treasure ..................................................................................... 41
6.
Risk in homeopathy: Classification of adverse events and homeopathic aggravations - A
cross sectional study among Norwegian homeopath patients. ........................................................................... 41
Pharmaceutical Research ........................................................................................................................................41
1.
Characterization of Potentized (Homeopathic, Anthroposophical and Antihomotoxic)
Medicines Registered and Notified In Brazil ................................................................................................................. 41
Review ............................................................................................................................................................................41
1.
Is There a Role for Homeopathy in Cancer Care? Questions and Challenges ................................ 41
Veterinary Research..................................................................................................................................................41
1.
Veterinary homeopathy: Systematic review of medical conditions studied by randomised
trials controlled by other than placebo ............................................................................................................................ 41
Upcoming Events ........................................................................................................................................................42
Research Updates Homeopathy

Application of High dilution in Basic and Allied Homeopathic
Research: Glimpses of Indias Major Contributions
Dr. Saurav Arora
Editor, International Journal of High Dilution Research (www.highdilution.org)
Founder, Initiative to Promote Research in Homeopathy (www.researchinhomeoapthy.org)
Email: info@audesapere.in
Abstract
The use of high dilutions are in vogue since inception of homeopathy, when Christian Samuel
Hahnemann, the founder of homeopathic system of medicine, began experimentation with
various substances of different origins, diluted and applied for therapeutic response (drug
proving) and clinical conditions (simile principle). The effects of high dilutions have been
repeatedly verified in various laboratory models, as well as in clinical practice. In addition to
homeopathy, high dilutions are also applied in isopathy, iso-endopathy, veterinary, dentistry and
agronomy etc. The basic and fundamental research is undertaken to understand basic tenants of
homeopathy, and to accept or reject the plausibility of homeopathy. A substantive work has been
done in this area by Indian scientists over past few decades. India has a history of more than five
decades of organized research, which is reflected through publications in the late 1960s. This
paper aims to provide a glimpses of work done by Indian scientists in fundamental, basic and
allied aspects of high dilution, by referring publications from 1969 till date.
Introduction
Although trained with strict academic standards, researchers have already realized that there is
a natural, poorly described and still unexplained phenomenon that involves high dilutions.i The
biomedical community remains critically skeptic to the therapeutic action of homeopathic
medicines, which are highly diluted. Such high dilutions are the preferred target of critics, as
above Avogadros limit it is assumed that no molecules remain in a solution. The term high
dilution is a relative term used for any substance subjected to serial dilution and rigorous
agitation/shaking (potentization), as in preparation of homeopathic medicines. High dilution
term is also comparable to terms like ultra-high dilutions (UHD), super dilutions, ultra dilutions
etc.
The use of high dilutions are in vogue since inception of homeopathy, when Christian Samuel
Hahnemann, the founder of homeopathic system of medicine, began experimentation with
various substances of different origins, diluted and applied for therapeutic response (drug
proving). He soon realized that these substances in diluted form may be applied to similar
clinical conditions (simile principle). This is how homeopathic system of medicine came into
existence. Since then use of high dilutions have gone beyond the clinical use. With the increasing
curiosities, constant skepticism and clinical efficacy, there has been a constant demand to study
the nature and action of high dilutions and homeopathy. The research in high dilution is also
warranted due to clinical success stories; increasing demand of homeopathic products
worldwide; lack of standardization in prescription, preparation and dissemination of medicines
etc. The fundamental questions still revolves around the mode of action of homeopathic
medicines and nature of the ultra-high dilutions.
31

