Вы находитесь на странице: 1из 4

Biological Sciences 102, Spring Quarter 2015 Section 002, CRN 43757 Relevant Information & Syllabus

Instructor:

Walter S. Leal, Ph.D., FRES Email: wsleal@ucdavis.edu Office Hours: Mon & Wed 4-5 PM, 2089 SLB http://daviswiki.org/Sciences_Laboratory_Building

Teaching

Silvia Hilt, PhD Candidate BMB/DEB Graduate

Assistants:

Groups Email: slhilt@ucdavis.edu Office Hours: Tue 1:30-2:30 PM, Fri 9-10AM, 3061 SLB

Corinne E. Rich, Viticulture & Enology Graduate Program Email: cerich@ucdavis.edu Office Hours: Mon, 5-6PM; Fri, 1:30-2:30 PM, 3061 SLB

If none of these time slots work for you and you are still interested in attending office hours, please take the following Doodle pool:

We will try to add another time slot, provided that we can make the logistics work.

Course Objectives: This course will enable students to describe how the structure of the major chemical compounds in cells determines their behavior and enables their biological roles. This includes understanding how chemical principles govern the structure and interactions of molecules with their environment and each other, and how quantitative methods can be used to examine molecular processes in living systems.

Students will: be able to apply these concepts to solve problems in biochemistry, be able to immediately recognize the primary types of biochemical molecules and know their essential chemical characteristics that enable their roles in cells, appreciate the central and essential importance of water as polar solvent in biological chemistry, be able to quantitatively determine the effects of hydrogen ion concentration on the ionization state and charge of biological molecules,

understand classical and modern methods of biochemical analysis and evaluate the meaning of experimental results, understand and quantitatively evaluate how chemical energetic principles drive all processes in cells, be able to describe how the set of weak chemical interactions drive folding of proteins and assembly of supramolecular structures such as protein complexes and biological membranes, be able to describe the molecular and energetic basis of enzymatic specificity and catalysis, quantitatively analyze enzymatic reaction rate data and use this information to determine the kinetic properties of an enzyme and properties of enzyme inhibitors, and understand how the function of protein molecules can be altered by binding other compounds present in their cellular environment.

Texts

Important Web Sites

Course Format

Optional: Biochemistry, Garrett & Grisham, ISBN-13: 978-1- 133-10629-6, 5 th Ed (the 4 th Ed could also be used). The publisher offers also eChapters at $6.99 per chapter:

Optional: Biochemical Calculations, 2nd Ed., I. H. Segel, John Wiley & Sons, Inc., 1976, ISBN 0-471-77421-9

Podcast and other important class material, possibly including PowerPoint lectures, will be posted on SmartSite. Other material, including eProblem solutions, may be posted on the website of the Instructor’s laboratory:

http://chemecol.ucdavis.edu/ and/or Adobe Connect (you may want to install Adobe Connect Mobile on your handheld device). We encourage the use of the Chat Room for discussion as we are unable to answer emails with individual questions. Additionally, there could be opportunities to ask questions through Adobe Connect before exams. In the event that we receive individual questions via email, we reserve the right to share them with all students via Chat Room, office hours, or the like so that the group as a whole would benefit from our answers or clarifications.

Lectures are on Tue and Thu from 12:10-1:30 PM, SocSci 1100, https://localwiki.org/davis/1100_Social_Science

Voluntary reviews and, possibly eReviews, will be arranged before midterms and the final exam. The instructor will make every effort possible to talk to students after class. However, the instructor will not be available immediately after lecture as there will be limited time (5-10 min) to disconnect all devices and make the room available for the next instructors. In short, the instructor is not available for 5- 10 min after class, but readily available thereafter. Likewise, the short period of time before the lecture is dedicated for technical arrangements.

Grading*

Midterm 1, Tue, January 26

Midterm 2, Thu February 18 30% Final Exam Sat, March 19 at 1 PM 45% Filming could take place during the exams! (Final is cumulative, but emphasis will be given to material covered after the second midterm) The two midterms and the final exam will be administered at assigned times only, except for students with documented evidence of loss or sickness per university policy and with instructor’s agreement. Extended times will be given for students with proper university documentation, but exams will start at the same time for all students. It is the student’s responsibility to make certain that his/her extended time will not overlap with the beginning of another final exam. If you have/will have university documentation for an extended exam and have another final exam scheduled for March 19 h before 5 PM, please contact the instructor as soon as possible but not later than January 26 so as to explore possible alternatives. After the first midterm, no alternative accommodations will be explored for the final exam.

25%

*Grades will be calculated on the basis of the class curve. Watch out for trade-ins and other opportunities (typically a one-time offer during classes)

Syllabus

Not necessarily in this order Introduction to Biochemistry; Biological Thermodynamics; Water Properties; Buffers; Lipids; Amino Acids; Protein Structure and Functions; Hemoglobin and Allostery; Separation and Characterization of Amino Acids and Proteins; Enzyme Kinetics & Inhibitors; Membranes

(Case studies, such as practical examples of isolation and characterization of proteins, enzyme kinetics and inhibition, as well as drug discovery, will be included to illustrate some of these topics)

Homework

How-to-do-well

Optional Reading

Homework may be assigned, but not graded.

To earn a good grade, follow previous students’ advice:

attend classes and office hours, and take advantage of additional material (e-Problems, e-Reviews, etc). Group study is also very helpful.

For Lectures from Jan. 5-21 (tentative schedule):

Garrett & Grisham, Chapters 1-4; Segel, Chapter 1, Chapter 3A, 3G. For Lectures from Jan. 28-Feb. 16 (tentative schedule): Garrett & Grisham, Chapters 5, 6, 13; Segel, Chapter 4A For Lectures from Feb. 23-March 10 (tentative schedule):

Garret and Grisham, Chapters 13 (cont’d)-15, 8, 9; Segel, Chapter 4A-4E (cont’d).