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Overview of vitamin D
Section Editors
Kathleen J Motil, MD, PhD
Marc K Drezner, MD
Deputy Editor
Jean E Mulder, MD
All topics are updated as new evidence becomes available and our peer review process is complete.
Literature review current through: Aug 2014. | This topic last updated: May 08, 2014.
INTRODUCTION Vitamin D is a fat-soluble vitamin. Very few foods naturally contain vitamin D (fatty fish livers are the
exception), so dermal synthesis is the major natural source of the vitamin. Vitamin D from the diet or dermal synthesis is
biologically inactive and requires enzymatic conversion to active metabolites (figure 1). Vitamin D is converted
enzymatically in the liver to 25-hydroxyvitamin D (25[OH]D), the major circulating form of vitamin D, and then in the kidney
to 1,25-dihydroxyvitamin D, the active form of vitamin D.
Vitamin D and its metabolites have a significant clinical role because of their interrelationship with calcium homeostasis
and bone metabolism. Rickets (children) and osteomalacia (children and adults) due to severe vitamin D deficiency are
now uncommon except in populations with unusually low sun exposure, lack of vitamin D in fortified foods, and
malabsorptive syndromes. Subclinical vitamin D deficiency, as measured by low serum 25(OH)D, is very common. In the
National Health and Nutrition Examination Survey (NHANES) 2005 to 2006, 41.6 percent of adult participants (20 years)
had 25(OH)D levels below 20 ng/mL (50 nmol/L) [1]. This degree of vitamin D deficiency may contribute to the
development of osteoporosis and an increased risk of fractures and falls in the elderly. Vitamin D may also regulate many
other cellular functions.
This topic review provides an overview of vitamin D. Other reviews discuss specific issues related to vitamin D:
(See "Causes of vitamin D deficiency and resistance".)
(See "Overview of rickets in children" and "Etiology and treatment of calcipenic rickets in children".)
(See "Epidemiology and etiology of osteomalacia" and "Clinical manifestations, diagnosis, and treatment of
osteomalacia".)
(See "Vitamin D deficiency in adults: Definition, clinical manifestations, and treatment" and "Vitamin D insufficiency
and deficiency in children and adolescents".)
(See "Vitamin D and extraskeletal health".)
(See "Calcium and vitamin D supplementation in osteoporosis".)
CHEMISTRY Vitamin D, or calciferol, is a generic term and refers to a group of lipid soluble compounds with a fourringed cholesterol backbone. 25-hydroxyvitamin D (25[OH]D) is the major circulating form of vitamin D. It has a half-life of
two to three weeks, compared with 24 hours for parent vitamin D [2]. It has activity at bone and intestine, but is less than 1
percent as potent as 1,25-dihydroxyvitamin D, the most active form of vitamin D. The half-life of 1,25-dihydroxyvitamin D is
approximately four to six hours. 1,25-dihydroxyvitamin D binds to intracellular receptors in target tissues and regulates
gene transcription [3]. It appears to function through a single vitamin D receptor (VDR), which is nearly universally
expressed in nucleated cells. The receptor is a member of the class II steroid hormone receptor, and is closely related to
the retinoic acid and thyroid hormone receptors [4]. Its most important biological action is to promote enterocyte
differentiation and the intestinal absorption of calcium. Other effects include a lesser stimulation of intestinal phosphate
absorption, direct suppression of parathyroid hormone (PTH) release from the parathyroid gland, regulation of osteoblast
function, and permissively allowing PTH-induced osteoclast activation and bone resorption (figure 1).
SOURCES Very few foods naturally contain vitamin D (fatty fish livers are the exception); dermal synthesis is the major
natural source of the vitamin. Previtamin D3 is synthesized nonenzymatically in skin from 7-dehydrocholesterol during
exposure to the ultraviolet (UV) rays in sunlight. Previtamin D3 undergoes a temperature-dependent rearrangement to
form vitamin D3 (cholecalciferol) (figure 1). This system is exceedingly efficient, and it is estimated that brief casual
exposure of the arms and face is equivalent to ingestion of 200 international units per day [5]. However, the length of daily
exposure required to obtain the sunlight equivalent of oral vitamin D supplementation is difficult to predict on an individual
basis and varies with the skin type, latitude, season, and time of day [6,7]. Prolonged exposure of the skin to sunlight does
not produce toxic amounts of vitamin D3 because of photoconversion of previtamin D3 and vitamin D3 to inactive
metabolites (lumisterol, tachysterol, 5,6-transvitamin D, and suprasterol 1 and 2) [8,9]. In addition, sunlight induces
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FGF23 inhibits renal production of 1,25-dihydroxyvitamin D by limiting 1-alpha-hydroxylase activity in the renal proximal
tubule and by simultaneously increasing expression of 24-alpha-hydroxylase and production of 24,25-dihydroxyvitamin D
(an inactive metabolite) [24]. 1,25-dihydroxyvitamin D stimulates FGF23, a phosphaturic hormone, creating a feedback
loop. Experimental data suggest that FGF23 decreases renal reabsorption of phosphate, and thereby counteracts the
increased gastrointestinal phosphate reabsorption induced by 1,25-dihydroxyvitamin D, maintaining phosphate
homeostasis [25].
