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Questions
z Do commensal /probiotic microbes have
environmental antigens
suppression of inflammation
diminished cellular immune response
prevention of harmful mucosal immune Th1
delayed hypersensitivity reactions
z Specialized responses:
co existence with commensals
containment of potential pathogens
Infection control
immune response.
leucocytes,
discriminative
activation of CaCO-2
cells was observed
between
enteropathogenic E
coli and nonpathogenic bacteria
IL-4
IFN-
Inflammation/ tolerance
Infection
Percent
50
40
CD8 RA
CD8 RO
30
20
10
0
Lacto
S. Epi
p=0.02
GBBS
% Activation
100
80
60
Term
40
Preterm
20
0
IL-6
IL-8
E Coli
IL-6
IL-8
LP 299v
% Activation
100
80
60
Term
40
Preterm
20
0
IL-10
IL-12
E Coli
IL-10
IL-12
LP 299v
Agarwal R, J Pediatr
Gastroenterol Nutr.
2003
Baseline
Post Treatment
20
K
19
g
18
17
16
#1 #2 13 20 34 89 116 142
Non Responders
8
7
6
5
4
3
2
1
0
1 2 3 4 5
1: p=0.003
2: p=0.024
3: p=0.05
4: p=0.049
5: p=0.016
1 2 3 4 5
RESPONDERS
NON RESPONDERS
14
* p=0.01
12
10
8
6
4
2
0
-2
1 2 3 4 5
1 2 3 4 5
MONTHS ON TREATMENT
Pre
Post
CPM
P<0.01
3500
3000
2000
60000
1500
40000
1000
20000
500
0
Lp299v
PHA
CPM
80000
2500
CPM
100000
Percent Positive
CD69 Expression
120
100
80
60
40
20
0
Controls
HIV+
NK
NK Bright
NKT
Percent
Activated
HIV+ Children
90
80
70
60
50
40
30
20
10
0
#1
#2
#3
CD3
NK
NK Bright
NKT
Conclusions
z
Specific? Regulatory?
Collaborators
NYC: Neonatal Studies
z Mirjana Nesin, MD
z AMF Tatad, MD ( Fellow,
Neonatology)
z John Peoples, BS
(CUMC Class of 2005)
z S.Cheung, BS
z Mohamed Mohamed, MD
(Fellow, Neonatology)
z Maciej Simm, BS
z A. Krauss, MD