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Practice Test II
Basic Sciences
Time: 2 hrs
UG/PG
PHARMACOLOGY
Read the instructions at the begining carefully. Subjects inlude Pharmacology &
Clinical Pharmacology. Answer sheets are provided separately.
Please Note: There is a Negative Marking of (-1) for each incorrect response. There
may be more than one correct answer(s).
C 97%
B 56%
D 50-60%
C Risperidone
B Olanzepine
D Flupenthixol
C Enalapril
B Captopril
D Fosinopril
C Valproate
B Gabapentin
D Fluoxymesterone
C Mirtazapine
B Haloperidol
D Chlorpromazine
B medulla
D limbic system
Medicine
-1-
MCQ Series
Practice Test II
C Fluoxetine
B Clomipramine
D Trazodone
C Terbinafine
B Cyclothiazide
D Rivastigmine
C pncA gene
B pfcrt gene
D ptcA gene
C Cefepime
B Ceftazidime
D Cefotaxime
C amplodipine
B Diltiazem
D Nifedipine
C Penfluridol
B Thioridazine
D Flupenthixol
C cytochrome c
B catalase
C Ribavirin
B Stavudine
D Tenofovir
C Papillary necrosis
Medicine
-2-
UG/PG
MCQ Series
Practice Test II
UG/PG
C Ondansetron
B Phenothiazine
D Quetiapine
C vasoconstriction
B vasodilation
18. All of the following anesthetic agents are nontoxic to liver except:
A Midazolam
C Sevoflurane
B Nitrous oxide
D Halothane
19. Regarding multi drug resistant bacteria, all of the following statements are correct
except:
A MRSA show resistance against
cephalosporin and penicillin
B A. Baumannii is an opportunistic
pathogen showing antibiotic
resistance
C Verapamil
B Bepridil
D Diltiazem
C phenylephrine
B verapamil
D diltiazem
C Clozapine
B Methysergide
D Risperidone
C enoxacin
B phenytoin
D desipramine
Medicine
-3-
MCQ Series
Practice Test II
UG/PG
C risperidone
B ziprasidone
D clozapine
C Sevoflurane
B Desflurane
D Halothane
C Exemestane
B Sulindac
D Aminoglutethimide
27. All of the following drugs are more likely to cause alopecia except:
A Cyclophosphamide
C Warfarin sod.
B Epirubicin
D Paclitaxel
C Ganciclovir
B Didanosine
D Idoxuridine
29. Bacteria that can produce -lactamases include all of the following except
A Pseudomonas aeruginosa
C Neisseria gonorrhoeae
B Haemophillus influenzae
D Klebsiella pneumoniae
C Acyclovir
B Didanosine
D Foscarnet
Medicine
-4-
MCQ Series
Practice Test II
UG/PG
33. The active ingredient of the topical nasal decongestant spray "Vicks"
A Phenylephrine
C Guanifenesin
B Orphenadrine
D Oxymetazoline
C Loratadine
B Trimeprazine
D Astemizole
C Vancomycin
B Erythromycin
D thiopental
A Alprazolam
C Triazolamine
B Nicotinic acid
D Nikethamide
C Cyclophosphamide
B Vincristine
D Doxorubicin
C Cyproheptadine
B Phentermine
D Oxymetazoline
Medicine
-5-
MCQ Series
Practice Test II
UG/PG
C Cyproheptadine
B Baclofen
D Pizotifen
C Rickettsia
B B. fragilis
D C. difficile
42. A drug that is free of teratogenic effects and safe to the fetus:
A Dicyclomine
C Ribavirin
B Miltefosine
D Doxylamine
C Azathioprine
B Cytarabin
D 6-thioinosinate
C Levocetirizine
B Betazole
D Ketotifen
C Glaucoma
B Parkinsonism
D Iridocyclitis
C lithium
B hypothermia
D ephedrine
Medicine
-6-
MCQ Series
Practice Test II
C Temazepam
B Clonazepam
D Oxazepam
49. Non-linear first pass kinetics is seen with all of the following drugs except
A hydralazine
C aspirin
B heparin
D propranolol
C Paroxetine
B Mazindol
D Venlafaxine
Section B
51. The action of Tubocurarine is reversed by
A Hydroxyzine
C Neostigmine
B Atropine
D Naloxone
C Ketamine + Fentanyl
B Ketamine + droperidol
D droperidol + Fentanyl
C Trimethadione
B Phenacemide
D Bromocriptine
C Listeria infections
B Tularemia
D Relapsing fever
C Cyproheptadine
B Cinnarizine
D Nicorandil
Medicine
-7-
UG/PG
MCQ Series
Practice Test II
UG/PG
56. 1-acid glycoprotein levels are increased in all of the following conditions except:
A rheumatoid arthritis
C trauma
B nephrotic syndrome
D stress
C Neutrophil granulocytes
B Bone marrow
D Macrophages
C Meprobamate
B Flumazenil
D Muscimol
C abciximab
B argatroban
D apixaban
C dl-racemic propranolol
B l-propranolol
D both a & b
C Ceftriaxone
B Cefadroxil
D Cefuroxime
C Desloratadine
B Loratadine
D Quetiapine
C Dexamethasone
B Glucocorticoids
D Phenytoin
C Verapamil
B Terbutaline
D Warfarin
Medicine
-8-
MCQ Series
Practice Test II
UG/PG
C Ceftriaxone
B Cefalexin
D Cefuroxime
66. Which of the following anti-hypertensives can be safely given to patients with
COPD or asthma?
