Академический Документы
Профессиональный Документы
Культура Документы
Manual of
Otorhinolaryngology
Head and Neck
Surgery
James B. Snow Jr, MD
Professor Emeritus,
University of Pennsylvania School of Medicine
Philadelphia, Pennsylvania
Former Director,
National Institute of Deafness and
other Communicative Disorders,
National Institutes of Health
Bethesda, Maryland
2002
BC Decker
Hamilton London
BC Decker Inc
P.O. Box 620, L.C.D. 1
Hamilton, Ontario L8N 3K7
Tel: 905-522-7017; 800-568-7281
Fax: 905-522-7839; 888-311-4987
E-mail: info@bcdecker.com
www.bcdecker.com
2003 BC Decker Inc
All rights reserved. No part of this publication may be reproduced, stored
in a retrieval system,
or transmitted, in any form or by an means, electronic, mechanical,
photocopying, recording,
or otherwise, without prior written permission from the publisher.
02 03 04 05/GSA/9 8 7 6 5 4 3 2 1
ISBN 1-55009-199-9
Printed in Spain
24
ACUTE AND CHRONIC
NASAL DISORDERS
Valerie J. Lund, MS, FRCS, FRCS(Ed)
Page 276-291
INFECTIOUS RHINITIS
25
SINUSITIS AND POLYPOSIS
Andrew P. Lane, MD
David W. Kennedy, MD
276
PATHOPHYSIOLOGY OF RHINOSINUSITIS
Rinosinusitis merupakan kelainan yang paling umum terjadi dan memiliki dampak yang signifikan
pada kualitas hidup individu dan meyebabkan beban ekonomi yang besar di Amerika secara
keseluruhan. Penyebab utama RSA banyak dan termasuk variasu host dan faktor lingkungan. Pada
akhirnya walaubagaimanapun, secara umum terjadinya RSA adanya bakteri pada sinus dengan
obstruksi ostium. Hal ini tidak hanya menghambat aliran anatomi normal sinus, namun juga
kegagalan fungsi klirens mukosilier dari mukosa yang biasanya akan mengeluarkan bakteri.
Obstruksi ostium yang reversibel dapat menyebabkan infeksi virus saluran nafas atas, alergi,
iritasi, barotrauma. Sumbatan ireversibel disebabkan oleh anatomi yang sudah terbentuk,
berkontribusi terhadap sumbatan atau merupakan penyebab satu-satunya. Ostium menjadi
tersumbat, hipoksia lokal terjadi pada sinus dan terjadi akumulasi sekret sinus. Kombinasi dari
tekanan oksigen yang rendah dan media kultur yang kaya akan sekresi ini menyebabkan
pertumbuhan bakteri. Silia epitel yang abnormal atau kualitas atau kuantitas dari mukus
menghalangi pengeluaran bakteri. Penyakit sistemik immunocompromised merupakan potensi
predisposisi pasien RSA. Penyakit kronik, seperti diabetes atau malnutrisi, gangguan metabolik,
kemoterapi, terapi lama kortikosteroid, akan bertendensi meningkatkan sinusitis akut. Rinosinusitis
selama 12 minggu diklasifikasikan sebagai rinosinusitis kronik. Patofisiologi yang mendasari
sinusitis kronik semestinya bukan infeksi dan sering merupakan proses inflamasi yang berlangsung
sendiri. Sedankan sinusitis akut secara histologi merupakan proses eksudatif dikarakteristikan oleh
infiltrasi neutrofil dan nekrosis, sinusitis kronik merupakan proses proliferasi yang menyebabkan
penebalan mukosa. Infiltrasi sel yang utama pada sinusitis kronik adalah eosinofil, pada pasien
alergi dan non alergi. Terdapat tanda yang berpengaruh There is evidence that potent
eosinophil-attracting chemokines diproduksi pada mukosa sinus, dikembangkan oleh variasi
tipe sel dibawah stimulasi sitokin memproduksi sel T dalam jumlah besar. Peningkatan level
interleukin-4 dan interleukin-5 pada sinonasal menaikkan migrasi dan memperpanjang waktu
kehidupan eosinofil. Jumlah proinflammatory cytokines diregulasi dan keterlibatan dalam proses
are up-regulated and participate in the process of directing lymphocyte and
granulocyte traffic while causing further production of cytokines in an autocrine
fashion. Degranulasi eosinofil melepaskan enzim destruktif yang merusak epitel. Hal ini
mengganggu fungsi pertahanan normal dan aktivitas mukosilier dari mukosa, menyebabkan
bakteri dan jamur membentuk koloni pada kavitas sinus. Kerusakan epitel mengiritasi ujung saraf
sensori, menyebabkan nyeri dan menstimulasi perubahan sekresi mukus dan permeabilitas endotel
melalui reflex pathways.
