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a Proposed Solution
Marga Reimer
Philosophy, Psychiatry, & Psychology, Volume 17, Number 1,
March 2010, pp. 65-75 (Article)
Published by The Johns Hopkins University Press
DOI: 10.1353/ppp.0.0273
Treatment
Adherence in the
Absence of Insight:
A Puzzle and a
Proposed Solution
Marga Reimer
Ms. A
Ms. A complains to her doctor about a cold that
she just cant shake. Shes had it for months! Her
doctor diagnoses her with seasonal allergies and
recommends that she try some diphenhydramine
(Benadryl). Ms. A remains convinced that she
has a cold, not allergies, but decides to give the
diphenhydramine a try anyway. Perhaps it will
help with her cold symptoms (sniffles, sore throat,
headache). It does indeed help and eventually her
cold goes away. However, Ms. A continues
with the diphenhydramine because, when taken
before bedtime, it allows her to sleep through her
husbands incessant snoring.
Ms. B
Ms. B goes to a dermatologist for an Obagi
Blue Peel, as the local salon informed her that
such (chemical) peels should only be performed in
a doctors office. During the mandatory pretreatment consultation, the doctor diagnoses Ms. B
with acne, a common skin disease. He recommends that she hold off on the chemical peel and
try some Retin-A for her acne. Ms. B is convinced
that the doctor is wrong, teenagers get acnenot
grandmothers like herself. She might have a few
blemishes, but she certainly does not have a
skin disease. However, she really wants the
chemical peel (shes seen the before and after
Reimer / Insight 67
Mr. C
Mr. C, whos in the middle of a contentious
divorce, always seems to be irritable. In fact, as
he informs his doctor, hes been feeling really
grumpy for the past two or three years. The
doctor diagnoses Mr. C with dysthymia, chronic
low-grade depression. She does not prescribe
medication, but instead recommends that Mr. C
exercise daily and improve his diet (more fruits
and vegetables, less fast food). Mr. C does not
agree with the doctors diagnosis and jokingly
remarks, Im not depressed, I just have grumpy
old man syndrome. Still, he adheres to the doctors recommendation because he wants to be in
good physical shape when he starts dating again.
After about six weeks, Mr. Cs irritability gradually
starts to subside. Within the year, he is back to his
old self and feels great. He attributes his new
lease on life to the ego-boost of being in such
fantastic shape. He vows to eat healthy and take
regular exercise for the rest of his life.
Why Adhere?
Why do these patients adhere to treatment
when they do not believe they have the condition
for which the treatment has been prescribed? The
answer is straightforward. The patients in question
associate treatment adherence with some clearly
identifiable benefit. The benefit varies from patient
to patient. Ms. A is able to sleep through her husbands snoring, Ms. B no longer has any wrinkles
around her eyes, and Mr. C, because hes gotten
into such great shape, feels fantastic. These three
hypothetical cases illustrate a pervasive, rather
than isolated, phenomenon. It is a phenomenon
with which we are all familiar. The toddler who
reminds his mother that its time to give him some
Application to Cases
Involving Psychosis
Now lets turn to cases involving psychosis.
Some psychotic patients might take medication,
not because they believe they have the illness for
which the medication has been prescribed, but
simply because they want to be rid of their distressing thoughts and experiences. Perhaps they want
something to calm their nerves, something to
reduce the strain that they are currently experiencing (David 1990, 800). Even if a patient is
convinced that the voices are real, he might
nevertheless believe that, with treatment adherence, those voices will eventually go away, or at
least subside. Similar considerations might apply
to a patient unable to focus on anything other
than her colleagues plot to get her fired. Perhaps
if she adheres to the prescribed treatment, she will
regain her ability to concentrate on other matters.
Previous experience with treatment adherence
might well support, and thereby strengthen, such
beliefs.
In these sorts of cases, what we have are patients taking medicine prescribed for illnesses they
do not believe they have. It would be misleading
to say (echoing Amador) that we have patients
taking medicine for illnesses they do not believe
they have. Whereas a physician might say of her
psychiatric patient that he is taking medicine for
his mental illness, the patient himself might em-
Empirical Support
Fortunately, there is more than common sense
to support the idea that psychotic patients without
insight might adhere to treatment simply because
they perceive such adherence as somehow benefiting them. There are experimental data, gathered
over several decades, that suggest as much. Some
of the more revealing data are discussed in McEvoys (1998) The Relationship Between Insight
in Psychosis and Compliance with Medication.
Indeed, the data suggest that perceived (or anticipated) treatment benefit may be an even better
predictor of treatment adherence than insight.
Consider, for instance, the study by Irwin et al.
(1985), involving 33 patients with schizophrenia.
As McEvoy reports:
Neither acknowledgment of illness, factual understanding about the medications, nor prior experience
of extrapyramidal side-effects predicted consent vs.
refusal. Rather, patients perceived benefits from prior
antipsychotic treatment most powerfully predicted
Reimer / Insight 69
Practical Implications
As noted by Amador (2006), poor insight
into psychosis is among the best predictors of
treatment non-adherence. One might therefore
suppose that adherence could be increased simply
Reimer / Insight 71
Reimer / Insight 73
If the patient already accepts some such framework, why should the therapist encourage him
to reject it and replace it with her own? Because
her framework is right and the patients is
wrong? Because discussions regarding diagnosis
and treatment should be conducted within the
conceptual scheme endorsed by therapist rather
than the patient? But such questions raise the issue of arrogance.
It might initially be thought that, by adopting
some such alternative framework, the patient
is less likely to adhere to treatment. However,
as suggested above and reinforced below, this is
not obviously true. What is important is that the
therapist, in explaining treatment benefits, avoid
employing a framework that is flatly inconsistent
with that adopted by the patient.
Thus, even if it were possible to improve insight
into psychosis, it is far from obvious that doing
so for purposes of treatment adherence would be
a good (practical, ethically sound) idea.
This still leaves us with a pressing practical
problem: How to increase treatment adherence
among psychotic patients with poor insight. Much
has already been written on this topic, and the
consensus (if there is one) is that simplification of
dosing and supervision of adherence are crucial
(Amador 2006). The present paper suggests an
approach to increasing treatment adherence that
is compatible with this consensus. Mental health
Notes
1. But see Beck-Sander (1998) for some concerns
regarding this claim, as well as other claims having to
do with the theoretical value of the concept of insight
into psychosis.
2. A qualification is in order. Because neuroleptics
are associated with potentially serious side effects,
adherence is arguably rational only if the seriousness
of these side effects is outweighed by the increased
quality of life that would result from clearer thinking
and better sleep.
3. On Davids (1990) multidimensional model of
insight, insight includes both treatment adherence
and the ability to re-label pathological thoughts/experiences as such.
4. In fact, some of the evidence that seems to support
the hypothesis that insight predicts adherence might
be the result of conflating insight (awareness of illness)
with perceived benefit from/need for treatment. That
this is so is suggested by McEvoys summary of the data
discussed in his 1998 paper, where he writes (p. 299),
we have demonstrated the link that those patients
who deny illness or need for treatment are significantly
more likely to be among the group who noncomply
(emphasis added). The present paper suggests that there
is a theoretically and practically important distinction to
be drawn between awareness of illness and awareness
of benefit from (or need for) medication. For a similar
point, see Beck-Sander 1998.
5. Talk in terms of tendencies is important here.
A patient might recognize that treatment adherence is
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