A labetolol
C nifedipine
B adenosine
D metoprolol
67. A phenylalkylamine calcium channel blocker (CCB) that have negative inotropic
action on heart
A Nifedifine
C Chlortalidone
B Verapamil
D Diltiazem
68. Match the following antibiotics according to their correct chemical and structural
origins:
A.
B.
C.
D.
E.
Azithromycin
Vancomycin
Bacitracin
Nystatin
Chloramphenicol
A.
B.
C.
D.
E.
Macrolide antibiotic
Polypeptide antibiotic
Nitrobenzene derivative
Glycopeptide antibiotic
Polyene antibiotic
C VLDL>LDL>HDL
B LDL>HDL>VLDL
D HDL>LDL>VLDL
C is a cardioselective
1-adrenoceptor antagonist
71. Which of the following drugs is least likely to produce neuromuscular blockade?
A Amikacin
C Tobramycin
B Streptomycin
D Neomycin
Medicine
-9-
MCQ Series
Practice Test II
UG/PG
C Levorphanol
B Mecamylamine
D Primidone
74. Which of the following antidepressants causes marked sedation without nausea
as a side effect?
A Trazodone
C Clomipramine
B Amitriptyline
D Dothiepin
C Diazepam
B Alprazolam
D Clonazepam
C Haloperidol
B Nicardipine
D Clozapine
C Streptokinase
B Alteplase
D Urokinase
C Carbenicillin
B Cefepime
D Meropenem
C Bupropion
B Doxacurium
D Tubocurarine
Medicine
- 10 -
MCQ Series
Practice Test II
UG/PG
C Cefoxitine
B Cefonicid
D Cefazolin
81. What could possibly explain the increased rate of thrombosis during pregnancy?
A Increased levels of plasminogen
activator inhibitor-2
B increased levels of tissue
Plasminogen Activator (tPA)
C clomifene
B lisuride
D carbaprost
83. Drugs capable of causing tinnitus in high doses includes all of the following
except:
A Gentamicin
C Aspirin
B Lidocaine
D Trimetazidine
C 70%
B 90%
D 25%
C Clofazimine
B Rifampin
D Ofloxacin
C Cellulose
B Dextran
D Starch
87. Regarding the action of digitalis (digoxin), which of the following is incorrect?
A increases cardiac output
Medicine
- 11 -
MCQ Series
Practice Test II
UG/PG
C fenoldopam
B phencyclidine
D bromocriptine
C Fexofenadine
B Epinastine
D Loratadine
C barbituric acid
B p-hydroxylphenyl
D phenylethylmalonamide
C acetazolamide
B phenoxybenzamine
D chloroquine
C salicin
B parthenolide
D picrotoxinin
94. The most powerful technique for structural elucidation of drugs and metabolites
A UV
C NMR
B Mass Spectrometry
D HPLC
C Platelets
B Endothelium
D Lung
Medicine
- 12 -
MCQ Series
Practice Test II
C Fexofenadine
B Cetirizine
D Dexchlorpheniramine
C Cotrimoxasole
B Norfloxacin
D Methyldopa
C Ergometrine
B Ergonovine
D LSD
C Pefloxacin
B Norfloxacin
D Ofloxacin
C Calcium chloride
B Dimercaprol
D Fomepizole
Section C
101. Which of the following NSAID is an enolic acid derivative?
A Indomethacin
C Naproxen
B Piroxicam
D Mefenamic acid
C ischemic stroke
B venous thrombosis
D frostbite
C Atropine
B Muscarine
D Carbachol
Medicine
- 13 -
UG/PG
MCQ Series
Practice Test II
UG/PG
C Polymyxin B
B Amphotericin B
D Griseofulvin
106. Which of the following is a substrate for enzyme cytochrome P450 CYP2C19?
A Metoprolol
C Diazepam
B Lansoprazole
D Rifampin
C Enflurane
B Halothane
D Sevoflurane
C Pimozide
B Olanzapine
D Ziprasidone
C endothelial cells
B platelets
D histiocytes
C bumetanide
B hydrochlorothiazide
D acetazolamide
C androstenedione
B pregnenelone
D androsterone
C ergotamine
B isoprenaline
D Cimetidine
Medicine
- 14 -
MCQ Series
Practice Test II
UG/PG
C Doxepin
B Valproic acid
D Methysergide
B vasoconstrictor
115. As an enzyme inducer, which of the following drugs enhances the metabolism of
thyroxine?
