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Belo Horizonte
2009
de
Ps-graduao
em
Cincias
da
Belo Horizonte
Faculdade de Medicina da UFMG
2009
DEDICATRIA
Agradecimentos
BENDITA A CURIOSIDADE
QUE SE CURVA SABEDORIA
DOS POVOS SOFREDORES
Prof. Dr. Carlos da Silva Lacaz
RESUMO
ABSTRACT
LOPES, O.C.C.V. Assessment of the Prevalence of Diarrhea in Patients with
HIV/Aids in a Reference Hospital in Belo Horizonte,2007. 96p. Dissertion
(Masters Degree). School of Medicine, Universidad Federal de Minas Gerais, Belo
Horizonte, 2009.
2007 in Hospital
Eduardo Menezes (Belo Horizonte, MG) were analyzed. 365 patients were included
in the study. RESULTS: Age ranged from 18 to 78 years, with a mean of 40.63
years. 253 cases (69.3%) were men. Mean hospitalization time was 28.04 1.72
days. During the hospitalizion, 55 (15.1%) deaths were observed. The main mode of
infection was heterosexual sex transmission. 117 (32.05%) patients had diarrhea, of
which 48 (41.03%) had chronic diarrhea. The main etiological agent was
Cryptosporidium, seen in 12.0% of all cases. Adhesion to therapy and atazanavir
were protecting factors for the development of diarrhea. Diarrhea led to longer
hospitalization times. CONCLUSION: Diarrhea is an important cause of morbidity in
patients with HIV. Diarrhea was associated with worse adherence to therapy.
LISTA DE ILUSTRAES
LISTA DE TABELAS
LISTA DE ABREVIATURAS
3TC
- Lamivudina
ADN
- cido desoxirribonuclico
ADT
AIDS
ARN
- cido ribonuclico
ARV
- Antirretrovirais
AZT
- Zidovudina
CD4
CMV
- Citomegalovrus
DDC
- Zalcitabina
DDI-
Didanosina
DLV
- Delavirdina
DPOC
EAEC
EFV
- Efavirenz
HEM
HIV
I. C.
- Intervalo de confiana
I.O.
- Infeco oportunista
IL
Interleucina
IP
- Inibidor de protease
ITRN
ITRNN
LOG
- Logaritmo
MAC
MAI
- Mycobacterium avium-intracellulare
MEC
MS
- Ministrio da Sade
NFV
-Nelfinavir
NVP
- Nevirapina
OMS
PCP
PCR
- Protena C reativa
R.R.
- Risco relativo
RTV
-Ritonavir
SAE
SAME
SQV
- Saquinavir
SUS
UDI
SUMRIO
RESUMO.....................................................................................................................6
ABSTRACT .................................................................................................................7
LISTA DE ILUSTRAES ..........................................................................................8
LISTA DE QUADROS .................................................................................................8
LISTA DE TABELAS ...................................................................................................9
LISTA DE ABREVIATURAS......................................................................................11
1 INTRODUO .......................................................................................................17
2 REVISO DA LITERATURA .................................................................................21
2.1 HIV ..................................................................................................................21
2.1.1 Epidemiologia ........................................................................................21
2.1.2 Patognese e Histria Natural ...............................................................23
2.1.3 Tratamento ............................................................................................26
2.2 Diarria............................................................................................................28
2.2.1 Definio................................................................................................28
2.2.2 Patognese............................................................................................28
2.2.3 Etiologia .................................................................................................32
2.2.4 Tratamento ............................................................................................34
2.3 HIV e Diarria..................................................................................................35
2.3.1 Epidemiologia ........................................................................................35
2.3.2 Etiologia .................................................................................................37
2.3.3 Abordagem diagnstica .........................................................................43
2.3.4 Tratamento ............................................................................................45
3 OBJETIVOS ...........................................................................................................48
3.1 Objetivo Geral .................................................................................................48
7 CONCLUSES ......................................................................................................76
8 PROPOSIES E RECOMENDAES ...............................................................78
9 Referncias Bibliogrficas ......................................................................................80
APNDICE A Protocolo de pesquisa .....................................................................90
ANEXO A - Parecer da comisso de tica em Pesquisa da Universidade Federal de
Minas Gerais .............................................................................................................93
Introduo
17
1 INTRODUO
frequente
em
pacientes
com
maior
grau
de
imunodeficincia;
em
18
19
Reviso da Literatura
21
2 REVISO DA LITERATURA
2.1 HIV
22
23
24
25
26
27
28
2.2 Diarria
2.2.1 Definio
29
30
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