Both 1,25-dihydroxyvitamin D and 25(OH)D are degraded in part by hydroxylation by a 24-hydroxylase [11,17]. The activity
of the 24-hydroxylase gene is increased by 1,25-dihydroxyvitamin D, which therefore promotes its own inactivation, and
decreased by PTH, thereby allowing more active hormone to be formed [17].
REQUIREMENTS
Adequate intake In 2010, the Institute of Medicine (IOM) released a report on dietary intake requirements for calcium
and vitamin D (table 1) [26]. Its Recommended Dietary Allowance (RDA) of vitamin D for children 1 to 18 years and adults
through age 70 years is 600 international units (15 mcg) daily. Its RDA is 800 international units (20 mcg) daily after age 71
years [26]. For pregnant and lactating mothers, it recommends 600 international units (15 mcg) per day. The intake can be
provided in the diet or as a vitamin D supplement. Vitamin D intake is often low in older adults, who also do not have
regular effective sun exposure. Thus, for older adults, we suggest supplementation with 600 to 800 international units of
vitamin D daily. Older persons confined indoors and other high risk groups may have low serum 25-hydroxyvitamin D
(25[OH]D) concentrations at this intake level and may require higher intakes (See "Vitamin D deficiency in adults:
Definition, clinical manifestations, and treatment", section on 'Groups at high risk for suboptimal intake'.)
The estimated adequate intake for infants up to 12 months is 400 international units (10 mcg) daily (table 2). Vitamin D
supplementation should be given to infants who are exclusively breast fed, because the vitamin D content of human milk is
low. The Lawson Wilkins Pediatric Endocrine Society also recommends supplementation with 400 international units daily
of vitamin D beginning within days of birth for infants who are exclusively breast-fed [27]. Most infant formulas contain at
least 400 units/L of vitamin D, so formula-fed infants will also require supplementation to meet this goal, unless they
consume at least 1000 mL daily of formula. Vitamin D intake of at least 400 units/day is also recommended for children
who do not consume at least one liter of vitamin D-fortified milk daily [27]. (See "Vitamin D insufficiency and deficiency in
children and adolescents", section on 'Prevention'.)
The recommendations for dietary vitamin D intake were based upon the beneficial effects of calcium and vitamin D on
skeletal health (see "Calcium and vitamin D supplementation in osteoporosis", section on 'Efficacy'). The evidence
supporting a benefit of vitamin D on extraskeletal outcomes was inconsistent, inconclusive as to causality, and insufficient,
and therefore was not used as a basis for dietary reference intake development [28]. (See "Vitamin D and extraskeletal
health".)
Estimates of vitamin D requirements vary and depend in part upon sun exposure and the standards used to define a
deficient state. The IOM committee assumed minimal sun exposure when establishing the dietary reference intakes for
vitamin D. Casual exposure to sunlight provides amounts of vitamin D that are adequate to prevent rickets in many people,
but is influenced by geographic location, season, use of sun block lotion, and skin pigmentation [29]. (See "Vitamin D
insufficiency and deficiency in children and adolescents", section on 'Decreased synthesis'.)
Vitamin D requirements also may depend on disease states and concomitant medications. As an example, patients
undergoing long-term treatment with glucocorticoids may benefit from higher levels of supplementation of vitamin D and
calcium. (See "Prevention and treatment of glucocorticoid-induced osteoporosis", section on 'Calcium and vitamin D'.)