A Meprobamate
C Phenobarbitone
B Rifampicin
D Carbamazepine
116. Which of the following types of drug transport is also known as "convective
transport"?
A Active transport
C Pore transport
B Carrier-mediated transport
D Ion-pair transport
C Diltiazem
B Hydralazine
D Nifedipine
C Risperidone
B Reserpine
D Clonidine
C Epoprostenol
B Misoprostol
D Colfosceril
C Dinoprost
B PGE2
D Thromboxanes
Medicine
- 15 -
MCQ Series
Practice Test II
UG/PG
C atosiban
B ritodrine
D carbaprost
C Bromocriptine
B Pergolide
D Apomorphine
C Rivastigmine
B Memantine
D Donepezil
C Etomidate
B Fentanyl
D Ketamine
C fentanyl
B ketamine
126. Which of the following plasma proteins is not an acute phase reactant?
A albumin
C 1-antitrypsin
B orosomucoid
D haptoglobin
C pyridoxine
B riboflavin
D niacin
128. Drugs contraindicated during lactation in nursing mothers includes all of the
following except:
A Atropine
C Phenobarbitone
B Chloramphenicol
D Phenylbutazone
C hypertension
Medicine
- 16 -
MCQ Series
Practice Test II
UG/PG
C Cefadroxil
B Cefaclor
D Cefotetan
C Appetite loss
B Nausea
D Insomnia
134. Drugs that precipitate Torsades de pointes includes all of the following except:
A Metoclopramide
C Cisapride
B Terfenadine
D Pimozide
C Carbapenem
B Oxacillin
D Vancomycin
136. The drug used as a test to differentiate myasthenic crisis from cholinergic crisis
A vecuronium
C ephedrine
B edrophonium
D physostigmine
C Cyproheptadine
B Fexofenadine
D Chlorpheniramine
C hydralazine
B cyclosporine
D carbamazepine
Medicine
- 17 -
MCQ Series
Practice Test II
UG/PG
C tyrosinase
B azurin
D amicyanin
141. Which of the following dihydropyridines (DHPs) have the shortest elimination t?
A amplodipine
C felodipine
B nifedipine
D verapamil
C Pizotifen
B Doxapram
D Ergotamine
C Azithromycin
B Ampicillin
D Penicillin G
C Doxylamine
B Prochlorperazine
D Mosapride
C Spironolactone
B Ranitidine
D metochlopramide
Medicine
- 18 -
MCQ Series
Practice Test II
C ACh
B PGE2
D Thromboxane A2 (TXA2)
C Selegiline
B metamphetamine
D apomorphine
C Vincristine
B Cisplatin
D Bleomycin
C 11 hr
B 6 hr
D 12 hr
Section D
151. Which of the following anesthetic agents is most cardiotoxic?
A Bupivacaine
C Lidocaine
B Propofol
D Ketamine
C Chlorpromazine
B Imipramine
D Nortriptyline
C Mosapride
B Domperidone
D Tiapride
C Isoproterenol
B Metaproterenol
D Salbutamol
Medicine
- 19 -
UG/PG
MCQ Series
Practice Test II
UG/PG
155. Ketamine is dangerous for patients with all these clinical conditions except:
A hypovolemia
D hypertension
156. Which of the following drugs has an aromatic ring system in its structure?
A Isoflurane
C mechlorethamine
B propranolol
D halothane
C Penicillin G
B Streptomycin
D Amphotericin B
C Amlodipine
B Verapamil
D Diltiazem
159. All of the following agents are used to treat malignant hyperthermia and malignant
neuroleptic syndrome except:
A i.v. adrenaline
C bicarbonate infusion
B i.v. dantrolene
D 100% O2 inhalation
C bioequivalence
D clearance (CL)
C Ketoconazole
B Terbinafine
D Caspofungin
C Linezolid
B Hamycin
D Clindamycin
Medicine
- 20 -
MCQ Series
Practice Test II
UG/PG
163. Match the following drugs with their correct pharmacokinetic properties:
A.
B.
C.
D.
E.
