BIOL2220 sample MC questions

1. Which of the following metabolites in plants may contain a carbon directly

derived from carbon dioxide?
I.
3-phosphoglycerate
II.
2-phosphoglycolate
III.
Oxaloacetate
IV.
Malate
A. i. iii, and iv
B.
C.
D.
E.

i, ii, and iii

i and ii
i and iii
iii and iv

2. Calvin cycle contain reactions which are also participating in which of the
following processes?
A. Pentose phosphate pathway
B. Gluconeogenesis
C. TCA cycle
D. Glyoxylate pathway
E. Glycolate pathway
3. Which of the following is true about the flight muscles of migrating birds?
A. Fatty acids are oxidized as the only source of ATPs because they are more
energy-rich than carbohydrates
B. They are white muscles which carry out aerobic respiration efficiently
C. They are white muscles which utilizes glycogen and protein to generate ATPs
D. They are red muscles which contains large number of mitochondria
E. They are red muscles which can convert fatty acids to glycogen
4. Which of the following is the location for fatty acid oxidation in plants?
A. Chloroplasts
B. Cytoplasm
C. Mitochondria
D. Glyoxysomes
E. Endoplasmic reticulum

5. Proton pumping is associated with electron transport through which of the

following protein complexes?
I.
Complex I
II.
Complex II
III.
Complex IV
IV.
Photosystem 1
V.
Photosystem 2
A. All of the above
B. I, II, and III only
C. I, III, IV, and V only
D. I and III only
E. IV and V only
6. In the TCA cycle, the step in which succinyl-CoA is converted to succinate is
classified as a ___________________ reaction.
A. Condensation
B. Substrate level phosphorylation
C. Decarboxylation
D. Dehydrogenation
E. Isomerization
7. Which of the following will not happen to pyrimidine nucleotides?
A. Degradation to form excretory products
B. Degradation to form metabolites that can be oxidized to make ATPs
C. Salvaged to form other pyrimidines
D. All of the above will happen
E. None of the above will happen
8. Which of the following process does not take place in mitochondria?
A. Urea cycle
B. Fatty acid biosynthesis
C. Ketone body formation
D. Formation of acetyl-CoA from pyruvate
E. Oxidative phosphorylation

9. Which of the following metabolites is not produced by liver?

A. Ketone bodies
B. Glucose
C. Urea
D. Lactate
E. Glycogen
10. Which of the following reaction types are not found in the Calvin cycle?
A. Carboxylation
B. Transketolase reaction
C. Transaldolase reaction
D. Oxidation/Reduction reaction
E. Substrate level phosphorylation
11. Which of the following nucleotide triphosphates is directly required for
biosynthesis of glycerolipids?
A. ATP
B. GTP
C. UTP
D. CTP
E. None of the above
12. Which of the following enzymes is a target for pain killers?
A. HMG-CoA synthase
B. Cyclooxgenase
C. Succinate dehydrogenase
D. Phosphofructose kinase
E. Aconitase
13. Which of the following enzymes does not require nucleotide triphosphates (ATP,
GTP, etc.) as a co-substrate?
A. Hexokinase
B. Protein kinase A
C. Citrate synthase
D. Succinyl-CoA synthetase
E. Acyl-CoA synthetase

14. Which of the following statements is TRUE?

A. Glycogen phosphorylase acts on the reducing ends of glycogen.
B. The reactions in complex II release very little free energy and do not contribute
directly to the proton concentration gradient.
C. Membrane- associated electron transport complexes I and II are linked by
ubiquinone (Q) while complexes II and IV are linked by cytochrome c.
D. Synthetases require ATP/ADP as a cofactor while synthases do not. The TCA
cycle requires a synthetase but not any synthases.
E. None of the above
15. Which of the following statements is FALSE?
A) In citrus fruits, the levels of citric acid are related to its ability to conduct a citric
acid cycle of reactions and not to its ability to act as a preservative or a reservoir
of carbon.
B) In mammals the oxidation of fatty acids produces a two-carbon product and the
synthesis of fatty acids begins with a two-carbon substrate.
C) Ketone bodies are normally synthesized in the liver during the time of starvation.
D) The electron flow in PS II is always non-cyclic, since there is a requirement for an
outside source of electrons.
E) All of the above
16. Which of the following statements is FALSE?
A) The only reaction in the TCA cycle to generate a C-C bond is catalyzed by citrate
synthase.
B) Photorespiration is a metabolically wasteful process which consumes oxygen and
releases carbon dioxide
C) All ten steps of the glycolytic pathway must have negative free energies for
glycolysis to proceed.
D) In plants and animals, fatty acid biosynthesis occurs in chloroplasts and cytoplasm,
respectively.
E) None of the above
17. Which statement is true about anabolic pathways?
A. They release energy for substrate level phosphorylation
B. They require NADPH as an oxidizing agent
C. They generate electron carriers for oxidative phosphorylation
D. They liberate smaller molecules from larger molecules
E. They include the nitrogen fixation process
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18. Which of the following compounds do(es) not require the use of a shuttle system
to move across the mitochondrial inner membrane?
I. NADH
II. Acetyl-CoA
III. Malate
IV. OAA
A.
B.

