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SHORT REPORT
Abstract
Two hundred and twenty nine patients
with generalised tonic-clonic seizures
were prospectively evaluated. Fourteen
were identified who had transient focal
neurological deficits thought to be Todd's
post-epileptic paralysis (PEP). Eight of
these 14 patients had underlying focal
brain lesions associated with the postictal
deficits. All patients with PEP were weak,
but there was wide variation in the pattern (any combination of face, arm, leg),
severity (plegia to mild), tone (spastic,
flaccid, or normal), and reflexes
(increased, decreased, or normal). Significant sensory loss occurred in only one
patient. The only other signs of PEP were
aphasia (in five patients all with underlying lesions) and gaze palsy (in four
patients). Post-epileptic paralysis persisted from half an hour to 36 hours (mean of
15 hours). Post-epileptic paralysis may
occur with the first seizure or after many
years of seizures and does not appear
after every seizure. The clinical features
of PEP are thus heterogeneous.
Houston Veterans
Affairs Medical Center
and Baylor College of
Medicine, Houston,
Texas, USA
L A Rolak
P Rutecki
T Ashizawa
Y Harati
Correspondence to:
Dr Rolak, Department of
Neurology, Baylor College of
Medicine, 6501 Fannin,
NB302, Houston, Texas
77030, USA
Received 18 February 1991.
Accepted 2 May 1991
Results
Two hundred and twenty nine patients (all
men, mean age 46 years) presented with generalised tonic-clonic seizures, of whom 14
(mean age 47 years) had transient focal postictal deficits (PEP). Their clinical features are
summarised in the table. Eight of the 14
Bravais in 1827 first noted that paralysis may patients with PEP had an underlying structural
follow a unilateral seizure, a condition he lesion, which in each case was a pre-existing
termed hemiplegia epileptique.' Todd used the ischaemic stroke in the hemisphere consame term (epileptic hemiplegia), apparently
tralateral to the paralysis. All strokes were in
arrived at independently, in his 1854 descrip- the middle cerebral artery territory, affecting
tion.2 He noted that paralysis may occur on the frontal or temporal lobe. Only 51 of the 215
only one side even when both sides had been patients without PEP had structural lesions (X2
convulsed and that in contrast to the spasticity 769, p < 0-01). Altogether, 69 of the 229 had
expected from a central nervous system lesion, structural lesions and eight had PEP. All
the limbs were flaccid. By 1890, Hughlings patients with PEP had weakness, but it varied
Jackson had extended these observations and from very mild paresis to complete plegia. The
described post-epileptic aphasia, sensory loss, weakness involved any combination of face or
stupor, and mania.3 Since then post-epileptic arm or leg. The tone could be flaccid, normal, or
paralysis (PEP) has become a well accepted spastic, and the reflexes decreased, normal, or
syndrome, and numerous post-epileptic symp- increased. Very miniimal sensory deficits
toms have been reported, including hemia- occurred in eight patients but only one comnopsia,4 complete blindness,5 weakness,&-I plained of noticeable numbness. Five patients,
unilateral pupillary dilatation,"2 aphasia,'3 all with pre-existing left hemisphere strokes,
bulimia,'4 and prolonged confusion.'5 These developeui aphasia, which was fluent in one and
descriptions, however, are all in the form of non-fluent in four. The only other neurological
deficit seen in PEP was gaze palsy, in four
case reports, and there has never been a prospective, systematic analysis of PEP to describe patients.
Post-epileptic paralysis persisted from half
its fundamental clinical features, such as
incidence, physical findings, duration, and rela- an hour to 36 hours, with a mean of 15 hours.
tion to underlying pathology. Focal findings are The nature, duration, and severity of PEP were
especially vexing after generalised (as opposed unrelated to the duration or severity of the
to partial) seizures because there is often no seizures, the presence or absence of underlying
structural (focal) brain lesion to account for lesions, or any changes on the EEG. Weakness
them. We studied the clinical characteristics of always persisted longer than other symptoms.
Post-epileptic paralysis occurred sporadically
PEP after generalised tonic-clonic seizures.
64
Duration of
epilepsy (years)
Cause of
seizures
50
10
2
3
4
5
6
7
28
25
31
36
28
51
1st seizure
15
1
3
5
1st seizure
Alcohol
withdrawal
Idiopathic
Idiopathic
Idiopathic
Idiopathic
Idiopathic
Stroke
54
1st seizure
Stroke
48
Stroke
10
11
61
63
10
8
Stroke
Stroke
12
70
Stroke
13
47
Stroke
14
66
24
Stroke
Patient
1
Weakness
EEG
Severity
NL
0/5
4+/5
NL
NL
NL
NL
NL
Focal
theta
Focal
spikes
+ delta
Focal
spikes
+ delta
NL
Focal
theta
Focal
spikes
+ delta
Focal
spikes
+ theta
NL
Pattern
Tone
Duration of
PEP (hours)
Reflexes
Extensor plantar
Yes
Gaze palsy
NL
No
No
No
No
No
No
None
Numbness
None
None
None
Gaze palsy
36
4
24
24
18
6
No
Gaze palsy +
aphasia
12
Other signs
F, A, L
4/5
4/5
4+/5
3/5
4/5
A
A, L
F, A, L
A, L
A, L
A, L
NL
NL
NL
NL
0/5
A, L
4 + /5
NL
NL
No
Aphasia
24
4/5
4/5
F, A
L
NL
t
NL
No
No
Aphasia
Aphasia
36
8
0/5
F, A, L
No
Gaze palsy
4/5
A, L
NL
NL
No
None
05
4/5
A, L
Yes
Aphasia
It
T
T
I
t
NL
Discussion
Transient focal neurological deficits after an
epileptic seizure are often called Todd's
paralysis in recognition of their description by
the British neurologist Robert Todd.2 Since
then, research has focused primarily on possible mechanisms of post-epileptic paralysis,"6
but its clinical features have never been systematically studied, and there is almost no
information about the nature, duration, or
aetiology of the deficits that occur after a
seizure. Our conclusions about PEP are limited
by the population studied (adult male veterans)
and the restriction to generalised tonic-clonic
seizures without ictal focality. In this group,
PEP was a heterogeneous syndrome encompassing a variety of neurological signs including
aphasia, gaze palsy, weakness, and (rarely)
numbness. The motor deficits were highly
variable, from mild to severe, flaccid to spastic,
focal to hemiparetic. Abnormalities never
persisted beyond 36 hours. Most patients with
PEP had an underlying structural lesion but,
interestingly, in many (43%) no cause was
16 Tortella FC, Long JB. Endogenous anticonvulsant substance in rat cerebrospinal fluid after a generalized seizure.