Doxepin
Cetirizine
Loratadine
Chlorpheniramine
Fexofenadine
A.
B.
C.
D.
E.
C Dextran
B Dextrin
D Dextrose
C increased fibrinolysis
D decreased fibrinolysis
C nausea
B orthostatic hypotension
D serotonin syndrome
167. A drug that is chemically different from aminoglycosides but having similar
mycobactericidal activity
A Amikacin
C Clavulanic acid
B Sisomycin
D Capreomycin
C amobarbital
B pentobarbital
D phenobarbital
Medicine
- 21 -
MCQ Series
Practice Test II
UG/PG
170. Match the following cytotoxic agents with their correct groups they belong:
A.
B.
C.
D.
E.
Folate antagonist
Nitrogen mustard
Pyrimidine antagonist
Purine antagonist
Nitrosoureas
A.
B.
C.
D.
E.
Azathioprine
5-Fluorouracil
Carmustine
Cyclophosphamide
Methotrexate
C Sulfadiazine
B Mitomycin C
D Daunorubicin
C Metralindole
B Moclobemide
D Chlorgyline
C pupillary constriction
B reduced salivation
D constipation
C Diabetic ketoacidosis
B Anaphylaxis
D Cushing's syndrome
C serum K+ concentration
B ACTH
C Ciprofloxacin
B Ceftriaxone
D Co-trimoxazole
C Colistin
B Erythromycin
D Vancomycin
Medicine
- 22 -
MCQ Series
Practice Test II
C Colistin
B Doxorubicin
D Actinomycin D
C Interferon-
B Interferon- 2b
D Interferon-
C Bacitracin
B Vancomycin
D Amikacin
C Lanreotide
B Octreotide
D Somatomedin
C Polymyxin B + Neomycin +
Bacitracin
D Polymyxin B + Neomycin +
Colistin
C Somatomedin
B Somatorelin
D Somatropin
C Aztreonam
B Griseofulvin
D Azithromycin
C Pegvisomant
B Tetracosactide
D Octreotide
Medicine
- 23 -
UG/PG
MCQ Series
Practice Test II
UG/PG
B mutation of catalase-peroxide
gene
D plasmid mediated
C Ganirelix
B Somatorelin
D Leuprorelin
C Ciprofloxacin
B Colistin
B are bactericidal
A Tetracycline
C Cephalosporin
B Choramphenicol
D Penicillin
C O=C bond
B N-CH bond
D C-N bond
C Magnesium hydroxide
B Calcium carbonate
D Magnesium trisilicate
Medicine
- 24 -
MCQ Series
Practice Test II
UG/PG
C digoxin
B ketoconazole
D nitrofurantoin
196. Match the following antineoplastic drugs with their respective adverse effects:
A.
B.
C.
D.
E.
Busulfan
Cyclosporin
5-Fluorouracil
6-Mercaptopurine
Vincristine
A.
B.
C.
D.
E.
peripheral neuropathy
nephrotoxicity
reversible jaundice
bone marrow depression
pulmonary fibrosis
C primarily tuberculocidal
D sucralfate inhibits its absorption
C Sotalol
B Atenolol
D Labetalol
C Furosemide
B Parathormone
D Thiazide
Medicine
- 25 -
MCQ Series
Practice Test II
C Calcium carbonate
B Thiazide diuretic
D Ethambutol
Medicine
- 26 -
UG/PG
MCQ Series
Practice Test II
UG/PG
Disclaimer: Every attempt has been made to validate each and every
question/answers. Any remaining error is regretted. Author will not be held responsible
for any errors. Please consult standard textbooks given in the reference section for any
discrepancy. Questions with wrong answers may better be left unattempted/
unanswered. This is a practice series available free to download designed for the
benefit of prospective PG candidates and UG medical students alike.
Reference Textbooks:
1. Essentials of Medical Pharmacology, 7th Edition, KD Tripathi
2. Basic & Clinical Pharmacology, 13th Edition, Katzung & Trevor
3. A Textbook of Clinical Pharmacology and Therapeutics, 5th Edition, Ritter, Lewis,
Mant & Ferro
4. Pharmacology & Therapeutics: Principles to Practice, Waldman and Terzic,
Saunders Elsevier
5. Goodman & Gilman's The Pharmacological basis of Therapeutics, Laurence Brunton,
12th Edition
6. Gareth Thomas, Medicinal Chemistry, An Introduction: Second Edition, Wiley
7. Textbook of Receptor Pharmacology, Foreman & Johansen, Second Edition CRC
Press
8. Wilson & Gisvold's Textbook of Organic Medicinal & Pharmaceutical Chemistry,
Beale & Block, 12th Edition
Medicine
- 27 -