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HPI
69 year old male with well known peripheral arterial disease (PAD)
and previous episodes of critical limb ischemia (CLI).
Now presenting with 3 week history of right foot pain at rest.
Sleeping in a chair because his right foot hurts severely while in bed.
He gets relief by standing or hanging the right leg from edge of the
bed.
Currently can walk only 20 feet before he gets disabling right
claudication.
Also with rapidly worsening right heel ulcer and increased right leg
swelling.
HPI
His symptoms significantly worsened since an unsuccessful attempt at
lysis of ilio-profunda graft thrombosis 2 months back.
He was offered right above knee amputation at 2 different outside
facilities.
He also has long standing left lower extremity symptoms. He feared
that right leg amputation would ultimately result in decreased activity
and lead to eventual amputation of the other leg.
Thus, he came to our PAD clinic for a 3rd minimally invasive option
before resorting to amputation of his right leg.
PHYSICAL EXAMINATION
Toes are hypersensitive to touch
Bilateral femoral and pedal pulses are not palpable
Extensive calcified atherosclerotic plaque throughout the aorta and its branch vessels.
There is a endoluminal external iliac artery stent extending from common iliac bifurcation to 4 cm proximal to the groin.
The stent is proximally partially collapsed and distally there is mild to moderate luminal narrowing.
LEFT
No signal
BRACHIAL
126 (0.74)
No signal
PROXIMAL
THIGH
80 (0.47)
No signal
HIGH CALF
64(0.37)
45 (0.26)
ANKLE PT
46 (0.27)
34 (0.20)
ANKLE DP
40 (0.23)
9 (0.05)
FIRST TOE
22 (0.13)
Results:
R ABI of 0.26 (monophasic)
R TBI of 0.05 (pressure of 9)
L ABI of 0.27 (monophasic)
L TBI of 0.13 (pressure of 22)
R right iliac to profunda bypass graft is
occluded.
EXTERNAL ILIAC: There is a endoluminal external iliac artery stent which extends from the common iliac bifurcation to approximately 4 cm
proximal to the groin. The majority of the stent is patent, though proximally it appears partially collapsed. Distal to stent there is mild to moderate
luminal narrowing.
COMMON FEMORAL: Occluded. There are occluded grafts from the CFA to the proximal SFA and to branch of the profunda femoris.
POPLITEAL : Occluded
ANTERIOR TIBIAL : Patent just distal to its origin
POSTERIOR TIBIAL : Patent
PERONEAL : Patent, with dense calcification near its origin, likely causing some stenosis.
Deformed posterior
tibial artery due to
previous stenting
Intact posterior
tibial artery
Intact dorsalis
pedis artery
Deformed posterior
tibial artery due to
previous stenting
Intact posterior
tibial artery
CHALLENGING ANATOMY
Extremely long (>55 cm) chronic total occlusion.
Occlusion of the distal right external iliac, CFA, SFA and proximal profunda.
Small right internal iliac artery with reconstituting discontinuous profunda.
Occluded prior right SFA stents.
Excessive diffuse calcification and hostile groin from previous interventions.
Occluded right popliteal artery.
Ostial occlusion of the right tibial arteries, But patent anterior tibial, distal
posterior tibial and peroneal arteries.
Deformed posterior tibial artery from previous stent placement.
In addition, the patient had advanced contralateral left lower extremity disease.
DECISION MAKING
Now what?
The patient had come to our institution as a last resort before considering above the knee amputation
of his right leg.
With his bilateral disease, amputation of the right leg will inevitably lead to decreased activity levels
which will most likely lead to disease progress in his left lower extremity.
With his extensive disease, conservative medical treatment alone would not control his symptoms or
stop/delay the progression of the disease process.
Vascular surgical or surgical/endovascular intervention was not feasible due the extent of vessel
involvement and hostile surgical field due to multiple previous interventions.
ENCOURAGING FINDINGS
Despite the extensive
above knee vessel disease,
the patient still had:
Patent distal 2/3 of right
anterior tibial artery with
patent dorsalis pedis
Patent distal of right
posterior tibial artery
with preserved continuity
to the plantar arch
Diseased but segmental
patency of the right
peroneal artery
Deformed posterior
tibial artery due to
previous stenting
Intact posterior
tibial artery
Intact dorsalis
pedis artery
Intact posterior
tibial artery
INTERVENTION: ACCESS #1
ACCESS THROUGH THE LEFT COMMON FEMORAL ARTERY
Initial access through the left common femoral artery.
