Вы находитесь на странице: 1из 4

RheumTutor.

com
Providingquality
educationin
rheumatology

2012SLICCSLECriteria
Criteriaarecumulativeandneednotbepresentconcurrently.Seenotes
below.

CLINICALCRITERIA
(1)AcuteCutaneousLupusORSubacuteCutaneousLupus

Acutecutaneouslupus:lupusmalarrash(donotcountifmalardiscoid),
bullouslupus,toxicepidermalnecrolysisvariantofSLE,maculopapularlupus
rash,photosensitivelupusrash(intheabsenceof
dermatomyositis)
Subacutecutaneouslupus:noninduratedpsoriaformand/orannular
polycycliclesionsthatresolvewithoutscarring,althoughoccasionallywith
postinflammatorydyspigmentationortelangiectasias)
(2)ChronicCutaneousLupus
Classicdiscoidrashlocalized(abovetheneck)orgeneralized(aboveand
belowtheneck),hypertrophic(verrucous)lupus,lupuspanniculitis
(profundus),mucosallupus,lupuserythematosustumidus,chillblainslupus,
discoidlupus/lichenplanusoverlap
(3)OralUlcersORNasalUlcers
Oral:palate,buccal,tongue
Nasalulcers
Intheabsenceofothercauses,suchasvasculitis,Behcetsdisease,
infection(herpesvirus),inflammatoryboweldisease,reactivearthritis,and
acidicfoods
(4)Nonscarringalopecia
Diffusethinningorhairfragilitywithvisiblebrokenhairs,intheabsenceof
othercausessuchasalopeciaareata,drugs,irondeficiency,andandrogenic
alopecia
(5)Synovitisinvolving2ormorejoints
Characterizedbyswellingoreffusion
ORtendernessin2ormorejointsandatleast30minutesofmorningstiffness
(6)Serositis
Typicalpleurisyformorethan1dayORpleuraleffusionsORpleuralrub
Typicalpericardialpain(painwithrecumbencyimprovedbysittingforward)
formorethan1dayORpericardialeffusionORpericardialrubORpericarditis
byelectrocardiography

Intheabsenceofothercauses,suchasinfection,uremia,andDresslers
pericarditis
(7)Renal
Urineproteintocreatinineratio(or24hoururineprotein)representing500
mgprotein/24hoursORredbloodcellcasts
(8)Neurologic
Seizures,psychosis,mononeuritismultiplex(intheabsenceofotherknown
causessuchasprimaryvasculitis),myelitis,peripheralorcranialneuropathy
(intheabsenceofotherknowncausessuchasprimaryvasculitis,infection,
anddiabetesmellitus),acuteconfusionalstate(intheabsenceofother
causes,includingtoxic/metabolic,uremia,drugs)
(9)Hemolyticanemia
(10)Leukopenia(<4000/mm3)ORLymphopenia(<1000/mm3)
Leucopeniaatleastonce:Intheabsenceofotherknowncausessuchas
Feltyssyndrome,drugs,andportalhypertension.
Lymphopeniaatleastonce:intheabsenceofotherknowncausessuchas
corticosteroids,drugs,andinfection
(11)Thrombocytopenia(<100,000/mm3)
Atleastonceintheabsenceofotherknowncausessuchasdrugs,portal
hypertension,andthromboticthrombocytopenicpurpura
IMMUNOLOGICCRITERIA
(1)ANAlevelabovelaboratoryreferencerange
(2)AntidsDNAantibodylevelabovelaboratoryreferencerange(or2foldthe
referencerangeiftestedbyELISA)
(3)AntiSm:presenceofantibodytoSmnuclearantigen
(4)Antiphospholipidantibodypositivity,asdeterminedby

Positivetestforlupusanticoagulant
Falsepositivetestresultforrapidplasmareagin
Mediumorhightiteranticardiolipinantibodylevel(IgA,IgG,orIgM)
Positivetestresultforanti2glycoproteinI(IgA,IgG,orIgM)
(5)Lowcomplement(C3,C4,orCH50)
(6)DirectCoombstest(intheabsenceofhemolyticanemia)