While high dilutions defy the dose-response relationship, the clinical experiences of homeopaths
indicate that the more diluted and agitated the drugs, the more thorough and refined their
effects. The effects of high dilutions have been repeatedly verified in various laboratory models,
as well as in clinical practice. Apart from researches, many authorities and Nobel Laureates have
supported plausibility of high dilutions and homeopathy. In an interview to journal Science,
Luc Montagnier quoted that, What I can say now is that the high dilutions are right. High
dilutions of something are not nothing. They are water structures which mimic the original
molecules. In response to an article published in journal New Scientist, expressing skepticism
about homoeopathy (October 18, 1997 and December 9, 2006), Nobel Laureate Brian Josephson
expressed, The phenomenon known as the memory of water has been established experimentally
by Jacques Benveniste and others. Its validity surpasses the importance of homeopathy itself and
illustrates the narrow mindedness of the modern scientific community, which, instead of testing
these claims, rejects them beforehand.
In addition to homeopathy, high dilutions are also applied in isopathy, iso-endopathy, veterinary
and dentistry etc.1 More recently their applicability has extended to new fields, like agronomy.
This new and far-reaching realm of applications of high dilutions might be represented with a
diagram given below:
Source: www.highdilution.org
Basic, Fundamental and Allied Research
It is a human tendency to explore what is not visible to naked eyes!
To understand basic research in homeopathy, we first need to understand the areas which ignite
research questions in homeopathy. Apart from clinical success, there are few areas which are of
interest to every scientific mind such as principle of symptom similarity; universal application of
law of similars; therapeutic action of homeopathic medicines; route of action of homeopathic
medicines in human body; logic behind potentization; standardization in preparation,
prescription, preservation and dissemination of medicines; homeopathic philosophy and its
32

applicability in human body; pharmacological aspects of high dilutions; physico-chemical nature
of high dilutions etc.
To address such issues, clinical research alone is not sufficient. We need to go to cellular,
molecular, biological, chemical, physical and meta-physical levels to observe, prove and disprove
phenomenon associated with high dilutions and homeopathy. In such scenario, the basic and
fundamental research is undertaken to understand basic tenets of homeopathy. Basic research is
done in an ideal environment on certain models to accept or reject the plausibility of
homeopathy and its effectiveness (absolute or relative). The basic research aims at
demonstrating biological, physicochemical and allied aspects of medicines and generating stable,
replicable and reliable models for future research.
Glimpses of Contribution of Indian Researchers

Basic and Fundamental Research
The history of basic research experiment goes beyond to late 1960s and early 1970s, as reported
from published literature, but possibility of experiments done prior to this cant be ruled out.
These five decades of contributions are therefore important to learn. A substantive work has
been done in this area by Indian scientists over the time. India has a history of more than five
decades of organized research, although the institutionalized research at governments level was
started after foundation of Central Council for Research in Homoeopathy (CCRH) in year in
1978ii. Some of the highly acclaimed work is summarized in this paper, which is an indicative
glimpse and not exhaustive.
During 1972 DD Data and team published a work about Spectrophotometric estimation of
elemental Sulphur in homoeopathic Sulphur mother tincture and 4x dilutioniii. During 1979 SK
Dwarkanath and MM Stanley reported a study on albino rats in which they observed effect of
China on rectal temperature in ratesiv. During 1977 1981 K Chandrasekhar and team published
series of paper, based on their experimentation on rats using homeopathic remedies
Caulophyllum and Pulsatilla.v,vi,vii,viii,ix
During 1977 78, S Prasad published four papers on action of Pulsatilla on reproductive
physiologyx; on Ovaries, the Uteri and the Thyroids of Female Albino Ratsxi; on Ovary and Uterus
of Pre-Pubertal and Ovary, Uterus and Thyroid of ESTROGEN Primed Pre-Pubertal Female
Albino Ratsxii; on the Ovaries, Uteri and Thyroids of Normally Cycling Recipientsxiii and on Rat
Ovary, Uterus and Thyroid.xiv
Dr. Jussal and team started experimenting on high dilutions and its homeopathic application in
as early as 1980s. There are couple of studies that were published during this time by them, e.g.
Dielectric dispersion of weak alcoholic solutions of some drugs at high frequencies using time
domain spectroscopyxv, Physical effects on the suspending Medium by compounds in
Asymptotically infinite dilutionsxvi, Effects of logarithmic serial dilutions of arsenicum album
(As2O3) on the excitability of the sciatic nerve of frog xvii, Biophysical, Biochemical and Biological
study of homoeopathic medicinexviii, Effect of ultradilutions on neurotransmitter/enzymesxix,
Effects of Nux Vomica and Agaricus Muscarius on the Neuronal Activity in Ratsxx etc. The studies
by Jussal et al put forth the viable existence of the high dilutions.
33

