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Introduction
Re-use of single-use catheters for intermittent catheterization is a common practice. At the Jesse Brown VA Medical
Center (JBVAMC), catheters are re-used
for one-week intervals. The frequency of
urinary tract infection (UTI) in this patient
population has not yet been established.
Purpose
To determine the frequency of antibiotictreated UTI associated with re-use of
catheters for clean intermittent catheterization (CIC) at JBVAMC.
Methods
A retrospective chart review of adult
males who re-use catheters for CIC was
conducted.
Results
The majority of patients undergoing CIC
(59.7%) did not have a UTI, while 40.3%
did have at least one UTI.
Conclusions
The results of this study are similar to
previously reported data on frequency of
UTI with CIC. Only the number of daily
catheterizations differed significantly
between patients who had a UTI and
those who did not. The mode was two
catheterizations per day for both groups.
Level of Evidence VI
(Melnyk & Fineout-Overholt, 2011)
Joe McCartney, BSN, RN, is a Registered Nurse, Genitourinary Clinic, Jesse Brown VA
Medical Center, Chicago, IL.
Acknowledgement: The authors would like to acknowledge the statistical support of the
University of Illinois at Chicago (UIC) Center for Clinical and Translational Science (CCTS)
which was funded in part by the National Center for Research Resources, National Institutes
of Health.
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Intermittent catheterization
(IC) is an effective management
option for incomplete bladder
emptying for those who are not
candidates for surgery or who
have failed medical management.
IC is performed by inserting a
catheter into the bladder to drain
urine. The catheter is then removed immediately after urine
drainage is complete (Getliffe,
Fader, Allen, Pinar, & Moore,
2007). This process may be
repeated several times a day,
depending on severity of the
retention. IC can be performed by
a patient with good manual dexterity and coordination, or by a
caregiver or health care personnel, such as a nurse.
Catheter-associated UTI (CAUTI)
is defined as UTI signs or symptoms
without another identified source of
infection along with at least 103
colony-forming units of bacteria
in one urine sample in patients
who have used a catheter within
the last 48 hours (Hooton et al.,
2010). Lower colony counts may
also be reasonably interpreted as
CAUTI if patients have symptoms. Signs and symptoms can be
local or systemic, and may
include fever, malaise, flank pain,
acute hematuria, dysuria, pelvic
discomfort, and urinary frequency. In catheterized patients,
asymptomatic pyuria is not diagnostic of UTI, nor is the presence
or absence of odorous or cloudy
urine. Guidelines stress that
asymptomatic bacteriuria should
not be treated except in cases
when urologic procedures are
planned or during pregnancy
because treatment will unlikely
result in clinical benefit and can
increase the rate of antibiotic
resistant (Drekonja & Johnson,
2008; Hooton et al., 2010). This
goal has been reaffirmed by the
U.S. Preventive Services Task
Force (2008), stating that asymptomatic bacteriuria should not be
treated. The Centers for Medicare
and Medicaid Services (CMS) also
made modification of hospital
reimbursement to eliminate payments to hospitals for treatment of
preventable complications, such
as CAUTIs (Wald & Kramer,
2007). If treatment is indicated,
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Sampling Technique
This study was a retrospective electronic chart review of
JBVAMC patients undergoing CIC
from January 1, 2002, to
December 31, 2007. A computergenerated list of patients receiving
red rubber catheters during the
study period was used to select
patients. This study was approved
by the institutions Investigational
Review Board (IRB). Patient con-
Eligibility Criteria
Criteria for inclusion were
male veterans at JBVAMC, 18 years
of age and older, and who had used
CIC for at least three months.
Exclusion criteria were patients
taking prophylactic antibiotics and
those who sought care for catheter
management from a provider outside of the Veterans Health
Administration. Patients lost to follow up prior to three months of
CIC, patients who concurrently
used other forms of catheterization, and patients who explicitly
did not re-use catheters for oneweek intervals were also excluded.
Data Collection
All clinician notes and medication records of patients who
met eligibility criteria from
January 1, 2002, to December 31,
2007, were reviewed. Indication
for CIC, number of daily catheterizations, documentation of education regarding clean technique,
and patient compliance with
clean technique were gathered via
retrospective chart review. The
medical specialty of the treating
physician, rationale for antibiotic
use along with urinalysis and culture, and antibiotic prescribed
with length of treatment were also
included. Antibiotic use was
determined by reviewing outpatient prescriptions for antibiotics
during the study period, as well as
by reviewing clinician notes to
capture inpatient administration
of antibiotics. All other data were
also collected by reviewing clinician notes.
All data were manually
entered into a Microsoft Excel
spreadsheet by one investigator.
Patient identifiers were removed
from the data, and each patient
was linked to a unique study
number when compiled into the
spreadsheet. A master list linking
identifiers to a unique study number was stored in a secure, password-protected computer file on a
secure electronic network.
