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1.

Which one is the 1st symptom observed by phenytoin overdose: dry mouth,
nonsteady gait,
2.

Which of the following drugs possesses the above structure: a) methothexate


b) azothioprin, c) 5 FU d) Mercaptopurine
3.

The above compound goes photoactive reaction in retina at Carbon-11


position. What type of chemical reaction occurs: a) oxidation B) epimerisom
C) Cis-trans isomerism D) Reduction E) Tautomerism
4. The drug insurance plan of a regular customer of your pharmacy covers
medications for only 30 days. Each prednisone contains 5mg and You got a
Rx from the customer as follows\;
Prednisone
40 mg for 2 weeks
30 mg for 2 weeks
20 mg for 2 weeks
You filled the Rx. For how many tablets will you bill for the insurance
company?
5. For the prophylaxis of Malaria, Mafloquine is used at a dose of 10mg/kg/week
or maximum 250 mg/week. Mr. MN of 50 kg body weigh is planning to travel
in malaria prone area. For prophylaxis, Mafloquine is used one week before
journey, during journey and four weeks after journey. How many tablets of
mafloquine is required for Mr. MN if each tablet contains 250 mg mafloquine.
6. Math regarding prophylaxis of malaria

7.

The above product acts on:


a) Folate reductase
c) xanthine oxidase
b) Nuclease
d) DNA polymerase
8. Dysgeusia is related to:
a) Swallow
d) saliva
b) Taste
e) urination
c) Digestion
9. Which of the following drug cause increase in Digoxin concentration:
a) Amiodarone
d) carbamazepine
b) Metoclorpromide
e) barbiturate
c) phenytoin
10.What effect fentanyl gives at therapeutic concentration?
a) Vomiting b) Sedation c) muscle relaxation
d) anesthesia
11.Math regarding CLT (total clearance) determination: the plasma half-life and
Vd was given.
12.Math partition coefficient:
An organic compound was dissolved in 200ml water and 100 ml of carbon
tetrachloride. After shaking vigorously the mixture was kept for a while. The
concentrations of the substance were 20 mcg/ml and 5mcg/ml in carbon
tetrachloride and water respectively. What is partition coefficient of the drug?
13.Math on concentration at time zero:
5 ml of an IV drug was administered and the plasma concentrations after
specific time were observed as below:
Time after administration (hr)
plasma concentration (mcg/ml)
4
16
8
4
10
2
What was the plasma concentration of the drug at time zero?
14.In marketing, SWOT analysis is done. What does T stand for?
a) Therapeutic
b) Threat
15.GLC uses which type of compound:
a) volatile, thermolabile
c) volatile, thermostable
b) non-volatile, thermolabile
d) non-volatile, thermostable

16.What is used to prevent hormone denaturation in freeze drying techniques:


a) Adsorbant
c) humactant
b) lyoprotectant
17.Surfactant is used in contact lenses solution for which purpose
a) To keep lenses wetting c) as disinfectant for lenses
b) To cleanse the lenses
18.
Question was from Genetic polymorphism( I cannot remember the
question exactly)
19.Which one is not use for life long therapy in ulcerative colitis
a) Methotrexate b) azathioprine
c) NSAIDs
20.Which of the following antiepileptic drug has least metabolic interaction with
drugs
a) Carbamazepine b) phenytoin c) gabapentin
21.Problem from RRR calculation: percent of a certain adverse effect after
administering a new drug and a conventional drug was given and the relative
risk reduction (RRR) was to be calculated.
22.Absolute risk reduction: percent of a certain adverse effect after
administering a new drug and a conventional drug was given and the
absolute risk reduction was to be calculated.
23.Cost benefit calculation: A simple problem was to calculate the cost-benefit
24.Two different drugs has same clinical efficacy and each has same potentiality
to create adverse effect. To add one of the two drugs in a hospital formulary,
the following pharmacoeconomic parameter is to be considered
Ans: Cost minimization:
25.A terminally ill cancer patient is on treatment of hydrocodone and phyllium.
Her young daughter came to a pharmacy with a prescription of hydrocodone
and lactulose. Which of the following is pharmacists concern:
Ans: Forgery prescription regarding hydrocodone

