Fourth Edition Chapter 2 Innate Immunity: The Immediate Response to Infection
Copyright Garland Science 2015
CHAPTER CONTENTS 2-1
2-2 2-3 2-4 2-5 2-6
Physical barriers colonized by commensal
microorganisms protect against infection by pathogens Intracellular and extracellular pathogens require different types of immune response Complement is a system of plasma proteins that mark pathogens for destruction At the start of an infection, complement activation proceeds by the alternative pathway Regulatory proteins determine the extent and site of C3b deposition Phagocytosis by macrophages provides a first line of cellular defense against invading microorganismstes
CHAPTER CONTENTS 2-7
The terminal complement proteins lyse
pathogens by forming membrane pores 2-8 Small peptides released during complement activation induce local inflammation 2-9 Several classes of plasma protein limit the spread of infection 2-10 Antimicrobial peptides kill pathogens by perturbing their membranes 2-11 Pentraxins are plasma proteins of innate immunity that bind microorganisms and target them to phagocytes
Innate Immunity: the Immediate
Response to Infection 2-1
Physical barriers colonized by commensal
microorganisms protect against infection by pathogens
2-1 Physical barriers colonized by commensal microorganisms
protect against infection by pathogens
Innate Immunity: the Immediate
Response to Infection 2-2
Intracellular and extracellular pathogens
require different types of immune response
2-2 Intracellular and extracellular pathogens require different types
of immune response
Innate Immunity: the Immediate
Response to Infection 2-3
Complement is a system of plasma proteins
that mark pathogens for destruction
2-3 Complement is a system of plasma proteins that mark pathogens
for destruction
2-3 Complement is a system of plasma proteins that mark pathogens
for destruction
2-3 Complement is a system of plasma proteins that mark pathogens
for destruction
Innate Immunity: the Immediate
Response to Infection 2-4
At the start of an infection, complement
activation proceeds by the alternative pathway
2-4 At the start of an infection, complement activation proceeds by
the alternative pathway
2-4 At the start of an infection, complement activation proceeds by
the alternative pathway
2-4 At the start of an infection, complement activation proceeds by
the alternative pathway
Innate Immunity: the Immediate
Response to Infection 2-5
Regulatory proteins determine the extent and
site of C3b deposition
2-5 Regulatory proteins determine the extent and site of C3b
deposition
Innate Immunity: the Immediate
Response to Infection 2-6
Phagocytosis by macrophages provides a first
line of cellular defense against invading microorganisms
2-6 Phagocytosis by macrophages provides a first line of cellular
defense against invading microorganisms
Innate Immunity: the Immediate
Response to Infection 2-7
The terminal complement proteins lyse
pathogens by forming membrane pores
2-7 The terminal complement proteins lyse pathogens by forming
membrane pores
2-7 The terminal complement proteins lyse pathogens by forming
membrane pores
2-7 The terminal complement proteins lyse pathogens by forming
membrane pores
2-7 The terminal complement proteins lyse pathogens by forming
membrane pores
2-7 The terminal complement proteins lyse pathogens by forming
membrane pores
2-7 The terminal complement proteins lyse pathogens by forming
membrane pores
Innate Immunity: the Immediate
Response to Infection 2-8
Small peptides released during complement
activation induce local inflammation
2-8 Small peptides released during complement activation induce
local inflammation
Innate Immunity: the Immediate
Response to Infection 2-9
Several classes of plasma protein limit the
spread of infection
2-9 Several classes of plasma protein limit the spread of infection
Innate Immunity: the Immediate
Response to Infection 2-10 Antimicrobial peptides kill pathogens by perturbing their membranes
2-10 Antimicrobial peptides kill pathogens by perturbing their
membranes
2-10 Antimicrobial peptides kill pathogens by perturbing their
membranes
2-10 Antimicrobial peptides kill pathogens by perturbing their
membranes
2-10 Antimicrobial peptides kill pathogens by perturbing their
membranes
2-10 Antimicrobial peptides kill pathogens by perturbing their
membranes
Innate Immunity: the Immediate
Response to Infection 2-11 Pentraxins are plasma proteins of innate immunity that bind microorganisms and target them to phagocytes
2-11 Pentraxins are plasma proteins of innate immunity that bind