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Data Analysis
All data were analyzed using
descriptive statistics to determine
primary and secondary outcomes.
An external statistician also analyzed individual catheter insertion and documentation of clean
technique education versus incidence of UTI using the Chisquared test. Age, average number
of daily catheterizations, and
length of catheterization were
analyzed using Wilcoxon RankSum test.
Table 1.
Initial Study Population (N = 515); Excluded Patients (n = 356)
Number of
Excluded Patients
132
121
36
Lost to follow up
29
Refused CIC
13
Female patients
11
10
356
Table 2.
Final Study Population Patient Characteristics (N = 159)
Average Age
69 11.3 years
Self = 153
Caretaker = 6
Education documented = 144
No documentation = 15
BPH = 71
Urethral stricture = 40
Neurogenic bladder = 27
Bladder neck contracture = 15
Other = 6
Table 3.
Average Number of Daily Catheterizations (N = 159)
Number of Daily Catheterizations
No UTI (n = 95)
UTI (n = 64)
Less than 1
26 (27.4%)
11 (17.2%)
Results
23 (24.2%)
13 (20.3%)
28 (29.5%)
21 (32.8%)
10 (10.5%)
10 (15.6%)
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(5.3%)
6 (9.4%)
(1.1%)
1 (1.6%)
(2.1%)
1 (1.6%)
1 (1.6%)
Table 4.
Patient Characteristics UTI Group vs. No-UTI Group (N = 159)
Median (Interquantile Range)
Variable
Age
UTI = 0
(n = 95)
UTI > 0
(n = 64)
p Value*
0.2033
0.0241
0.7651
Figure 1.
Documentation of Clean Technique Education (N = 159)
UTI=0
UTI>0
8%
11%
92%
89%
Documentation Completed
No Documation
Table 5.
Patient Characteristics UTI Group vs. No-UTI Group (N = 159)
Percentage
Variable
UTI = 0
(n = 95)
UTI > 0
(n = 64)
1.0002
Self/Caretaker
Self
Caretaker
95.79
96.88
4.21
3.13
0.85581
25.26
23.44
MD note
66.32
65.63
8.42
10.94
No documentation
1
2
p Value
45
Figure 2.
Months Since Start of CIC When UTI Occurred (n = 64)
50
45
40
27
30
20
10
0
0-6
Months
7 - 12
Table 6.
Prescribing Provider for UTI Treatment (n = 64)
Prescribing
Service
Number
of UTIs
56
ER
Physician
Inpatient
Physician
Table 7.
Number of UTIs per Patient (n = 64)
Number of UTIs
Number of Patients
27
18
Greater than 5
Multiple
UTIs
(n = 37)
Table 8.
Patient Characteristics vs. Number of UTIs (n = 64)
Median (Interquantile Range)
Variable
UTI = 1
(n = 27)
UTI = 2
(n = 18)
UTI = 3
(n = 8)
UTI = 4
(n = 6)
UTI = 5
(n = 5)
p Value*
75.00
(63.00, 80.00)
72.50
(64.00, 77.00)
69.00
(67.00, 71.50)
74.50
(59.00, 77.00)
76.00
(65.00, 80.00)
0.7064
Average number of
daily catheterizations
2.00
(0.50, 3.00)
2.00
(1.00, 3.00)
2.00
(1.00, 2.41)
2.50
(1.50, 3.50)
2.50
(2.00, 3.00)
0.6882
Length of CIC
15.00
(5.00, 31.00)
13.50
(9.00, 36.00)
20.50
(13.50, 46.00)
17.50
(16.00, 20.00)
60.00
(26.00, 72.00)
0.1138
Age
Table 9.
Secondary Endpoint Data vs. Number of UTIs (n = 64)
Percentage
Variable
UTI = 1
(n = 27)
UTI = 2
(n = 18)
UTI = 3
(n = 8)
UTI = 4
(n = 6)
UTI 5
(n = 5)
1.0002
Self/Caretaker
Self
Caretaker
96.30
94.44
100.00
100.00
100.00
3.70
5.56
0.00
0.00
0.00
0.72591
1
2
p Value
RN note
25.93
11.11
25.00
33.33
40.00
MD note
11.11
22.22
0.00
0.00
0.00
No docuementation
62.96
66.67
75.00
66.67
60.00
Implications
Despite these limitations,
findings from this study are of
interest and can be expanded in
the future. Since the informational letter from the Under Secretary
for Health was issued, the
JBVAMC has now begun providing patients with catheters for single-use. It would be interesting to
study the frequency of UTIs in the
single-use catheter and compare
these data to the current study,
noting if there are any changes
incidence of UTIs.
After initiation of this study,
CMS also began mandating insurance coverage of up to 200
catheters per month for patients
who intermittently catheterize to
avoid re-use of catheters (Howard,
2009). These recommendations
contrast with IDSA guidelines,
which state the re-use of catheters
is acceptable, as well as with this
current study results showing the
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