Optimal serum 25-hydroxyvitamin D The best laboratory indicator of vitamin D adequacy is the serum 25(OH)D
concentration [30]. The lower limit of normal for 25(OH)D levels varies depending on the geographic location and sunlight
exposure of the reference population (range 8 to 15 ng/mL). However, there is no consensus on the optimal 25(OH)D
concentration for skeletal or extraskeletal health. The IOM concluded that a serum 25(OH)D concentration of 20 ng/mL (50
nmol/L) is sufficient for most individuals [2], but other experts (Endocrine Society, National Osteoporosis Foundation
[NOF], International Osteoporosis Foundation [IOF], American Geriatrics Society [AGS]) suggest that a minimum level of
30 ng/mL (75 nmol/L) is necessary in older adults to minimize the risk of falls and fracture [31-35]. The serum parathyroid
hormone (PTH) level typically is inversely related to 25(OH)D levels in adults, and may be a useful secondary indicator of
vitamin D insufficiency. In general, this relationship is weak for children. Controversies surrounding the optimal serum
25(OH)D concentration are reviewed separately. (See "Vitamin D deficiency in adults: Definition, clinical manifestations,
and treatment", section on 'Defining vitamin D sufficiency'.)
DEFICIENCY AND RESISTANCE Vitamin D deficiency or resistance is caused by one of four mechanisms (see
"Causes of vitamin D deficiency and resistance"):
Impaired availability of vitamin D, secondary to inadequate dietary vitamin D, fat malabsorptive disorders, and/or lack
of sunlight (photoisomerization)
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they answer the four or five key questions a patient might have about a given condition. These articles are best for patients
who want a general overview and who prefer short, easy-to-read materials. Beyond the Basics patient education pieces
are longer, more sophisticated, and more detailed. These articles are written at the 10th to 12th grade reading level and are
best for patients who want in-depth information and are comfortable with some medical jargon.
Here are the patient education articles that are relevant to this topic. We encourage you to print or e-mail these topics to
your patients. (You can also locate patient education articles on a variety of subjects by searching on patient info and the
keyword(s) of interest.)
Basics topics (see "Patient information: Vitamin D deficiency (The Basics)" and "Patient information: Calcium and
vitamin D for bone health (The Basics)" and "Patient information: Vitamin D for babies and children (The Basics)")
Beyond the Basics topics (see "Patient information: Vitamin D deficiency (Beyond the Basics)" and "Patient
information: Calcium and vitamin D for bone health (Beyond the Basics)")
SUMMARY AND RECOMMENDATIONS
Very few foods naturally contain vitamin D; fatty fish and eggs are the exceptions. Dermal synthesis and foods
fortified with vitamin D are the major sources of the vitamin. (See 'Sources' above.)
Vitamin D3 (cholecalciferol) is synthesized nonenzymatically in skin from 7-dehydrocholesterol during exposure to the
ultraviolet (UV) rays in sunlight. Vitamin D3 from the skin or diet must be 25-hydroxylated in the liver, then 1hydroxylated in the kidneys to the active form, 1,25-dihydroxycholecalciferol (calcitriol) (figure 1). (See 'Metabolism'
above.)
The Recommended Dietary Allowance (RDA) for vitamin D is 600 international units (units) daily for adults through
age 70 years and for children 1 to 18 years of age (table 2). For adults 71 years and older, 800 units (20 micrograms)
daily is recommended for the prevention and treatment of osteoporosis. Vitamin D intake and effective sun exposure
are often inadequate in older adults. In older adults, particularly those at increased risk of falls and fracture, we
suggest supplementation with vitamin D (Grade 2B). We administer 600 to 800 international units daily. (See
'Requirements' above and "Calcium and vitamin D supplementation in osteoporosis".)
Vitamin D deficiency can be caused by unusually low sun exposure combined with lack of vitamin D-fortified foods or
malabsorption. Alternatively, impaired hydroxylation of vitamin D in liver or kidney can prevent metabolism into the
physiologically active form. Rarely, genetic defects may cause the end organs to be unresponsive to vitamin D, as in
hereditary vitamin D-resistant rickets (HVDRR). (See 'Deficiency and resistance' above and "Causes of vitamin D
deficiency and resistance".)
Vitamin D intoxication generally occurs after inappropriate use of vitamin D preparations. Prolonged exposure of the
skin to sunlight does not produce toxic amounts of vitamin D3 because of photoconversion of previtamin D3 and
vitamin D3 to inactive metabolites. Symptoms of acute intoxication are due to hypercalcemia and include confusion,
polyuria, polydipsia, anorexia, vomiting, and muscle weakness. Long-term intoxication can cause bone
demineralization and pain. In children, the hypercalcemia can cause brain injury. (See 'Excess' above and
"Diagnostic approach to hypercalcemia" and "Treatment of hypercalcemia".)
The Institute of Medicine (IOM) has defined the "tolerable upper intake level" (UL) for vitamin D as 100 micrograms
(4000 units) daily for healthy adults and children 9 to 18 years (table 2). The UL for infants and children up to nine
years old is lower. (See 'Excess' above.)
