Beta-thalassemia

Drug: trifluoperazine (The other result, trihydrochloride, is not a drug.)

Trifluoperazine can treat psychotic disorders and anxiety. It can also treat nausea and vomiting
caused by chemotherapy.
Beta-thalassemia is a blood disorder that reduces the production of hemoglobin. In people
with beta thalassemia, low levels of hemoglobin lead to a lack of oxygen in many parts of the
body. Affected individuals also have a shortage of red blood cells, which can cause pale skin,
weakness, fatigue, and more serious complications

1.) ..the results reported herein represent clear-cut evidence for the specific binding of
chlorpromazine and trifluoperazine to ferrous human adult haemoglobin..
http://www.ncbi.nlm.nih.gov/pubmed/?term=low+hemoglobin+trifluoperazine
Paolo, A., Alberto, B., Massimo, C. and Antonio, L. (1999), Stabilization of the T-state of ferrous human adult
haemoglobin by chlorpromazine and trifluoperazine. Biotechnology and Applied Biochemistry, 30: 185187.
doi: 10.1111/j.1470-8744.1999.tb00911.x

2.) Analogous binding behavior has also been obtained with trifluoperazine binding to
haemoglobin and myoglobin
http://www.ncbi.nlm.nih.gov/pubmed/8910864
Bhattacharyya, J., Bhattacharyya, M., Chakraborti, A. S., Chaudhuri, U. and Poddar, R. K. (1996), Trifluoperazine is
More Effective than Chlorpromazine in Releasing Oxygen from Haemoglobin and Myoglobin. Journal of Pharmacy
and Pharmacology, 48: 965967. doi: 10.1111/j.2042-7158.1996.tb06013.x

3.) , previous research has shown that low hemoglobin level (anemia) is associated with
more depressive symptoms. Such an association could be expected since symptoms of low
hemoglobin level also often occur when having depressive (or anxiety) symptoms.
http://www.sciencedirect.com/science/article/pii/S002239991400021X

4.) A majority of the Beta-thalassemia patients were also suffered from mild to severe
depression, anxiety, and stress.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779154/
Adib-Hajbaghery M, Ahmadi M, S P. Health Related Quality of Life, Depression, Anxiety and Stress in Patients with
Beta-Thalassemia Major. Iranian Journal of Pediatric Hematology and Oncology. 2015;5(4):193-205.

Choroideremia
Choroideremia (CHM) is a rare inherited disorder that causes progressive vision loss, ultimately
leading to complete blindness.
Drug: Tipifarnib-P1, Enzalutamide (Xtandi)
Tipifarnib is a class of experimental cancer drugs that target protein farnesyltransferase with the
downstream effect of preventing the proper functioning of the Ras (protein), which is commonly
abnormally active in cancer.
Enzalutamide is a synthetic, non-steroidal pure antiandrogen used for the treatment of
metastatic castration-resistant prostate cancer.
1.) There was a case of sudden loss of vision due to breast cancer metastasis to the eyeball.
http://www.ncbi.nlm.nih.gov/pubmed/25038605

2.) There was a case of a pregnant woman with lung cancer presenting with choroidal
metastasis.
http://www.ncbi.nlm.nih.gov/pubmed/25962199

Angioimmunoblastic lymphadenopathy with dysproteinemia (AITL)

(AKA Angioimmunoblastic T-cell lymphoma)
Lymphoma is the most common blood cancer. The body has two main types of lymphocytes that
can develop into lymphomas: B- lymphocytes (B-cells) and T-lymphocytes (T-cells).
Angioimmunoblastic T-cell lymphoma (AITL) is a rare, aggressive (fast-growing) form of
peripheral T-cell lymphoma.
Drug: Digoxin, Penfluridol
Digoxin can treat heart failure and heart rhythm problems.
Penfluridol is a highly potent, first generation antipsychotic.

1.) There was a case of a dog with right-sided congestive heart failure because of a primary
intracavitary myocardial lymphoma.
http://www.ncbi.nlm.nih.gov/pubmed/25708789

2.) Survivors of childhood lymphoma (CL) have markedly increased risk of developing heart
failure.
http://www.ncbi.nlm.nih.gov/pubmed/24948492

Fanconi Anaemia
FA is a rare genetic disease.People with FA have hbone marrow failure, physical abnormalities,
organ defects.
90 percent of people with Fanconi anemia have impaired bone marrow function that leads to a
decrease in the production of all blood cells (aplastic anemia).Most develop cancer(AML)
FA is the result of a genetic defect in a cluster of proteins responsible for DNA repair
Treatment : Gene Therapy,Blood Transplant
medcines called growth factors (such as erythropoietin, G-CSF, and GM-CSF) can improve blood counts for a short
while.

Carbaprostacyclin also called Prostacyclin, PGI2: When infused in rabbits or dogs, it

inhibits ex vivo platelet aggregation
Paper 1
Whittle, B.J.R., Moncada, S., Whiting, F., et al. Carbacyclin - a potent stable prostacyclin
analogue for the inhibition of platelet aggregation. Prostaglandins 19605-627 (1980).
It inhibits platelet activation

Barrett's Esophagus
Barrett's esophagus is a serious complication of GERD, which stands for gastroesophageal reflux
disease.
In Barrett's esophagus, normal tissue lining the esophagus changes to tissue that resembles the
lining of the intestine.
BE has strong associaton with esophageal adenocarcinoma, a very often deadly cancer
In high-grade dysplasia, the risk of developing cancer might be at 10% per patient-year or greater.

Treatment: laser, Radiofrequency

NSAIDS like aspirin
Stomach acid supressant: Omeprazole (Prilosec), Esomeprazole (Nexium), Lansoprazole
(Prevacid) ,Rabeprazole (AcipHex)

Paper1 Cediranib 20 mg/day in combination with cisplatin and S-1 or capecitabine was tolerable, with
no new toxicities identified, and showed preliminary evidence of antitumour activity.

Phase I study of cediranib in combination with cisplatin plus fluoropyrimidine (S-1 or

capecitabine) in Japanese patients with previously untreated advanced gastric cancer.
http://www.ncbi.nlm.nih.gov/pubmed/21853311/
it underwent Phase I clinical trials for the treatment of non-small cell lung cancer, kidney cancer,
and colorectal cancer in adults. Is a VEGF inhibitor Vascular endothelial growth factor
Prostate
http://www.ncbi.nlm.nih.gov/pubmed/24788563
Ovarian cancer
Cediranib, when given orally with chemotherapy and continued as maintenance, yielded a meaningful in
progression-free survival in women with recurrent platinum-sensitive ovarian cancer

http://www.ncbi.nlm.nih.gov/pubmed/27025186

Cediranib with mFOLFOX6 versus bevacizumab with mFOLFOX6 as first-line treatment for
patients with advanced colorectal cancer: a double-blind, randomized phase III study
(HORIZON III).
http://www.ncbi.nlm.nih.gov/pubmed/22965961

Bacterial infection