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2 are encoded by distinct genes and have serine protease domain (Ip et al, 2009). The MASP-3
and MAp19 are alternatively spliced products MASP-1 and MASP-2 respectively (Ip et al,
2009). Schwaeble (as cited in Youssif et al., 2012) found MAp19 lack of serine protease domain
and it regulates lectin pathway by competing for binding of MASPs to the carbohydrate
molecule. The MASPs normally circulate as zymogens in complexes with MBL (Sorensen &
Thiel, 2005).
The other basic components of complexes. The complexes involve in the activation of
mannose-binding lectin pathway includes C4, C2, C3 and C5. These complexes are important as
when they are cleaved into fragments, the bigger fragments will bind to the surface of pathogens
and initiate the formation of membrane attack complex (MAC) that leads to lysis of the cell. On
the other hand, the smaller fragments of cleaved complexes such as C3a, C4a and C5a known as
anaphylatoxins. Anaphylatoxins are fragments that are produced after the activation of
complement system. The anaphylatoxins act on mast cells to release histamine and promotes
inflammation.
Lastly is the membrane attack complex (MAC). Membrane attack complex made up of
C5b6789 which anchor on the surface of pathogens cell membrane and make a channel that
causes the internal cell moves out of the cell called cell lysis.