26.A new customer came to you pharmacy and told you that he was a patient of
chronic illnesses and he had to buy medications for handsome amount every
month. Recently he had moved to this area and his previous pharmacy did
not charge him is insurance copayment. He requested you to waive the
copayment. You told him that none of you customers get such facility. When
the customer decided to move to other pharmacy, you decided to waive his
copayments. Which of the ethical principle did you violet?
Ans: violation of justice

27.A newly invented drug has a high efficacy to a certain indication. If you want
to know whether the drug is available in Canada, you will search:
a) Health Canada product database c) CPS
b) Therapeutic Choice
28.Megaloblastic anemia is due to deficiency of folic acid and vitamin B12
29.Graves disease: which drug is not used:
a) Lugol solution b) propyluracil

c) triiodothyroninine

30.There was a question regarding Insulin regular and lsipro


31.Which one causes the most expenditure for Canadian private insurance: Ans:
Pharmaceutical cost
32.In Canadian health care system, Pharmaceuticals costs are paid by publicly
funded from taxation of federal and provincial govt. private insurance,
employed benefit and paid by customers
33.A reaction with structure was given and question was about the type or
reaction:
Ans: amino-reduction
34.Which one is the Nicotine patch side effect counselling:
Ans: it may produce redness and itching at the side of application
35.There was a question regarding Verenicline side effect
36.Antipsychotic drug acts on which receptor

37.Which is not used in Parkinsons diseases with BPH? Ans: BENZOTROPINE

38.Which one is not symptom of BPH? Ans: infrequent urination


39.The following pharmacokinetic parameters were given for Drug A and drug B
Drug A
Drug B
Dose: 100 mg
200mg
tmax : 2 hr
2.5 hr
Cmax:4 mc/ml
4 mc/ml
AUC: 240
480
Which one of the following is true regarding drug A in comparison to drug B
a) Immediate release

b) sustained release

40.Which is not used as lubricant? Ans: sodium laurel sulfate


41.Gliding definition was a question

42.Which one is true regarding Tobramycin (Aminoglycoside) effect?


Ans: Pharmacokinetics and pharmacological effect not well-understood
43.There was a case of a patient with edema and left side failure (cannot
remember full question). Answer was Furosemide
44.Drugs with Q-T prolongation is of great concern. Because the QT prolongation
may cause:
Ans: ventricular fibrilation
45.ud in a prescription means:
Ans: as directed
46.A solution requires Ca+ 5 mili equivalent per litre. How many grams of
Ca2CO4.2H2O (molecular weight was given) is required to prepare 250ml of
such solution.
47.Which secretion is not found in duodenum
a) Pancreatic secretion b) gastric content c) Adrenal gland
gland

c) salivary

48.Which one does inhibit intestinal starch and glucose absorption


a) Acarbose b) Orlistat
c) Biguanide
49.All are Atropine side effects except
Ans: Diarrhoea
50.All are bacterial diseases except:
Ans: hepatitis
51.Wart is caused by:
Ans: papilloma virus
52.Which gives fast relief in heart burn?
Ans: mg and al antacid
53.Which one is true in Iron deficiency anemia?
Ans: it causes microcytic anemia
54.There was a question regarding Blood brain barrier??
55.Genetic variation may affect the metabolism of which of the following drug??
(forgot the options)

56.Congestive Heart failure may be caused of all except:


a) ishchemic heart disease,
b) fibrillation,hypertension,
c) hematologic disorder
57.Acute prerenal failure is caused all except
a) sepsis
c) heart problem
b) hypertension
d) gentamycin
58.In angina pain goes to left wrist such pain is called
a) reffered pain
c) neuropathic
b) myopathic pain d) neorologic
59.Difference bet ipratropium and tiotropium
Ans: ipratropium is comparative short acting and tiotropium is comparatively
long active
60. Which one is true in Renal clearance?
Ans: decreased by reabsorption
61.Which one cause hyperkalemia
Ans: cell destruction cause release of potassium
62.Vit D3 is precursor of which one of the following:
Ans: 7-dehydrocholesterol
63. Grape fruit juice increases drug blood conc but Antacid decrease renal
clearance. What type of drug is it?
A) Acidic
b) Basic
c) neutral
64.

