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Book Question 2
Patient C.S. is 35-yr old female weighing 60 kg, and is to
be given multiple IV bolus injection of an antibiotic. The
effective concentration is 15 mg/ml. After the patient is
given a single IV dose, the t1/2 and V are determined to
be 3 hr and 196 ml/kg.
a. Determine the multiple IV regimen for C.S.
b. After the condition of CS is stabilized, CS will continue on therapy
with an oral tablet with F = 0.9. What will be the oral regimen?
c. If the oral tablets are available in 125, 250 and 500 mg. How will the
dose for CS be prescribed?
d. If your regimen requires tablets of different strengths, it needs to be
modified because CS has difficulty in distinguishing the products of
different strengths.
e. Verify your oral regimen.
11/11/2015
Book Question 2
Provided: t1/2=3hr; k = 0.693/3 = 0.231 hr-1
V = 196 ml/kg * 60 kg = 11.76 L
a. Determine the multiple IV regimen for C.S.
Css ave = F.D/CL. = 15 mg/L
Therefore, D/ = 15 * 0.231 * 11.76 / (1) = 40.75 mg/hr
A reasonable will be 8 hr, so D = 40.75 * 8 = 325.98 mg
b. After the condition of CS is stabilized, CS will continue on therapy with an oral
tablet with F = 0.9. What will be the oral regimen?
Aiming at the same Css ave of 15 mg/L,
Css=FD/CL*
15 = (0.9) * D / (0.231 * 11.76 * 8) = 362 mg
11/11/2015
Book Question 2
Provided: t1/2=3hr; k = 0.693/3 = 0.231 hr-1
V = 196 ml/kg * 60 kg = 11.76 L
c. If the oral tablets are available in 125, 250 and 500 mg. How will the
dose for CS be prescribed?
We can give 1 X 250 mg + 1 X 125 mg tablets (total = 375 mg)
Verify: Css ave = (0.9 * 375)/(0.231 * 11.76 * 8) = 15.6 mg/L
Acceptable regimen!
d. If that is the case, then simply give 3 X 125 mg tablets which totals to
375mg.
e. Same as verification in part c.
Verify: Css ave = (0.9 * 375)/(0.231 * 11.76 * 8) = 15.6 mg/L
Acceptable regimen!
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Book Question 3
What pharmacokinetic parameter is most
important in determining the time at which the
steady state plasma drug level (C av) is reached?
Book Question 4
Name two ways in which fluctuation of plasma conc.
(between Cmax and Cmin ) can be minimized for a
person on a multiple dose regimen without altering
Cav
Reduce dose
Reduce dosing interval
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Book Question 11
The body clearance of sumatriptan (Imitrex) is 250
mL/min. The drug is about 14% bioavailable. What
would be the average plasma drug concentration
after 5 doses of 100 mg PO every 8 hours in a
patient?(Assume steady state was reached.)
Provided: CL= 15L/hr;
= 8h;
F = 0.14
D= 100mg
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Question 12
Cefotaxime has a Vd of 0.17L/kg and elimination half life of 1.5 hr. What
is the peak plasma drug conc. in a patient weighing 75 kg after receiving
1 g IV of the drug 3 times daily for 3 days.
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THANK YOU
QUESTIONS???
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