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Women diagnosed with complete spinal cord injury (SCI) at T10 or higher
report sensations generated by vaginal-cervical mechanical self-stimulation
(VCSS). In this paper we review brain response to sexual arousal and
orgasm in such women, and further hypothesize that the afferent pathway
for this unexpected perception is provided by Vagus nerves, which bypass the
spinal cord. Using functional magnetic resonance imaging (fMRI), we ascer-
tained that the region of the medulla oblongata to which the vagus nerves
project (the Nucleus of the Solitary Tract or NTS) is activated by VCSS. We
also used an objective measure, VCSS-induced analgesia response to experi-
mentally-induced finger pain, to ascertain the functionality of this pathway.
During VCSS, several women experienced orgasms. Brain regions activated
during orgasm included the hypothalamic paraventricular nucleus, amyg-
dala, accumbens-bed nucleus of the stria terminalis-preoptic area, hippocam-
pus, basal ganglia (especially putamen), cerebellum, and anterior cingulate,
insular, parietal and frontal cortices, and lower brainstem (central gray, mes-
encephalic reticular formation, and NTS). We conclude that the vagus nerves
provide a spinal cord-bypass pathway for vaginal-cervical sensibility and
that activation of this pathway can produce analgesia and orgasm.
Key Words: brain imaging. fMRI, orgasm, spinal cord, vagina, Vagus nerves.
1
2 B. KOMISARUK & B. WHIPPLE
contains axons that convey pain impulses to the brain. In such cases as
the intractable pain of cancer, the spinothalamic tract may be thera-
peutically transected by surgery. For one noninjured male patient, this
procedure has been reported to block genitally stimulated orgasm
along with blocking the pain. His pain blockage persisted for several
months; when the pain reappeared, so did his genital orgasmic
response (Elliott, 1969).
Our hypothesis that the Vagus nerves provide an additional genital
sensory pathway in women is plausible as follows. Evidence for a
vaginocervical sensory role for the Vagus was first presented by Gue-
vara-Guzman and colleagues, based on their studies in the laboratory
rat (Ortega-Villalobos et al., 1990). They reported that the neural tracer,
horseradish peroxidase, when injected into the cervix, produced labeling
of neurons in the nodose ganglion, which is the dorsal root (i.e., sensory)
ganglion of the Vagus nerves. More recently, the innervation of the
uterus and cervix by the Vagus nerves in the rat was confirmed by
Papka and colleagues (Collins, Lin, Berthoud, & Papka, 1999).
Support for a vaginocervical sensory role for the Vagus nerves in the
rat was also provided by functional studies. Vagal electrical stimulation
has been shown to produce analgesia in rats (Maixner & Randich, 1984;
Ness, Randich, Fillingim, Faught, & Backensto, 2001; Randich & Geb-
hart, 1992) and in humans (Kirchner, Birklein, Stefan, & Handwerker,
2000), and we reported that vaginocervical probing in rats produces
analgesia even after combined bilateral transection of the known geni-
tospinal nerves (pudendal, pelvic, and hypogastric; Cueva-Rolon et al.,
1996). In the same individual rats (Cueva-Rolon et al., 1994), the anal-
gesia was abolished after subsequent bilateral transection of the Vagus
nerves. Furthermore, in a separate study in rats, we found that signifi-
cant pupil dilatation in response to vaginocervical stimulation per-
sisted, although at a diminished magnitude, after total surgical ablation
of the spinal cord at the midthoracic level (T7); subsequent bilateral
transection of the Vagus nerves at the subdiaphragmatic level abolished
that pupil dilatation response (Komisaruk, Bianca, et al.1996). Further-
more, electrical stimulation of the central end of the transected Vagus
nerves produced marked and immediate pupil dilatation (Bianca et al.,
1994; Komisaruk et al., 1995). In addition, Hubscher and Berkley (1994,
1995) reported that neurons of the Nucleus of the Solitary Tract (NTS)
in the medulla oblongata) in rats responded to mechanical stimulation
of the vagina, cervix, uterus, or rectum, and that vagotomy altered
these responses. Thus, various lines of evidence, both anatomical and
functional, support a genital sensory role for the Vagus nerves, at least
in the laboratory rat.
BRAIN MRI OF WOMEN DURING ORGASM 7
Figure 2. Activation of the NTS by cervical self-stimulation in five women with spinal
cord injury. (In this and the following figures, for clarity, the regions of interest have been
highlighted with outlining and/or arrows.) The level and completeness of the spinal cord
injury are specified below each image. The ASIA criteria signify the lowest dermatomal
level at which normal bilateral cutaneous (pinprick and/or cotton wisp) sensibility exists.
