The IR spectra of MEL sample (Fig.

3) showed bands at 1346, 3498, 1618, 3288 and

1529 cm2 attributing to sulphones, phenolic OH, carboxyl (C = O), -C-NH- and aromatic
ring respectively. The absorption bands remained unchanged in the solid dispersion sample.
The results were consistent with those of the thermal and X-ray diffraction studies and
confirmed the absence of any chemical interaction between MEL and polymer. (Shenoy dan
Pandey, 2008)
FT-IR spectra of meloxicam showed a distinct peak at 3291 cm1, 1620 cm1 (NH),
and 1580 cm1 (CO). The corresponding IR for PEG 6000 and SLS formulation (experiment
run number 54) showed broader peaks at 3384 cm1, 1631 cm1 (NH), and 1582 cm1 (CO).
Thus, it indicates that there is a physical interaction between meloxicam and the carrier
molecules; the shift in the bands may be due to overlapping of the hydroxyl bands (Dehgan
dan Jafar, 2006)
Figure 2 shows the IR spectra of meloxicam, PEG-4000, PVP K30, and their
formulations. IR spectrum of pure meloxicam showed characteristic peaks at 1620 cm-1
(C=O stretching), 3292 cm-1 (secondary -NH or OH) and some prominent bands such as
846 to 567 cm-1 (-CH aromatic ring bending and heteroaromatics) and 1346 to 1163 cm-1
(S=O stretching). (Barhate et al., 2009)
IR studies indicate that there is only physical entrapment of meloxicam with carrier
molecule (Saleem dan Bala, 2010)
FT-IR Analysis FT-IR spectroscopy detects the vibration characteristics of chemical
functional groups in a sample. When an infrared light interacts with the matter, chemical
bonds will stretch, contract and bend. Therefore, existence of any interaction can be exhibited
in order to investigate drugexcipient compatibility.14) According to the graphs of pure drugs
and their transdermal films (MX-HPMC-10 and LX-HPMC-10), drugs and transdermal film
excipients were chemically compatible (Figs. 2, 3). Changes in areas of peaks occur simply
due to mixing of components independent of any chemical interactions.
Characteristic bands of MX were observed at 1619.34 cm_1 (C_0 streching band),
16201420 cm_1 (C_C streching bands), 1550.511064.22 cm_1 (CN streching bands),
1302.38 cm_1 (NC streching band), 1290.98 cm_1 and 1162.571131.88 cm_1 (SO2
asymmetric and symmetric tension), 1044.20 cm_1 (aromatic CH streching band) and
855.98650 cm_1 (aliphatic CH vibrations) (Fig. 2a). CH, NH and OH streching bands
are also available at 3290.62 cm_1. Main bands of MX were detected with lower intensity
caused by PG in the spectrum of MX transdermal patch (Fig. 2b). Broader and sharp peaks
indicated secondary and tertiary hydroxyls of PG shealding MX peaks as expected from the
matrix structure of the film. However, streching bands and vibrations from MX can be seen in
this spectrum. A broader OH streching band and CH, NH and SH streching bands caused
by PG and MX were observed at 33003289.68 cm_1 and 2970.342878.07 cm_1.
Characteristic bands of pure LX were observed at 1645.96 cm_1 (C_0 streching band),
1619.50 (aromatic C_C streching band), 1500.93 cm_1 (aromatic C_C skeleton streching),
1381.05 cm_1 (NC streching band), 1340.91 cm_1 and 1144.75 cm_1 (SO2 asymmetric and

symmetric tension), 1325.361236.19 cm_1 (streching bands of aromatic amine), 1236.19

cm_1 (aromatic CH vibrations) and 764.87 cm_1 (CCl streching band) (Fig. 3a). CH, N
H and OH streching bands are also available at 3101.74 2875.27 cm_1. Main bands of LX
were also detected with lower intensity caused by PG in the spectrum of MX transdermal
patch (Fig. 3b). A broader OH streching band at 3341.62 cm_1 caused by PG can be seen in
the spectrum of LX transdermal patch. CH, NH and SH streching bands of LX with CH
and CC streching bands of PG were determined at 2971.582877.67 cm_1. Broader and
sharp peaks indicated secondary and tertiary hydroxyls of PG shealding LX peaks were as
detected at 1135.421020 cm_1.
CH streching bands caused by HPMC were detected at 33003289.68 cm_1 in both
of the transdermal film spectrums (Figs. 2b, 3b). ROR streching bands and vibrations
related to HPMC were not observed in the finger print area due to hydrophilic and lipophilic
residues of PG although their presence was known. Data obtained from the spectrums might
be indicated decrease in glass transition temperature, Tg, of HPMC.
PG was also thought to affect crystallization behaviours of drugs due to its hydrophilic
and lipophilic residues. These findings are supported in part by data obtained from DSC
experiments below (Yener et al., 2010

IR spektrum MEL sampel (Gambar. 3) menunjukkan band di 1346, 3498, 1618, 3288
dan 1529 cm2 menghubungkan ke sulfon, fenolik -OH, karboksil (C = O), masing-masing
-C-NH- dan cincin aromatik. Pita serapan tetap tidak berubah dalam sampel dispersi padat.
Hasilnya konsisten dengan studi termal dan difraksi sinar-X dan dikonfirmasi tidak adanya
interaksi kimia antara MEL dan polimer. (Shenoy Dan Pandey, 2008)