Dr. Anisur Rahman Khuda-Bukhsh, Prof. Emeritus, University of Kalyani, West Bengal, India has
been involved in undertaking a substantive work towards understanding the extract of
medicines, their nature and application of highly diluted homeopathic medicines on various
models especially cancer cell lines. Dr. Bukhsh proposed the famous Gene Regulatory
Hypothesis, more than two decades back, to put forth the probable pathway of action of
homeopathic medicines. Since then many research publications have been published to support
this hypothesis. Dr. Bukhsh has published more than 100 peer reviewed publication in various
national and international journals of repute. Some of his studies are indexed in, Compendium of
Abstracts of Studies on extracts, homeopathy and high dilution published by Prof. Anisur Rahman
Khuda-Bukhsh et alxxi. A quick glimpse of conclusions of some of his work can be summarized
as:
Much progress has been made in understanding the molecular mechanism in the light of
the gene regulatory hypothesis that can explain the action of the homeopathic high
dilutions in all living organisms, both in higher and lower animals as well as in plants. The
present review focuses mainly on research in support of the gene regulatory hypothesis,
and mention has been made of some relevant physical and biological aspects at cellular
and molecular levels.xxii
Overall results validate anti-cancer potential of Conium and provide support for its use in
traditional systems of medicine.xxiii
The anticancer efficacy of an ethanolic extract of Condurango for treating BaP-induced

lung cancer in rats lends support for its use in various traditional systems of medicine. xxiv
Condurango 30C could trigger epigenetic modification in lung cancer via modulation of
DNA hypermethylation.xxv
Results indicate that action of the potentized drugs was more than placebo and these
ultra-highly diluted drugs acted primarily through modulation of gene expression.xxvi
Thuja 30C ameliorates BaP-induced toxicity, stress and DNA damage in perfused lung cells
of mice and it apparently has no effect on normal lung cells.xxvii
Thus, the highly-diluted, dynamized homeopathic remedies Lycopodium 5C and 15C

demonstrated their capabilities to induce apoptosis in cancer cells, signifying their possible
use as supportive medicines in cancer therapy.xxviii
Ars Alb 30C ameliorated arsenic toxicity and DNA damage, validating efficacy of ultrahighly diluted remedies used in homeopathy.xxix
Dr. N. C. Sukul, Department of Zoology, Visva-Bharati University, Santiniketan, West Bengal,

India has also contributed a good number of studies in basic, fundamental and applied aspects of
high dilutions. Dr. Sukul and team has contributed to basic and fundamental research in
homeopathy to strengthen its roots. The team is constantly involved in bringing many aspects of
understanding the mode of action of high dilutions on biological system. Dr Sukul et al have
proposed the global water molecular network as the channel through which high dilutions
34