“A” signifies “complete” spinal cord injury (i.e., no sensation or voluntary movement below
that level, and no awareness of digital anal stimulation); “B” signifies “incomplete”
injury; in this case, there was no sensation or voluntary movement below the level of
injury, but there was awareness of digital anal stimulation. The label Neur is the more
stringent categorization of the injury that we used in our earlier study of women with
spinal cord injury (Komisaruk, Gerdes, et al., 1997)— that is, the lowest level at which
there was any sensation at all, rather than the ASIA criterion of the lowest level of “nor-
mal” sensation. In addition, the numbers “1” and “2” represent impaired and normal sen-
sibility, respectively. Thus, “1@T7” in the case of woman AN signifies that there was
impaired sensibility at T7, but no sensibility below T7, and “2@T7” in the case of partici-
pant VA signifies that there was normal sensibility at T7, but no sensibility below T7.
Both these women experienced an increase in pain detection threshold measured at the
fingers in response to VCSS — by 21.4% and 45.3%, respectively, over resting control lev-
els. Concurrently, tactile thresholds, measured at the hand using von Frey fibers,
remained unchanged.
stated that she had a sensation of “touch inside” and of vaginal muscle
contraction when the stimulator was inserted. EL showed an increase
in pain detection threshold of 39.6%. As indicated in Figure 2, some of
these women also experienced orgasms during VCSS while we were
recording their fMRI activity. This enabled us to observe regional brain
activity during VCSS prior to, during, and after the occurrence of
orgasm. Figure 3 provides an overall view of the brain at the beginning
of CSS compared with the activity at orgasm. Note the much greater
and widespread activation in the lower brainstem, forebrain, and cere-
bellum during orgasm. This pattern of widespread activation of the
brain during orgasm was a common observation in the women.
Figure 4 shows, at two different threshold imaging criteria (p < 0.05
and p < 0.01), that brain regions activated during orgasm included
10 B. KOMISARUK & B. WHIPPLE
Figure 3. Activity at sequential levels of the brain (“sections” in the frontal plane) during
cervical self-stimulation before, compared to during, orgasm.
The involvement of the amygdala in orgasm per se, more than its “sim-
ply” showing a sensory response to CSS, is evidenced in Figure 5. In this
case, CSS was applied continuously, generating multiple orgasms that
occurred during only the first 3 of the 5 min shown. The CSS was main-
tained during the entire 5 min. In this case, activation of the amygdala
occurred only during the 3 min when orgasms were occurring. During the
last 2 min, although CSS continued, both the activation of the amygdala
and the orgasms ceased. We concluded that the amygdala does not simply
respond sensorially to CSS, but instead its activation is concomitant with
vaginocervical-induced orgasm per se. It is not possible to discern from
this finding whether activation of amygdala is a cause or an effect of
orgasm, but it is possible to conclude that the amygdala is not simply a
sensory target region for genital afferent activity.
Figure 6 shows fMRI images at two different brain regions, the hypo-
thalamus (upper and lower images on the right) and anterior to that,
the preoptic and/or bed nucleus of the stria terminalis region (upper
and lower images on the left). The upper images show the fMRI activity
at orgasm; the lower images show the same activity superimposed on
the corresponding brain anatomy. Note the activation in the region of
the paraventricular nucleus of the hypothalamus, amygdala, cingulate
cortex, insular cortex, and region of the nucleus accumbens.
Figure 7 shows fMRI activity in the region of the paraventricular
nucleus of the hypothalamus during orgasm. The schematic view on the
right shows an artist’s diagram (Netter, 1986) of this region, locating
the paraventricular nucleus to the left and slightly below the anterior
commissure. The anatomical MRI image shows the comparable region,
Figure 5. Repeated “snapshots” of amygdala activity in a woman with spinal cord injury.
Note that the amygdala was activated only while orgasm was occurring, despite continu-
ous cervical self-stimulation.
12 B. KOMISARUK & B. WHIPPLE
Figure 10. Brain regions activated during orgasm generated by thought alone, without
physical stimulation.
Discussion
Tetel et al., 1993); and, based on local release of dopamine, the nucleus
accumbens (Pfaus, Damsma, Wenkstern, & Fibiger, 1995).