III only
I, II, and III only

C. I, III, and IV only

D. I and II only
E. All of the above
19. Which of the following protein complexes are involved in electron transfer from
NADH to oxygen?
I. NADH dehydrogenase
II. Succinate dehydrogenase
III. Cytochrome bc1
IV. Cytochrome oxidase
A. I and II only
B. I, II, and III only
C. I, III, and IV only
D. II, III, and IV only
E. All of the above
20. Which is the proper order of substrates in the synthesis of starch?
A. Glucose 1-P Glucose 6-P ADP-glucose Starch
B. Glucose 1-P Fructose 6-P UDP-fructose Starch
C. Glucose 3-P Glucose 1-P ADP-glucose Starch
D. Glucose 6-P Glucose 1-P ADP-glucose Starch
E. Glucose 6-P Glucose 1-P UDP-glucose Starch

21. Which of the following about acetyl-CoA (shown below) is correct?

H3C

S CoA

A. The two carbon atoms of an incoming acetyl-CoA are removed

immediately as carbon dioxide during the first TCA cycle.
B. Acetyl-CoA can be generated from pyruvate by oxidative decarboxylation
C. Acetyl-CoA can be used to synthesize carbohydrates in liver.
D In glyoxysomes, acetyl-CoA generated from fatty acid oxidation is
retained in the same organelle for entering the TCA cycle.
E. None of the above is correct
22. What is the correct sequence for the following components in photosynthesis as
described by the Z scheme?
A. NADPH P700 P700* cyt bf complex P680 P680* water
B. water P700 P700* cyt bf complex P680 P680* NADPH
C. water P680 P680* cyt bf complex P700 P700* NADPH
D. NADPH P680 P680* cyt bf complex P700 P700* water
E. None of the above is correct
23. Which of the following metabolic cycles allows the conversion of fatty acids to
sugars in plants?
A. Urea cycle
B. TCA cycle
C. Calvin cycle
D. Glyoxylate cycle
E. None of the above

24. In skeletal muscle, the net gain of ATP from complete oxidation of one glucose is
A. 28
B. 30
C. 32
D. 34
E. 2

25.

What is the preferred fuel molecule utilized by the brain?

A. fatty acid;
B.
proteins;
C.
glucose;
D.
glycogen;
E.
ketone bodies.

26. Which of the following is NOT an anaplerotic reaction to replenish TCA cycle
intermediates?
A. Oxaloacetate + Acetyl-CoA to citrate
B.
C.
D.
E.

Pyruvate to Oxaloacetate
Propionyl-CoA to Succinyl-CoA
Aspartate to Oxaloacetate
All of the above are anaplerotic reactions

27. What is the main advantage for plants that use C4 pathway in addition to the
Calvin cycle for the fixation of carbon dioxide?
A. Fewer ATP are consumed to produce carbohydrates using the C4 pathway
as opposed to the Calvin cycle.
B. The C4 pathway allows for fixation of carbon dioxide at night.
C. The C4 pathway aids in the avoidance of the oxygenation reaction by
RUBISCO
D. The C4 pathway allows photosynthesis to occur at a wide range of
wavelengths of light
E. All of the above
28. Malonate (shown below) is an inhibitor of which of the following TCA cycle
enzymes?

A.
B.
C.
D.
E.

Malate dehydrogenase
Aconitase
Succinate dehydrogenase
Fumarase
Succinyl-CoA synthetase

29. An intermediate found in gluconeogenesis but NOT glycolysis is

7

A.
B.
C.
D.
E.

2-Phosphoglycerate
OAA
PEP
Fructose 1, 6-bisphosphate
Glucose 6-phosphate

30. Which of the following sugars is activated by the addition of pyrophosphate to its
no. 1 carbon as the initial step of purine biosynthesis?
A. fructose
B.
C.
D.
E.

ribulose-5-phosphate
ribose-5-phosphate
ribose
deoxyribose

For the following questions, select from the following choices (A-W).
only one correct answer for each question.
A. Malonyl-CoA
B. UDP-Glucose
C. Acetyl-CoA
D. Dihydroxyacetone phosphate (DHAP)
E. Oxaloacetate (OAA)
F. ADP-Glucose
G. Glycolate
H. 6-Phosphogluconate
I. -Ketoglutarate (-KG)
J. Fumarate
K. Phenylalanine
L. Leucine
M. Alanine
N. Glutamate dehydrogenase
O. Ornithine transcarbamoylase
P. Succinate dehydrogenase
Q. Arginase
R. Glutamate
S. Glutamine
T. Ubiquinone (Q)
U. Cytochrome b
8

There is

V. Glyoxylate
W. Succinate
X. Fructose 1,6-bisphosphate
Y. Fructose 2,6-bisphosphate
31. It is a metabolite committed for fatty acid biosynthesis in animal cells.
32. It is the C-4 compound after carbon dioxide fixation in C4 plants.
33. It is a metabolite derived from photorespiration.
34. This urea cycle enzyme is found in the cytosol.
35. It is involved during the conversion of galactose into a glycolytic metabolite
36. It serves as a universal acceptor for amino group in transamination reactions.
37. Plants can use this 2-C compound to make glucose, but animals cannot.
38. It is a membrane-bound enzyme.
39. It is an intermediate in the oxidative phase of pentose phosphate pathway.
40. This is an outgoing product in the glyoxylate cycle.

Key
1.
2.
3.
4.
5.
6.
7.
8.

A
B
D
A
D
B
A
B

9.
10.
11.
12.
13.

D
E
D
B
C

14.
15.
16.
17.

B
A
C
D

18.
19.
20.
21.
22.
23.
24.
25.
26.

A
C
D
B
C
D
B
C
A

27.
28.
29.
30.
31.
32.
33.
34.
35.

C
C
B
C
A
E
G
Q
B

36. I
37. C; 38. P; 39. H; 40. W
10