transfer therapeutic information to a biological system. His latest publication in IJHDR proposes
the action of high dilutions through capillary systemxxx. Some of the acclaimed studies by Sukul
et al are Altered solution structure of alcoholic medium of potentized Nux vomica underlies its
antialcoholic effectxxxi; Reduction of alcohol induced sleep time in albino mice by potentized Nux
vomica prepared with 90% ethanolxxxii; Potentized Mercuric chloride and Mercuric iodide
enhance -amylase activity in vitroxxxiii; Haloperidol-induced catalepsy in mice and rats
suppressed by orally pre-administered potentized Agaricusxxxiv; Dose-dependent suppression of
haloperidol-induced catalepsy by potentized Agaricus muscariusxxxv etc. Dr. Sukul et al have
many more studies to their credit.
Apart from series of study, many researchers have contributed many important research works
to homeopathy. For example, CR Patil and team have shown the immunomodulatory activity of
Rhus toxidendron in experiemental rats.xxxvi, xxxvii, xxxviii
In year 2010, the whole homeopathic fraternity got a long awaited thesis to prove the existence
of homeopathy at nano domain level, when Prof. PS Chikrammane and team published one of
this highly acclaimed papers on nano-particlesxxxix. The team showed that nano particles are
presented even at dilution more than Avogadros limit, which may be one the mode of actions of
homeopathic medicine in human beings. The article is one of the highly accessed and cited
papers globally. Prof. PS Chikrammane and team further took the experiments, and recently
(2014) published another article, Why Extreme Dilutions Reach Non-zero Asymptotes: A
Nanoparticulate Hypothesis Based on Froth Flotationxl
In the meantime, Dr. T Maity and team form Bengal Engineering and Science University, India
put forth another hypothesis that high dilutions have a particular, unique dielectric dispersionxli.
More recently, Dr. Gaurishankar Sa, Professor, Division of Molecular Medicine, Bose Institute,
India undertook experiments at his own level, as well as in collaboration with CCRH, India and
published his work which shows that homeopathic medicines have anti-cancer properties and
they act through certain genetic pathways. He has published three studies in series viz
Calcarea carbonica induces apoptosis in cancer cells in p53-dependent manner via an

immuno-modulatory circuitxlii
Contribution of the ROS-p53 feedback loop in thuja-induced apoptosis of mammary

epithelial carcinoma cellsxliii and
Sulphur alters NFB-p300 cross-talk in favour of p53-p300 to induce apoptosis in nonsmall cell lung carcinomaxliv
Dr. Upma Bagai, Associate professor, Panjab University, India is working on Immunology and
chemotherapy aspects of Plasmodium berghei. She has explored the role of homeopathic high
dilutions on malaria in experimental models. Some of her peer reviewed publications are:
Rajan A and Bagai U (2011). SEM studies on blood cells of Plasmodium berghei infected
Balb/C mice treated with Artesunate and homeopathic medicine China. Journal of
Parasitic Diseases. 35(2):134-139.
35
Rajan A and Bagai U (2010) Effect of homeopathic medicine Chelidonium against blood
stage infection of rodent malaria parasite, Advances in parasitology; a novel approach
towards a disease free world, 22nd National Congress of Parasitology, eds, P.K.
Bandyopadhyay, (ISBN : 978-93-5067-220-4), October 30 to November1, University of
Kalyani, West Bengal, India, 27-31.
Bagai U, Rajan A and Chandel S (2008). Efficacy of eucalyptus ( a homeopathic medicine)

in combination with artesunate to clear Plasmodium berghei infection in Balb/c mice.
Current Trends in Parasitology. In: Proceedings, 20th National Congress of Parasitology,
November3-5, NEHU, Shillong, India, pp: 203-211.
There are many more such studies by Indian scientist which are worth mentioning. Some of
them are:
Bandopadhyay B, Das S, Sengupta M, Saha C, Das KC, Sarkar D, Nayak C. Decreased