FT-IR spektrum meloxicam menunjukkan puncak yang berbeda di 3291 cm-1, 1620
cm-1 (NH), dan 1580 cm-1 (CO). Yang sesuai IR untuk PEG 6000 dan formulasi SLS
(percobaan menjalankan nomor 54) menunjukkan puncak yang lebih luas di 3384 cm-1, 1631
cm-1 (NH), dan 1582 cm-1 (CO). Dengan demikian, hal ini menunjukkan bahwa ada
interaksi fisik antara meloxicam dan molekul pembawa; pergeseran band mungkin karena
tumpang tindih band hidroksil (Dehgan Dan Jafar, 2006)

Gambar 2 menunjukkan spektrum IR meloxicam, PEG-4000, PVP K30, dan formulasi

mereka. spektrum IR meloxicam murni menunjukkan puncak karakteristik pada 1620 cm-1
(C = O peregangan), 3292 cm-1 (-NH sekunder atau -OH) dan beberapa band terkemuka
seperti 846-567 cm-1 (-CH cincin aromatik lentur dan heteroaromatics) dan 1346-1163 cm-1
(S = O peregangan). (Barhate et al., 2009)

Studi IR menunjukkan bahwa hanya ada jebakan fisik meloxicam dengan molekul
pembawa (Saleem Dan Bala, 2010)

spektroskopi FT-IR Analisis FT-IR mendeteksi karakteristik getaran dari kelompok

fungsional kimia dalam sampel. Ketika cahaya inframerah berinteraksi dengan masalah ini,
ikatan kimia akan meregangkan, kontrak dan tikungan. Oleh karena itu, adanya interaksi
apapun dapat dipamerkan dalam rangka untuk menyelidiki obat-eksipien compatibility.14)
Menurut grafik obat murni dan film transdermal mereka (MX-HPMC-10 dan LX-HPMC-10),
obat dan eksipien Film transdermal yang secara kimia kompatibel (Gambar. 2, 3). Perubahan
di daerah puncak terjadi hanya karena pencampuran komponen terlepas dari interaksi kimia.
band karakteristik MX yang diamati pada 1.619,34 cm_1 (C=0 streching band), 16201420 cm_1 (C=C streching band), 1.550,51-1064,22 cm_1 (C-N streching band), 1.302,38
cm_1 (N-C streching band), 1.290,98 cm_1 dan 1.162,57-1131,88 cm_1 (SO2 asimetris dan
simetris ketegangan), 1.044,20 cm_1 (aromatik C-H) dan 855,98-650 cm_1 (alifatik C-H
getaran) (Gambar. 2a). C-H, N-H dan O-H streching band juga tersedia di 3.290,62 cm_1.
band utama MX terdeteksi dengan intensitas yang lebih rendah disebabkan oleh PG di
spektrum MX patch transdermal (Gbr. 2b). puncak yang lebih luas dan tajam menunjukkan
hidroksil sekunder dan tersier dari PG shealding MX puncak seperti yang diharapkan dari
struktur matriks film. Namun, streching band dan getaran dari MX dapat dilihat pada

spektrum ini. Sebuah O-H streching Band yang lebih luas dan C-H, N-H dan S-H streching
band yang disebabkan oleh PG dan MX diamati pada 3300-3289,68 cm_1 dan 2.970,342878,07 cm_1.
band karakteristik murni LX diamati di 1.645,96 cm_1 (C_0 streching band), 1619,50
(aromatik C_C streching band), 1.500,93 cm_1 (C_C aromatik kerangka streching), 1.381,05
cm_1 (N-C streching band), 1.340,91 cm_1 dan 1.144,75 cm_1 (SO2 asimetris dan simetris
ketegangan), 1.325,36-1236,19 cm_1 (streching band amina aromatik), 1.236,19 cm_1
(aromatik C-H getaran) dan 764,87 cm_1 (C-Cl streching band) (Gambar. 3a). C-H, N-H dan
O-H streching band, juga tersedia di 3101.74- 2.875,27 cm_1. band utama LX juga terdeteksi
dengan intensitas yang lebih rendah disebabkan oleh PG di spektrum MX patch transdermal
(Gambar. 3b). Sebuah O-H streching Band yang lebih luas di 3.341,62 cm_1 disebabkan oleh
PG dapat dilihat dalam spektrum LX patch transdermal. C-H, N-H dan S-H streching band
dari LX dengan C-H dan C-C streching band dari PG ditentukan pada 2.971,58-2877,67
cm_1. Lebih luas dan puncak tajam menunjukkan hidroksil sekunder dan tersier dari PG
puncak shealding LX adalah sebagai terdeteksi pada 1.135,42-1020 cm_1.
C-H streching band yang disebabkan oleh HPMC terdeteksi pada 3300-3289,68 cm_1
di kedua spektrum Film transdermal (Gambar. 2b, 3b). R-O-R streching band dan getaran
yang berkaitan dengan HPMC tidak diamati di daerah sidik jari karena residu hidrofilik dan
lipofilik dari PG meskipun kehadiran mereka dikenal. Data yang diperoleh dari spektrum
mungkin diindikasikan penurunan suhu transisi gelas, Tg, dari HPMC.
PG juga diduga mempengaruhi perilaku kristalisasi obat karena residu hidrofilik dan
lipofilik nya. Temuan ini didukung sebagian oleh data yang diperoleh dari percobaan DSC
bawah (Yener et al., 2010