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Basic Principles
Tomography is term derived from the Greek word
tomos , meaning to write a slice or section
Conventional Tomography was developed to reduce
super-imposition effect of simple radio graph; in this
arrangement , x-ray tube and photographic film are
moved in synchronization so that one plane of the
patient is focused while all other planes are blurred
Mathematical principles of Computed Tomography
were first developed in 1917 by Radon
It was proved that an image of an unknown object could
be produced :
if one had an infinite number of projections through the
object
Basic Principles
Conventional X-ray image reduces the 3D patient anatomy
to a 2D projection image
It is generated by projection from the x-ray source through
the object onto the film
Density at a given point on an image represents :
Basic Principles
Basic Principles
With a conventional radiograph, information with respect
to the dimension parallel to the x-ray beam is lost
Limitation can be overcome, to some degree, by acquiring
images through several direction .
For objects that can be identified in these images, provide
location information
This may not be practical because of the higher exposure
received by the patient
In CT anatomical information is digitally reconstructed
from x-ray transmission data
These data obtained by scanning an area from many
directions in the same plane to visualise information in that
plane.
The ideas involved were originally developed for imaging
Basic Principles
With a conventional radiograph, information with respect to
the dimension parallel to the x-ray beam is lost
Limitation can be overcome, to some degree, by acquiring
images through several direction .
For objects that can be identified in these images, provide
location information
This may not be practical because of the higher exposure
received by the patient
In CT, pictures displayed are not photographs but are
digitally reconstructed from a large no. of absorption profiles
Profiles are taken at regular intervals around a slice, with each
profile being made up from a parallel set of absorption values
through the object
Tomographic Images
Basic Principles
In CT , x-rays from a collimated source are passed through a
slice of the object or patient from a variety of directions
For directions along which the path length through-tissue are
longer, fewer x-rays are transmitted as compared to directions
where there is less attenuating the x-ray beam
Also, structures in the patient such as bone , may attenuate
X-rays more than a similar volume of less dense soft tissue
In principle CT involves determination of attenuation
characteristics for each small volume of tissue in patient slice
This constitute transmitted radiation intensity recorded from
various irradiation directions
It is these calculated tissue attenuation characteristics that
actually compose the CT image.
Basic Principles
For monochromatic X-ray beam , the tissue attenuation
characteristics can be described by :
Basic Principles
Let a slice of heterogeneous tissue is irradiated
the slice is divided into volume elements or voxels with
each voxel having its own attenuation constant
Sum of the voxels attenuation coefficients for each x-ray
beam direction can be determined from experimentally
measured beam intensities for given voxel width.
However , each individual voxel attenuation coefficient
remains unknown.
CT uses knowledge of attenuation coefficient sums
derived from X-ray intensity measurement made at all the
various irradiation directions
And calculate attenuation coefficients of each individual
voxel to form the CT image.
Tomographic Images
The tomographic image is a picture of a slab of the
patients anatomy
The 2D CT image corresponds to a 3D section of the
patient
CT slice thickness is very thin (1 to 10 mm) and is
approximately uniform
The 2D array of pixels in the CT image corresponds to an
equal number of 3D voxels (volume elements) in the
patient
Each pixel on CT image displays average x-ray attenuation
properties of the tissue in the corresponding voxel
Tomographic Images
Tomographic acquisition
Single transmission measurement through the
patient made by a single detector at a given
moment in time is called a ray
A series of rays that pass through the patient at the
same orientation is called a projection or view
Two projection geometries have been used in CT
imaging:
Parallel beam geometry with all rays in a projection
parallel to one another
Fan beam geometry, in which the rays at a given
projection angle diverge
Tomographic acquisition
Purpose of CT scanner hardware is :
to pass beam through the patient at different positions
acquire a large number of transmission measurements
Single CT image may involve approximately 800 rays
taken at 1,000 different projection angles
Before the acquisition of the next slice, the table that the
patient lies on is moved slightly in the cranial-caudal
direction (the z-axis of the scanner)
Tomographic acquisition
Purpose of CT scanner hardware is :
to pass beam through the patient at different positions
acquire a large number of transmission measurements
Single CT image may involve approximately 800 rays
taken at 1,000 different projection angles
Before the acquisition of the next slice, the table that the
patient lies on is moved slightly in the cranial-caudal (
Head -tail) direction (the z-axis of the scanner)
Tomographic reconstruction
Each ray acquired in CT is a transmission
measurement through the patient along a line
The unattenuated intensity of the x-ray beam is
also measured during the scan by a reference
detector
t
I t I0e
ln( I 0 / I t ) t
Tomographic Reconstruction
There are numerous reconstruction algorithms
Filtered backprojection reconstruction is most
widely used in clinical CT scanners
Builds up the CT image by essentially reversing
the acquistion steps
The value for each ray is smeared along this
same path in the image of the patient
Data from a large number of rays are back projected onto the image matrix
areas of high attenuation tend to reinforce one
another, as do areas of low attenuation, building
up the image
Ring artifacts
The rotate/rotate geometry of 3rd generation scanners
leads to a situation in which each detector is responsible
for the data corresponding to a ring in the image
Drift in the signal levels of the detectors over time affects
the t values that are back-projected to produce the CT
image, causing ring artifacts
th
7
Processing Unit Of CT
For constructing CT image , patient slice is divided up
into numerous three dimensional voxels
Image of the slice is two dimensional picture in which
each picture element ( pixel) value corresponds to
attenuation coefficient of a voxel in object slice
Successive approximation or iterative method is used
to obtain an image of attenuation coefficients from
measured intensity data; Example
More and more iterations, image matrix matches more
and more closely with the object matrix.
Thus image is generated with help of computer
Information received by the computer from the
scanning gantry needs to be processed for
reconstructing of picture
Processing Unit Of CT
What is PET?
Positron Emission Tomography (PET) is a non-invasive
test, PET scans accurately image the cellular function of
the human body
In single PET scan physician can examine entire body
PET and CT scans are both standard imaging tools that
physicians use to pinpoint disease states in the body
A PET scan demonstrates the biological function of the
body before anatomical changes take place, while the
CT scan provides information about the body's anatomy
such as size, shape and location
PET scan can distinguish between benign and
malignant disorders (or between alive and dead tissue)
Other imaging technologies merely confirm presence
of a mass