intensity of Japanese encephalitis yirus infection in chick chorioallantoic membrane
under influence of ultradiluted Belladonna extract. American Journal of Infectious
Diseases 2010;6(2):24-28.
Bandyopadhyay B et al. Suckling Mice of Belladonna 200 Fed Mothers Evade Virulent
Nakayama Strain Japanese Encephalitis Virus Infection. International Journal of
Microbiological Research 2011;2 (3): 252-57.
Upadhyay RP, Nayak C. Homeopathy emerging as nanomedicine. International Journal of
High Dilution Research 2011;10(37):299-310.
Sampath S et al. Studies on anti-diabetic effects of homeopathic preparations of
Syzygium jambolanum and Cephalandra indica on liver of high fat and high fructoseinduced type-2 diabetic rats. Homeopathy 2013;102:160-171
Veterinary Research
Use of homeopathy and high dilutions for veterinary ailments goes back to Hahnemannian era.
Since inception, veterinary usage of homeopathy has been successful, cost effective and safe. In
the past few decades this usage has been increased. Below are some of the glimpses of work
done by Indian scientists and clinicians in this area:
Dr. CH Day reported use of homeopathy for control of stillbirths in pigs in 1984xlv. During 1990s
M Nandi and group showed the dose-dependent effect of homopathic medicines on serum lipid
concentration in chickens, which was published in British Homeopathic Journalxlvi.
It is worth mentioning here the contributions of Dr. J. P. Varshney and team. Dr. Varshney is
Senior Consultant (Veterinary Medicine), Gujarat; formerly at Indian Veterinary Research
Institute, India, has been working on use of homeopathic medicines in various ailments of
animals. Dr. Varshney and team have published several papers in journals of national and
international repute. Some of their papers are:
Rajkumar R, Srivastava SK, Yadav MC, Varshney VP, Varshney JP, Kumar H. Effect of a
Homeopathic complex on oestrus induction and hormonal profile in anoestrus cows,
Homeopathy 2006;95(3):131-35.
Varshney JP, Naresh R. Comparative efficacy of homeopathic and allopathic systems of
medicine in the management of clinical mastitis of Indian dairy cows. Homeopathy
2005;94(2):81-85
36
Varshney JP, Naresh R. Evaluation of a homeopathic complex in the clinical management