Placement of 5 french arterial sheath.
Advancement of glidewire into the right external iliac
INTERVENTION: ACCESS #2
ACCESS THROUGH THE RIGHT SFA STENT
With the calcification as guidance,
right mid SFA was accessed and a
Glidewire was advanced retrograde
to the right groin.
Sharp recanalization of the occluded
right common femoral and distal
external iliac artery was performed
with the stiff end of a Glidewire.
This wire was snared from the left
common femoral access site and the
recanalized common femoral artery
and the proximal SFA was balloon
dilated.
Sequential subintimal recanalization
with angioplasty of the right distal
external iliac, common femoral and
proximal superficial femoral artery
was performed.
Most of the recanalized segment of
the right common femoral and the
right superficial femoral artery was
performed subintimal.
INTERVENTION: ACCESS #3
PEDAL (AT) ACCESS
We then attempted to perform subintimal recanalization of the distal SFA and the popliteal artery.
A pre-existing occluded Nitinol stent in the distal SFA extensive heavy calcified arteries made this procedure extremely difficult.
With the help of multiple quick cross catheters and multiple guidewires, we were finally able to enter the occluded Nitinol stent and through the stent reached to the level of
intercondylar fossa. However we could not re-enter the true lumen of the popliteal artery.
We then decided to recanalize the leg arteries through a pedal access. The right anterior tibial artery was accessed at the level of the ankle.
A 4-French stiff micropuncture sheath was advanced into the distal anterior tibial artery.
INTERVENTION: ACCCESS #4
ACCESS THROUGH PROXIMAL AT
DIRECTLY FACING THE BEND
Retrograde recanalization of proximal AT
and the tibioperoneal trunk was
performed with a combination of 0.018
compatible quick cross catheter, V18 wire,
and multiple 0.018 glide wires. Once again
we could not enter into the popliteal
artery at the knee joint.
INTERVENTION: ACCESS #5
THROUGH PT AND RECANALIZATION OF TP TRUNK
Recanalization of the tibia peroneal trunk and the proximal tibial vessels resulted in widely open proximal arteries
with continuous flow into the foot.
INTERVENTION
Fluoro time: 120 minutes.
Contrast used: Isovue-300, 100cc
Estimated blood loss: 50 cc
Heparin 13,000 units
ACT: 250 to 300
Post procedure anticoagulation
Loading dose of plavix
2 weeks after
intervention
Right PT
45 (0.26)
78 (0.66)
Right DP
34 (0.20)
73 (0.61)
Right ABI
0.26
0.66
2 weeks after
intervention
Most recent
results
Right PT
45 (0.26)
78 (0.66)
1.36 (0.84)
Right DP
34 (0.20)
73 (0.61)
117 (0.72)
Right ABI
0.26
0.66
0.84
Operator should also strive to open two or more tibial arteries and plantar arch.
Treat both sides so the patient can start a supervised exercise program, which provides the most benefit post procedurally.
Frequent surveillance by Doppler and graft scans is essential.
Clinician should have low threshold for re-intervention with recurrence of symptoms and/or abnormal graft scans.
Patient with long segment Viabahn grafts are treated with oral anticoagulation in accordance to similar interventions
performed by vascular surgery.
REFERENCE
Conroy RM, Gordon IL, Tobis JM, et al. (2000) Angioplasty and stent placement in
chronic occlusion of the superficial femoral artery: Technique and results. J Vasc
Intervent Radiol 11:10091020.
Spinosa DJ, Harthun NL, Bissonette EA, et al. (2005) Subintimal arterial flossing
with antegrade-retrograde intervention (SAFARI) for subintimal recanalization to
treat chronic critical limb ischemia. J Vasc Intervent Radiol 16:3744.
Spinosa DJ, Leung DA, Harthun NL, et al. (2003) Simultaneous antegrade and
retrograde access for subintimal recanalization of pheripheral arterial occlusion. J
Vasc Intervent Radiol 14:14491454.
Yilmaz S, Sindel T, Yegin A, et al. (2003) Subintimal angioplasty of long superficial
femoral artery occlusions. J Vasc Intervent Radiol 14:9971010.