COMPLICATIONS OF RHINOSINUSITIS
Komplikasi sinusitis dapat dibagi The complications of sinusitis can be divided broadly into
those involving the orbits and those that involve the intracranial
space. In the antibiotic era, such complications have
become less commonplace, but they still have the potential for serious morbidity or even mortality.
Awareness and early
recognition of complications are necessary to minimize
adverse sequelae. Fortunately, improved diagnostic modalities
and advances in medical and surgical techniques have
significantly reduced the risk of blindness or life-threatening
intracranial infections. Ethmoiditis most commonly leads to
orbital involvement, followed by infections of the maxillary,
frontal, and sphenoid sinuses. Infections of the ethmoid can
directly erode the thin lamina papyracea or extend through
suture lines or foramina into the orbit. Intracranial complications
of sinusitis occur less frequently than orbital complications
but are potentially life-threatening if not recognized and
treated. Most intracranial infections arise from the frontal
sinus, although extension from the other sinuses is possible.
The most frequent route of spread is retrograde thrombophlebitis
via valveless veins in the posterior table of the
frontal sinus that communicate directly with dural veins. The
types of complications that may develop include osteomyelitis
of the frontal bone, meningitis, epidural abscess,
subdural empyema, and intracerebral abscess. Potts puffy
tumor is a well-circumscribed swelling of the forehead
caused by anterior extension of frontal sinusitis. The edema
of the skin and soft tissue overlies a collection of pus under
the periosteum of the anterior table of the frontal sinus.
In cases of orbital complications, the decision to proceed
to surgery is made based on a number of factors and is individualized
to the particular patient. Progressive visual loss
demands aggressive management and drainage of the source
of infection. Surgical intervention should be considered when
there is disease progression after 24 hours of antibiotics or no
improvement after 2 to 3 days of therapy. Ideally, surgery
involves approaching both the orbital complication and
underlying sinusitis simultaneously. The mainstay of therapy
for suspected intracranial complications is intravenous antibiotics
capable of crossing the blood-brain barrier. If cultures can be obtained from the affected sinuses,
this will guide specific
antibiotic choice. A neurosurgical consultation is sought
when a procedure may be necessary to drain an intracranial
collection. Corticosteroids are usually not used during an
active infectious process; however, they are sometimes
employed to reduce severe brain edema. Surgery should be
directed at the involved sinuses as well as the intracranial
process unless the patients condition limits operative time, in
which case, the neurosurgical procedure takes precedence.
DIAGNOSIS OF RHINOSINUSITIS
denture wearers.
The nasal complications are typically related to the septoplasty
portion of the procedure. These include septal perforation,
saddle deformity, and tip deformity. Epistaxis and
wound infection are also possible nasal problems postoperatively.
There are potentially serious neurologic and vascular
complications that may occur in sphenoid surgery since the
carotid artery and optic nerves travel in the lateral wall of the
sinus. Even if the optic nerve is not injured directly during
surgery, overpacking of the sinus with fat can cause optic chiasmal
compression and visual loss. Another possible complication
is cerebrospinal fluid leak, which should be treated
when it is recognized intraoperatively. During the postoperative
period, patients must be closely monitored for evidence
of change in mental status or signs of active bleeding. The
cause of these findings will generally be discovered through
radiologic evaluation, and proper intervention can be planned
and undertaken by the operative team.