PATHOPHYSIOLOGY

Predisposing Factors: Precpitating Factors:

-Advancing Age (>30 yrs old) -Multiparity (More than 3-5 pregnancies)
-Gender (Female) Idiopathic -Stress
-Early menstruation

Activation of Disruption of
SNS estrogen production
Increased
exposure to Potential injury to the
estrogen endometrial and
myometrial layer of the Secretion of
uterus. Norepinephrine Abrupt withdrawal
causes an increased
estrogen production

Proliferation of Repeated
cells in the uterus exposure to
stress

Overgrowth of the
endometrial lining Hyperstimulation
of SNS

Development of Increased uterine

fibroid tissues to contractility
different sites
within the uterus
 Myoma uteri

Subserous Intramural Submucous

Growth outside Develops inside Growth on the

folds of broad the organ endometrium
ligament

Obstruction on the
Obstruction in the Increased growth in the blood vessels of
omentum site give rise to the endometrium
obstruction within the
organ thus impeding blood Pain
flow and increasing
Ligament becomes congestion within the site.
thinner

Deterioration at the
Menorrhagia part of the fibroid and
endometrial lining

Sloughing off of
endometrial layers Dysmenorrhea
 Hypotension
Dizziness Severe Bleeding

Decreased Hemoglobin
Decreased Hematocrit
Fatigue
Anemia Activity Intolerance
Difficulty of Breathing
Confusion

If treated: If not treated

- Iron Supplements

- Blood Transfusion

- Antibiotics Severe bleeding Increase in tumor

size
- Radiation therapy
(in rare cases)
Obstructs other
organs

Good Prognosis
Decreased blood
Hypovolemic supply
Shock

Tissue hypoxia

Necrosis

Death Organ malfunction