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REFERENCES
1. Forrest KY, Stuhldreher WL. Prevalence and correlates of vitamin D deficiency in US adults. Nutr Res 2011; 31:48.
2. http://books.nap.edu/openbook.php?record_id=13050 (Accessed on December 08, 2010).
3. Lowe KE, Maiyar AC, Norman AW. Vitamin D-mediated gene expression. Crit Rev Eukaryot Gene Expr 1992; 2:65.
4. DeLuca HF. Overview of general physiologic features and functions of vitamin D. Am J Clin Nutr 2004; 80:1689S.
5. Haddad JG. Vitamin D--solar rays, the Milky Way, or both? N Engl J Med 1992; 326:1213.
6. Terushkin V, Bender A, Psaty EL, et al. Estimated equivalency of vitamin D production from natural sun exposure
versus oral vitamin D supplementation across seasons at two US latitudes. J Am Acad Dermatol 2010; 62:929.e1.
7. Binkley N, Novotny R, Krueger D, et al. Low vitamin D status despite abundant sun exposure. J Clin Endocrinol
Metab 2007; 92:2130.
8. Holick MF. Vitamin D: A millenium perspective. J Cell Biochem 2003; 88:296.
9. Holick MF, MacLaughlin JA, Doppelt SH. Regulation of cutaneous previtamin D3 photosynthesis in man: skin
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41. Morgan SL, Weinsier RL. Fundamentals of clinical nutrition, Mosby, St. Louis 1998. p.3.
42. Jacobus CH, Holick MF, Shao Q, et al. Hypervitaminosis D associated with drinking milk. N Engl J Med 1992;
326:1173.
43. Vogiatzi MG, Jacobson-Dickman E, DeBoer MD, Drugs, and Therapeutics Committee of The Pediatric Endocrine
Society. Vitamin D supplementation and risk of toxicity in pediatrics: a review of current literature. J Clin Endocrinol
Metab 2014; 99:1132.
44. Nair-Shalliker V, Clements M, Fenech M, Armstrong BK. Personal sun exposure and serum 25-hydroxy vitamin D
concentrations. Photochem Photobiol 2013; 89:208.
45. Barger-Lux MJ, Heaney RP. Effects of above average summer sun exposure on serum 25-hydroxyvitamin D and
calcium absorption. J Clin Endocrinol Metab 2002; 87:4952.
46. Wortsman J, Matsuoka LY, Chen TC, et al. Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr 2000;
72:690.
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GRAPHICS
Pathways of vitamin D synthesis
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Vitamin D
Estimated
average
Recommended
dietary
Upper
level
Estimated
average
Recommended
dietary
Upper
level
requirement
(mg/day)
allowance
(mg/day)
intake
(mg/day)
requirement
(IU/day)
allowance
(IU/day)
intake
(IU/day)
Infants 0 to 6
months
1000
1000
Infants 6 to 12
months
1500
1500
1 to 3 years old
500
700
2500
400
600
2500
4 to 8 years old
800
1000
2500
400
600
3000
9 to 13 years old
1100
1300
3000
400
600
4000
14 to 18 years old
1100
1300
3000
400
600
4000
19 to 30 years old
800
1000
2500
400
600
4000
31 to 50 years old
800
1000
2500
400
600
4000
51 to 70 year old
males
800
1000
2000
400
600
4000
51 to 70 year old
females
1000
1200
2000
400
600
4000
1000
1200
2000
400
800
4000
14 to 18 years
1100
1300
3000
400
600
4000
800
1000
2500
400
600
4000
old,
pregnant/lactating
19 to 50 years
old,
pregnant/lactating
* For infants, adequate intake is 200 mg/day for 0 to 6 months of age and 260 mg/day for 6 to 12 months of
age.
For infants, adequate intake is 400 IU/day for 0 to 6 months of age and 400 IU/day for 6 to 12 months of age.
Modified with permission from: Dietary Reference Intakes: The Essential Guide to Nutrient Requirements. Otten
JJ, Hellwig JP, Meyers LD (Eds), The National Academies Press, Washington, DC 2006. pp.530-541. Copyright
2006, National Academy of Sciences.
Sources: Dietary reference intakes for Thiamin, Riboflavin, Niacin, Vitamin B 6 , Folate, Vitamin B 12 , Panthothenic
acid, Biotin, and Choline (1998); Dietary reference intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids
(2000); Dietary Reference Intake reports of the Food and Nutrition Board, Institute of Medicine (2010). These
reports may be accessed via www.nap.edu.