of udder diseases of riverine buffaloes. Homeopathy 2004;93(1):17-20.
Varshney JP, Chaudhuri S. Atrial Paroxysmal Tachycardia in Dogs and its Management
with Homeopathic Digitalistwo case reports. Homeopathy 2007;96(4):270-72
Varshney JP. Clinical management of idiopathic epilepsy in dogs with homeopathic
Belladonna 200C: a case series. Homeopathy 2007;96(1):46-48.
Chaudhuri S, Varshney JP. Clinical management of babesiosis in dogs with homeopathic
Crotalus horridus 200C. Homeopathy 2007;96(2)90-94.
Agronomy Research
Since few decades, the realm of application of high dilution has been increased. High dilution are
now extensively used in agronomy too. Their use has been observed to increase the yield and
decrease the pathogenicity of diseases. India has a long back history of use of high dilutions in
agronomy. The reported literature goes back to as early in 1970s. Some of the reference of
reported literature may be summarized below:
Dr. K K Khanna and team has to their credit a handful of studies undertaken between 1970s and
1990s.
Khatri HL, and Singh I. Biochemic Salts and Homoeopathic Drugs as Inhibitors of a TMVIsolate from Tobacco. Ind. J. Mycol. Pl. Pathol. 1975:29.
Khanna KK, Chandra S. Effect of some homoeopathic drugs on the spore germination of
four isolates of alternate. Ind. Phytopathol 1976;29:195-97.
Khanna KK, Chandra S. Control of tomato fruit rot caused by fusarium roseeum with
homoeopathic drugs. Ind. Phytopathol. 1976;29:269-72.
Khanna KK, Chandra S. Control of Guava fruit rot caused by pestolotia psidi with
homoeopathic drugs. Pl. Dis. Rep. 1977;61: 362-66.
Khanna KK, Chandra S. Control of leaf blight of wheat caused by alternative alternate
with homoeopathic drugs. Ind. Phytopathol. 1977;30:320-22.
Khanna KK, Chandra S. A homoeopathic Drug Controls Mango Fruit Rot caused by
Pestalotia Mangifera Henn. Experientia 1978;34:1167-68.
Kumar R, Sharma RK. Effect of Certain Homoeopathic Medicines on Larval Hatching of
Mealoidogyne Incognita (Kofoid & White) Chitwood. J. Sci. Res. Pl. Med. 1979;1:15-16.
Kumar R, Kumar S. Effect of Homoeopathic Medicines on Fungal Growth and Conidial
Germination. Ind. Phytopathol. 1980;33:620-21.
Khanna KK, Chandra S. Homoeopathic Drug Induced Abnormalities in the Germ Tubes of
Pestalotia Mangifera, Gloeosporium Psidii. Adv. Homoeo. 1981;1:35-36.
Khanna KK, Chandra S. Possible Mode of Actions of Homoeopathic Drugs on the Spore
Germination and Growth of Fusarium Roseum Link, Causal Agent of Tomato Fruit Rot.
Ind. J. Homoeo. 1982;6:164-67.
Mishra N. Inhibition of Asperqillus Niger van Tiegh. by Homoeopathic Drugs Causing
Deterioration of Coriander and Cumin Seeds in storage. Nat. Acad. Sci. Letters
1983;6:139-41.
Ray S, Pradhan AK. Homeo-drugs show nematicidal properties against tomato root-knot
nematode in vitro. Hahnemannian Gleanings 1985; 447-449.
Khanna KK, Chandra S. Spore germination, growth and sporulation of certain fruit-rot
pathogens as affected by homeopathic drugs. [Proc]. Natl Acad Sci India 1987;57:160-70.
37
Khanna KK, Chandra S. Further investigations on the control of storage rot of mango,
guava, and tomato fruits with homeopathic drugs. Indian Phytopath 1989;42:436-40.
Khanna KK. Suppression of Fusarium oxysporum Schlecht, a pathogen causing seedling
blight and foot rot of wheat, with homeopathic drugs. [Proc] Natl Acad Sci Lett
1993;63:353-60.
Apart from series of work, following work has also been reported from time to time (1969 till
date)
Verma HN, Verma GS, Verma VK, Krishna R, Srivastava KM. Homeopathic and
pharmacopoeial drugs as inhibitors of tobacco mosaic virus. Indian Phytophathol 1969;
22:188-93.
Verma HN, Awasthi LP. Effect of biochemic drugs on the infection of TMV. Geobios
1978;5:84-86.
Chaube KMR, Dixit SN, Tripathi SC. Effect of some homoeopathic on spore germination of
certain fungi. Nat. Acad. Sci. Letters 1978;1:355-56.
Sarma JB, Moses GJ. Studies on Antibacterial Activity of Synthetic and Homoeopathic
Compounds and Plant Extracts on Phytopathogenic Bacteria in Vitro. [3rd Intern. Symp.]
Pl. Path., IPS, ICAR & IARI, New Delhi, 14th 18th Dec. 1980:177-78.
Chandra H, Asthana A, Dubey KN, Tripathi RD, Dixit SN. Effect of some Homoeopathic
Drugs against spore germination of some fungi. Nat. Acad. Sci. Letters 1981;4:161-62.
Singh BS, Gupta G. Effect of Homoeopathic Drugs on the Growth of Alternaria Tenuis
Auct., and Curvularia Lunata (Wokker) Boedijin, the Common Leaf Spot Pathogen of
Ornamental and Cultivated Plants. Adv. Homoeo. 1981;1:117-21.
Chandra H, Khanna KK. Homoeopathic Drugs in the control of Plant diseases. in:
BILGRAMI, K.S., K.M. Vyas: Recent advances in the biology of Microorganisms. Part II.,
Bishen Singh, Mahendra Pal Singh Publishers, Dehra dun, 1982:513-18.
Shukla K, Joshi RD), Inhibition by some Homoeopathic Drugs of Sugarcane Mosaic Virus
in Sorghum. Sugarcane Pathol. Newsletter, 1982;29:48-50.
Singh BG. Sensitivity of keratinophilic fungi to some homeopathic medicines.
Hahnemannian Gleanings 1983;50:154-56.
Dua VK, Atri DC. Effect of homoeopathic drugs on growth of two plant pathogens.
Hahnemannian Gleanings 1983;50:411-13.
Kehri KH, Chandra S. Control of Botryodiplodia rot of guava with a homeopathic drug.
Natl Acad Sci Lett 1986;9:301-02.
Saxena A, Pandey ML, Gupta RC. Effect of certain homeopathic drugs on incidence of seed
borne fungi and seed germination of Abelmoschus esculentus. Indian J Mycol Plant Pathol
1987; 17:191-92.
Sukul NC, Sukul A. Potentized Cina reduced root-knot disease of cowpeas. Environment
Ecol. 1999; 17:269-73.
Datta SC. Effects of Cina on root-knot disease of mulberry. Homeopathy 2006;95:144-47.
Sukul NC, Ghosh S, Sukul A, Sinhababu SP. Amelioration of root-knot disease of lady's
finger plants by potentized Cina and Santonin. Homeopathy, 2006;95(3):144-47.
Hiware CJ. Effect of fortification of Mulberry leaves with homeopathic drug Nux Vomica
on Bombyx Mori. L. Homeopathy 2006; 95(3):148-50.
Gangar HU. Management and control of Genetic Processes in Cotton Plants through
Homoeopathy. Indian Journal for research in Homoeopathy; 2007(1):1-12.
38
Gupta VK, Ray JR, Singh VK, Pathak SD, Nayak C, Darokar MP. Dose dependent effect of
Zinc sulph on plant growth. Indian Journal for Research in Homeopathy 2014;8(1):19-23.
Contribution to Basic and Fundamental Research by CCRH