The above resonance structure makes aniline:


a) Weak basic
b) strong basic
c) weak acidic
acidic

d) strong

65.Which one is not Role of health Canada:


a) Promote public health b) develop health brochure for travellers diarrhoea
c) monitoring drugs marketed in Canada.
66. All are true regarding of Emergency contraceptive,except:
a) 1.5mg norgesterol is used
b) it is effective for unprotective intercourse
within 7 days

67. Side effect of progestin only oral contraceptive (forgot the options)
68.
69. Enterohepatic portal system connects liver with:
a) stomach b) colon
c) small intestine
70.Protein C plays role in:
a) Maintaining osmotic pressure in blood,

b) prevention of blood clotting

71.Which is the 1st symptom of ASA overdose in child


a) Vomiting b) Fever
c) acidosis
72.Which one is used as antidote of organophosphate insecticide
Ans: Atropine
73.Bisphosphonate is related to which one of the following chemical compound
Ans: pyrophosphate
74.Which nitrogenous base is present in DNA but not RNA?
Ans: Thiamine
75.In ovulation which is true:
Ans: fsh nad LH increased
76.Which type of RNA contains information of gene:
Ans: mRNA
77.Carboxyhemoglobulin is formed due to:
Ans: carbon monoxide toxicity
78.There was a question regarding Penicillin allergy to infant from mother ?????
79.Pharyngitis is responsible for the following type of bacteria:
Ans: Beta hemolytic Group A streptococcus
80.A drugs plasma conc is 4.5 microgram/ml and its concentration in breast milk
is 7.0 microgram/ml. which one is true about this drug:
Ans: the drug is basic in nature,
81.Decreased oxygen in kidney causes release:
Ans: erythropoitein
82.Bradykinin is released from: ??????
83.Which one is true regarding Tamiflue: ?????
84.Which one is the function of peroxisome:????
85.Compared to young elder patient has low serum creatinin conc. This is due
to :

Ans: low muscle mass in elderly


86.Which one is found in urine in ketoacidosis, except:
a) betahydroxy butyric acid,
b) acetoacetic acid,
c) acetone, d)
lactic acid
87.Aids patient with CD4 count ( number is given) is required for prophylaxis
treatment of which infection:
a) CMV,
b) champhylobacter jejuni,
c) Mycobacterium avium
complex
(Mycobacterium avium complex (MAC) is an opportunistic infection caused by species of
Mycobacterium that can produce severe illness in people with advanced AIDS but rarely
affects others. The risk of disseminated MAC (DMAC) is directly related to the severity of
immunosuppression. DMAC typically occurs in persons with CD4 counts of <50 cells/L,
and its frequency increases as the CD4 count declines. In the absence of antibiotic
prophylaxis, DMAC occurs in up to 40% of AIDS patients with CD4 counts of <50
cells/L. Antimicrobial therapy, especially if given in conjunction with antiretroviral
therapy (ART) that achieves immune reconstitution, can be successful in treating MAC
disease. Specific antimicrobial prophylaxis and effective ART also may be used to
prevent MAC in patients with advanced AIDS (see chapter Opportunistic Infection
Prophylaxis)
88.Question on cold sore??????
89.Which one is not recommended in osteoporosis:
a) horseback riding
b) jogging, c) walking,
weight lifting

d) basketball,

e)

90.Hemophilia related question: A woman is a carrier of Hemophilia; she had a


child from a man who is hemophilic. Which one is not true:
Ans: a girl without hemophilia or carrier of hemophilia.
91.A nucleosides is formed to nucleotide with incorporation of:
Ans: Phosphate
92.Which one is true regarding vaccination:
a) tetanus toxoid is given every 2 years upto adolescent, b) booster dose is
given.. c) pneumococcal vaccine is given annually
93.Infliximab is used in Rheumatoid arthritis. It acts as:
Ans: TNF inhibitor
94.Which one is true regarding Alzhimer disease:
Ans: decrease in Ach
95.A drug has no 1st pass effect and it mainly eliminated by hepatic metabolism.
For such type of drug, bioavailability is F = 1-X, here x means: ?????
a) E b) B c) A

96.Prodrugs require modification to be in active form. Such process is called:


a) Biotransformation
b) Bioactivation
97.All are given once daily dose, except:
a) loratidine,
b) cetirizine,
c) diphenhydramine,
fexofenadine

d)

98.For the treatment of meningocoal infection resistance is the major concern of


which drug:
a) cephazoline,
b) imipenem/cilastine,
c) Piperacillin,.
99.The dose dumping of membrane type insulin pump is due to:
Ans: rupture or imparement of membrane of the pump
100.
101.

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