Graphic 71669 Version 9.0
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Nutrient
RDA*/AI
UL
Micrograms daily
Micrograms daily
Age group
Adverse
effects of
excess
Vitamin A
1 mcg retinol
activity eqivalent
= 3.3 unit
vitamin A
Infants
0 to 6 months
400
600
7 to 12 months
500
600
1 to 3 years
300
600
4 to 8 years
400
900
9 to 13 years
600
1700
14 to 18 years
900
2800
19 years
900
3000
9 to 13 years
600
1700
14 to 18 years
700
2800
19 years
700
3000
<18 years
750
2800
19 years
770
3000
<18 years
1200
2800
19 years
1300
3000
Ataxia, alopecia,
hyperlipidemia,
hepatotoxicity,
bone and muscle
pain; teratogenic
Children
Males
Females
Pregnancy
Lactation
Vitamin D
Micrograms daily
(calciferol)
1 mcg calciferol
= 40 int. unit
Micrograms daily
Infants
0 to 12 months
0 to 6 months: 25
(1000 int. unit)
6 to 12 months: 37.5
(1500 int. unit)
Hypercalcemia,
hypercalciuria,
polydipsia,
polyuria, confusion,
anorexia, vomiting,
bone
demineralization
1 to 3 years: 62.5
(2500 int. unit)
4 to 8 years: 75
(3000 int. unit)
9 to 18 years: 100
(4000 int. unit)
50 to 70 years
15
100
>70 years
100
Vitamin E
(alpha-
Milligrams daily
Milligrams daily
Increased risk of
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tocopherol)
1 mg = 1.47 int.
unit "natural
source" vitamin
E, or 2.2 int.
unit synthetic
vitamin E
bleeding; possibly
Infants
0 to 6 months
ND
7 to 12 months
ND
1 to 3 years
200
4 to 8 years
300
Children
increased risk of
necrotizing
enterocolitis in
infants
11
600
14 to 18 years
15
800
>18 years
15
1000
18 years
19
800
>19 years
19
1000
Lactation
Vitamin K
Micrograms daily
Micrograms daily
Infants
No adverse effects
associated with
vitamin K
0 to 6 months
ND
7 to 12 months
2.5
ND
1 to 3 years
30
ND
consumption from
food or
supplements have
been reported,
however data are
4 to 8 years
55
ND
limited
9 to 13 years
60
ND
14 to 18 years
75
ND
>19 years
120
ND
Children
Males
60
ND
14 to 18 years
75
ND
>19 years
90
ND
Vitamin A doses given as retinol activity equivalents (RAE). 1 RAE = 1 mcg retinol, 12 mcg beta-carotene,
14 mcg alpha-carotene, or 24 mcg beta-cryptoxanthin.
RDA: recommended dietary allowance; AI: adequate intake; UL: upper tolerable level.
* The RDA is the level of dietary intake that is sufficient to meet the daily nutrient requirements of 97 percent of
the individuals in a specific life stage group.
The AI represents an approximation of the average nutrient intake that sustains a defined nutritional state,
based on observed or experimentally determined values in a defined population.
The UL is the maximum level of daily nutrient intake that is likely to pose no risk of adverse health effects in
almost all individuals in the specified life-stage or gender group.
Modified with permission from: Dietary Reference Intakes: The Essential Guide to Nutrient Requirements. Otten
JJ, Hellwig JP, Meyers LD (Eds), The National Academies Press, Washington, DC 2006. pp.530-541. Copyright
2006, National Academy of Sciences.
Sources: Dietary reference intakes for Thiamin, Riboflavin, Niacin, Vitamin B 6 , Folate, Vitamin B 12 , Panthothenic
acid, Biotin, and Choline (1998); Dietary reference intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids
(2000); Dietary Reference Intake reports of the Food and Nutrition Board, Institute of Medicine (2010). These
reports may be accessed via www.nap.edu.
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Disclosures
Disclosures: Sassan Pazirandeh, MD Nothing to disclose. David L Burns, MD Nothing to disclose.
Kathleen J Motil, MD, PhD Consultant/Advisory Boards: NPS Pharmaceuticals [Short gut syndrome
(Teduglutide)]. Marc K Drezner, MD Nothing to disclose. Jean E Mulder, MD Employee of
UpToDate, Inc.
Contributor disclosures are reviewed for conflicts of interest by the editorial group. When found, these
are addressed by vetting through a multi-level review process, and through requirements for
references to be provided to support the content. Appropriately referenced content is required of all
authors and must conform to UpToDate standards of evidence.
Conflict of interest policy
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