The Central Council for Research in Homoeopathy (CCRH) is an apex organization under the
Ministry of AYUSH, Government of India for undertaking, co-ordinating, developing,
disseminating and promoting research in Homoeopathy on scientific lines. The CCRH has
adopted the state of art tools and techniques of research management, viz. research
prioritization, research programming and research management information system, making
India a global leader in the field of homoeopathic research. CCRH has a separate section for
fundamental and collaborative section. CCRH has conducted and concluded studies of
international repute since foundation of its section in 2005. The studies have contributed a
substantial support to basic and fundamental research in homeopathy. Few of concluded
research studies are:
Investigations into the action of Homoeopathic potencies on Autonomous nervous

system and variability in physiological parameter using indigenous Impedance
Plethosmography (IPG), Vasomon / Medical analyzer (MA) and Anu Photo-rheography
on healthy human subjects.
Effect of Homoeopathic drugs on Central nervous System and their safety evaluation,
Efficacy & safety evaluation of Homoeopathic drugs in experimental study
Endocrinological study.
Effect of Homoeopathic Medicine on Japanese Encephalitis Virus infection on chorioallantoic membrane (CAM) & suckling mice.
A structural study of homoeopathic medicine; A pilot study
Studies on anti-diabetic properties of Homoeopathic preparation of Syzigium
jambolanum and Cephalandra-indica.
Protective role of Homoeopathic preparation of Berberis vulgaris to alleviate kidney
stone disease and its influence on molecular events leading to Calcium oxalate crystal
deposition.
Changes in Electro-Physiological markers in muscle fatigue with homoeopathic
preparation of Arnica montana A comprehensive study.
Pharmacological evaluation of homoeopathic medicines.
Safety and efficacy studies of Homoeopathic drugs
Preliminary pharmacological studies of Homoeopathic drugs
Role of homoeopathic medicines in cancer regression and rejuvenation of depressed
immune system: a mechanism study Extension study
Efficacy of Homoeopathic Therapy on duration of labour
A complete list of concluded studies till June 2015 is available at
http://ccrhindia.org/pdf/concluded%20studiesnational.pdf.
There are many ongoing studies on basic and fundamental research by CCRH in collaboration
with institutes of repute like Centre for Cellular and Molecular Biology, Hyderabad; School of
Biotechnology, West Bengal University of Technology, West Bengal; Dayal Singh College,
University of Delhi, New Delhi etc. (http://ccrhindia.org/ongoing1.asp)
39