To our knowledge, we are the first to report activation of hypothala-
mus during orgasm in men or women. An earlier study of orgasm in
men, based on positron emission tomography (PET), reported activation
in prefrontal cortex, but not subcortical structures (Tiihonen, et al.,
1994). Also in men, using PET, Holstege and colleagues (Georgiadis et
al., 2002; Holstege et al., 2003) reported that the mesodiencephalic
area, cerebellum pontine reticular formation, basal ganglia (putamen
and claustrum), and several cortical regions, including the lateral pre-
frontal cortex but not the hypothalamus, were activated during orgasm.
In men during sexual arousal (but not orgasm) elicited by their viewing
photographs, Wallen and colleagues (Hamann, Herman, Nolan, & Wallen,
2002) reported that fMRI activity was increased relative to the activity in
women in the amygdala, hippocampus, and hypothalamus. Striatal
regions (caudate and nucleus accumbens) were activated in both men and
women. In a separate study (Karama et al., 2002), when the fMRI of men
and women were compared while they watched erotic film segments, the
men showed greater activity than the women in the hypothalamus and
thalamus. The level of hypothalamic activity correlated with the subjective
level of sexual arousal reported by the men. Brain regions activated in
both the men and women were the amygdala, ventral striatum, and the
following cortices: anterior cingulate, insular, orbitofrontal, medial pre-
frontal, and occipitotemporal. In an fMRI study of women observing erotic
visual stimuli (Park et al., 2001), activation was found in the thalamus,
striatum (caudate and globus pallidus), and the following cortical regions:
cingulate, insular, inferior temporal, inferior frontal, occipital, and corpus
callosum. The occipital cortex (visual cortex) was much more highly acti-
vated by the erotic than the nonerotic films.
There does not seem to be a simple means of accounting for the dif-
ferences in brain area activation reported among the various studies
summarized above. Although one could generate some “just-so” cogni-
tive neuroscience stories (e.g., different brain areas independently found
in other studies to be related to “emotional,” “expectancy,” “initiative,”
etc. responses), it seems more prudent to postpone such speculation
pending information generated by “differential diagnostic” types of
studies. We, however, not heeding this caveat, throw caution to the
winds and make the following speculations.
orgasm. This process occurs in three stages: The PVN neurons secrete
oxytocin, which is stored in the posterior pituitary gland (Cross & Wak-
erley, 1977); vaginal or cervical stimulation releases the oxytocin from
the posterior pituitary gland into the bloodstream, in the Ferguson
Reflex (Ferguson, 1941); orgasm releases the oxytocin into the blood-
stream (Blaicher et al., 1999; Carmichael, et al., 1987, 1994). Thus, it is
probable that this release of oxytocin is due to the activation of the PVN
observed at orgasm.
During orgasm, the insular cortex and anterior cingulate cortices are
active, as they have been reported to be during response to pain (Born-
hovd et al., 2002; Casey, Morrow, Lorenz, & Minoshima, 2001; Ploner,
Gross, Timmermann, & Schnitzler, 2002). These reports suggest an
interesting local interaction between regions of the brain. Further
research is needed to compare, within the same individual, brain
regions activated during pleasure with those activated during pain (i.e.,
a “differential diagnosis” study). The region of the nucleus accumbens
also showed activation during orgasm in the present study, suggesting
it has a role in mediating orgasmic pleasure in women. This brain
region has also been reported to show fMRI activation during the “rush”
induced by an intravenous injection of nicotine (Stein et al., 1998).
Reliably, the cerebellum was activated during orgasm. The cerebel-
lum modulates muscle tension via the gamma efferent system, and it
receives proprioceptive information (Netter, 1986). Muscle tension can
reach peak levels during orgasm (Masters & Johnson, 1966) and con-
tribute to the sensory pleasure of orgasm (Komisaruk & Whipple,
1998, 2000). It is likely that the cerebellum thereby plays a significant
motoric role in orgasm; our present research makes it tempting to
speculate that it has a significant perceptual/cognitive-hedonic role in
orgasm.
& Will, 1997), in other cases they have been described as pleasurable.
One woman was reported to have refused anti-epileptic medication or
brain surgery because she enjoyed her orgasmic auras and did not want
them eliminated (Janszky et al., 2004).
An interesting and instructive observation in the case of these orgas-
mic auras is that they are not necessarily experienced as involving geni-
tal sensation. In contrast, other reports document epileptic seizures
originating in the sensory cortex, the region to which the genitalia pro-
ject. In the latter cases, the individuals reported an experience of geni-
tal sensation developing into an orgasm that feels as if it were indeed
generated by genital stimulation (e.g., Calleja et al., 1988).
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