CHOLINERGIC AGONISTS

Direct ABCMNP (directly stimulates, para kasi silang Ach or Nicotine)

Acetyl-ine
BethaneBBB for urinary retention, constipation to activate smooth muscles
Carbarare, for glaucoma in surgery
Metha-ine
asthma, bronchial hyperactivity
Nicotine
Pilocarpine for glaucoma (from eyes to brain = convulsions, hallucinations)
Indirect INPEPPE (ISO NEO PHYte ED in ECO PARk) (cholinesterase inhibitors)
Isoflurophate
ORGANO
Neostigmine ileus, urinary retention, CURE MG
Parathion
ORGANO
Ecothiophate
ORGANO
Physostigmine
2nd for glaucoma, antidote for atropine, phenothiazine, TCA
overdose (cataract, muscle paralysis) (PHYSO = I saw = for
glaucoma)
Pyridostigmine
MG, very long effect (3-6 hrs), increases strength
(FIRE=STRENGTH)
Edrophonium
to diagnose MG, worsens cholinergic crisis
ED diagnostician, NEO cure, DODONG maintenance
Basta organophosphates (IPE), inhibits Ach irreversibly for 1week
IE for glaucoma
Antidote is Pralidoxime, treatment is Atropine, Lavage, Charcoal
ADR is DDUMBELSS (para except sweating)
CHOLINERGIC ANTAGONISTS
Muscarinic Antagonists ASHPTC (A HOMO SCOrpion saw PIRE in the
TROPICal CYCLOne)
Atropine
blocks SLUD, doesnt cross BBB, sympathetic to, FOR brady,
fundoscopy,
GI secretions, para ndi maihi at mata, TREATMENT TO
FOR ORGANOPHOSPHATE POISONING
Atropine toxicity is DRY, HOT, RED, BLIND, MAD
NOT FOR NARROW ANGLE GLAUCOMA
Lasts 4 hours, 72 if in the eyes
Scopolamine
HomAtropine
Pirenzipine
Tropicamide
Cyclopentolate
Isama narin yung mga anti anti (HAPDi, DI Ba, THOR?)
anti Histamine
- Diphenhydramine
anti Asthma - Ipratropium
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anti Parkinson
- Benztropine
anti Depressant- Thorazine
NMJB Agents (basta may curonium for curare, plus suso ni choline)
Tubocurarine
Muscle relaxants pag galling sa curare, pababa yung effect from
face to respi
Pancuronium
Reversal is through NEO, ED, or other cholinesterase inhibitors
Atracuronium
Vecuronium
Succinylcholine
the only depolarizing agent
For muscle paralysis in surgery or mech vent
3-6 mins duration, adjuvant to general anes
ADR is Malignant Hyperthermia (parang HOT dun sa atropine)
Dantrolene ang antidote (prevents Calcium release from SR
of muscles)
Phase I: prolonged depo; Phase II: repo but blocked (antidote
is NEO)
Ganglionic Blockers HeMMaN
Hexamthonium
All of them block nicotinic neuronal receptors of both
Sympa and Para
Mecamylamine I
Rarely used
Mecamylamine
For HPN emergencies
Nicotine
Parang atropine toxicity rin

ADRENERGIC AGONIST (parang cholinergic antagonist lang)

DIRECT (Alpha, Beta, Alpha-Beta)
INDIRECT
MIXED
Alpha (CaMMP) ; Basta 1, EXCITES, 2 RELAXES
CLONidine
(A2) for Hypertension (to decrease BP), valium and opiate
withdrawal
ADR: ORTHOSTATIC HYPOTENSION, parang nag take ng valium
METHOXamine
(A1) for Hypotension (to increase BP)
METHYLdopa
PHENYLephrine
(A1) Nasal Congestion
Beta (ISO ALBus D, M.T) ; Basta 1, EXCITES, 2 RELAXES
Isoproterenol
B1 = B2 (kya nga ISO e, equal)
Same lang sa dobu pero lowers PVR
For unstable CHF and shock
ISO him, kya na SHOCK ako, muntik na ko magka CHF
Albuterol

B2 selective

Dobutamine

B1 > B2
Pampataas ng BP PERO smooth muscle relaxant, kasi B1 excites
heart, B2 relaxes lungs

Metaproterenol

B2 selective

Terbutaline

B2 selective
FOR PREMATURE LABOR

Pag B2 selective, para sa bronchial asthma and COPD, so relaxes bronchioles and
uterus
Alpha and Beta (DEN)
Dopamine
D1=D2 > B > A (wala ring B2)
For shock (vasoconstriction ng A1 and B1), ARF (vasodilation ng
D), CHF (parang ISO, pero may ARF)
Epi

all Alpha (low dose) and Beta (high dose)

Pag may block dawn g A receptors (by phenoxybenzamine),
bagsak ang BP (AKA epinephrine reversal) kasi B receptors and
activated, which are inhibitory to vascular smooth muscles

Norepi

all except B2
Reflex brady
NO CEILING DOSE
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Indirect Agonist (nagSHABU si TYRA)

Ampethamine
Can enter CNS and release Norepi and Dopamine
For ADHD and pampapayat
Tyramine
WALANG SILBI, can cause HPN emergency with MAOI (found in
red wine, beer, cheese)
MExed (Meta ni Ephe)
Metaraminol
Release NE; for hypotension
Ephedrine
Release NE; for urinary incontinence, bronchospasm,
hypotension (bale A1, B1, B2)
ADRENERGIC ANTAGONIST (Sympatholytics)
Alpha Blockers (YO! DOX PHENOX PRAZ TERAZ PHENTs? Parang Yo! Does
phoenix praise teras pants?)
Yohimbine
A2 selective, for impotence
Doxazosin
Phenoxybenzaminefor Phaeochromocytoma, BPH, HPN 2ndary to SC injury with
hyperreflexia (ortho hypo, reflex tachy)
The only A blocker that is IRREVERSIBLE
INHIBITS EJACULATION
Prazosin
Terazosin
Phentolamine
short term control of Phaeochromocytoma
Pag zosin, A1 selective, for HPN and urinary retention in BPH (1st dose ortho hypo,
dizziness, headache)
Beta Blockers (EMPPAALC olol/utol)
Esmolol
SMALL, shortest acting
Metoprolol
Propanolol
Non selective blocker
Pindolol
Some B agonistic prop, B1 selective, for HPN prone to
bradycardia
Atenolol
Acetabutol
Some B agonistic prop, B1 selective, for HPN prone to
bradycardia
Labetolol
A blocking activity, for HPN, do not use with acute CHF
Carvedilol
A blocking activity, do not use with acute CHF
Generalizations: for glaucoma; A-M is selective, N-Z non-selective
B1 blockers: blocks B2 at high doses
For HPN
Non-selective:
decrease BP and CO, cause bronchoconstriction, decrease
glycogenolysis, increase VLDL and decrease HDL, for angina, HPN,
thyroid stoem, panic attacks, migraines
B blocker toxicity
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Impotence
Exacerbation of asthma
Bradycardia
AV block
CHF
Sedation
Sleep
Indirect (RESERved GUAva)
Reserpine
may cause CNS depression and bradycardia
Guanethidine
may cause ortho hypo and sexual disfunction
Does not block A or B; blocks NE
Treats HPN