The road ahead
Research in high dilution and homeopathy has a long way to go. There are many areas in which
we need extensive, state-of-art research to establish the plausibility of homeopathy, and that is
only possible when research is supported from every aspect. Homeopathy in India is supported
at both individual and government level. Indian scientists and researchers have played an
important role in supporting homeopathy from scientific point of view. The whole world is now
seeing India as an emerging global leader in homeopathy. India has also being involved in the
international cooperation and liaison when it comes to research in homeopathy. The need of
hour is to undertake more number of rigorous studies both at national as well as international
level, by means of mutual collaborations, to establish the global acceptability of homeopathy.
Online version of the article is available at http://bit.ly/1NtN0gC
Studies to be Read
Abstracts of peer reviewed studies published during July September 2015
Fundamental Research
1. Syzygium jambolanum and Cephalandra indica homeopathic preparations inhibit
albumin glycation and protect erythrocytes: an in vitro study. Homeopathy
2015;104(3):197-204. Link to study: http://bit.ly/1VmiWrZ
2. Effects of Tarantula cubensis D6 on aflatoxin-induced injury in biochemical
parameters in rats. Homeopathy 2015;104(3):205-210. Link to study:
http://bit.ly/1j0glCZ
3. Homeopathic remedies with antineoplastic properties have immunomodulatory
effects in experimental animals. Homeopathy 2015;104(3):211-19. Link to study:
http://bit.ly/1RfhbXy
4. An evaluation of Avogadros number in the light of HRTEM and EDS studies of high
dilutions of Ferrum metallicum 6, 30, 200, 1M, 10M and 50Mc. Int J High Dil Res.
2015;14(3):3-9. Link to study: http://bit.ly/1JBCoVv
5. The Association of Ponderal Benznidazole with its Ultra-high Diluted Formula
Reduces the Toxic Effects and Allows Increasing of Dose in Dose-dependent
Protocol in Mice Infected with Trypanosoma cruzi. Int J High Dil Res. 2015;14(3):1019. Link to study: http://bit.ly/1FHbUH9
6. Chemometrics meets homeopathy-an exploratory analysis of infrared spectra of
homeopathic granules. J Pharm Biomed Anal. 2015 Nov 10;115:36-8. Link to study:
http://1.usa.gov/1YNLGZT
Clinical Research
1. Model validity of randomised placebo-controlled trials of individualised
homeopathic treatment. Homeopathy 2015;104(3)164-69. Link to study:
http://bit.ly/1L3r0qG
2. Utilization of psychotropic drugs by patients consulting for sleeping disorders in
homeopathic and conventional primary care settings: the EPI3 cohort study.
Homeopathy 2015;104(3)170-75. Link to study: http://bit.ly/1P4ZYkH
40

3. The homeopathic choice for children: a qualitative research on the decision
making process of the families. Homeopathy 2015;104(3)176-81. Link to study:
http://bit.ly/1iKnW7X
4. Some intrapersonal qualities of SA homeopaths who have established successful
private
practices.
Homeopathy
2015;104(3)182-89.
Link
to
study:
http://bit.ly/1KQR0Bh
5. Data collection: Treat every variable as a treasure. Homeopathy 2015;104(3)190-96.
Link to study: http://bit.ly/1Wx7Nl7
6. Risk in homeopathy: Classification of adverse events and homeopathic
aggravations - A cross sectional study among Norwegian homeopath patients.
Complement
Ther
Med.
2015
Aug;23(4):535-43.
Link
to
study:
http://1.usa.gov/1VqMzmI
Pharmaceutical Research
1. Characterization of Potentized (Homeopathic, Anthroposophical and
Antihomotoxic) Medicines Registered and Notified In Brazil. Int J High Dil Res.
2015;14(3):20-35. Link to study: http://bit.ly/1Gg4hlY
Review
1.
Is There a Role for Homeopathy in Cancer Care? Questions and Challenges. Curr
Oncol Rep. 2015 Sep;17(9):43. Link to study: http://1.usa.gov/1VqM2Bg
1.
Veterinary homeopathy: Systematic review of medical conditions studied by

randomised trials controlled by other than placebo. BMC Vet Res. 2015 Sep
15;11(1):236. Link to study: http://1.usa.gov/1VqKTth
Veterinary Research
41
Upcoming Events
Visit http://researchinhomeopathy.org/calendar/ for more details. To add your event
to the calendar email the content at info@audesapere.in
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profiling manifests homeopathy effect as more than placebo. Int J High Dilution Res. 2013;12(45):162-167.
xxvii
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xxviii
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43
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44

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