[Pancreatic hyperenzymemia: new advances in the field of clinical-diagnostic approach, with particular attention about Gullo's syndrome.

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R Catanzaro

Article
[Pancreatic hyperenzymemia: new advances in the field of
clinical-diagnostic approach, with particular attention about
Gullo's syndrome.]
R Catanzaro

A Italia

Unit Operativa Complessa di Medicina Interna "A. Francaviglia", Dipartimento di Medicina

Interna e Patologie Sistemiche, Azienda Ospedaliero-Universitaria, "Policlinico-Vittorio
Emanuele", Catania, Italia - .
Minerva medica (Impact Factor: 1.2). 10/2012; 103(5):393-412.
Source: PubMed
ABSTRACT An increase in serum levels of pancreatic enzymes is a well-known
manifestation of pancreatic disease, especially of inflammatory or neoplastic nature, even if
several extrapancreatic diseases can equally cause that increase. In addition to this
pathological type of hyperenzymemia, different "non-pathological" forms have also been
identified, including macroamylasemia, salivary, and mixed salivary and pancreatic
hyperamylasemia, in all of which only amylase elevations are seen. Nevertheless, in 1996
a new syndrome characterized by an abnormal, chronic, benign increase in levels of serum
amylase, pancreatic isoamylase, lipase and trypsin, asymptomatic and usually discovered
incidentally, was described for the first time by Lucio Gullo et al.
Hyperamylasemia/hyperlipasemia's observation is nowadays on the increase because
general practitioners tend to include more frequently amylase and lipase in routine blood
tests and, moreover, because the constant evaluation of this biochemical alteration in the
Emergency Unit: for this reason, this syndrome was clearly identified only recently.
Therefore, it's characterized by serum elevation of all pancreatic enzymes in the absence
of underlying diseases; it occurs in either sporadic or familial form and it persists over time
with considerable fluctuation in serum enzyme concentrations, including frequent
normalizations. Proper diagnosis of this form of hyperenzymemia is important because it
reassures the subjects having this anomaly that the syndrome is benign, and because it
can prevent multiple and expensive diagnostic tests or useless hospitalizations or
therapies.
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CITED IN (1)

Article: A 5-Year Experience of Benign Pancreatic

Hyperenzymemia.
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[Show abstract]
Pancreas 04/2014; 3.01 Impact Factor

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[Pancreatic hyperenzymemia: new advances in the field of clinical-diagnostic approach, with particular attention about Gullo's syndrome.] - ResearchGate
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